Dynamics Of Blood Cell Suspensions In Microflows PDF Download
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Author | : Annie Viallat |
Publisher | : CRC Press |
Total Pages | : 476 |
Release | : 2019-12-09 |
Genre | : Medical |
ISBN | : 1315395126 |
Download Dynamics of Blood Cell Suspensions in Microflows Book in PDF, ePub and Kindle
Blood microcirculation is essential to our bodies for the successful supply of nutrients, waste removal, oxygen delivery, homeostasis, controlling temperature, wound healing, and active immune surveillance. This book provides a physical introduction to the subject and explores how researchers can successfully describe, understand, and predict behaviours of blood flow and blood cells that are directly linked to these important physiological functions. Using practical examples, this book explains how the key concepts of physics are related to blood microcirculation and underlie the dynamic behavior of red blood cells, leukocytes, and platelets. This interdisciplinary book will be a valuable reference for researchers and graduate students in biomechanics, fluid mechanics, biomedical engineering, biological physics, and medicine. Features: The first book to provide a physical perspective of blood microcirculation Draws attention to the potential of this physical approach for novel applications in medicine Edited by specialists in this field, with chapter contributions from subject area specialists
Author | : Valerie Deplano |
Publisher | : John Wiley & Sons |
Total Pages | : 259 |
Release | : 2022-06-01 |
Genre | : Science |
ISBN | : 1119986591 |
Download Biological Flow in Large Vessels Book in PDF, ePub and Kindle
This book examines recent methods used for blood flow modeling and associated in vivo experiments, conducted using experimental data from medical imaging. Different strategies are proposed, from small-scale models to complex 3D modeling using modern computational codes. The geometries are wide-ranging and deal with the narrowing and widening of sections (stenoses, aneurysms), bifurcations, geometries associated with prosthetic elements, and even cases of vessels with smaller dimensions than those of the blood cells circulating in them. Biological Flow in Large Vessels provides answers to the question of how medical and biomechanical knowledge can be combined to address clinical problems. It offers guidance for further development of numerical models, as well as experimental protocols applied to clinical research, with tools that can be used in real-time and at the patient's bedside, for decision-making support, predicting the progression of pathologies, and planning personalized interventions.
Author | : T. Christian Gasser |
Publisher | : Elsevier |
Total Pages | : 636 |
Release | : 2024-06-18 |
Genre | : Science |
ISBN | : 0323954855 |
Download Biomechanics of the Aorta Book in PDF, ePub and Kindle
Biomechanics of the Aorta: Modelling for Patient Care is a holistic analysis of the aorta towards its biomechanical description. The book addresses topics such as physiology, clinical imaging, tissue and blood flow modeling, along with knowledge that is needed in diagnostics, aortic rupture prediction, assist surgical planning, and more. It encompasses a wide range of topics from the basic sciences (Vascular biology, Continuum mechanics, Image analysis) to clinical applications, as well as describing and presenting computational studies and experimental benches to mimic, understand and propose the best treatment of aortic pathologies. The book begins with an introduction to the fundamental aspects of the anatomy, biology and physiopathology of the aorta and proceeds to present the main computational fluid dynamic studies and biomechanical and mechanobiological models developed over the last decade. With approaches, methodologies and findings from contributors all over the world, this new volume in the Biomechanics of Living Organs series will increase understanding of aortic function as well as improve the design of medical devices and clinical interventions, including surgical procedures. Represents a comprehensive means for those involved in the aortic research and the related developments in the industry Introduces the most recent imaging technologies to characterize factors, such as aortic geometry, mechanical properties of the aortic tissue, and the local cellular activity in the vessel wall Synthesizes advances in vascular biomechanics, medical imaging and computational finite element fluid and solid models to increase understanding of aorta function
Author | : Sergey S. Shevkoplyas |
Publisher | : |
Total Pages | : 258 |
Release | : 2006 |
Genre | : |
ISBN | : |
Download Microcirculation-on-a-chip Book in PDF, ePub and Kindle
Abstract: The primary physiological function of the cardiovascular system, i.e. the delivery of oxygen and nutrients to and the removal of metabolic waste products from living tissues, is performed by the microcirculation. It is also where key events of the immune response such as leukocyte margination, rolling and subsequent diapedesis take place. Microvascular blood flow dynamics have a major impact on all of these vital processes. We used silicon micromachining and polydimethylsiloxane replica molding to create microchannel networks with dimensions and topology similar to the real microcirculation. These networks provide high quality of imaging and unprecedented control over all hemodynamically relevant parameters. We reproduced and documented a number of key blood flow dynamics and phenomena characteristic of the microcirculation in vivo using whole blood and blood cell suspensions of varying composition. This suggests the possibility to use this system as a convenient microfluidic platform for experimental studies of the mechanics of the microcirculation. The impact of blood cell rheology and interactions, plasma composition, network architecture and channel wall surface properties on microvascular network blood flow dynamics can now be addressed without interference from active biological regulation. This system will, for the first time, provide a viable bridge between computer simulations and experiments in vivo. Finally, we created a simple microfluidic device that takes advantage of plasma skimming and leukocyte margination to provide positive, continuous flow selection of leukocytes directly from microliter samples of whole blood. It produces a 34-fold enrichment of the leukocyte-to-erythrocyte ratio and requires no preliminary labeling of cells. This effortless, efficient and inexpensive technology can be used as a lab-on-a-chip component for initial whole blood sample preparation. Its integration into microanalytical devices that require leukocyte enrichment will enable accelerated transition of these devices into the field for point-of-care clinical testing.
Author | : |
Publisher | : |
Total Pages | : 446 |
Release | : 2015 |
Genre | : |
ISBN | : |
Download Study of Dynamics of Blood in Microcirculation Book in PDF, ePub and Kindle
Blood is the primary transport medium in the human body that delivers necessary substances such as nutrients and oxygen to the cells, transports metabolic waste products away from those same cells and responds to injury and inflammation. It is complex in the microstructural and mechanical sense, being multiphase non-Newtonian viscoelastic fluid. The physical nature of blood as a multiphase fluid is intimately related to its biological functions. For flow at micron scales, the concentration of red blood cells (RBCs) is higher near the center of the channel and a red cell-free layer is found near the endothelial wall. White blood cells and platelets are also distributed nonuniformly in flow, but in contrast to red cells they are preferentially found near the walls of the flow channel, a phenomenon called "margination''. Origins of the flow-induced segregation and margination is not understood and is of great application in targeted drug delivery, diagnostics, cell sorting and filtration and many other microfluidic applications. The simulation results and subsequent theoretical development done in this work points, for the first time, towards a unified understanding of how physical parameters of particles like blood component or drug carriers can affect their margination propensity and result in flow induced segregation. Most importantly, the mechanistic nature of the simplified drift-diffusion theory presented here leads to substantial and systematic insight into the origin of margination; this study will complement detailed simulations and experiments in guiding the development of technologies involving blood and other multicomponent suspensions at microscales. A novel model for RBC is presented which comprehensively captures its key membrane properties and reveal multiple dynamical modes of single RBC in shear flow. We discovered some new RBC motions and present a comprehensive phase diagram of RBC dynamics. In simulation of RBC suspension with long-chained polymer additives, polymers are seen to suppress endothelial wall-induced migration to the center of channel and shear-induced diffusion of RBCs resulting in reduced cell-free layer thickness and paradoxically the resistance to flow; explaining beneficial hemodynamic effect and improved survival seen upon addition of polymers in animal models.
Author | : Vladimir Pletser |
Publisher | : BoD – Books on Demand |
Total Pages | : 245 |
Release | : 2020-09-02 |
Genre | : Technology & Engineering |
ISBN | : 1789851386 |
Download Preparation of Space Experiments Book in PDF, ePub and Kindle
This book explains how researchers design, prepare, develop, test and fly their science experiments on microgravity platforms before sending them to space. All preparation phases are explained and presented, including aircraft parabolic flights as part of spaceflight preparation. Twenty international authors, all experts in their own microgravity research field, contribute to chapters describing their experience to prepare experiments before space flights. Fields covered are Physical Sciences and Life Sciences. Physical Sciences covers fluid physics (vibration effects on diffusion; red blood cell dynamics; cavitation in microgravity; capillary driven flows) and material sciences (electromagnetic levitator onboard International Space Station). Life Sciences includes human physiology (sampling earlobe blood; human cardiovascular experiments; tumours in space) and neurophysiology (dexterous manipulation of objects in weightlessness).
Author | : |
Publisher | : |
Total Pages | : |
Release | : 2008 |
Genre | : |
ISBN | : |
Download Particle and Blood Cell Dynamics in Oscillatory Flows Final Report Book in PDF, ePub and Kindle
Our aim has been to uncover fundamental aspects of the suspension and dislodgement of particles in wall-bounded oscillatory flows, in flows characterized by Reynolds numbers en- compassing the situation found in rivers and near shores (and perhaps in some industrial processes). Our research tools are computational and our coverage of parameter space fairly broad. Computational means circumvent many complications that make the measurement of the dynamics of particles in a laboratory setting an impractical task, especially on the broad range of parameter space we plan to report upon. The impact of this work on the geophysical problem of sedimentation is boosted considerably by the fact that the proposed calculations can be considered ab-initio, in the sense that little to no modeling is done in generating dynamics of the particles and of the moving fluid: we use a three-dimensional Navier Stokes solver along with straightforward boundry conditions. Hence, to the extent that Navier Stokes is a model for an ideal incompressible isotropic Newtonian fluid, the calculations yield benchmark values for such things as the drag, buoyancy, and lift of particles, in a highly controlled environment. Our approach will be to make measurements of the lift, drag, and buoyancy of particles, by considering progressively more complex physical configurations and physics.
Author | : University of Minnesota. Institute for Mathematics and Its Applications |
Publisher | : |
Total Pages | : 34 |
Release | : 1990 |
Genre | : |
ISBN | : |
Download Feedback, Delays and the Origin of Blood Cell Dynamics Book in PDF, ePub and Kindle
Author | : Rohan Ranganath Vernekar |
Publisher | : |
Total Pages | : |
Release | : 2019 |
Genre | : |
ISBN | : |
Download Numerical Study of Microfluidic Effects and Red Blood Cell Dynamics in 'deterministic Lateral Displacement' Geometries Book in PDF, ePub and Kindle
Author | : Devkumar Ram Sainani |
Publisher | : |
Total Pages | : 494 |
Release | : 1996 |
Genre | : Chaotic behavior in systems |
ISBN | : |
Download Nonlinear Dynamical Analysis of Microvascular Red Blood Cell Flow Book in PDF, ePub and Kindle