Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Dynamics Feedback Loops And Control In Biology From Physiological To Individual Cell Models PDF full book. Access full book title Dynamics Feedback Loops And Control In Biology From Physiological To Individual Cell Models.
| Author | : Jarosław Śmieja |
| Publisher | : |
| Total Pages | : 172 |
| Release | : 2011 |
| Genre | : |
| ISBN | : 9788373358256 |
| Author | : Andrzej Świerniak |
| Publisher | : Springer |
| Total Pages | : 241 |
| Release | : 2016-05-19 |
| Genre | : Mathematics |
| ISBN | : 3319280953 |
This book focuses on the analysis of cancer dynamics and the mathematically based synthesis of anticancer therapy. It summarizes the current state-of-the-art in this field and clarifies common misconceptions about mathematical modeling in cancer. Additionally, it encourages closer cooperation between engineers, physicians and mathematicians by showing the clear benefits of this without stating unrealistic goals. Development of therapy protocols is realized from an engineering point of view, such as the search for a solution to a specific control-optimization problem. Since in the case of cancer patients, consecutive measurements providing information about the current state of the disease are not available, the control laws are derived for an open loop structure. Different forms of therapy are incorporated into the models, from chemotherapy and antiangiogenic therapy to immunotherapy and gene therapy, but the class of models introduced is broad enough to incorporate other forms of therapy as well. The book begins with an analysis of cell cycle control, moving on to control effects on cell population and structured models and finally the signaling pathways involved in carcinogenesis and their influence on therapy outcome. It also discusses the incorporation of intracellular processes using signaling pathway models, since the successful treatment of cancer based on analysis of intracellular processes, might soon be a reality. It brings together various aspects of modeling anticancer therapies, which until now have been distributed over a wide range of literature. Written for researchers and graduate students interested in the use of mathematical and engineering tools in biomedicine with special emphasis on applications in cancer diagnosis and treatment, this self-contained book can be easily understood with only a minimal basic knowledge of control and system engineering methods as well as the biology of cancer. Its interdisciplinary character and the authors’ extensive experience in cooperating with clinicians and biologists make it interesting reading for researchers from control and system engineering looking for applications of their knowledge. Systems and molecular biologists as well as clinicians will also find new inspiration for their research.
| Author | : Rene Thomas |
| Publisher | : CRC Press |
| Total Pages | : 328 |
| Release | : 1990-09-25 |
| Genre | : Science |
| ISBN | : 9780849367663 |
Clearly explaining the logical analysis of biological control phenomena, Biological Feedback answers questions concerning everything from regulation to logic. This rare monograph presents a formal methodology for analyzing the dynamic behavior of complex systems. The easy-to-read text describes a simple logical formalization called "kinetic logic". The reader discovers how this method is used to predict all possible patterns of behavior of which a system is capable. It includes specific conditions required for each pattern. It also explains how to modify an incorrect model in order to account for the observed behavior. The authors give special attention to the two basic types of simple feedback loops: positive and negative. This volume is filled with easy-to-use tables, providing quick reference throughout the book. The subject matter is of great interest to everyone working in molecular genetics and developmental biology. Researchers, immunologists, physical chemists, physicists, electrical engineers, economists, and mathematicians will find this unique text to be an informative, indispensable resource.
| Author | : Joseph DiStefano III |
| Publisher | : Academic Press |
| Total Pages | : 886 |
| Release | : 2015-01-10 |
| Genre | : Science |
| ISBN | : 0124104932 |
Dynamic Systems Biology Modeling and Simuation consolidates and unifies classical and contemporary multiscale methodologies for mathematical modeling and computer simulation of dynamic biological systems – from molecular/cellular, organ-system, on up to population levels. The book pedagogy is developed as a well-annotated, systematic tutorial – with clearly spelled-out and unified nomenclature – derived from the author’s own modeling efforts, publications and teaching over half a century. Ambiguities in some concepts and tools are clarified and others are rendered more accessible and practical. The latter include novel qualitative theory and methodologies for recognizing dynamical signatures in data using structural (multicompartmental and network) models and graph theory; and analyzing structural and measurement (data) models for quantification feasibility. The level is basic-to-intermediate, with much emphasis on biomodeling from real biodata, for use in real applications. Introductory coverage of core mathematical concepts such as linear and nonlinear differential and difference equations, Laplace transforms, linear algebra, probability, statistics and stochastics topics The pertinent biology, biochemistry, biophysics or pharmacology for modeling are provided, to support understanding the amalgam of “math modeling” with life sciences Strong emphasis on quantifying as well as building and analyzing biomodels: includes methodology and computational tools for parameter identifiability and sensitivity analysis; parameter estimation from real data; model distinguishability and simplification; and practical bioexperiment design and optimization Companion website provides solutions and program code for examples and exercises using Matlab, Simulink, VisSim, SimBiology, SAAMII, AMIGO, Copasi and SBML-coded models A full set of PowerPoint slides are available from the author for teaching from his textbook. He uses them to teach a 10 week quarter upper division course at UCLA, which meets twice a week, so there are 20 lectures. They can easily be augmented or stretched for a 15 week semester course Importantly, the slides are editable, so they can be readily adapted to a lecturer’s personal style and course content needs. The lectures are based on excerpts from 12 of the first 13 chapters of DSBMS. They are designed to highlight the key course material, as a study guide and structure for students following the full text content The complete PowerPoint slide package (~25 MB) can be obtained by instructors (or prospective instructors) by emailing the author directly, at: [email protected]
| Author | : Susan Mertins |
| Publisher | : Frontiers Media SA |
| Total Pages | : 137 |
| Release | : 2024-08-22 |
| Genre | : Science |
| ISBN | : 283255346X |
The vast amount of knowledge in Cell Signaling gathered through reductionist efforts and omics technology is poised to approach a Systems Biology understanding of precise representations of cell structure and function and predictions at multi-scale levels despite the complexity. Super-resolution microscopy and single cell analysis are also providing opportunities to explore both spatial and temporal landscapes. Notably, many basic biological processes have been studied capturing mechanistic detail with the goal to understand cellular proliferation and differentiation, gene regulation, morphogenesis, metabolism, and cell-cell communication. Similarly, at the intracellular level, addressing functions such as self-assembly, phase separation, and transport is leading to insights not readily understood as linear pathways. Therefore, network-based mathematical modeling, delineating dynamic biochemical reactions through ordinary and partial differential equations, promises to discover emergent biological properties not heretofore expected.
| Author | : |
| Publisher | : ScholarlyEditions |
| Total Pages | : 1115 |
| Release | : 2013-05-01 |
| Genre | : Medical |
| ISBN | : 1490110585 |
Issues in Physiology, Cell Biology, and Molecular Medicine: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Experimental Physiology. The editors have built Issues in Physiology, Cell Biology, and Molecular Medicine: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Experimental Physiology in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Physiology, Cell Biology, and Molecular Medicine: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
| Author | : Robert B. Northrop |
| Publisher | : CRC Press |
| Total Pages | : 474 |
| Release | : 2020-11-26 |
| Genre | : Medical |
| ISBN | : 1000151808 |
From a biomedical engineering perspective, this book takes an analytic, quantitative approach to describing the basic components of physiological regulators and control systems (PRCs). In Endogenous and Exogenous Regulation and Control of Physiological Systems, the author provides grounding in the classical methods of designing linear and nonlinear systems. He also offers state-of-the-art material on the potential of PRCs to treat immune system ailments, most notably AIDS and cancer. The book focuses on certain "wet" physiological regulators, such as those using endocrine hormones as parametric control substances. Endogenous and Exogenous Regulation and Control of Physiological Systems includes simulations that illustrate model validations and the putative control of cancer and HIV proliferation. It explores novel, untried immunotherapies on the cutting-edge of PRC treatment and explores the latest technologies.
| Author | : Pablo A. Iglesias |
| Publisher | : MIT Press |
| Total Pages | : 359 |
| Release | : 2010 |
| Genre | : Biological control systems |
| ISBN | : 0262013347 |
A survey of how engineering techniques from control and systems theory can be used to help biologists understand the behavior of cellular systems.
| Author | : Shigui Ruan |
| Publisher | : American Mathematical Soc. |
| Total Pages | : 524 |
| Release | : |
| Genre | : Science |
| ISBN | : 9780821871294 |
This book presents the proceedings from the International Conference held in Halifax, NS in July 1997. Funded by The Fields Institute and Le Centre de Recherches Mathématiques, the conference was held in honor of the retirement of Professors Lynn Erbe and Herb I. Freedman (University of Alberta). Featured topics include ordinary, partial, functional, and stochastic differential equations and their applications to biology, epidemiology, neurobiology, physiology and other related areas. The 41 papers included in this volume represent the recent work of leading researchers over a wide range of subjects, including bifurcation theory, chaos, stability theory, boundary value problems, persistence theory, neural networks, disease transmission, population dynamics, pattern formation and more. The text would be suitable for a graduate or advanced undergraduate course study in mathematical biology. Features: An overview of current developments in differential equations and mathematical biology. Authoritative contributions from over 60 leading worldwide researchers. Original, refereed contributions.
| Author | : Brian C. Goodwin |
| Publisher | : |
| Total Pages | : 268 |
| Release | : 1976 |
| Genre | : Science |
| ISBN | : |
