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Dynamical Biostatistical Models

Dynamical Biostatistical Models
Author: Daniel Commenges
Publisher: CRC Press
Total Pages: 391
Release: 2015-10-02
Genre: Mathematics
ISBN: 1498729681

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Dynamical Biostatistical Models presents statistical models and methods for the analysis of longitudinal data. The book focuses on models for analyzing repeated measures of quantitative and qualitative variables and events history, including survival and multistate models. Most of the advanced methods, such as multistate and joint models, can be ap


Statistical Methods for Modeling Human Dynamics

Statistical Methods for Modeling Human Dynamics
Author: Sy-Miin Chow
Publisher: Taylor & Francis
Total Pages: 445
Release: 2011-02-25
Genre: Psychology
ISBN: 1135262594

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This interdisciplinary volume features contributions from researchers in the fields of psychology, neuroscience, statistics, computer science, and physics. State-of-the-art techniques and applications used to analyze data obtained from studies in cognition, emotion, and electrophysiology are reviewed along with techniques for modeling in real time and for examining lifespan cognitive changes, for conceptualizing change using item response, nonparametric and hierarchical models, and control theory-inspired techniques for deriving diagnoses in medical and psychotherapeutic settings. The syntax for running the analyses presented in the book is provided on the Psychology Press site. Most of the programs are written in R while others are for Matlab, SAS, Win-BUGS, and DyFA. Readers will appreciate a review of the latest methodological techniques developed in the last few years. Highlights include an examination of: Statistical and mathematical modeling techniques for the analysis of brain imaging such as EEGs, fMRIs, and other neuroscience data Dynamic modeling techniques for intensive repeated measurement data Panel modeling techniques for fewer time points data State-space modeling techniques for psychological data Techniques used to analyze reaction time data. Each chapter features an introductory overview of the techniques needed to understand the chapter, a summary, and numerous examples. Each self-contained chapter can be read on its own and in any order. Divided into three major sections, the book examines techniques for examining within-person derivations in change patterns, intra-individual change, and inter-individual differences in change and interpersonal dynamics. Intended for advanced students and researchers, this book will appeal to those interested in applying state-of-the-art dynamic modeling techniques to the the study of neurological, developmental, cognitive, and social/personality psychology, as well as neuroscience, computer science, and engineering.


Dynamic Models in Biology

Dynamic Models in Biology
Author: Stephen P. Ellner
Publisher: Princeton University Press
Total Pages: 352
Release: 2011-09-19
Genre: Science
ISBN: 1400840961

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From controlling disease outbreaks to predicting heart attacks, dynamic models are increasingly crucial for understanding biological processes. Many universities are starting undergraduate programs in computational biology to introduce students to this rapidly growing field. In Dynamic Models in Biology, the first text on dynamic models specifically written for undergraduate students in the biological sciences, ecologist Stephen Ellner and mathematician John Guckenheimer teach students how to understand, build, and use dynamic models in biology. Developed from a course taught by Ellner and Guckenheimer at Cornell University, the book is organized around biological applications, with mathematics and computing developed through case studies at the molecular, cellular, and population levels. The authors cover both simple analytic models--the sort usually found in mathematical biology texts--and the complex computational models now used by both biologists and mathematicians. Linked to a Web site with computer-lab materials and exercises, Dynamic Models in Biology is a major new introduction to dynamic models for students in the biological sciences, mathematics, and engineering.


Handbook of Statistical Systems Biology

Handbook of Statistical Systems Biology
Author: Michael Stumpf
Publisher: John Wiley & Sons
Total Pages: 624
Release: 2011-09-09
Genre: Science
ISBN: 1119952042

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Systems Biology is now entering a mature phase in which the key issues are characterising uncertainty and stochastic effects in mathematical models of biological systems. The area is moving towards a full statistical analysis and probabilistic reasoning over the inferences that can be made from mathematical models. This handbook presents a comprehensive guide to the discipline for practitioners and educators, in providing a full and detailed treatment of these important and emerging subjects. Leading experts in systems biology and statistics have come together to provide insight in to the major ideas in the field, and in particular methods of specifying and fitting models, and estimating the unknown parameters. This book: Provides a comprehensive account of inference techniques in systems biology. Introduces classical and Bayesian statistical methods for complex systems. Explores networks and graphical modeling as well as a wide range of statistical models for dynamical systems. Discusses various applications for statistical systems biology, such as gene regulation and signal transduction. Features statistical data analysis on numerous technologies, including metabolic and transcriptomic technologies. Presents an in-depth presentation of reverse engineering approaches. Provides colour illustrations to explain key concepts. This handbook will be a key resource for researchers practising systems biology, and those requiring a comprehensive overview of this important field.


Advances in Complex Data Modeling and Computational Methods in Statistics

Advances in Complex Data Modeling and Computational Methods in Statistics
Author: Anna Maria Paganoni
Publisher: Springer
Total Pages: 210
Release: 2014-11-04
Genre: Mathematics
ISBN: 3319111493

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The book is addressed to statisticians working at the forefront of the statistical analysis of complex and high dimensional data and offers a wide variety of statistical models, computer intensive methods and applications: network inference from the analysis of high dimensional data; new developments for bootstrapping complex data; regression analysis for measuring the downsize reputational risk; statistical methods for research on the human genome dynamics; inference in non-euclidean settings and for shape data; Bayesian methods for reliability and the analysis of complex data; methodological issues in using administrative data for clinical and epidemiological research; regression models with differential regularization; geostatistical methods for mobility analysis through mobile phone data exploration. This volume is the result of a careful selection among the contributions presented at the conference "S.Co.2013: Complex data modeling and computationally intensive methods for estimation and prediction" held at the Politecnico di Milano, 2013. All the papers published here have been rigorously peer-reviewed.


Statistical Methods for Dynamic Treatment Regimes

Statistical Methods for Dynamic Treatment Regimes
Author: Bibhas Chakraborty
Publisher: Springer Science & Business Media
Total Pages: 220
Release: 2013-07-23
Genre: Medical
ISBN: 1461474280

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Statistical Methods for Dynamic Treatment Regimes shares state of the art of statistical methods developed to address questions of estimation and inference for dynamic treatment regimes, a branch of personalized medicine. This volume demonstrates these methods with their conceptual underpinnings and illustration through analysis of real and simulated data. These methods are immediately applicable to the practice of personalized medicine, which is a medical paradigm that emphasizes the systematic use of individual patient information to optimize patient health care. This is the first single source to provide an overview of methodology and results gathered from journals, proceedings, and technical reports with the goal of orienting researchers to the field. The first chapter establishes context for the statistical reader in the landscape of personalized medicine. Readers need only have familiarity with elementary calculus, linear algebra, and basic large-sample theory to use this text. Throughout the text, authors direct readers to available code or packages in different statistical languages to facilitate implementation. In cases where code does not already exist, the authors provide analytic approaches in sufficient detail that any researcher with knowledge of statistical programming could implement the methods from scratch. This will be an important volume for a wide range of researchers, including statisticians, epidemiologists, medical researchers, and machine learning researchers interested in medical applications. Advanced graduate students in statistics and biostatistics will also find material in Statistical Methods for Dynamic Treatment Regimes to be a critical part of their studies.


Models of Science Dynamics

Models of Science Dynamics
Author: Andrea Scharnhorst
Publisher: Springer Science & Business Media
Total Pages: 292
Release: 2012-01-24
Genre: Social Science
ISBN: 3642230687

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Models of Science Dynamics aims to capture the structure and evolution of science, the emerging arena in which scholars, science and the communication of science become themselves the basic objects of research. In order to capture the essence of phenomena as diverse as the structure of co-authorship networks or the evolution of citation diffusion patterns, such models can be represented by conceptual models based on historical and ethnographic observations, mathematical descriptions of measurable phenomena, or computational algorithms. Despite its evident importance, the mathematical modeling of science still lacks a unifying framework and a comprehensive study of the topic. This volume fills this gap, reviewing and describing major threads in the mathematical modeling of science dynamics for a wider academic and professional audience. The model classes presented cover stochastic and statistical models, system-dynamics approaches, agent-based simulations, population-dynamics models, and complex-network models. The book comprises an introduction and a foundational chapter that defines and operationalizes terminology used in the study of science, as well as a review chapter that discusses the history of mathematical approaches to modeling science from an algorithmic-historiography perspective. It concludes with a survey of remaining challenges for future science models and their relevance for science and science policy.


Introduction to Statistical Modelling

Introduction to Statistical Modelling
Author: Annette J. Dobson
Publisher: Springer
Total Pages: 133
Release: 2013-11-11
Genre: Mathematics
ISBN: 1489931740

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This book is about generalized linear models as described by NeIder and Wedderburn (1972). This approach provides a unified theoretical and computational framework for the most commonly used statistical methods: regression, analysis of variance and covariance, logistic regression, log-linear models for contingency tables and several more specialized techniques. More advanced expositions of the subject are given by McCullagh and NeIder (1983) and Andersen (1980). The emphasis is on the use of statistical models to investigate substantive questions rather than to produce mathematical descriptions of the data. Therefore parameter estimation and hypothesis testing are stressed. I have assumed that the reader is familiar with the most commonly used statistical concepts and methods and has some basic knowledge of calculus and matrix algebra. Short numerical examples are used to illustrate the main points. In writing this book I have been helped greatly by the comments and criticism of my students and colleagues, especially Anne Young. However, the choice of material, and the obscurities and errors are my responsibility and I apologize to the reader for any irritation caused by them. For typing the manuscript under difficult conditions I am grateful to Anne McKim, Jan Garnsey, Cath Claydon and Julie Latimer.


Bayesian Forecasting and Dynamic Models

Bayesian Forecasting and Dynamic Models
Author: Mike West
Publisher: Springer
Total Pages: 682
Release: 1999-03-26
Genre: Mathematics
ISBN: 0387947256

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This text is concerned with Bayesian learning, inference and forecasting in dynamic environments. We describe the structure and theory of classes of dynamic models and their uses in forecasting and time series analysis. The principles, models and methods of Bayesian forecasting and time - ries analysis have been developed extensively during the last thirty years. Thisdevelopmenthasinvolvedthoroughinvestigationofmathematicaland statistical aspects of forecasting models and related techniques. With this has come experience with applications in a variety of areas in commercial, industrial, scienti?c, and socio-economic ?elds. Much of the technical - velopment has been driven by the needs of forecasting practitioners and applied researchers. As a result, there now exists a relatively complete statistical and mathematical framework, presented and illustrated here. In writing and revising this book, our primary goals have been to present a reasonably comprehensive view of Bayesian ideas and methods in m- elling and forecasting, particularly to provide a solid reference source for advanced university students and research workers.