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Dynamic Deformation and Mechanical Properties of Brain Tissue

Dynamic Deformation and Mechanical Properties of Brain Tissue
Author: Yuan Feng
Publisher:
Total Pages: 147
Release: 2012
Genre: Electronic dissertations
ISBN:

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Traumatic brain injury is an important medical problem affecting millions of people. Mathematical models of brain biomechanics are being developed to simulate the mechanics of brain injury and to design protective devices. However, because of a lack of quantitative data on brain-skull boundary conditions and deformations, the predictions of mathematical models remain uncertain. The objectives of this dissertation are to develop methods and obtain experimental data that will be used to parameterize and validate models of traumatic brain injury. To that end, this dissertation first addresses the brain-skull boundary conditions by measuring human brain motion using tagged magnetic resonance imaging. Magnetic resonance elastography was performed in the ferret brain to measure its mechanical properties in vivo. Brain tissue is not only heterogeneous, but may also be anisotropic. To characterize tissue anisotropy, an experimental procedure combining both shear testing and indentation was developed and applied to white matter and gray matter. These measurements of brain-skull interactions and mechanical properties of the brain will be valuable in the development and validation of finite element simulations of brain biomechanics.


Mechanosensitivity of the Nervous System

Mechanosensitivity of the Nervous System
Author: Andre Kamkin
Publisher: Springer Science & Business Media
Total Pages: 355
Release: 2008-09-22
Genre: Science
ISBN: 1402087160

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This book presents the latest findings in mechanosensitivity of the nervous system. The nervous system stands out from a number of tissues because besides reacting to the mechanical stress it is transmitting its own response to other organs and tissues, which are located downstream of its signaling pathway. For this reason any type of mechanical stimulation of the nervous system, which is capable of triggering a physiological response, has high scientific and practical significance, since it allows its use beyond a particular experimental model anywhere where it is contributing to a particular pathological condition. This book is a unique collection of reviews outlining the current knowledge and the future developments in this rapidly growing field. Currently, investigations of the effects of mechanical stress on the nervous system are focused on several issues. The majority of studies investigate the effects of mechanical stimulation on mechanosensitive channels, as its primary target and interactive agent, and aim on description of downstream intracellular signaling pathways together with addressing general issues of biomechanics of the nervous system. Knowledge of biomechanics, and mechanisms, which underlie it on organism, organ, tissue and cellular level, is necessary for understanding of the normal functioning of living organisms and allows to predict changes which arise due to alterations of their environment, and possibly will allow to develop new methods of artificial intervention. The book brings up the problem closer to the experts in related medical and biological sciences as well as practicing doctors besides just presenting the latest achievements in the field.


ASME 69-BHF-6

ASME 69-BHF-6
Author: G. T. Fallenstein
Publisher:
Total Pages: 8
Release: 1969
Genre: Brain
ISBN:

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Biomechanics of the Brain

Biomechanics of the Brain
Author: Karol Miller
Publisher: Springer
Total Pages: 353
Release: 2019-08-08
Genre: Science
ISBN: 3030049965

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This new edition presents an authoritative account of the current state of brain biomechanics research for engineers, scientists and medical professionals. Since the first edition in 2011, this topic has unquestionably entered into the mainstream of biomechanical research. The book brings together leading scientists in the diverse fields of anatomy, neuroimaging, image-guided neurosurgery, brain injury, solid and fluid mechanics, mathematical modelling and computer simulation to paint an inclusive picture of the rapidly evolving field. Covering topics from brain anatomy and imaging to sophisticated methods of modeling brain injury and neurosurgery (including the most recent applications of biomechanics to treat epilepsy), to the cutting edge methods in analyzing cerebrospinal fluid and blood flow, this book is the comprehensive reference in the field. Experienced researchers as well as students will find this book useful.


Magnetic Resonance Elastography

Magnetic Resonance Elastography
Author: Sudhakar K. Venkatesh
Publisher: Springer
Total Pages: 143
Release: 2014-10-01
Genre: Medical
ISBN: 1493915754

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The first book to cover the groundbreaking development and clinical applications of Magnetic Resonance Elastography, this book is essential for all practitioners interested in this revolutionary diagnostic modality. The book is divided into three sections. The first covers the history of MRE. The second covers technique and clinical applications of MRE in the liver with respect to fibrosis, liver masses, and other diseases. Case descriptions are presented to give the reader a hands-on approach. The final section presents the techniques, sequence and preliminary results of applications in other areas of the body including muscle, brain, lung, heart, and breast.


Neural Tissue Biomechanics

Neural Tissue Biomechanics
Author: Lynne E. Bilston
Publisher: Springer Science & Business Media
Total Pages: 288
Release: 2011-07-23
Genre: Technology & Engineering
ISBN: 364213890X

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Damage to the central nervous system resulting from pathological mechanical loading can occur as a result of trauma or disease. Such injuries lead to significant disability and mortality. The peripheral nervous system, while also subject to injury from trauma and disease, also transduces physiological loading to give rise to sensation, and mechanotransduction is also thought to play a role in neural development and growth. This book gives a complete and quantitative description of the fundamental mechanical properties of neural tissues, and their responses to both physiological and pathological loading. This book reviews the methods used to characterize the nonlinear viscoelastic properties of central and peripheral neural tissues, and the mathematical and sophisticated computational models used to describe this behaviour. Mechanisms and models of neural injury from both trauma and disease are reviewed from the molecular to macroscopic scale. The book provides a comprehensive picture of the mechanical and biological response of neural tissues to the full spectrum of mechanical loading to which they are exposed. This book provides a comprehensive reference for professionals involved in pre prevention of injury to the nervous system, whether this arises from trauma or disease.


Dynamic Behavior of Materials, Volume 1

Dynamic Behavior of Materials, Volume 1
Author: Tom Proulx
Publisher: Springer Science & Business Media
Total Pages: 455
Release: 2011-03-31
Genre: Technology & Engineering
ISBN: 1441982280

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Dynamic Behavior of Materials, Volume 1: Proceedings of the 2010 Annual Conference on Experimental and Applied Mechanics, the first volume of six from the Conference, brings together 71 contributions to this important area of research and engineering. The collection presents early findings and case studies on fundamental and applied aspects of Materials Science, including papers on Composite Materials, Dynamic Failure and Fracture, Dynamic Materials Response, Novel Testing Techniques, Low Impedance Materials, Metallic Materials, Response of Brittle Materials, Time Dependent Materials, High Strain Rate Testing of Biological and Soft Materials, Shock and High Pressure Response, Energetic Materials, Optical Techniques for Imaging High Strain Rate Material Response, and Modeling of Dynamic Response.


Handbook of Biomaterial Properties

Handbook of Biomaterial Properties
Author: William Murphy
Publisher: Springer
Total Pages: 676
Release: 2016-06-11
Genre: Technology & Engineering
ISBN: 1493933051

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This book provides tabular and text data relating to normal and diseased tissue materials and materials used in medical devices. Comprehensive and practical for students, researchers, engineers, and practicing physicians who use implants, this book considers the materials aspects of both implantable materials and natural tissues and fluids. Examples of materials and topics covered include titanium, elastomers, degradable biomaterials, composites, scaffold materials for tissue engineering, dental implants, sterilization effects on material properties, metallic alloys, and much more. Each chapter author considers the intrinsic and interactive properties of biomaterials, as well as their appropriate applications and historical contexts. Now in an updated second edition, this book also contains two new chapters on the cornea and on vocal folds, as well as updated insights, data, and citations for several chapters.


Structure-Based Mechanics of Tissues and Organs

Structure-Based Mechanics of Tissues and Organs
Author: Ghassan S. Kassab
Publisher: Springer
Total Pages: 491
Release: 2016-01-28
Genre: Science
ISBN: 1489976302

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This book portrays the commonality of tissue micro-structure that dictates physiological function in various organs (microstructure-function relation). Tissue and organ models are used to illustrate physiological functions based on microstructure. Fiber scale properties such as orientation and crimp are described in detail. Structurally-based constitutive models are given throughout the book, not only to avoid ambiguities in material characterization, but also to offer insights into the function, structure, and mechanics of tissue components. A statement of future directions of the field is also given, including how advancements, such as state-of-the-art computational modeling and optical measurements of tissue/cells structures, are taking structure-based modeling to the next level. This book also: Provides a comprehensive view of tissue modeling across multiple systems Broadens readers’ understanding of state-of-the-art computational modeling and optical measurements of tissue/cells structures Describes in detail fiber scale properties such as orientation and crimp


Noback's Human Nervous System, Seventh Edition

Noback's Human Nervous System, Seventh Edition
Author: Norman L. Strominger
Publisher: Springer Science & Business Media
Total Pages: 481
Release: 2012-06-07
Genre: Medical
ISBN: 1617797790

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With this seventh edition, Noback’s Human Nervous System: Structure and Function continues to combine clear prose with exceptional original illustrations that provide a concise lucid depiction of the human nervous system. The book incorporates recent advances in neurobiology and molecular biology. Several chapters have been substantially revised. These include Development and Growth, Blood Circulation and Imaging, Cranial Nerves and Chemical Senses, Auditory and Vestibular Systems, Visual System, and Cerebral Cortex. Topics such as neural regeneration, plasticity and brain imaging are discussed. Each edition of The Human Nervous System has featured a set of outstanding illustrations drawn by premier medical artist Robert J. Demarest. Many of the figures from past editions have been modified and/or enhanced by the addition of color, which provides a more detailed visualization of the nervous system. Highly praised in its earlier versions, this new edition offers medical, dental, allied health science and psychology students a readily understandable and organized view of the bewilderingly complex awe-inspiring human nervous system. Its explanatory power and visual insight make this book an indispensable source of quick understanding that readers will consult gratefully again and again.