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Author | : Peter Curtis-Prior |
Publisher | : John Wiley & Sons |
Total Pages | : 654 |
Release | : 2004-07-16 |
Genre | : Medical |
ISBN | : 047002061X |
Download The Eicosanoids Book in PDF, ePub and Kindle
This comprehensive reference work, updated from the first edition, brings together the knowledge and expertise of contributors from around the world. It includes new topics such as prostaglandin synthetase enzyme, new synthetic eicosanoids, innovative analytical methods, the influence of cytokines in the regulation of synthesis and actions, newer eicosanoids that influence the cardiovascular system, and newly discovered roles in reproduction and interactions with nitric oxide. This book satisfies a surge of interest in prostaglandins—NSAIDS (e.g. aspirin) are the biggest selling drugs of all time, and the field has been refreshed by the advent of new types (selective COX-2 inhibitors, anti-leukotiene drugs).
Author | : Hugh Young |
Publisher | : Springer Science & Business Media |
Total Pages | : 431 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 9401106797 |
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Author | : C.N. Serhan |
Publisher | : Springer Science & Business Media |
Total Pages | : 286 |
Release | : 2013-03-14 |
Genre | : Science |
ISBN | : 3662040476 |
Download Advances in Eicosanoid Research Book in PDF, ePub and Kindle
Over the last few years, we have witnessed tremendous progress in the field of eicosanoids and their therapeutic applications. Receptor an tagonists for leukotrienes have been tested as anti-inflammatories and are on the market as a treatment for asthma. Receptor agonists for pro stacyclin are being tested for the treatment of peripheral vascular dis ease, and selective inhibitors of cyclooxygenase type II were just ap proved for the treatment of rheumatoid arthritis. All these developments are the culmination of many years and man-hours of careful research. The field has now entered an upswing that will result in novel thera peutic applications within the next 10 years. New molecules and me diators have been identified, new enzymes and pathways elucidated and new therapeutic approaches have emerged. The concept of ei cosanoids as "pro-inflammatory" molecules is being challenged, and their role as regulators is increasingly recognized. In fact, some of these molecules may be important endogenous anti-inflammatory agents.
Author | : Giancarlo C. Folco |
Publisher | : Springer Science & Business Media |
Total Pages | : 208 |
Release | : 2013-06-29 |
Genre | : Medical |
ISBN | : 1489902007 |
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Proceedings of a NATO ASI held in Erice, Italy, April 27-May 1, 1995.
Author | : A. L. Willis |
Publisher | : CRC Press |
Total Pages | : 288 |
Release | : 2017-11-22 |
Genre | : Medical |
ISBN | : 1351363212 |
Download Handbook of Eicosanoids (1987) Book in PDF, ePub and Kindle
Building upon the extensive compilation of biochemical data featured in Volume I of the Handbook of Eicosanoids, the new Volume II describes the past, present, and potential future impact of eicosanoid research on new drug development. The reader is taken from a historical perspective through state-of-the-art basic concepts to extensive tabulation of molecular structures of compounds known to act via the eicosanoid system. Much emphasis is given to recent breakthroughs in the mechanism of action of anti-inflammatory corticosteroids and the development of receptor antagonists for prostaglandins and leukotrienes. There is also an introductory chapter that proposes areas that require further investigation and novel approaches using existing technology. This handbook will thus be invaluable for medicinal chemists, pharmacologists, and all those involved in basic research in the eicosanoid area. In addition, many parts of this handbook are suitable for use by university lecturers and students. There are 20 figures and 44 extensive tables as well as a bibliography containing more than 2,000 references that complement the text.
Author | : A. L. Willis |
Publisher | : CRC Press |
Total Pages | : 455 |
Release | : 2017-11-22 |
Genre | : Medical |
ISBN | : 1351363263 |
Download Handbook of Eicosanoids (1987) Book in PDF, ePub and Kindle
Building upon the extensive compilation of biochemical data featured in Volume I of the Handbook of Eicosanoids, the new Volume II describes the past, present, and potential future impact of eicosanoid research on new drug development. The reader is taken from a historical perspective through state-of-the-art basic concepts to extensive tabulation of molecular structures of compounds known to act via the eicosanoid system. Much emphasis is given to recent breakthroughs in the mechanism of action of anti-inflammatory corticosteroids and the development of receptor antagonists for prostaglandins and leukotrienes. There is also an introductory chapter that proposes areas that require further investigation and novel approaches using existing technology. This handbook will thus be invaluable for medicinal chemists, pharmacologists, and all those involved in basic research in the eicosanoid area. In addition, many parts of this handbook are suitable for use by university lecturers and students. There are 20 figures and 44 extensive tables as well as a bibliography containing more than 2,000 references that complement the text.
Author | : M.K. Church |
Publisher | : Springer Science & Business Media |
Total Pages | : 231 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 9400912838 |
Download Eicosanoids in Inflammatory Conditions of the Lung, Skin and Joints Book in PDF, ePub and Kindle
The original series, Advances in Prostaglandin Research, edited by Sultan M. M. Karim, was published by MTP Press in three volumes in 1975 and 1976. A glance at those books illustrates the progress that has been made since then. The thromboxanes were mentioned twice (first publication 1975) and prostacyclin not once (first publication 1976); leukotrienes were only on the horizon. The amazing generation of research data in the last 10-15 years has given new, broad insights into many areas, including asthma, inflammation, renal, cardiovascular and gastrointestinal diseases and in reproduction, and has led in some instances to real clinical benefit. This series, Advances in Eicosanoid Research, reflects the current understanding of prostaglandins, thromboxanes and leukotrienes. The aim is to provide an introductory background to each topic and the most up-to-date information available. Although each book stands alone, the eicosanoids cut across many boundaries in their basic actions; selected chapters from each book in the series will provide illuminating and productive information for all readers which will advance their education and research. In the production of this series, I must acknowledge with pleasure my collaboration with editors and authors and the patient endeavours of Dr Michael Brewis and the staff at MTP Press.
Author | : Bengt Samuelsson |
Publisher | : Springer |
Total Pages | : 412 |
Release | : 1985 |
Genre | : Medical |
ISBN | : |
Download Drugs Affecting Leukotrienes and Other Eicosanoid Pathways Book in PDF, ePub and Kindle
Author | : K. Hillier |
Publisher | : Springer Science & Business Media |
Total Pages | : 229 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 9400912811 |
Download Eicosanoids and the Gastrointestinal Tract Book in PDF, ePub and Kindle
The original series, Advances in Prostaglandin Research, edited by Sultan M. M. Karim, was published by MTP Press in three volumes in 1975 and 1976. A glance at those books illustrates the progress that has been made since then. The thromboxanes were mentioned twice (first publication 1975) and prostacyclin not once (first publication 1976); leukotrienes were only on the horizon. The amazing generation of research data in the last 10-15 years has given new, broad insights into many areas, including asthma, inflammation, renaL cardiovascular and gastrointestinal diseases and in reproduction, and has led in some instances to real clinical benefit. This series,AdvancesinEicosanoidResearch, reflects the current understanding of prostaglandins, thromboxanes and leukotrienes. The aim is to provide an introductory background to each topic and the most up-to-date information available. Although each book stands alone, the eicosanoids cut across many boundaries in their basic actions; selected chapters from each book in the Series will provide illuminating and productive information for all readers which will advance their education and research. In the production of this series, I must acknowledge with pleasure my collaboration with editors and authors and the patient endeavours of Dr. Michael Brewis and the staff at MTP Press.
Author | : B. Samuelson |
Publisher | : Springer Science & Business Media |
Total Pages | : 258 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 1468479385 |
Download Prostanoids and Drugs Book in PDF, ePub and Kindle
This volume, the sixth in the series "The Prostaglandin System" assembles most of the lecture notes from the International School of Pharmacology on "Prostanoids and Drugs" that took place in Erice, Sicily, at the "Ettore Majorana Center for Scientific Culture" on Sept 5-15, 1989. The course, which was a NATO Advanced Study Institute, comprised detailed discussion of basic metabolic pathways of arachidonic acid as well as their location in the everyday practice of clinical medicine. The current status of our knowledge on drugs affecting prostanoid metabolic pathways, and/or their functinal effects, together with the use of prostanoids as drugs, has been reviewed in depth by distinguished experts. In certain instances a few chapters might overlap with others to present divergent viewpoints of authors, for a better assessment of the complexity of eicosanoid biology. It is likely that as our knowledge of prostanoids in different diseases increases, new diseases may also be targets for drugs related to these lipid mediators. We hope that this boo~will encourage basic scientists and clinicians to pursue additional biomedical investigations along these lines of inquiry. Moreover we would like to take this opportunity to express our gratitude to all the invited speakers not only for their important contributions before and during the course but also for their ability in creating an atmosphere in which all questions were legitimate and all lines of investigations were encouraged.