Drugs as Teratogens
Author | : James L. Schardein |
Publisher | : |
Total Pages | : 318 |
Release | : 1976 |
Genre | : Medical |
ISBN | : |
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Author | : James L. Schardein |
Publisher | : |
Total Pages | : 318 |
Release | : 1976 |
Genre | : Medical |
ISBN | : |
Author | : Thomas H. Shepard |
Publisher | : JHU Press |
Total Pages | : 564 |
Release | : 2004 |
Genre | : Teratogenic agents |
ISBN | : 9780801879531 |
Links information on experimental teratogenic agents with the congenital defects in human beings.
Author | : T.V.N. Persaud |
Publisher | : Springer Science & Business Media |
Total Pages | : 240 |
Release | : 2012-12-06 |
Genre | : Science |
ISBN | : 9401159106 |
The study of birth defects has assumed an importance even greater now than in the past because mortality rates attributed to congenital anomalies have declined far less than those for other causes of death, such as infectious and nutritional diseases. It is estimated that as many as 50% of all pregnancies terminate as miscarriages. In the majority of cases this is the result of faulty development. Major congenital malformations are found in at least 2% of all liveborn infants, and 22% of all stillbirths and infant deaths are associated with severe congenital anomalies. Teratological studies of an experimental nature are neither ethical nor justifiable in humans. Numerous investigations have been carried out in laboratory animals and other experimental models in order to improve our understanding of abnormal intra-uterine development. In less than two decades the field of experimental teratology has advanced phenomenally. As a result of the wide range of information that is now accumulating, it has become possible to obtain an insight into the causes, mechanisms and prevention of birth defects. However, considerable work will be needed before these problems can be resolved. This book brings together some of the more recent and important research findings related to the mechanisms and pathogenesis of abnormal develop ment. It is not only a documentation of the latest experimental work, but it also points out future directions that seem productive and challenging.
Author | : Jan Marshall Friedman |
Publisher | : |
Total Pages | : 816 |
Release | : 2000 |
Genre | : Medical |
ISBN | : |
"This new edition will continue to serve as a reference for use by clinical and research geneticists, teratologists, obstetricians, and pediatricians."--BOOK JACKET.
Author | : Alison Fiander |
Publisher | : Cambridge University Press |
Total Pages | : 557 |
Release | : 2016-10-13 |
Genre | : Education |
ISBN | : 1107667135 |
A fully updated and illustrated handbook providing comprehensive coverage of all curriculum areas covered by the MRCOG Part 1 examination.
Author | : Jennifer R. Niebyl |
Publisher | : |
Total Pages | : 264 |
Release | : 1988 |
Genre | : Chemotherapy |
ISBN | : |
Abstract: This book addresses the use of drug groups for various clinical indications during pregnancy. In general, non-pharmacologic remedies are recommended if these will suffice before drug therapy is instituted. Known adverse effects of drugs are documented and caution is advised because of the many unknowns about long-term effects of drug exposure to the developing fetus. Drugs used for the common cold, antituberculosis agents, antihypertensives, anticonvulsants, and marijuana and cocaine are included.
Author | : Brian L. Strom |
Publisher | : John Wiley & Sons |
Total Pages | : 1220 |
Release | : 2019-12-16 |
Genre | : Medical |
ISBN | : 1119413419 |
This classic, field-defining textbook, now in its sixth edition, provides the most comprehensive guidance available for anyone needing up-to-date information in pharmacoepidemiology. This edition has been fully revised and updated throughout and continues to provide a rounded view on all perspectives from academia, industry and regulatory bodies, addressing data sources, applications and methodologies with great clarity.
Author | : Agency for Healthcare Research and Quality/AHRQ |
Publisher | : Government Printing Office |
Total Pages | : 396 |
Release | : 2014-04-01 |
Genre | : Medical |
ISBN | : 1587634333 |
This User’s Guide is intended to support the design, implementation, analysis, interpretation, and quality evaluation of registries created to increase understanding of patient outcomes. For the purposes of this guide, a patient registry is an organized system that uses observational study methods to collect uniform data (clinical and other) to evaluate specified outcomes for a population defined by a particular disease, condition, or exposure, and that serves one or more predetermined scientific, clinical, or policy purposes. A registry database is a file (or files) derived from the registry. Although registries can serve many purposes, this guide focuses on registries created for one or more of the following purposes: to describe the natural history of disease, to determine clinical effectiveness or cost-effectiveness of health care products and services, to measure or monitor safety and harm, and/or to measure quality of care. Registries are classified according to how their populations are defined. For example, product registries include patients who have been exposed to biopharmaceutical products or medical devices. Health services registries consist of patients who have had a common procedure, clinical encounter, or hospitalization. Disease or condition registries are defined by patients having the same diagnosis, such as cystic fibrosis or heart failure. The User’s Guide was created by researchers affiliated with AHRQ’s Effective Health Care Program, particularly those who participated in AHRQ’s DEcIDE (Developing Evidence to Inform Decisions About Effectiveness) program. Chapters were subject to multiple internal and external independent reviews.
Author | : Edith Louise Potter |
Publisher | : Mosby |
Total Pages | : 1074 |
Release | : 2007 |
Genre | : Medical |
ISBN | : |
This comprehensive reference addresses all aspects of fetal and neonatal pathology, including complicated pregnancies, multiple pregnancies, abortion, placental pathology, and disorders affecting the full-term neonate. A consistent organization allows for quick access to specific guidance, and nearly 2,500 illustrations - 2,350 in full color - depict conditions and abnormalities as they present in practice, facilitating diagnosis. An Image Bank on CD-ROM - new to this edition - features all of the illustrations from the 2-volume set, downloadable for presentations. Offers comprehensive coverage of all common and rare embryonic, fetal, and infant disorders in one source. Correlates clinical, pathologic, and genetic findings for each systemic disease. Emphasizes the genetic and molecular basis of birth defects. Features nearly 2,500 illustrations - 2,350 in full color - which depict each abnormality or condition as they present in practice. Presents practical information on autopsy techniques and protocols. Provides the latest guidance on molecular pathology, immunohistochemistry, DNA technology, and more. Offers an expanded discussion of developmental biology related to the pathogenesis of birth defects. Features user-friendly summary tables and diagnostic flow charts, making information quick and easy to find. Includes a CD-ROM featuring all of the illustrations from the 2-volume set.
Author | : Miriam Melis |
Publisher | : Academic Press |
Total Pages | : 362 |
Release | : 2022-08-18 |
Genre | : Psychology |
ISBN | : 0128236418 |
Marijuana is the most commonly used psychotropic drug in the United States, after alcohol. With the legalization and decriminalization of cannabis, momentum continues to build and propelled by the reduction of stigma associated to its consumption, there is growing concern regarding the long-term impact on brain function and behavior. Cannabis and the Developing Brain aims to provide comprehensive research on the effects of cannabis during neurodevelopment stages (i.e., perinatal and adolescent ages). This book introduces readers to vivo neural circuits, molecular and cellular mechanisms affected by cannabis exposure during three different temporal windows of brain vulnerability. Second, it offers a unique insight to shared neurobiological features of cannabinoid exposure during different developmental periods. Lastly, Cannabis and the Developing Brain determines the adverse impact of developmental cannabinoid exposure on specific cognition, emotion and behaviors. Reviews exposure effects on different areas and circuits of the brain Identifies effects of exposure at prenatal, perinatal, infant, and adolescent ages Includes cannabis interaction with known genetic and environmental risk factors Contains neurodevelopment and neuropsychiatric disorders associated with cannabis exposure