Drug Discovery For Leishmaniasis PDF Download
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| Author | : Luis Rivas |
| Publisher | : Royal Society of Chemistry |
| Total Pages | : 422 |
| Release | : 2017-10-26 |
| Genre | : Science |
| ISBN | : 1788012585 |
Download Drug Discovery for Leishmaniasis Book in PDF, ePub and Kindle
For human health, leishmaniasis is among the most important protozoan diseases, superseded only by malaria. Globally, 10 to 12 million people are infected with 1.5 million new cases every year. The development of cheaper new drugs is urgently needed for this neglected disease that is developing resistance to current treatments. Chemotherapy remains the only treatment option for the bulk of patients. However, this is largely unaffordable for most. In the past three years numerous advances in drug discovery have been made for treating this disease by exploiting diverging metabolic pathways between the Leishmania enzymes and their hosts, using nanotechnology to target the immune cell phagolysosomes where Leishmania resides. Drug Discovery for Leishmaniasis aims to provide a perspective of the current treatments and their challenges, blended with the emerging strategies and methodologies that will drive new target appraisals and drug developments, as well as addressing the molecular basis of resistance in Leishmania. Recent studies have shown that leishmaniasis affects some of the poorest people in the world, with 95% of fatal cases occurring in only 6 countries. With the WHO goal of eliminating this public health problem in the South-east Asia Region by 2020, this book will be important for anyone who is interested in neglected tropical diseases.
| Author | : Taís Fontoura de Almeida |
| Publisher | : Frontiers Media SA |
| Total Pages | : 133 |
| Release | : 2024-05-15 |
| Genre | : Science |
| ISBN | : 2832548997 |
Download Strategies in the drug discovery and development for leishmaniasis: immunomodulators, natural products, synthetic compounds, and drug repositioning Book in PDF, ePub and Kindle
Leishmaniases are a group of tropical diseases that affect millions of people worldwide. They are considered neglected diseases prevalent in emerging countries in Latin America, West Africa, and Southeast Asia and still occurring in Mediterranean countries. There is no human vaccine available to prevent and control the disease infection. For the last 70 years, the available chemotherapy has been constituted by first-line (pentavalent antimonials) and second-line drugs (amphotericin B, pentamidine, paramomycin, and miltefosine). Its route of administration is difficult, the treatment is long, and its efficiency varies depending on the parasite species and clinical manifestations, which results in the emergence of resistant cases. Moreover, they present high toxicity to patients, and even some less toxic formulations available, are still expensive for the poorest countries’ vulnerable populations. This often leads to abandonment and failure of treatment. The medical-scientific community is facing difficulties to overcome these issues with new suitable therapies, and the identification of new drug targets. So, it means that efforts to identify new strategies must continue.
| Author | : Mukesh Samant |
| Publisher | : Academic Press |
| Total Pages | : 281 |
| Release | : 2021-08-18 |
| Genre | : Medical |
| ISBN | : 0128227982 |
Download Pathogenesis, Treatment and Prevention of Leishmaniasis Book in PDF, ePub and Kindle
Leishmaniasis is a neglected tropical disease that is known to be transmitted by 90 different species of sandflies which carry 20 Leishmania species that cause human infection particularly in endemic countries. Pathogenesis, Treatment, and Prevention of Leishmaniasis aims to provide information on this vector-borne disease and explore strategies for diagnosis and treatment. The book begins with an overview of leishmaniasis which includes historical and future perspectives of the disease. It also discusses the clinical manifestation of the disease, mechanisms of infection, therapeutic strategies, diagnostics, prevention, and cure of Leishmania parasite. The book goes on to explain new insights and challenges in the development of promising drug targets, biomarkers identification and advance vaccination strategies against leishmaniasis. Chapter contributions brings together diverse areas of expertise making Pathogenesis, Treatment, and Prevention of Leishmaniasis aims to bring together elements of leishmaniasis into one place and be a valuable resource for researchers, health care professionals, and graduate students, working in the field of leishmaniasis. Provides an overview Leishmania and leishmanisis which include its history, transmission, clinical picture, and treatment Discusses novel approaches to study parasite infection and treatment Explores recent advances in the development of diagnostic kits, drug development and various vaccination strategies
| Author | : Alicia Ponte-Sucre |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 458 |
| Release | : 2012-09-04 |
| Genre | : Medical |
| ISBN | : 3709111250 |
Download Drug Resistance in Leishmania Parasites Book in PDF, ePub and Kindle
One of the main problems concerning therapeutic tools for the treatment of parasitic diseases, including leishmaniasis, is that some field parasites are naturally resistant to the classical drugs; additionally, current therapies may select parasites prone to be resistant to the applied drugs. These features are (at least partially) responsible for the disappointing persistence of the disease and resultant deaths worldwide. This book provides a comprehensive view of the pathology of the disease itself, and of parasitic drug resistance, its molecular basis, consequences and possible treatments. Scientists both from academic fields and from the industry involved in biomedical research and drug design, will find in this book a valuable and fundamental guide that conveys the knowledge needed to understand and to improve the success in combating this disease worldwide.
| Author | : Gildardo Rivera |
| Publisher | : Frontiers Media SA |
| Total Pages | : 171 |
| Release | : 2021-12-20 |
| Genre | : Science |
| ISBN | : 2889717925 |
Download Discovery and Development of Drugs for Neglected Diseases: Chagas Disease, Human African Trypanosomiasis, and Leishmaniasis Book in PDF, ePub and Kindle
| Author | : Andrés F. Flórez |
| Publisher | : |
| Total Pages | : |
| Release | : 2012 |
| Genre | : |
| ISBN | : 9789535102748 |
Download Current Advances in Computational Strategies for Drug Discovery in Leishmaniasis Book in PDF, ePub and Kindle
| Author | : Madhu Dikshit |
| Publisher | : Springer |
| Total Pages | : 0 |
| Release | : 2022-02-11 |
| Genre | : Medical |
| ISBN | : 9789811580048 |
Download Drug Discovery and Drug Development Book in PDF, ePub and Kindle
Over the years, India has attained a prominent global position in the manufacture of Generic Drugs. This success can be attributed to its synthetic organic chemistry and chemical engineering strengths, nurtured by the timely policies of the Government of India. However, breakthrough successes in New Drug Discovery have remained elusive, despite the brilliant and sustained efforts of many Indian researchers and Pharma establishments. The Indian National Science Academy thought it appropriate to document India’s New Drug Discovery Research (NDDR) journey to date. Gathering contributions from prominent researchers in the Indian Pharma Industry and Academia, this book highlights their efforts, achievements, and the status quo of Indian NDDR.
| Author | : Atta-ur-Rahman |
| Publisher | : Bentham Science Publishers |
| Total Pages | : 370 |
| Release | : 2013-09-15 |
| Genre | : Medical |
| ISBN | : 160805912X |
Download Frontiers in Anti-Infective Drug Discovery Book in PDF, ePub and Kindle
This ebook series brings updated reviews to readers interested in advances in the development of anti-infective drug design and discovery. The scope of the ebook series covers a range of topics including rational drug design and drug discovery, medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. Frontiers in Anti-Infective Drug Discovery is a valuable resource for pharmaceutical scientists and post-graduate students seeking updated and critically important information for developing clinical trials and devising research plans in this field. The third volume of this series features 6 chapters that cover a variety of topics including: - Drug Discovery for TB - Therapeutic Limitations due to Antibiotic Drug Resistance - Applications for Virus Vaccine Vectors in Infectious Disease Research - NewCastle Disease Virus - Anti-Infective Therapy Against Leishmaniasis - Anti-Viral Activity of Proanthocyanidins.
| Author | : Timo Jäger |
| Publisher | : John Wiley & Sons |
| Total Pages | : 850 |
| Release | : 2013-03-19 |
| Genre | : Medical |
| ISBN | : 3527670408 |
Download Trypanosomatid Diseases Book in PDF, ePub and Kindle
This is the first resource to provide researchers in academia and industry with an urgently needed update on drug intervention against trypanosomatides. As such, it covers every aspect of the topic from basic research findings, via current treatments to translational approaches in drug development and includes both human and livestock diseases. The outstanding editor and contributor team reads like a Who?s Who of the field, thus guaranteeing the outstanding quality of this ready reference.
| Author | : David Claborn |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 538 |
| Release | : 2014-03-19 |
| Genre | : Medical |
| ISBN | : 9535112325 |
Download Leishmaniasis Book in PDF, ePub and Kindle
Of all the parasitic diseases, leishmaniasis is one of the most diverse, with a variety of manifestations, from relatively minor cutaneous lesions to deadly visceral infections. It is also widespread, causing human disease in the Americas, Asia, Europe and Africa. The environments in which this disease occurs range from desert to tropical jungle to urban habitats. Not surprisingly, the literature on this disease is written in a variety of languages including Portuguese, Arabic, English and French among others. This book provides a synopsis in English of much of the recent research on leishmaniasis, with a focus on the epidemiology, diagnosis and treatment of the disease as described by researchers around the world, but with a focus on the research from Brazil and the Middle East.
