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| Author | : Richard B. Silverman |
| Publisher | : Elsevier |
| Total Pages | : 650 |
| Release | : 2012-12-02 |
| Genre | : Science |
| ISBN | : 0080513379 |
Download The Organic Chemistry of Drug Design and Drug Action Book in PDF, ePub and Kindle
Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that allow the reader to extrapolate to many related classes of drug molecules. The Second Edition reflects the significant changes in the drug industry over the past decade, and includes chapter problems and other elements that make the book more useful for course instruction. New edition includes new chapter problems and exercises to help students learn, plus extensive references and illustrations Clearly presents an organic chemist's perspective of how drugs are designed and function, incorporating the extensive changes in the drug industry over the past ten years Well-respected author has published over 200 articles, earned 21 patents, and invented a drug that is under consideration for commercialization
| Author | : Richard B. Silverman |
| Publisher | : Academic Press |
| Total Pages | : 537 |
| Release | : 2014-03-29 |
| Genre | : Medical |
| ISBN | : 0123820316 |
Download The Organic Chemistry of Drug Design and Drug Action Book in PDF, ePub and Kindle
The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition includes updates to all chapters, including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage. This text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries. Updates to all chapters, including new examples and references Chapter 1 (Introduction): Completely rewritten and expanded as an overview of topics discussed in detail throughout the book Chapter 2 (Lead Discovery and Lead Modification): Sections on sources of compounds for screening including library collections, virtual screening, and computational methods, as well as hit-to-lead and scaffold hopping; expanded sections on sources of lead compounds, fragment-based lead discovery, and molecular graphics; and deemphasized solid-phase synthesis and combinatorial chemistry Chapter 3 (Receptors): Drug-receptor interactions, cation-p and halogen bonding; atropisomers; case history of the insomnia drug suvorexant Chapter 4 (Enzymes): Expanded sections on enzyme catalysis in drug discovery and enzyme synthesis Chapter 5 (Enzyme Inhibition and Inactivation): New case histories: for competitive inhibition, the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib and Abelson kinase inhibitor, imatinib for transition state analogue inhibition, the purine nucleoside phosphorylase inhibitors, forodesine and DADMe-ImmH, as well as the mechanism of the multisubstrate analog inhibitor isoniazid for slow, tight-binding inhibition, the dipeptidyl peptidase-4 inhibitor, saxagliptin Chapter 7 (Drug Resistance and Drug Synergism): This new chapter includes topics taken from two chapters in the previous edition, with many new examples Chapter 8 (Drug Metabolism): Discussions of toxicophores and reactive metabolites Chapter 9 (Prodrugs and Drug Delivery Systems): Discussion of antibody–drug conjugates
| Author | : Richard B. Silverman |
| Publisher | : Elsevier |
| Total Pages | : 437 |
| Release | : 2012-12-02 |
| Genre | : Science |
| ISBN | : 0080571239 |
Download The Organic Chemistry of Drug Design and Drug Action Book in PDF, ePub and Kindle
This is a new approach to the teaching of medicinal chemistry. The knowledge of the physical organic chemical basis of drug design and drug action allows the reader to extrapolate to the many related classes of drugs described in standard medicinal chemistry texts. Students gain a solid foundation to base future research endeavors upon: drugs not yet developed are thus covered! n Emphasizes the use of the principles of physical organic chemistry as a basis for drug design n Discusses organic reaction mechanisms of clinically important drugs with mechanistic schemes n Uses figures and literature references extensively throughout n This text is not merely a "compilation of drugs and uses," but features selected drugs as examples of the organic chemical basis for any and all drug design applications
| Author | : H. John Smith |
| Publisher | : CRC Press |
| Total Pages | : 863 |
| Release | : 2005-10-10 |
| Genre | : Medical |
| ISBN | : 1135299757 |
Download Smith and Williams' Introduction to the Principles of Drug Design and Action Book in PDF, ePub and Kindle
Advances in knowledge and technology have revolutionized the process of drug development, making it possible to design drugs for a given target or disease. Building on the foundation laid by the previous three editions, Smith and Williams Introduction to the Principles of Drug Design and Action, Fourth Edition includes the latest informatio
| Author | : Gerhard Klebe |
| Publisher | : Springer |
| Total Pages | : 0 |
| Release | : 2013-07-10 |
| Genre | : Medical |
| ISBN | : 9783642179068 |
Download Drug Design Book in PDF, ePub and Kindle
Unique work on structure-based drug design, covering multiple aspects of drug discovery and development. Fully colored, many images, computer animations of 3D structures (these only in electronic form). Makes the spatial aspects of interacting molecules clear to the reader, covers multiple applications and methods in drug design. Structures by mode of action, no therapeutic areas. Of high relevance for academia and industrial research. Focus on gene technology in drug design, omics-technologies computational methods experimental techniques of structure determination multiple examples on mode of action of current drugs, ADME-tox properties in drug development, QSAR methods, combinatorial chemistry, biologicals, ribosome, targeting protein-protein interfaces.
| Author | : Victor E. Marquez |
| Publisher | : CRC Press |
| Total Pages | : 566 |
| Release | : 2021-11-15 |
| Genre | : Medical |
| ISBN | : 1000462943 |
Download The Ups and Downs in Drug Design Book in PDF, ePub and Kindle
The Ups and Downs in Drug Design: Adventures in Medicinal Chemistry highlights the necessity for an integrative approach in medicinal chemistry and chemical biology. As medicinal chemistry is not a monolithic science, it is important to emphasize the other various disciplines that are required for successful drug design. This book presents the author’s own personal experience in this field and describes the "ups" and "downs" that come with drug discovery. It is an excellent companion text for graduate and postgraduate students who would like further insight into the parameters of drug design, including the challenges that come with the project. Key Features Illustrates "real-life" examples in medicinal chemistry Integrates the use of physical, chemical, and biological concepts that are important in drug design Highlights the "ups" and "downs" that come with drug discovery Aims to inspire students who may be struggling with the challenges and thought process in drug design Intends to be an excellent companion text for graduate and postgraduate students
| Author | : Joaquín M. Campos Rosa |
| Publisher | : Walter de Gruyter GmbH & Co KG |
| Total Pages | : 302 |
| Release | : 2023-12-18 |
| Genre | : Technology & Engineering |
| ISBN | : 3111317218 |
Download Drug Design and Action Book in PDF, ePub and Kindle
A slow and consistent study of the approaches for drug design can help the foundation for a good scientific intuition. This edition includes over 30 new illustrations, numerous new mechanistic schemes and enhanced original figures. In addition, the use of color makes its study more pleasant and impressive. The Second Edition has been thoroughly revised with a modern look. The chapters on QSAR and Drug Metabolism have been extended, emphasizing concepts, such as the hyperconjugative effect or the anomeric effect, in which the student normally finds it difficult to understand. Stereoelectronic effects are essential to explain the mechanism of action of drugs and therefore, its agile and intuitive handling will allow the student access to both chemical and biological mechanisms, in a more rational way. The text is illustrated with hundreds of formulas and many tables that facilitate the understanding of this interesting discipline, which is halfway between Organic Chemistry, Biochemistry and Pharmacology. This Volume is aimed at building basis principles on drug design and it is likely to be of interest to students reading, pharmacy, pharmacology, and pharmaceutical chemistry. This book emphasizes general principles of drug design and drug action from an organic chemical perspective, rather than from the overview of specific classes of drugs, allowing the reader to extrapolate information to many related classes of drug molecules. This volume presents an organic chemistry’s perspective of how drug are designed and assuming no prior knowledge of biochemistry, and pharmacology. It is written in an informal, clear style so that undergraduates can easily understand the concepts presented.
| Author | : János Fischer |
| Publisher | : John Wiley & Sons |
| Total Pages | : 258 |
| Release | : 2015-05-04 |
| Genre | : Medical |
| ISBN | : 3527336850 |
Download Successful Drug Discovery, Volume 1 Book in PDF, ePub and Kindle
The first volume of the book series "Successful Drug Discovery" is focusing on new drug discoveries during the last decade, from established drugs to recently introduced drugs of all kinds: small-molecule-, peptide-, and protein-based drugs. The role of serendipity is analyzed in some very successful drugs where the research targets of the lead molecule and the drug are different. Phenotypic and target-based drug discovery approaches are discussed from the viewpoint of pioneer drugs and analogues. This volume gives an excellent overview of insulin analogues including a discussion of the properties of rapid-acting and long-acting formulations of this important hormone. The major part of the book is devoted to case histories of new drug discoveries described by their key inventors. Eight case histories range across many therapeutic fields. The goal of this book series is to help the participants of the drug research community with a reference book series and to support teaching in medicinal chemistry with case histories and review articles of new drugs.
| Author | : Richard B. Silverman |
| Publisher | : Academic Press |
| Total Pages | : |
| Release | : 2005-01-19 |
| Genre | : Medical |
| ISBN | : 9780126437331 |
Download The Organic Chemistry of Drug Design and Drug Action Book in PDF, ePub and Kindle
This CD-ROM edition of Silverman's Organic Chemisry of Drug Design and Drug Action, Second Edition reflects the significant changes in the drug industry in recent years, using an accessible interactive approach. This CD-ROM integrates the author's own PowerPoint slides, indexed and linked to the book pages in PDF format. The three-part structure includes an all-electronic text with full-text search capabilites and nearly 800 powerpoint slides. This is a unique and powerful combination of electronic study guide and full book pages. Users can hyperlink seamlessly from the main text to key points and figures on the outline and back again. It serves as a wonderful supplement for instructors as well as a fully integrated text and study aid for students. * Three-part package includes 1) powerpoint, 2) integrated powerpoint and pdf-based text, and 3) fully searchable PDF-based text with index * Includes new full-color illustrations, structures, schemes, and figures as well as extensive chapter problems and exercises * User-friendly buttons transition from overview (study-guide) format to corresponding book page and back with the click of a mouse * Full-text search capabality an incomparable tool for researchers seeking specific references and/or unindexed phrases
| Author | : Joaquín M. Campos Rosa |
| Publisher | : Walter de Gruyter GmbH & Co KG |
| Total Pages | : 302 |
| Release | : 2023-12-18 |
| Genre | : Technology & Engineering |
| ISBN | : 3111317218 |
Download Drug Design and Action Book in PDF, ePub and Kindle
A slow and consistent study of the approaches for drug design can help the foundation for a good scientific intuition. This edition includes over 30 new illustrations, numerous new mechanistic schemes and enhanced original figures. In addition, the use of color makes its study more pleasant and impressive. The Second Edition has been thoroughly revised with a modern look. The chapters on QSAR and Drug Metabolism have been extended, emphasizing concepts, such as the hyperconjugative effect or the anomeric effect, in which the student normally finds it difficult to understand. Stereoelectronic effects are essential to explain the mechanism of action of drugs and therefore, its agile and intuitive handling will allow the student access to both chemical and biological mechanisms, in a more rational way. The text is illustrated with hundreds of formulas and many tables that facilitate the understanding of this interesting discipline, which is halfway between Organic Chemistry, Biochemistry and Pharmacology. This Volume is aimed at building basis principles on drug design and it is likely to be of interest to students reading, pharmacy, pharmacology, and pharmaceutical chemistry. This book emphasizes general principles of drug design and drug action from an organic chemical perspective, rather than from the overview of specific classes of drugs, allowing the reader to extrapolate information to many related classes of drug molecules. This volume presents an organic chemistry’s perspective of how drug are designed and assuming no prior knowledge of biochemistry, and pharmacology. It is written in an informal, clear style so that undergraduates can easily understand the concepts presented.
