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| Author | : Mark Schena |
| Publisher | : Practical Approach Series |
| Total Pages | : 236 |
| Release | : 1999 |
| Genre | : Medical |
| ISBN | : 9780199637768 |
Download DNA Microarrays Book in PDF, ePub and Kindle
DNA Microarrays: A Practical Approach is the first comprehensive overview of an exciting and powerful new technology. DNA microarrays, or biochips, are small glass chips embedded with ordered rows of DNA, providing a massive parallel platform for data gathering and representing a fundamental technical advance in biomedical research. Such biochips gather data at an unprecedented rate by enabling the use of advanced fabrication, detection, and data mining technologies. Written and edited by experts in the field, this book provides fascinating insight into this remarkable advancement. It opens with an introduction to the technology of DNA microarrays, emphasizing the methodological fundamentals of biochips, and continues with descriptions of the use of confocal scanning in microarray detection and techniques for the efficient cloning and screening of differentially expressed genes. The chapters address many topics, among them assay optimization, antisense scanning arrays, the manufacture of molecular arrays, and gene expression analysis. Also addressed are the uses of expression data in bioinformatics, of active microelectronic arrays for DNA hybridization analysis, and of microarray technology in pharmacogenomics. DNA Microarrays: A Practical Approach is ideal for researchers investigating patterns of gene expression (and the relationship with disease), and it is essential for any researcher interested in the use of biochips.
| Author | : David B. Allison |
| Publisher | : CRC Press |
| Total Pages | : 391 |
| Release | : 2005-11-14 |
| Genre | : Mathematics |
| ISBN | : 1420028790 |
Download DNA Microarrays and Related Genomics Techniques Book in PDF, ePub and Kindle
Considered highly exotic tools as recently as the late 1990s, microarrays are now ubiquitous in biological research. Traditional statistical approaches to design and analysis were not developed to handle the high-dimensional, small sample problems posed by microarrays. In just a few short years the number of statistical papers providing approaches
| Author | : Mark Schena |
| Publisher | : Scion Publishing Ltd |
| Total Pages | : 289 |
| Release | : 2007-10-01 |
| Genre | : Science |
| ISBN | : 1907904395 |
Download DNA Microarrays Book in PDF, ePub and Kindle
DNA Microarrays: Methods Express covers the very latest in DNA microarray technology, with a clear focus on how these techniques can be used in the lab to gain the very best results. The authors are from some of the leading laboratories in the field and write with real authority on the latest methodology. Every chapter provides detailed step-by-step protocols with valuable hints and tips for success, as well as giving typical experimental results and selected literature citations. This book is a 'must have' manual for researchers in all fields of biology, medicine and agriculture.
| Author | : Steen Knudsen |
| Publisher | : John Wiley & Sons |
| Total Pages | : 148 |
| Release | : 2011-09-23 |
| Genre | : Science |
| ISBN | : 0471461180 |
Download A Biologist's Guide to Analysis of DNA Microarray Data Book in PDF, ePub and Kindle
A great introductory book that details reliable approaches to problems met in standard microarray data analyses. It provides examples of established approaches such as cluster analysis, function prediction, and principle component analysis. Discover real examples to illustrate the key concepts of data analysis. Written for those without any advanced background in math, statistics, or computer sciences, this book is essential for anyone interested in harnessing the immense potential of microarrays in biology and medicine.
| Author | : Pierre Baldi |
| Publisher | : Cambridge University Press |
| Total Pages | : 238 |
| Release | : 2011-04-28 |
| Genre | : Science |
| ISBN | : 9781139437608 |
Download DNA Microarrays and Gene Expression Book in PDF, ePub and Kindle
Massive data acquisition technologies, such as genome sequencing, high-throughput drug screening, and DNA arrays are in the process of revolutionizing biology and medicine. Using the mRNA of a given cell, at a given time, under a given set of conditions, DNA microarrays can provide a snapshot of the level of expression of all the genes in the cell. Such snapshots can be used to study fundamental biological phenomena such as development or evolution, to determine the function of new genes, to infer the role individual genes or groups of genes may play in diseases, and to monitor the effect of drugs and other compounds on gene expression. Originally published in 2002, this inter-disciplinary introduction to DNA arrays will be of value to anyone with an a interest in this powerful technology.
| Author | : Steen Knudsen |
| Publisher | : John Wiley & Sons |
| Total Pages | : 194 |
| Release | : 2005-03-04 |
| Genre | : Science |
| ISBN | : 047167026X |
Download Guide to Analysis of DNA Microarray Data Book in PDF, ePub and Kindle
Written for biologists and medical researchers who don't have any special training in data analysis and statistics, Guide to Analysis of DNA Microarray Data, Second Edition begins where DNA array equipment leaves off: the image produced by the microarray. The text deals with the questions that arise starting at this point, providing an introduction to microarray technology, then moving on to image analysis, data analysis, cluster analysis, and beyond. With all chapters rewritten, updated, and expanded to include the latest generation of technology and methods, Guide to Analysis of DNA Microarray Data, Second Edition offers practitioners reliable information using concrete examples and a clear, comprehensible style. This Second Edition features entirely new chapters on: * Image analysis * Experiment design * Automated analysis, integrated analysis, and systems biology * Interpretation of results Intended for readers seeking practical applications, this text covers a broad spectrum of proven approaches in this rapidly growing technology. Additional features include further reading suggestions for each chapter, as well as a thorough review of available analysis software.
| Author | : B.R. Jordan |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 139 |
| Release | : 2013-12-01 |
| Genre | : Medical |
| ISBN | : 3642565174 |
Download DNA Microarrays: Gene Expression Applications Book in PDF, ePub and Kindle
This complete and practical manual on expression measurement using DNA arrays covers the existing methods (from nylon macroarrays to oligonucleotide chips) and includes detailed protocols. It has been written by practising scientists who have experienced the difficulties involved in actually using microarrays, and provides helpful advice and hints on setting up these powerful but sometimes tricky methods. Software, data mining procedures and probable future developments, which should be useful to any practising scientist interested in expression measurement, are also covered in this book.
| Author | : Dhammika Amaratunga |
| Publisher | : John Wiley & Sons |
| Total Pages | : 320 |
| Release | : 2014-01-27 |
| Genre | : Mathematics |
| ISBN | : 111836452X |
Download Exploration and Analysis of DNA Microarray and Other High-Dimensional Data Book in PDF, ePub and Kindle
Praise for the First Edition “...extremely well written...a comprehensive and up-to-date overview of this important field.” – Journal of Environmental Quality Exploration and Analysis of DNA Microarray and Other High-Dimensional Data, Second Edition provides comprehensive coverage of recent advancements in microarray data analysis. A cutting-edge guide, the Second Edition demonstrates various methodologies for analyzing data in biomedical research and offers an overview of the modern techniques used in microarray technology to study patterns of gene activity. The new edition answers the need for an efficient outline of all phases of this revolutionary analytical technique, from preprocessing to the analysis stage. Utilizing research and experience from highly-qualified authors in fields of data analysis, Exploration and Analysis of DNA Microarray and Other High-Dimensional Data, Second Edition features: A new chapter on the interpretation of findings that includes a discussion of signatures and material on gene set analysis, including network analysis New topics of coverage including ABC clustering, biclustering, partial least squares, penalized methods, ensemble methods, and enriched ensemble methods Updated exercises to deepen knowledge of the presented material and provide readers with resources for further study The book is an ideal reference for scientists in biomedical and genomics research fields who analyze DNA microarrays and protein array data, as well as statisticians and bioinformatics practitioners. Exploration and Analysis of DNA Microarray and Other High-Dimensional Data, Second Edition is also a useful text for graduate-level courses on statistics, computational biology, and bioinformatics.
| Author | : |
| Publisher | : Elsevier |
| Total Pages | : 506 |
| Release | : 2006-08-28 |
| Genre | : Science |
| ISBN | : 0080464661 |
Download DNA Microarrays, Part B: Databases and Statistics Book in PDF, ePub and Kindle
Modern DNA microarray technologies have evolved over the past 25 years to the point where it is now possible to take many million measurements from a single experiment. These two volumes, Parts A & B in the Methods in Enzymology series provide methods that will shepard any molecular biologist through the process of planning, performing, and publishing microarray results. Part A starts with an overview of a number of microarray platforms, both commercial and academically produced and includes wet bench protocols for performing traditional expression analysis and derivative techniques such as detection of transcription factor occupancy and chromatin status. Wet-bench protocols and troubleshooting techniques continue into Part B. These techniques are well rooted in traditional molecular biology and while they require traditional care, a researcher that can reproducibly generate beautiful Northern or Southern blots should have no difficulty generating beautiful array hybridizations. Data management is a more recent problem for most biologists. The bulk of Part B provides a range of techniques for data handling. This includes critical issues, from normalization within and between arrays, to uploading your results to the public repositories for array data, and how to integrate data from multiple sources. There are chapters in Part B for both the debutant and the expert bioinformatician. Provides an overview of platforms Includes experimental design and wet bench protocols Presents statistical and data analysis methods, array databases, data visualization and meta analysis
| Author | : Jang B. Rampal |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 268 |
| Release | : 2008-02-02 |
| Genre | : Science |
| ISBN | : 1592592341 |
Download DNA Arrays Book in PDF, ePub and Kindle
Microarray technology provides a highly sensitive and precise te- nique for obtaining information from biological samples, with the added advantage that it can handle a large number of samples simultaneously that may be analyzed rapidly. Researchers are applying microarray technology to understand gene expression, mutation analysis, and the sequencing of genes. Although this technology has been experimental, and thus has been through feasibility studies, it has just recently entered into widespread use for advanced research. The purpose of DNA Arrays: Methods and Protocols is to provide instruction in designing and constructing DNA arrays, as well as hybridizing them with biological samples for analysis. An additional purpose is to p- vide the reader with a broad description of DNA-based array technology and its potential applications. This volume also covers the history of DNA arrays—from their conception to their ready off-the-shelf availability—for readers who are new to array technology as well as those who are well versed in this field. Stepwise, detailed experimental procedures are described for constructing DNA arrays, including the choice of solid support, attachment methods, and the general conditions for hybridization. With microarray technology, ordered arrays of oligonucleotides or other DNA sequences are attached or printed to the solid support using au- mated methods for array synthesis. Probe sequences are selected in such a way that they have the appropriate sequence length, site of mutation, and T .
