Discovery Dmpk Quick Guide PDF Download
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Author | : S. Cyrus Khojasteh |
Publisher | : |
Total Pages | : 0 |
Release | : 2022 |
Genre | : |
ISBN | : 9783031106927 |
Download Discovery DMPK Quick Guide Book in PDF, ePub and Kindle
This book is intended for a broad readership, in particular, those working or interested in drug discovery coming from various disciplines such as medicinal chemistry, pharmacology, drug metabolism and pharmacokinetics, bioanalysis, clinical sciences, biochemistry, pharmaceutics, and toxicology. It provides, for the first time, a completely integrated look at multiple aspects of ADME sciences (absorption, distribution, metabolism, and excretion) in a summary format that is clear, concise, and self-explanatory. DMPK in Drug Discovery - Guide to Data Interpretation and integration leverages the prior knowledge from the first book that covers the basics of each concept (Drug Metabolism and Pharmacokinetics Quick Guide). This reference book is meant to be used day to day and provides many useful tables (used for data interpretation), figures, and case studies that can facilitate drug discovery. The case studies are intended to be short and relevant to the topic discussed and present another dimension to the discussions.
Author | : S. Cyrus Khojasteh |
Publisher | : Springer Nature |
Total Pages | : 241 |
Release | : 2022-12-12 |
Genre | : Medical |
ISBN | : 3031106911 |
Download Discovery DMPK Quick Guide Book in PDF, ePub and Kindle
This book is intended for a broad readership, in particular, those working or interested in drug discovery coming from various disciplines such as medicinal chemistry, pharmacology, drug metabolism and pharmacokinetics, bioanalysis, clinical sciences, biochemistry, pharmaceutics, and toxicology. It provides, for the first time, a completely integrated look at multiple aspects of ADME sciences (absorption, distribution, metabolism, and excretion) in a summary format that is clear, concise, and self-explanatory. DMPK in Drug Discovery - Guide to Data Interpretation and integration leverages the prior knowledge from the first book that covers the basics of each concept (Drug Metabolism and Pharmacokinetics Quick Guide). This reference book is meant to be used day to day and provides many useful tables (used for data interpretation), figures, and case studies that can facilitate drug discovery. The case studies are intended to be short and relevant to the topic discussed and present another dimension to the discussions.
Author | : Siamak Cyrus Khojasteh |
Publisher | : Springer Science & Business Media |
Total Pages | : 222 |
Release | : 2011-04-07 |
Genre | : Medical |
ISBN | : 1441956298 |
Download Drug Metabolism and Pharmacokinetics Quick Guide Book in PDF, ePub and Kindle
Drug Metabolism and Pharmacokinetics Quick Guide covers a number of aspects of drug assessment at drug discovery and development stages, topics such as pharmacokinetics, absorption, metabolism, enzyme kinetics, drug transporters, drug interactions, drug-like properties, assays and in silico calculations. It covers key concepts, with useful tables on physiological parameters (eg. blood flow to organs in x-species, expression and localization of enzymes and transporters), chemical structure, nomenclature, and moieties leading to bioactivation (with examples). Overall it includes a number of key topics useful at the drug discovery stage, which would serve as a quick reference with several examples from the literature to illustrate the concept.
Author | : Li Di |
Publisher | : Elsevier |
Total Pages | : 549 |
Release | : 2010-07-26 |
Genre | : Science |
ISBN | : 0080557619 |
Download Drug-like Properties: Concepts, Structure Design and Methods Book in PDF, ePub and Kindle
Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties. Serves as an essential working handbook aimed at scientists and students in medicinal chemistry Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies Discusses improvements in pharmacokinetics from a practical chemist's standpoint
Author | : Jim Kozubek |
Publisher | : Cambridge University Press |
Total Pages | : 453 |
Release | : 2016-10-18 |
Genre | : Law |
ISBN | : 1107172160 |
Download Modern Prometheus Book in PDF, ePub and Kindle
This book tells the dramatic story of Crispr and the potential impact of this gene-editing technology.
Author | : Abdishakur Hassan |
Publisher | : Packt Publishing Ltd |
Total Pages | : 165 |
Release | : 2019-05-31 |
Genre | : Computers |
ISBN | : 1789809339 |
Download Geospatial Data Science Quick Start Guide Book in PDF, ePub and Kindle
Discover the power of location data to build effective, intelligent data models with Geospatial ecosystems Key FeaturesManipulate location-based data and create intelligent geospatial data modelsBuild effective location recommendation systems used by popular companies such as UberA hands-on guide to help you consume spatial data and parallelize GIS operations effectivelyBook Description Data scientists, who have access to vast data streams, are a bit myopic when it comes to intrinsic and extrinsic location-based data and are missing out on the intelligence it can provide to their models. This book demonstrates effective techniques for using the power of data science and geospatial intelligence to build effective, intelligent data models that make use of location-based data to give useful predictions and analyses. This book begins with a quick overview of the fundamentals of location-based data and how techniques such as Exploratory Data Analysis can be applied to it. We then delve into spatial operations such as computing distances, areas, extents, centroids, buffer polygons, intersecting geometries, geocoding, and more, which adds additional context to location data. Moving ahead, you will learn how to quickly build and deploy a geo-fencing system using Python. Lastly, you will learn how to leverage geospatial analysis techniques in popular recommendation systems such as collaborative filtering and location-based recommendations, and more. By the end of the book, you will be a rockstar when it comes to performing geospatial analysis with ease. What you will learnLearn how companies now use location dataSet up your Python environment and install Python geospatial packagesVisualize spatial data as graphsExtract geometry from spatial dataPerform spatial regression from scratchBuild web applications which dynamically references geospatial dataWho this book is for Data Scientists who would like to leverage location-based data and want to use location-based intelligence in their data models will find this book useful. This book is also for GIS developers who wish to incorporate data analysis in their projects. Knowledge of Python programming and some basic understanding of data analysis are all you need to get the most out of this book.
Author | : |
Publisher | : |
Total Pages | : 24 |
Release | : 1995 |
Genre | : Drugs |
ISBN | : |
Download Toxicokinetics Book in PDF, ePub and Kindle
Author | : Sanjeev Kumar Singh |
Publisher | : Springer Nature |
Total Pages | : 334 |
Release | : 2021-02-02 |
Genre | : Science |
ISBN | : 9811589364 |
Download Innovations and Implementations of Computer Aided Drug Discovery Strategies in Rational Drug Design Book in PDF, ePub and Kindle
This book presents various computer-aided drug discovery methods for the design and development of ligand and structure-based drug molecules. A wide variety of computational approaches are now being used in various stages of drug discovery and development, as well as in clinical studies. Yet, despite the rapid advances in computer software and hardware, combined with the exponential growth in the available biological information, there are many challenges that still need to be addressed, as this book shows. In turn, it shares valuable insights into receptor-ligand interactions in connection with various biological functions and human diseases. The book discusses a wide range of phylogenetic methods and highlights the applications of Molecular Dynamics Simulation in the drug discovery process. It also explores the application of quantum mechanics in order to provide better accuracy when calculating protein-ligand binding interactions and predicting binding affinities. In closing, the book provides illustrative descriptions of major challenges associated with computer-aided drug discovery for the development of therapeutic drugs. Given its scope, it offers a valuable asset for life sciences researchers, medicinal chemists and bioinformaticians looking for the latest information on computer-aided methodologies for drug development, together with their applications in drug discovery.
Author | : Michael K. Pugsley |
Publisher | : Springer |
Total Pages | : 477 |
Release | : 2015-06-19 |
Genre | : Medical |
ISBN | : 366246943X |
Download Principles of Safety Pharmacology Book in PDF, ePub and Kindle
This book illustrates, in a comprehensive manner, the most current areas of importance to Safety Pharmacology, a burgeoning unique pharmacological discipline with important ties to academia, industry and regulatory authorities. It provides readers with a definitive collection of topics containing essential information on the latest industry guidelines and overviews current and breakthrough topics in both functional and molecular pharmacology. An additional novelty of the book is that it constitutes academic, pharmaceutical and biotechnology perspectives for Safety Pharmacology issues. Each chapter is written by an expert in the area and includes not only a fundamental background regarding the topic but also detailed descriptions of currently accepted, validated models and methods as well as innovative methodologies used in drug discovery.
Author | : Han van de Waterbeemd |
Publisher | : John Wiley & Sons |
Total Pages | : 649 |
Release | : 2009-09-18 |
Genre | : Medical |
ISBN | : 3527623876 |
Download Drug Bioavailability Book in PDF, ePub and Kindle
The gold standard for industrial research now completely revised in line with current trends in the field, with all contributions extensively updated or rewritten. In 21 chapters readers can benefit from the key working knowledge of today's leading pharmaceutical companies, including Pfizer, AstraZeneca, and Roche. Drug developers from industry and academia present all the factors governing drug bioavailability, complete with practical examples and real-life data. Part I focuses on in vitro and in vivo measurements of physicochemical properties, such as membrane permeability and ionization. Part II discusses solubility and gastrointestinal absorption, while the third part is devoted to metabolism and excretory mechanisms. The much revised and expanded part IV surveys current in silico approaches to predict drug properties needed to estimate the bioavailability of any new drug candidate. The final part shows how poor bioavailability may be improved by various approaches during the development process. No other publication offers the same level of treatment on this crucial topic in modern drug development.