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Author | : Stamos Metzidakis |
Publisher | : BRILL |
Total Pages | : 290 |
Release | : 2012-01-01 |
Genre | : Literary Criticism |
ISBN | : 9004358013 |
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This is the first book to examine the precise relationship between pluralism and the production of Western literature and criticism from the eighteenth century to the present. It underscores the historical rather than exclusively epistemological reasons behind what is here called “the rise of literary pluralism.” This rise entails, on the one hand, the modern day phenomenon of an ever-increasing number of readings of both canonical and contemporary works of verbal art; and, on the other, our ever-growing body of literature written with an eye towards different types of characters, situations, forms and styles. Reviewing a wide range of authors and thinkers—from German, French and English Romantics to Anglo-American and European poststructuralist theorists—it shows how and why the current literary emphasis on difference derives from an unquestioned allegiance to the notion of cultural pluralism. While never denying the value of the latter, it seeks instead to analyze the oftentimes unquestioned implications of this historically-situated belief within the specific realm of literary studies.
Author | : Michigan State University. Library |
Publisher | : |
Total Pages | : 64 |
Release | : 1880 |
Genre | : |
ISBN | : |
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Author | : Michigan State Library |
Publisher | : |
Total Pages | : 660 |
Release | : 1874 |
Genre | : |
ISBN | : |
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Author | : Neal Shusterman |
Publisher | : Simon and Schuster |
Total Pages | : 336 |
Release | : 2016-12-13 |
Genre | : Juvenile Fiction |
ISBN | : 1481457241 |
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Find out what happens to Connor, Risa, and Lev now that they've finally destroyed the Proactive Citizenry in this collection of short stories set in the world of the New York Times bestselling Unwind Dystology by Neal Shusterman. Connor Lassiter's fight to bring down Proactive Citizenry and find a suitable alternative to unwinding concluded in UnDivided. Now Connor, Risa, and Lev are free to live in a peaceful future--or are they? Neal Shusterman brings back his beloved Unwind characters for his fans to see what's left for those who were destined to be unwound.
Author | : |
Publisher | : |
Total Pages | : 688 |
Release | : 1874 |
Genre | : |
ISBN | : |
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Author | : Andrea Deghi |
Publisher | : International Monetary Fund |
Total Pages | : 54 |
Release | : 2022-11-11 |
Genre | : Business & Economics |
ISBN | : |
Download The Sovereign-Bank Nexus in Emerging Markets in the Wake of the COVID-19 Pandemic Book in PDF, ePub and Kindle
The COVID-19 pandemic has brought the relationship between sovereigns and banks—the so-called sovereign-bank nexus—in emerging market economies to the fore as bank holdings of domestic sovereign debt have surged. This paper examines the empirical relevance of this nexus to assess how it could amplify macro-financial stability risks. The findings show that an increase in sovereign credit risk can adversely affect banks’ balance sheets and credit supply, especially in countries with less-well-capitalized banking systems. Sovereign distress can also impact banks indirectly through the nonfinancial corporate sector by constraining their funding and reducing their capital expenditure. Notably, the effects on banks and corporates are strongly nonlinear in the size of the sovereign distress.
Author | : Michigan |
Publisher | : |
Total Pages | : 1372 |
Release | : 1881 |
Genre | : Michigan |
ISBN | : |
Download Joint Documents of the State of Michigan Book in PDF, ePub and Kindle
Author | : Jian Zhang |
Publisher | : Springer Nature |
Total Pages | : 384 |
Release | : 2019-11-09 |
Genre | : Medical |
ISBN | : 9811387192 |
Download Protein Allostery in Drug Discovery Book in PDF, ePub and Kindle
The book focuses on protein allostery in drug discovery. Allosteric regulation, ʹthe second secret of lifeʹ, fine-tunes virtually most biological processes and controls physiological activities. Allostery can both cause human diseases and contribute to development of new therapeutics. Allosteric drugs exhibit unparalleled advantages compared to conventional orthosteric drugs, rendering the development of allosteric modulators as an appealing strategy to improve selectivity and pharmacodynamic properties in drug leads. The Series delineates the immense significance of protein allostery—as demonstrated by recent advances in the repertoires of the concept, its mechanistic mechanisms, and networks, characteristics of allosteric proteins, modulators, and sites, development of computational and experimental methods to predict allosteric sites, small-molecule allosteric modulators of protein kinases and G-protein coupled receptors, engineering allostery, and the underlying role of allostery in precise medicine. Comprehensive understanding of protein allostery is expected to guide the rational design of allosteric drugs for the treatment of human diseases. The book would be useful for scientists and students in the field of protein science and Pharmacology etc.
Author | : K. Dane Wittrup |
Publisher | : MIT Press |
Total Pages | : 593 |
Release | : 2020-01-07 |
Genre | : Science |
ISBN | : 0262042657 |
Download Quantitative Fundamentals of Molecular and Cellular Bioengineering Book in PDF, ePub and Kindle
A comprehensive presentation of essential topics for biological engineers, focusing on the development and application of dynamic models of biomolecular and cellular phenomena. This book describes the fundamental molecular and cellular events responsible for biological function, develops models to study biomolecular and cellular phenomena, and shows, with examples, how models are applied in the design and interpretation of experiments on biological systems. Integrating molecular cell biology with quantitative engineering analysis and design, it is the first textbook to offer a comprehensive presentation of these essential topics for chemical and biological engineering. The book systematically develops the concepts necessary to understand and study complex biological phenomena, moving from the simplest elements at the smallest scale and progressively adding complexity at the cellular organizational level, focusing on experimental testing of mechanistic hypotheses. After introducing the motivations for formulation of mathematical rate process models in biology, the text goes on to cover such topics as noncovalent binding interactions; quantitative descriptions of the transient, steady state, and equilibrium interactions of proteins and their ligands; enzyme kinetics; gene expression and protein trafficking; network dynamics; quantitative descriptions of growth dynamics; coupled transport and reaction; and discrete stochastic processes. The textbook is intended for advanced undergraduate and graduate courses in chemical engineering and bioengineering, and has been developed by the authors for classes they teach at MIT and the University of Minnesota.
Author | : Edgar Jacoby |
Publisher | : Methods in Molecular Biology |
Total Pages | : 340 |
Release | : 2009-09-17 |
Genre | : Medical |
ISBN | : |
Download Chemogenomics Book in PDF, ePub and Kindle
The establishment, analysis, prediction, and expansion of a comprehensive ligand-target Structure-Activity Relationship (SAR) in the post-genomic era presents a key research challenge for this century. In Chemogenomics: Methods and Applications, experts from academia and industry explore cutting-edge in vitro and in silico approaches available today and outline the relevant aspects of chemistry, biology, and molecular informatics which are the cornerstones of chemogenomics, thus combining introductory concepts with detailed methods and protocols. Covering topics such as target family-oriented compound library design, drug discovery targeting the purinome and co-factor binding sites, as well as the pocketome engine and molecular interaction field approaches, the book emphasizes systemization as an advantage to furthering the difficult science of drug discovery. As a volume in the highly successful Methods in Molecular BiologyTM series format, this work provides the kind of detailed description and implementation advice that is crucial for getting optimal results. Authoritative and practical, Chemogenomics: Methods and Applications presents content which will be of enormous value to those striving for the discovery of new and better therapies for diseases.