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Determining discriminating concentrations of insecticides for monitoring resistance in sand flies

Determining discriminating concentrations of insecticides for monitoring resistance in sand flies
Author: World Health Organization
Publisher: World Health Organization
Total Pages: 62
Release: 2023-01-10
Genre: Medical
ISBN: 9240064419

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The document presents outcome of a WHO multi-centre study (2020–2022) performed by eight laboratories in different WHO regions and the WHO expert consultations that made recommendations to WHO on insecticide discriminating concentrations (DCs) for monitoring resistance in sand fly vectors of leishmaniases. It describes use of the WHO bottle bioassay as a new method for testing susceptibility of sand flies to insecticides that are not suitable for impregnation on filter papers and makes recommendations to WHO on monitoring of insecticide resistance in field populations of sand flies. It also proposes further research to test the new DCs for sand flies in other settings and conditions and to collect evidence from the national disease control programmes and share them with WHO for further assessment and revision of the DCs if required. The current edition of the WHO manual for monitoring insecticide resistance in mosquito vectors and selecting appropriate interventions will be revised using the recommendations made to WHO including for the new DCs for sand flies. The report will be useful to the national vector-borne disease control programmes and the research community for resistance monitoring, and to academia, the pesticide regulatory agencies and the pesticide industry for further innovation in this area and to address the research questions. Please send your suggestions and comments to [email protected] indicating the title of the report and the relevant section and page.


Standard operating procedure for testing the susceptibility of adult sand flies to insecticides in WHO bottle bioassays

Standard operating procedure for testing the susceptibility of adult sand flies to insecticides in WHO bottle bioassays
Author: World Health Organization
Publisher: World Health Organization
Total Pages: 32
Release: 2023-07-11
Genre: Medical
ISBN: 9240074600

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This document contains the standard operating procedure (SOP) for evaluating the susceptibility of adult sand fly vectors (Phlebotomus spp. and Lutzomyia longipalpis) to insecticides in WHO bottle bioassays. Some species of sand flies are vectors of leishmaniases. The SOP includes instructions on preparing materials, exposing sand flies, and recording and interpreting test results. This procedure should be followed to test the susceptibility of sand flies to insecticides that are unstable and/or cannot be impregnated on usual Whatman No. 1 filter papers. This SOP will fulfil the long-awaited need of vector-borne disease control programmes in health ministries in countries endemic for or at risk of visceral and cutaneous leishmaniasis, researchers and the pesticide industry to monitor insecticide resistance in wild populations of sand fly vectors. It can be adapted to determine discriminating concentrations of new insecticide compounds with susceptible strains of sand fly vectors in laboratories.


Public health pesticide management: a course module

Public health pesticide management: a course module
Author: World Health Organization
Publisher: World Health Organization
Total Pages: 298
Release: 2023-11-22
Genre: Medical
ISBN: 924007614X

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The course module provides the students with the knowledge and skills for developing and implementing effective strategies to control disease vectors and domestic pests (e.g. integrated vector management), with emphasis on improved management of public health pesticides throughout their life cycle. Alternative methods and strategies for pest and vector control, their cost-effectiveness and their sustainability are discussed. Students will also examine the WHO strategies, policies and guidelines for using pesticides in public health. This course was first developed in 2012 by the World Health Organization (WHO) in collaboration with the University of Cape Town (South Africa) and was revised in 2015. The current version incorporates major revisions and updates of the course material.


Standard operating procedure for testing the susceptibility of adult sand flies to insecticides in WHO tube tests

Standard operating procedure for testing the susceptibility of adult sand flies to insecticides in WHO tube tests
Author: World Health Organization
Publisher: World Health Organization
Total Pages: 26
Release: 2023-07-04
Genre: Medical
ISBN: 9240074627

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This document contains the standard operating procedure (SOP) for evaluating the susceptibility of adult sand fly vectors (Phlebotomus spp. and Lutzomyia longipalpis) to insecticides with the WHO tube test. Some species of sand flies are vectors of leishmaniases. The SOP includes instructions on preparing materials, exposing sand flies, and recording and interpreting test results. This procedure should be followed to test the susceptibility of sand flies to insecticides that can be impregnated onto filter papers. This SOP will fulfil the long-awaited need of vector-borne disease control programmes in health ministries in countries endemic for or at risk of visceral and cutaneous leishmaniasis, researchers and the pesticide industry to monitor insecticide resistance in wild populations of sand fly vectors. It can be adapted to determine discriminating concentrations of new insecticide compounds with susceptible strains of sand fly vectors in laboratories.


Leishmaniases as Re-emerging Diseases

Leishmaniases as Re-emerging Diseases
Author: Farhat Afrin
Publisher: BoD – Books on Demand
Total Pages: 234
Release: 2018-10-10
Genre: Medical
ISBN: 1789841011

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Leishmania parasites plague the mammalian host causing high morbidity and mortality. The parasites persist in the hostile milieu, crippling its defensive arsenal. In the face of mounting resistance to an antiquated drug arsenal, new approaches are urgently desired to keep the infection at bay. Furthermore, to strengthen the leishmaniasis elimination drive, particular emphasis has to be laid on identification of new targets and vaccination strategies. This book gives a brief glimpse of the epidemiology of leishmaniasis, immune evasion, vaccination, and therapeutic modalities that may work by untangling the immunological cross-wires of pathogenic cross-talk. The Conventional treatment and its drawbacks, the prospects of phytotherapy and nanomedicines, are also discussed. The identification of drug targets with the aim of designing inhibitors is also exemplified.


Toolkit for Integrated Vector Management in Sub-Saharan Africa (A)

Toolkit for Integrated Vector Management in Sub-Saharan Africa (A)
Author: World Health Organization
Publisher: World Health Organization
Total Pages: 242
Release: 2016-07-27
Genre: Medical
ISBN: 9241549653

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This toolkit for integrated vector management (IVM) is designed to help national and regional programme managers coordinate across sectors to design and run large IVM programmes. It is an extension of earlier guidance and teaching material published by the World Health Organization (WHO): Handbook for integrated vector management Monitoring and evaluation indicators for integrated vector management Guidance on policy-making for integrated vector management and Core structure for training curricula on integrated vector management. The toolkit provides the technical detail required to plan implement monitor and evaluate an IVM approach. IVM can be used when the aim is to control or eliminate vector-borne diseases and can also contribute to insecticide resistance management. This toolkit provides information on where vector-borne diseases are endemic and what interventions should be used presenting case studies on IVM as well as relevant guidance documents for reference. The diseases that are the focus of this toolkit are malaria lymphatic filariasis dengue leishmaniasis onchocerciasis human African trypanosomiasis and schistosomiasis. It also includes information on other viral diseases (Rift Valley fever West Nile fever Chikungunya yellow fever) and trachoma. If other vector-borne diseases appear in a country or area vector control with an IVM approach should be adopted as per national priorities. Malaria as one of the most important vector-borne diseases in sub-Saharan Africa is the main focus of this document. Programmes targeting other vector-borne diseases can learn from the experiences gained from malaria vector control and presented here.


Bibliography of Agriculture

Bibliography of Agriculture
Author:
Publisher:
Total Pages: 1922
Release: 1975
Genre: Agriculture
ISBN:

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Public Health Significance of Urban Pests

Public Health Significance of Urban Pests
Author: Xavier Bonnefoy
Publisher: World Health Organization
Total Pages: 293
Release: 2008
Genre: Medical
ISBN: 9289071885

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The second half of the 20th century and the beginning of the 21st century witnessed important changes in ecology, climate and human behaviour that favoured the development of urban pests. Most alarmingly, urban planners now face the dramatic expansion of urban sprawl, in which city suburbs are growing into the natural habitats of ticks, rodents and other pests. Also, many city managers now erroneously assume that pest-borne diseases are relics of the past. All these changes make timely a new analysis of the direct and indirect effects of present-day urban pests on health. Such an analysis should lead to the development of strategies to manage them and reduce the risk of exposure. To this end, WHO invited international experts in various fields - pests, pest-related diseases and pest management - to provide evidence on which to base policies. These experts identified the public health risk posed by various pests and appropriate measures to prevent and control them. This book presents their conclusions and formulates policy options for all levels of decision-making to manage pests and pest-related diseases in the future. [Ed.]