Determinants of Coding Sequence Evolution
Author | : Tobias Warnecke |
Publisher | : |
Total Pages | : |
Release | : 2010 |
Genre | : |
ISBN | : |
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Author | : Tobias Warnecke |
Publisher | : |
Total Pages | : |
Release | : 2010 |
Genre | : |
ISBN | : |
Author | : Tobias Warnecke |
Publisher | : |
Total Pages | : |
Release | : 2010 |
Genre | : |
ISBN | : |
Author | : Gina M. Cannarozzi |
Publisher | : Oxford University Press |
Total Pages | : |
Release | : 2012-02-23 |
Genre | : Science |
ISBN | : 0191624179 |
Codon-based models of evolution are a relatively new addition to the toolkit of computational biologists, and in recent years remarkable progress has been made in this area. The study of evolution at the codon level captures information contained in both amino acid and synonymous DNA substitutions. By combining these two types of information, codon analyses are more powerful than those of either amino acid or DNA evolution alone. This is a clear benefit for most evolutionary analyses, including phylogenetic reconstruction, detection of selection, ancestral sequence reconstruction, and alignment of coding DNA. Despite the theoretical advantages of codon based models, their relative complexity delayed their widespread use. Only in recent years, when large-scale sequencing projects produced sufficient genomic data and computational power increased, did their usage become more common. In Codon Evolution, leading researchers in the field of molecular evolution provide the latest insights from codon-based analyses of genetic sequences. The first part of the book provides comprehensive coverage of the developments of various types of codon substitution models such as parametric and empirical models used in maximum likelihood as well as Bayesian frameworks. Subsequent chapters examine the use of codon models to infer selection and other applications of codon models to biological systems. The second part of the book focuses on codon usage bias. Both the underlying mechanisms as well as current methods to analyse codon usage bias are presented.
Author | : Majeti Narasimha Vara Prasad |
Publisher | : John Wiley & Sons |
Total Pages | : 562 |
Release | : 1996-12-24 |
Genre | : Science |
ISBN | : 9780471131571 |
Twenty-nine, prominent, international researchers provide contributions which deal with understanding the basic ecophysiological and molecular principles governing the functioning of plant systems in relation to their environment. Divided into two headings: biotic and abiotic; the first consists of abiotic, natural environmental factors--light, ultraviolet radiation, chilling and freezing, high temperatures, drought, flooding, salt and trace metals. The latter half presents anthropogenic aspects including allelochemicals, herbicides, polyamines, air pollutants, carbon dioxide, radioisotopes and fire.
Author | : National Research Council |
Publisher | : National Academies Press |
Total Pages | : 128 |
Release | : 1988-01-01 |
Genre | : Science |
ISBN | : 0309038405 |
There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised? Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a highly readable explanation of the technical aspects of genetic mapping and sequencing, and they recommend specific interim and long-range research goals, organizational strategies, and funding levels. They also outline some of the legal and social questions that might arise and urge their early consideration by policymakers.
Author | : Christine Mordstein |
Publisher | : |
Total Pages | : |
Release | : 2017 |
Genre | : |
ISBN | : |
Author | : David Mittelman |
Publisher | : Springer Science & Business Media |
Total Pages | : 284 |
Release | : 2013-03-12 |
Genre | : Medical |
ISBN | : 1461462800 |
The discovery of stress-induced mutagenesis has changed ideas about mutation and evolution, and revealed mutagenic programs that differ from standard spontaneous mutagenesis in rapidly proliferating cells. The stress-induced mutations occur during growth-limiting stress, and can include adaptive mutations that allow growth in the otherwise growth-limiting environment. The stress responses increase mutagenesis specifically when cells are maladapted to their environments, i.e. are stressed, potentially accelerating evolution then. The mutation mechanism also includes temporary suspension of post-synthesis mismatch repair, resembling mutagenesis characteristic of some cancers. Stress-induced mutation mechanisms may provide important models for genome instability underlying some cancers and genetic diseases, resistance to chemotherapeutic and antibiotic drugs, pathogenicity of microbes, and many other important evolutionary processes. This book covers pathways of stress-induced mutagenesis in all systems. The principle focus is mammalian systems, but much of what is known of these pathways comes from non-mammalian systems.
Author | : Roderick D.M. Page |
Publisher | : John Wiley & Sons |
Total Pages | : 352 |
Release | : 2009-07-14 |
Genre | : Science |
ISBN | : 1444313363 |
The study of evolution at the molecular level has given the subject of evolutionary biology a new significance. Phylogenetic 'trees' of gene sequences are a powerful tool for recovering evolutionary relationships among species, and can be used to answer a broad range of evolutionary and ecological questions. They are also beginning to permeate the medical sciences. In this book, the authors approach the study of molecular evolution with the phylogenetic tree as a central metaphor. This will equip students and professionals with the ability to see both the evolutionary relevance of molecular data, and the significance evolutionary theory has for molecular studies. The book is accessible yet sufficiently detailed and explicit so that the student can learn the mechanics of the procedures discussed. The book is intended for senior undergraduate and graduate students taking courses in molecular evolution/phylogenetic reconstruction. It will also be a useful supplement for students taking wider courses in evolution, as well as a valuable resource for professionals. First student textbook of phylogenetic reconstruction which uses the tree as a central metaphor of evolution. Chapter summaries and annotated suggestions for further reading. Worked examples facilitate understanding of some of the more complex issues. Emphasis on clarity and accessibility.
Author | : Richard Dawkins |
Publisher | : Oxford University Press, USA |
Total Pages | : 372 |
Release | : 1989 |
Genre | : Medical |
ISBN | : 9780192860927 |
Science need not be dull and bogged down by jargon, as Richard Dawkins proves in this entertaining look at evolution. The themes he takes up are the concepts of altruistic and selfish behaviour; the genetical definition of selfish interest; the evolution of aggressive behaviour; kinshiptheory; sex ratio theory; reciprocal altruism; deceit; and the natural selection of sex differences. 'Should be read, can be read by almost anyone. It describes with great skill a new face of the theory of evolution.' W.D. Hamilton, Science
Author | : Michael Paul Scherrer |
Publisher | : |
Total Pages | : 216 |
Release | : 2013 |
Genre | : |
ISBN | : |
Evolutionary rates vary vastly across intraspecific genes and the determinants of these rates is of central concern to the field of comparative genomics. Tradition has held that preservation of protein function conserved the sequence, however mounting evidence implicates the biophysical properties of proteins themselves as the elements that constrain sequence evolution. Of these properties, the exposure of a residue to solvent is the most prevalent determinant of its evolutionary rate due to pressures to maintain proper synthesis and folding of the structure. In this work, we have developed a model that considers the microenvironment of a residue in the estimation of its evolutionary rate. By working within the structural context of a protein's residues, we show that our model is better able to capture the overall evolutionary trends affecting conservation of both the coding sequences and the protein structures from a genomic level down to individual genes.