Design Modeling And Fabrication Of Shear Mode Bulk Acoustic Wave Sensor As A Potential Biosensor PDF Download
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| Author | : Chi-Jung Cheng |
| Publisher | : |
| Total Pages | : 117 |
| Release | : 2012 |
| Genre | : |
| ISBN | : |
Download Design, Modeling and Fabrication of Shear Mode Bulk Acoustic Wave Sensor as a Potential Biosensor Book in PDF, ePub and Kindle
There has been an increasing interest in development of thin film bulk acoustic wave resonator devices for chemical and biological sensing applications in the environmental and biomedical industries. The zinc oxide thin film FBAR devices provide attractive advantages, such as high resonant frequency, small size, and rapid response. Typically, the ZnO-based FBAR devices are operated in the longitudinal wave mode where the ZnO crystallites are perpendicular to the substrate. However, the longitudinal wave mode is adversely affected when used in liquid environments. To overcome this limitation, the shear mode solidly mounted film bulk acoustic wave resonator device is presented in this dissertation.
| Author | : Adam Daniel Wathen |
| Publisher | : |
| Total Pages | : |
| Release | : 2011 |
| Genre | : Acoustic surface wave devices |
| ISBN | : |
Download Acoustic Wave Biosensor Arrays for the Simultaneous Detection of Multiple Cancer Biomarkers Book in PDF, ePub and Kindle
The analysis and development of robust sensing platforms based on solidly-mounted ZnO bulk acoustic wave devices was proposed. The exploitation of acoustic energy trapping was investigated and demonstrated as a method to define active sensing areas on a substrate. In addition, a new "hybrid" acoustic mode experiencing acoustic energy trapping was studied theoretically and experimentally. This mode was used as an explanation of historical inconsistencies in observed thickness-shear mode velocities. Initial theoretical and experimental results suggest that this mode is a coupling of thickness-shear and longitudinal particle displacements and, as such, may offer more mechanical and/or structural information about a sample under test. Device development was taken another step further and multi-mode ZnO resonators operating in the thickness-shear, hybrid, and longitudinal modes were introduced. These devices were characterized with respect to sample viscosity and conductivity and preliminary results show that, with further development, the multi-mode resonators provide significantly more information about a sample than their single-mode counterparts. An alternative to resonator-based platforms was also presented in the form of bulk acoustic delay lines. Initial conceptual and simulation results show that these devices provide a different perspective of typical sensing modalities by using properly designed input pulses, device tuning, and examining overall input and output signal spectra.
| Author | : Thomas B. Pollard |
| Publisher | : |
| Total Pages | : 620 |
| Release | : 2013 |
| Genre | : Acoustic surface wave devices |
| ISBN | : |
Download Modeling, Design, Packaging and Experimental Analysis of Liquid-Phase Shear-Horizontal Surface Acoustic Wave Sensors Book in PDF, ePub and Kindle
| Author | : Michael J. Bartkovsky |
| Publisher | : |
| Total Pages | : |
| Release | : 2005 |
| Genre | : Chemical engineering |
| ISBN | : |
Download Computer- Aided Design and Fabrication of a Mems Based Acoustic-wave Biosensor Book in PDF, ePub and Kindle
| Author | : Pierre Laszlo |
| Publisher | : Elsevier |
| Total Pages | : 317 |
| Release | : 2012-12-02 |
| Genre | : Science |
| ISBN | : 0323156347 |
Download Chemical and Biochemical Applications Book in PDF, ePub and Kindle
NMR of Newly Accessible Nuclei, Volume 1: Chemical and Biochemical Applications is a 10-chapter text that explores the properties, advantages, developments, and chemical and biochemical applications of NMR technique. This book describes first the operation of an NMR spectrometer under its two aspects, namely, the instrumental and the computational aspects. The next chapters are devoted to some of the most important pulse sequences. The discussion then shifts to the various factors determining the position of the observed absorption and those responsible for the various relaxation processes. The last chapters deal with the specific applications of NMR, including in cation salvation, calcium-binding proteins, polyelectrolyte systems, halogens, and antibiotic ionophores. This book is of value to inorganic and analytical chemists, and biophysicists.
| Author | : Gérald Thouand |
| Publisher | : Springer |
| Total Pages | : 992 |
| Release | : 2021-10-01 |
| Genre | : Science |
| ISBN | : 9783030232160 |
Download Handbook of Cell Biosensors Book in PDF, ePub and Kindle
This handbook is an interdisciplinary and comprehensive reference covering all aspects of cell biosensors. It is divided into four main sections which are led and organized by numerous international experts. The scope of coverage includes: Fundamentals and genetics for biosensor applications Transducers, Materials and Systems Markets, innovation and education Application of biosensors in business Biosensor research is an exciting hybrid world where biologists, chemists, physicists, engineers and computer engineers come together. This handbook will serve as an invaluable living resource for all researchers in academia and industry working with cell biosensors.
| Author | : |
| Publisher | : |
| Total Pages | : 269 |
| Release | : 2009 |
| Genre | : |
| ISBN | : |
Download Development of Highly Sensitive Bulk Acoustic Wave Device Biosensor Arrays for Screening and Early Detection of Prostate Cancer Book in PDF, ePub and Kindle
In this research, I present several novel contributions to the field of microelectronic acoustic biosensors that approach the goal of developing a cost-effective, highly sensitive and highly selective sensor array for the detection of early cancer proliferation. First I report on the development of a novel solidly mounted shear-mode resonator employing piezoelectric ZnO as an appropriate base device for liquid-phase sensing applications. Second I report on the development of a novel and appropriate chemical surface preparation protocol for the covalent immobilization of monoclonal IgG antibodies to the surface of this device, thereby functionalizing it as a biosensor. Proof of functionality is demonstrated employing these sensors for the detection of various known cancer biomarkers in complex media as well as progress towards developing a packaged disposable sensor array system is also reported.
| Author | : Toonika Rinken |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 364 |
| Release | : 2013-03-13 |
| Genre | : Medical |
| ISBN | : 9535110047 |
Download State of the Art in Biosensors Book in PDF, ePub and Kindle
As biosensors comprise a prospective alternative to traditional chemical analyses, enabling fast on- and in-line measurements with sufficient selectivity, the field is expanding rapidly and is offering new ideas and developments every day. This book aims to cover the present state of the art in the biosensor technology and introduce the general aspects of biosensor- based techniques and methods. The book consists of 13 chapters by 44 authors and is divided into 3 sections, focused on bio-recognition techniques, signal transduction methods and signal analysis.
| Author | : Vishal Dhagat |
| Publisher | : |
| Total Pages | : |
| Release | : 2017 |
| Genre | : Electronic dissertations |
| ISBN | : |
Download Surface Acoustic Wave Sensor for Protein Characterization: Fabrication, Modeling and Simulation Book in PDF, ePub and Kindle
This thesis investigates the usage of surface acoustic wave (SAW) devices as sensors in the determination of viscosity of Newtonian fluids such as Bovine Serum Albumin (BSA). Specifically, conductance and susceptance data of the SAW device in the presence of Bovine Serum Albumin and other liquids, comprising of proteins in small quantities (~35 nL). A two-port SAW device (320 MHz) was fabricated and tested with different concentrations of a water-miscible BSA in deionized water (DI water) and glycerol. The study examines several designs and type of substrates. There is a strong correlation of the measured sensor data to the corresponding computer simulations. A Finite Element Model (FEM) of the Two-Port Surface Acoustic Device is used to simulate the Sensor characteristics. COMSOL Multiphysics Modeling and simulation of surface acoustic wave devices are also utilized for protein characterization. The models predict how the presence of fluid in the groove lowers the resonance frequency. The SAW Sensor simulation detects changes in the viscosity of a protein using thermoviscous acoustic - piezoelectric interactions. The model accurately predicts the behavior of the SAW and fluid interactions. Rigorous analysis of viscosity and resultant variations in conductance, susceptance, and admittance, as a function of Protein concentration and morphology, establish SAW sensors as significant characterization devices. New drug discovery and development is costly; of all compounds investigated for use in humans, only small fractions are approved for treatments. The pharmaceutical industry has started switching from molecular drugs to protein-based drugs due to high specificity, enhanced efficacy, affinity, solubility, and low toxicity. Novel proteins in elevated concentrations are very expensive to produce. On the other hand, their solution properties, especially the viscosity is very critical to the stability, processing, manufacturing, and delivery of such drugs.
| Author | : Marco G. Beghi |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 616 |
| Release | : 2013-08-28 |
| Genre | : Technology & Engineering |
| ISBN | : 9535111892 |
Download Modeling and Measurement Methods for Acoustic Waves and for Acoustic Microdevices Book in PDF, ePub and Kindle
Acoustics is a mature field which enjoys a never ending youth. New developments are induced by either the search for a better understanding, or by technological innovations. Micro-fabrication techniques introduced a whole new class of microdevices, which exploit acoustic waves for various tasks, and in particular for information processing and for sensing purposes. Performance improvements are achievable by better modelling tools, able to deal with more complex configurations, and by more refined techniques of fabrication and of integration in technological systems, like wireless communications. Several chapters of this book deal with modelling and fabrication techniques for microdevices, including unconventional phenomena and configurations. But this is far from exhausting the research lines in acoustics. Theoretical analyses and modelling techniques are presented, for phenomena ranging from the detection of cracks to the acoustics of the oceans. Measurement methods are also discussed, which probe by acoustic waves the properties of widely different systems.
