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Design and Evaluation of Colon Specific Drug Delivery System

Design and Evaluation of Colon Specific Drug Delivery System
Author: Nirav Patel
Publisher: LAP Lambert Academic Publishing
Total Pages: 288
Release: 2011
Genre: Colon (Anatomy)
ISBN: 9783844394825
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Colonic drug delivery has gained increased importance not just for the delivery of the drugs for the treatment of local diseases associated with the colon like Crohn s diseases, ulcerative colitis, irritable bowl syndrome but also for the potential it holds for the systemic delivery of proteins and therapeutic peptides. Targeted drug delivery to the colon would therefore, ensure direct treatment at the disease site and, consequently, lower dosing and reducing systemic side effects. The most critical challenge in such drug delivery approach is to preserve the formulation during its passage through the stomach and about first six meters of small intestine. In the present investigations, two drugs mesalamine and budesonide was selected for ulcerative colitis in colon. An attempt was made to prepare formulations which could not release the drug into stomach for up to 2 h. which is residence time for it, also it could not release the drug into small intestine up to 3 h. which is residence time for it and could release the drug up to 24 h to 3 days which is residence time for colon. These attempts formulate the colon targeted controlled release dosage form for ulcerative colitis.

Design and Development of Colon Targeted Drug Delivery System

Design and Development of Colon Targeted Drug Delivery System
Author: Mukesh R. Patel
Publisher: LAP Lambert Academic Publishing
Total Pages: 96
Release: 2012-06
Genre:
ISBN: 9783847309765
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The oral administration is the most convenient and commonly used method for drug delivery. Traditionally, solid oral dosage forms have been designed to release their drug load in the upper region of the gastrointestinal tract, where conditions are more suited to drug dissolutions and absorptions. Recently, greater emphasis has been placed on controlling site of drug release from oral formulations for the purposes of improving patient compliance and treatment efficiency . Many protein and peptide drugs like insulin cannot be administered through the oral route because of their degradation by the digestive enzymes of the stomach and the small intestine. Colon-specific drug delivery systems offer several potential therapeutic advantages.The opportunity to reduce adverse effects in the treatment of colonic diseases like, ulcerative colitis, colorectal cancer, Chorn s diseases and amoebiasis by topical application of drugs, active at the mucosal level The elucidation of the mode of action of some nonsteroidal anti-inflammatory drugs (NSAIDs) such as sulindac (metabolized in the colon to the active moiety, sulindac sulfide) that were found to interfere with the proliferation of co

Oral Colon-Specific Drug Delivery

Oral Colon-Specific Drug Delivery
Author: David R. Friend
Publisher: CRC Press
Total Pages: 292
Release: 1992-07-27
Genre: Medical
ISBN: 9780849366888
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Oral Colon-Specific Drug Delivery covers approaches used to deliver a variety of drugs to the colon. Anatomy and physiology of the gastrointestinal tract as it affects colonic drug delivery and pharmacokinetics are reviewed, as well as drug absorption from the colon. The book presents valuable information on a variety of topics, including oral peptide/protein delivery, dextran-based delivery systems, glycoside/glycosidase-based delivery, azo-bond prodrugs, hydroxypropyl methacrylamide copolymers for colonic delivery, and matrices for colonic drug delivery. Special emphasis is placed on delivery systems, especially biochemical approaches to delivery, such as the use of degradable polymers and both low and high molecular weight prodrugs. Oral Colon-Specific Drug Delivery will provide a valuable reference resource for gastroenterologists, pharmaceutical scientists, and other researchers working with drug delivery to the colon.

Advanced Drug Delivery Systems for Colonic Disorders

Advanced Drug Delivery Systems for Colonic Disorders
Author: Harish Dureja
Publisher: Elsevier
Total Pages: 463
Release: 2023-11-04
Genre: Medical
ISBN: 0443140456
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Advanced Drug Delivery Systems for Colonic Disorders present the current state of the art methods for targeted drug delivery to the colon. These methods can prolong drug half-lives, improve bioavailability, optimize pharmacokinetics, and reduce medication dosing frequency. Chapters are written in a way that allows the audience to not only become familiar with the most recent advancement in the field, but to better understand them by referring to various illustrations, figures, and informative tables. The contents cover an overview of colonic diseases, the cellular and molecular mechanisms involved, current and traditional therapeutic approaches, biomaterials, oral drug delivery methods, targeted drug delivery, nutraceuticals and herbal medicine approaches, prebiotics, probiotics and symbiotics, nanomedicine approaches, and the current status of clinical trials in the area. Advanced Drug Delivery Systems for Colonic Disorders is the perfect resources for researchers in pharma, biomaterials, and nutrition to familiarize themselves with new and upcoming therapeutic methods. Research physicians in GI can also benefit from reading this book for its clinical applications. Covers recent perspectives and challenges towards the treatment of colonic disorders Provides insights into how advanced drug delivery systems can be effectively used for the management of various types of colonic disorders Discusses drug delivery strategies to manage inflammatory bowel disease (chronic inflammation in the digestive tract), ulcerative colitis (inflammation and ulcers in colon), Crohn's disease, Colonic polyps, Shigellosis, Colon Bleeding or Hemorrhage, Diverticulosis and colon cancer

Colon Specific Drug Delivery System

Colon Specific Drug Delivery System
Author: Chirag Patel
Publisher: LAP Lambert Academic Publishing
Total Pages: 92
Release: 2013
Genre:
ISBN: 9783659275692
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The present study has been a satisfactory attempt to formulate microparticulate system for colon targeted delivery of albendazole using natural polysaccharides sodium alginate and chitosan. Targeted drug delivery to the colon, by means of combination of one or more controlled release mechanisms, hardly releases drug in the upper part of the GIT but releases in the colon following oral administration. Specifically delivering drug to the colon, a lot of benefits would be acquired in terms of improving safety and reducing toxicity when treating local or systemic chronic diseases. We sincerely hope that this book will helpful to student as well as industry and academic professionals involved in pharmaceutical and other related science.

Design of Controlled Release Drug Delivery Systems

Design of Controlled Release Drug Delivery Systems
Author: Xiaoling Li
Publisher: McGraw Hill Professional
Total Pages: 453
Release: 2005-11-24
Genre: Technology & Engineering
ISBN: 0071588833
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The goal of every drug delivery system is to deliver the precise amount of a drug at a pre-programmed rate to the desired location in order to achieve the drug level necessary for the treatment. An essential guide for biomedical engineers and pharmaceutical designers, this resource combines physicochemical principles with physiological processes to facilitate the design of systems that will deliver medication at the time and place it is most needed.