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Deep Eutectic Solvents for Medicine, Gas Solubilization and Extraction of Natural Substances

Deep Eutectic Solvents for Medicine, Gas Solubilization and Extraction of Natural Substances
Author: Sophie Fourmentin
Publisher: Springer Nature
Total Pages: 321
Release: 2020-10-19
Genre: Science
ISBN: 3030530698

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Initially considered as a sub-class of ionic liquids, eutectic mixtures are formed by mixtures of low cost, often biodegradable Lewis or Bronsted acids and bases. Eutectic mixtures have gathered a growing scientific interest by the academic and industrial communities as they are interesting for many applications ranging from metal processing to biomass treatment or pharmaceuticals. This volume gathers contributions by some of the most active research groups in the world using eutectic mixtures for applications in separation, extraction or pharmaceutical and medical applications. The different contributions aim at a large overview of the field for these particular applications by reviewing literature data and presenting ground breaking research in the different fields.


Eutectic Solvents

Eutectic Solvents
Author: Piotr Cysewski
Publisher: MDPI
Total Pages: 126
Release: 2021-02-24
Genre: Science
ISBN: 3036500227

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Natural deep eutectic solvents (NADES) are pharmaceutically accepted systems not only because they typically offer a serious enhancement of active pharmaceutical ingredient (API) solubility, but also due to their non-toxicity. This fortunate conjuncture allows for designing new media for escalation and controlled release of APIs. For example, composition optimisation of a series of NADES comprising choline chloride with multi-hydroxyl compounds was successfully performed for a set of sulphonamide-based drugs. These results confirmed that NADES in general, and the ones based on choline chloride and glycerol particularly, are an attractive alternative to traditional solvents for sulphonamide dissolution. Experiments augmented with in silico modelling can offer deeper insights into the thermodynamic characteristics of these systems and an explanation for the origin of the observed solubility enhancement. Research of this type offers universal resolutions to the problem of low solubility issues for many types of drugs. Of particular interest is that such screening is not restricted to artificial in vitro environments but can be also easily adopted for the study of modelled in vivo situations. One of very important and interesting examples is a new curcumin–NADES formulation preserving its beneficial properties even after dilution with FaSSIF solution, which mimicks intestinal absorption.


Green Extraction of Natural Products

Green Extraction of Natural Products
Author: Farid Chemat
Publisher: John Wiley & Sons
Total Pages: 384
Release: 2016-03-11
Genre: Science
ISBN: 3527676813

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Extraction processes are essential steps in numerous industrial applications from perfume over pharmaceutical to fine chemical industry. Nowadays, there are three key aspects in industrial extraction processes: economy and quality, as well as environmental considerations. This book presents a complete picture of current knowledge on green extraction in terms of innovative processes, original methods, alternative solvents and safe products, and provides the necessary theoretical background as well as industrial application examples and environmental impacts. Each chapter is written by experts in the field and the strong focus on green chemistry throughout the book makes this book a unique reference source. This book is intended to be a first step towards a future cooperation in a new extraction of natural products, built to improve both fundamental and green parameters of the techniques and to increase the amount of extracts obtained from renewable resources with a minimum consumption of energy and solvents, and the maximum safety for operators and the environment.


Deep Eutectic Solvents

Deep Eutectic Solvents
Author: Yizhak Marcus
Publisher: Springer
Total Pages: 200
Release: 2018-12-05
Genre: Science
ISBN: 3030006085

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This is one of the first books fully dedicated to the rapidly advancing and expanding research area of deep eutectic solvents. Written by the internationally recognized expert in solution chemistry, it supplies full information regarding preparation of these new eco-friendly solvents, their properties and applications. The current and potential applications of deep eutectic solvents as organic reaction media, catalytic system, in biomass processing, nanotechnology and metal finishing industry, as well as for extraction and separation are extensively discussed.This highly informative and carefully presented book will appeal to practicing chemists (organic chemists, polymer chemists, biochemists) as well as chemical engineers and environmental scientists.


Current Developments in Biotechnology and Bioengineering

Current Developments in Biotechnology and Bioengineering
Author: Ashish Pandey
Publisher: Elsevier
Total Pages: 446
Release: 2022-09-10
Genre: Technology & Engineering
ISBN: 0323999565

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Deep eutectic solvents represent the newest addition among all other non-conventional and alternate solvent systems. Deep Eutectic Solvent Fund Emerging Applications provides detailed insights on these neoteric solvents, their synthesis methods, types, physicochemical properties, and sustainable applications in emerging scientific areas. The book follows a mechanistic approach on understanding the role of DESs as sustainable media for CO2 capture, biomass pretreatment, as catalysts, as reaction media for material synthesis, cross coupling reactions, templates for drug delivery, etc. The book offers a springboard for encouraging vital discussions and inspiring further innovations in the field of environmentally benign eutectic solvent systems. Provides a detailed account of development on DESs with special focus on hydrophilic /hydrophobic DESs Describes experimental and theoretical outlook on the physical and chemical properties of DESs Discusses the toxicity profiling of DESs and their importance in designing biocatalytic routes Includes DESs in emerging areas - pharmaceuticals, drug discovery, functional materials and membrane science Covers use of DESs in CO2 capture, biomass transformations, organic reactions, etc.


Valorization of Agri-Food Wastes and By-Products

Valorization of Agri-Food Wastes and By-Products
Author: Rajeev Bhat
Publisher: Academic Press
Total Pages: 1026
Release: 2021-08-25
Genre: Technology & Engineering
ISBN: 0128242604

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Valorization of Agri-Food Wastes and By-Products: Recent Trends, Innovations and Sustainability Challenges addresses the waste and by-product valorization of fruits and vegetables, beverages, nuts and seeds, dairy and seafood. The book focuses its coverage on bioactive recovery, health benefits, biofuel production and environment issues, as well as recent technological developments surrounding state of the art of food waste management and innovation. The book also presents tools for value chain analysis and explores future sustainability challenges. In addition, the book offers theoretical and experimental information used to investigate different aspects of the valorization of agri-food wastes and by-products. Valorization of Agri-Food Wastes and By-Products: Recent Trends, Innovations and Sustainability Challenges will be a great resource for food researchers, including those working in food loss or waste, agricultural processing, and engineering, food scientists, technologists, agricultural engineers, and students and professionals working on sustainable food production and effective management of food loss, wastes and by-products. Covers recent trends, innovations, and sustainability challenges related to food wastes and by-products valorization Explores various recovery processes, the functionality of targeted bioactive compounds, and green processing technologies Presents emerging technologies for the valorization of agri-food wastes and by-products Highlights potential industrial applications of food wastes and by-products to support circular economy concepts


Evidence-Based Validation of Herbal Medicine

Evidence-Based Validation of Herbal Medicine
Author: Pulok K. Mukherjee
Publisher: Elsevier
Total Pages: 858
Release: 2022-07-12
Genre: Business & Economics
ISBN: 0323984568

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Evidence-Based Validation of Herbal Medicines: Translational Research on Botanicals brings together current thinking and practice in the characterization and validation of natural products. The book describes different approaches and techniques for evaluating the quality, safety and efficacy of herbal medicine, particularly methods to assess their activity and understand compounds responsible and their probable underlying mechanisms of action. This book brings together the views, expertise and experiences of scientific experts in the field of medicinal plant research, hence it will be useful for researcher who want to know more about the natural lead with their validation and also useful to exploit traditional medicines. Includes state-of-the-art methods for detecting, isolating and performing structure elucidation by degradation and spectroscopic techniques Highlights the trends in validation and value addition of herbal medicine with different scientific approaches used in therapeutics Contains several all-new chapters on topics such as traditional-medicine-inspired drug development to treat emerging viral diseases, medicinal plants in antimicrobial resistance, TLC bio profiling, botanicals as medicinal foods, bioprospecting and bioassay-guided isolation of medicinal plants, immunomodulators from medicinal plants, and more


Deep Eutectic Solvents in Liquid-Liquid Extraction

Deep Eutectic Solvents in Liquid-Liquid Extraction
Author: Papu Kumar Naik
Publisher: CRC Press
Total Pages: 204
Release: 2022-11-07
Genre: Science
ISBN: 1000708608

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Deep eutectic solvents (DESs) are a new class of green solvents that open a whole new world of opportunities for separation challenges. This book comprehensively provides a detailed discussion of their application as an extractive solvent in separation processes, adopting molecular dynamics (MD) simulations for atomistic insight into the solute transfer across bi-phasic systems. Furthermore, it explains ternary and quaternary mixtures, including MD simulation of relevant DES systems. Features in this volume include the following: Applications of DESs in the extraction of aromatics and polyaromatics from fuel oil by liquid–liquid extraction Eutectic behavior with respect to hydrocarbon and aqueous solutions MD insights on extraction using DESs Possible industrial applicability of potential DESs Results from Gaussian, NAMD, and PACKMOL software packages This book is aimed at researchers and graduate students working in the field of fuels and petrochemicals, separation science, chromatography, and chemical processing and design.


Deep Eutectic Solvents

Deep Eutectic Solvents
Author: Diego J. Ramón
Publisher: John Wiley & Sons
Total Pages: 384
Release: 2020-01-13
Genre: Science
ISBN: 3527345183

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A useful guide to the fundamentals and applications of deep eutectic solvents Deep Eutectic Solvents contains a comprehensive review of the use of deep eutectic solvents (DESs) as an environmentally benign alternative reaction media for chemical transformations and processes. The contributors cover a range of topics including synthesis, structure, properties, toxicity and biodegradability of DESs. The book also explores myriad applications in various disciplines, such as organic synthesis and (bio)catalysis, electrochemistry, extraction, analytical chemistry, polymerizations, (nano)materials preparation, biomass processing, and gas adsorption. The book is aimed at organic chemists, catalytic chemists, pharmaceutical chemists, biochemists, electrochemists, and others involved in the design of eco-friendly reactions and processes. This important book: -Explores the promise of DESs as an environmentally benign alternative to hazardous organic solvents -Covers the synthesis, structure, properties (incl. toxicity) as well as a wide range of applications -Offers a springboard for stimulating critical discussion and encouraging further advances in the field Deep Eutectic Solvents is an interdisciplinary resource for researchers in academia and industry interested in the many uses of DESs as an environmentally benign alternative reaction media.


Advances in the development and application of deep eutectic solvents

Advances in the development and application of deep eutectic solvents
Author: Maria Luisa Di Gioia
Publisher: Frontiers Media SA
Total Pages: 113
Release: 2024-02-09
Genre: Science
ISBN: 283254455X

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The continuous effort to perform a more sustainable chemistry has led to the development of new materials that accomplish the principles of green chemistry. In this context, deep eutectic solvents (DESs) have arisen as a new generation of solvents that respond well to most of the characteristics that an ideal green solvent must possess: they are easy and cheap to prepare, stable, easy to handle (they show chemical stability, non-flammability and conductivity), separable from the reaction products, biodegradable and safe for both humans and the environment. At the same time, they show chemical-physical properties similar to ionic liquids, such as low volatility, conductivity and high solvent power. These characteristics mean that DESs are today classified as 2-st century solvents. DESs have been raising a lot of attention and a sharp increase of their applications in numerous sectors of chemistry: they are mainly used as alternative solvents and/or catalysts for various organic transformations including metal-catalyzed reactions, biotransformations, polymerization, in sample preparation and analytical techniques as well as in the design of pharmaceutical formulations and drug delivery systems.