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| Author | : Ting Gang Chew |
| Publisher | : Frontiers Media SA |
| Total Pages | : 151 |
| Release | : 2022-01-25 |
| Genre | : Science |
| ISBN | : 2889741605 |
| Author | : Jose C. Jimenez-Lopez |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 344 |
| Release | : 2017-05-17 |
| Genre | : Science |
| ISBN | : 9535131699 |
The cytoskeleton is a highly dynamic intracellular platform constituted by a three-dimensional network of proteins responsible for key cellular roles as structure and shape, cell growth and development, and offering to the cell with "motility" that being the ability of the entire cell to move and for material to be moved within the cell in a regulated fashion (vesicle trafficking). The present edition of Cytoskeleton provides new insights into the structure-functional features, dynamics, and cytoskeleton's relationship to diseases. The authors' contribution in this book will be of substantial importance to a wide audience such as clinicians, researches, educators, and students interested in getting updated knowledge about molecular basis of cytoskeleton, such as regulation of cell vital processes by actin-binding proteins as cell morphogenesis, motility, their implications in cell signaling, as well as strategies for clinical trial and alternative therapies based in multitargeting molecules to tackle diseases, that is, cancer.
| Author | : Heide Schatten |
| Publisher | : Springer |
| Total Pages | : 395 |
| Release | : 2015-08-21 |
| Genre | : Science |
| ISBN | : 1493929046 |
This volume addresses the structural and functional roles of the cytoskeleton and its dysfunctions which often lead to disease. It provides thorough discussion of microtubules, microfilaments, intermediate filaments, and cytoskeletal functions and dysfunctions in different organ systems. Comprehensive yet concise. The Cytoskeleton In Health And Disease presents cutting-edge discoveries balanced with background information and highlights the new aspects of the research and its impact on the design of new strategies or the identification of new targets for therapeutic intervention. There is a significant need for a book on this topic, as interest in the cytoskeleton continues to grow as causes and cures for cytoskeletal diseases are further explored in biomedical research. This book is essential reading for scientists, students, and teachers interested in expanding their knowledge related to the cytoskeleton. New researchers entering the field will find classic and well as contemporary information not easily found in the current literature or internet resources.
| Author | : Ronald L. Huston |
| Publisher | : |
| Total Pages | : 458 |
| Release | : 2020 |
| Genre | : Cells |
| ISBN | : 9811208956 |
| Author | : Bruce Alberts |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2002 |
| Genre | : Cytology |
| ISBN | : 9780815332183 |
| Author | : J. Reinert |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 336 |
| Release | : 2013-06-29 |
| Genre | : Science |
| ISBN | : 354037390X |
It is instructive to compare the response of biologists to the two themes that comprise the title of this volume. The concept of the cell cycle-in contra distinction to cell division-is a relatively recent one. Nevertheless biologists of all persuasions appreciate and readily agree on the central problems in this area. Issues ranging from mechanisms that initiate and integrate the synthesis of chro mosomal proteins and DNA during S-phase of mitosis to the manner in which assembly of microtubules and their interactions lead to the segregation of metaphase chromosomes are readily followed by botanists and zoologists, as well as by cell and molecular biologists. These problems are crisp and well-defined. The current state of "cell differentiation" stands in sharp contrast. This, one of the oldest problems in experimental biology, almost defies definition today. The difficulties arise not only from a lack of pertinent information on the regulatory mechanisms, but also from conflicting basic concepts in this field. One of the ways in which this situation might be improved would be to find a broader experimental basis, including a better understanding of the relationship between the cell cycle and cell differentiation.
| Author | : Ricardo B. Maccioni |
| Publisher | : Oxford University Press, USA |
| Total Pages | : 406 |
| Release | : 1987 |
| Genre | : Language Arts & Disciplines |
| ISBN | : |
| Author | : Dorothea Rudnick |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2016-04-19 |
| Genre | : Science |
| ISBN | : 9780691653006 |
Here are the recent investigations of several distinguished biologists originally presented at the Fourteenth Symposium of the Society for the Study of Development and Growth. New tools and methods are used as they examine a wide range of cellular activities at various levels of plant and animal life. Originally published in 1956. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.
| Author | : |
| Publisher | : |
| Total Pages | : |
| Release | : 19?? |
| Genre | : |
| ISBN | : 9789535131700 |
| Author | : Satyaprakash Nayak |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2010 |
| Genre | : |
| ISBN | : |
Deregulation of cellular mechanisms responsible for cell growth, reproduction and differentiation is one of the hallmarks of all cancers. This study aims to elucidate the mechanisms underlying cell growth and differentiation using innovative computational and experimental tools. In the current study, we first review the basic cell cycle mechanisms in a typical eukaryotic cell (Chapter 1). In chapter 2, we analyze three published cell-cycle models and test our hypothesis that cell-cycle control architecture follow the "robust yet fragile" or the Highly Optimized Tolerance (HOT) paradigm. A very important fragile sub-system in the cell-cycle, revealed in our analysis of the cell-cycle models is protein translation. In chapter 3, we study the process of protein translation in detail, especially protein translation initiation. We formulate a detailed, mechanistic model of translation initiation from interactions validated in the literature. Novel systemsbiology tools such as coupling analysis are developed and employed to gain insight into critical components of translation initiation. This study reveals the importance of the Akt and mTOR proteins in the presence of growth factors and that of negative regulators such as PTEN and 4E-BP1 in their absence. Differentiation is the process by which a less specialized cell becomes more committed in its lineage, in response to the external environment. Chapter 4 presents an experimental study of Arsenic Trioxide on Human Leukemia (HL-60) myeloblastic cells. Our results show that Arsenic Trioxide enhances All Trans Retinoic Acid (ATRA) induced differentiation of HL-60 cells. This increase in differentiation is associated with an increase in the sustained Mitogen Activate Protein Kinase (MAPK) response. Chapter 5 presents an ensemble approach to model the response of HL-60 cells to ATRA and the role of sustained MAPK in differentiation. The model and its analysis present a systematic method to understand mechanisms involved in programmed cell differentiation in adult stem cells. In Chapter 6, we present a model combining hormone growth factor receptor signaling and prostate specific antigen (PSA) in LNCaP prostate adenocarcinoma cells. Finally, the concluding chapter discusses future directions of the current study.
