Crystal Structure Studies Of Kringle Domains And A Peptidomimetic Inhibitor Complex Of Alpha Thrombin PDF Download
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Author | : Tswei-Ping Wu |
Publisher | : |
Total Pages | : 406 |
Release | : 1993 |
Genre | : Antithrombins |
ISBN | : |
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Author | : |
Publisher | : |
Total Pages | : 1256 |
Release | : 1994 |
Genre | : Medicine |
ISBN | : |
Download Cumulated Index Medicus Book in PDF, ePub and Kindle
Author | : |
Publisher | : |
Total Pages | : 2676 |
Release | : 2002 |
Genre | : Chemistry |
ISBN | : |
Download Chemical Abstracts Book in PDF, ePub and Kindle
Author | : |
Publisher | : |
Total Pages | : 658 |
Release | : 1994 |
Genre | : Dissertations, Academic |
ISBN | : |
Download Dissertation Abstracts International Book in PDF, ePub and Kindle
Author | : Norbert Sewald |
Publisher | : Wiley-VCH Verlag GmbH |
Total Pages | : 562 |
Release | : 2002-01-01 |
Genre | : Science |
ISBN | : 9783527304059 |
Download Peptides Book in PDF, ePub and Kindle
Peptides play a decisive role in many physiological processes, whether as neurotransmitters, hormones or antibiotics. The rapid developments in peptide research over the past few decades make it almost impossible for newcomers to gain an overview. This means an easily comprehensible yet concise introduction is vital. This unique work covers all the important aspects of this wide-ranging field in one handy volume. On the basis of the fundamental chemical and structural properties of peptides, this reference runs the gamut from analysis, the occurrence and biological importance of peptides, via chemical, biochemical and genetic methods of peptide synthesis, right up to peptide libraries, peptide design and their role in drug research. Yet this book offers much more than a mere overview of the latest level of research. An encyclopedic appendix with valuable data on more than 500 biological relevant peptides and proteins, a comprehensive register and details of further literature references make this the ideal reference for all questions regarding peptide research. For newcomers and specialists alike. On the basis of the fundamental chemical and structural properties of peptides, this reference runs the gamut from analysis, the occurrence and biological importance of peptides.
Author | : Padma V. Devarajan |
Publisher | : Springer Nature |
Total Pages | : 560 |
Release | : 2019-11-09 |
Genre | : Medical |
ISBN | : 3030291685 |
Download Targeted Intracellular Drug Delivery by Receptor Mediated Endocytosis Book in PDF, ePub and Kindle
This book elaborates on drug delivery targeting via intracellular delivery, specifically through the Receptor Mediated Endocytosis (RME) approach, due to the involvement of cellular receptors in various grave diseases. Targeted delivery relies on two basic approaches, passive and active targeting. While passive targeting approaches have shown great promise, the improved selectivity achieved with active targeting approaches has resulted in significantly higher efficacy. Interestingly there are numerous strategies for active targeting, many of which are already highlighted in , Targeted Drug Delivery: Concepts and Applications. Nevertheless an exciting and practical strategy for active targeting, which could enable high intracellular delivery, is through exploitation of RME. Cells in the body express receptors to enable various physiological and biochemical processes. As a result, many of these receptors are overexpressed in pathological conditions, or newer receptors expressed due to defective cellular functioning. RME is based on exploitation of such receptors to achieve intracellular delivery. While targeted delivery can have manifold applications, in this book we focus on two major and challenging therapeutic areas; i) Cancer and ii) Infectious Diseases. Targeted Intracellular Drug Delivery by Receptor Medicated Endocytosis discusses the major receptors that are useful for targeted delivery for these afflictions. A major section of this book is dedicated to details regarding their occurrence and location, the recognition domain of the receptor, structure activity relationship of substrate /ligand for selective binding, ligands explored, antagonists for ligand binding and relevance of these aspects for therapy of cancer and infectious diseases. These facets are elucidated with the help of specific examples from academic research and also emphasize commercial products, wherever relevant. In vitro cellular models relied on for assessing receptor mediated cellular targeting and in vivo models depicting clinical efficacy are focused on in a separate section. Finally, we briefly discuss the regulatory and toxicity issues that may be associated specifically with the RME approach of intracellular drug delivery.
Author | : Beverly A. Teicher |
Publisher | : Springer Science & Business Media |
Total Pages | : 585 |
Release | : 2008-01-08 |
Genre | : Medical |
ISBN | : 1597451843 |
Download Antiangiogenic Agents in Cancer Therapy Book in PDF, ePub and Kindle
This volume represents a compendium of scientific findings and approaches to the study of angiogenesis in cancer. The second edition of Antiangiogenic Agents in Cancer Therapy is intended to give a current perspective on the state-of-the-art of angiogenensis and therapy directed at this process. Antiangiogenesis is a dynamic and evolving field in oncology. New therapeutic targets continue to emerge followed by the rapid development of new therapeutic agents to be investigated in clinical trials. Optimizing the therapeutic potential of antiangiogenic agents in combination with the other therapies in the armamentarium to fight cancer will be an on-going challenge.
Author | : Daan J. A. Crommelin |
Publisher | : CRC Press |
Total Pages | : 456 |
Release | : 2002-11-14 |
Genre | : Medical |
ISBN | : 9780415285018 |
Download Pharmaceutical Biotechnology Book in PDF, ePub and Kindle
The field of pharmaceutical biotechnology is evolving rapidly. A whole new arsenal of protein pharmaceuticals is being produced by recombinant techniques for cancer, viral infections, cardiovascular and hereditary disorders, and other diseases. In addition, scientists are confronted with new technologies such as polymerase chain reactions, combinatorial chemistry and gene therapy. This introductory textbook provides extensive coverage of both the basic science and the applications of biotechnology-produced pharmaceuticals, with special emphasis on their clinical use. Pharmaceutical Biotechnology serves as a complete one-stop source for undergraduate pharmacists, and it is valuable for researchers and professionals in the pharmaceutical industry as well.
Author | : Rajesh Krishna |
Publisher | : Springer Science & Business Media |
Total Pages | : 416 |
Release | : 2007-09-20 |
Genre | : Medical |
ISBN | : 038772379X |
Download Biopharmaceutics Applications in Drug Development Book in PDF, ePub and Kindle
The highly experienced authors here present readers with step-wise, detail-conscious information to develop quality pharmaceuticals. The book is made up of carefully crafted sections introducing key concepts and advances in the areas of dissolution, BA/BE, BCS, IVIC, and product quality. It provides a specific focus on the integration of regulatory considerations and includes case histories highlighting the biopharmaceutics strategies adopted in development of successful drugs.
Author | : Eva Böttcher-Friebertshäuser |
Publisher | : Springer |
Total Pages | : 0 |
Release | : 2018-05-31 |
Genre | : Medical |
ISBN | : 9783319754734 |
Download Activation of Viruses by Host Proteases Book in PDF, ePub and Kindle
This book will give an overview on viruses undergoing proteolytic activation through host proteases. The chapters will be organized in three themed parts, the first part describing respective viruses and their characteristics in detail. In the second part the molecular and cellular biology of the proteases involved as well as their physiological functions will be further explored. The third part will contain a chapter on protease inhibitors that are promising tools for antiviral therapy. This book will engage scholars in virology and medical microbiology as well as researchers with an interest in enzymology and protein structure and function relationship.