Construction And Characterization Of Gene Regulatory Networks In Yeast PDF Download
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| Author | : Daniel K. Jedrysiak |
| Publisher | : |
| Total Pages | : |
| Release | : 2013 |
| Genre | : Gene regulatory networks |
| ISBN | : |
Download Construction and Characterization of Gene Regulatory Networks in Yeast Book in PDF, ePub and Kindle
Two major roadblocks in synthetic biology are the difficulties associated with the physical assembly of gene regulatory networks (GRNs) and the lack of characterized biological parts. In this work we aimed to address both of these issues. We developed a novel method for the assembly of GRNs called Brick- Mason assembly. We have shown that the method can assemble a 6 part network in a single day and provides significant advancements over traditional cloning methods. We used BrickMason to assemble GRNs that would allow us to compare natural yeast mechanisms of repression to the steric hindrance based mechanisms that are commonly used in synthetic GRNs in yeast. Our results show that the two mechansisms of repression are not equivalent. This finding opens possibilities for using a new class of repressor in a synthetic context in yeast.
| Author | : Alberto Fuente |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 135 |
| Release | : 2014-01-03 |
| Genre | : Science |
| ISBN | : 3642451616 |
Download Gene Network Inference Book in PDF, ePub and Kindle
This book presents recent methods for Systems Genetics (SG) data analysis, applying them to a suite of simulated SG benchmark datasets. Each of the chapter authors received the same datasets to evaluate the performance of their method to better understand which algorithms are most useful for obtaining reliable models from SG datasets. The knowledge gained from this benchmarking study will ultimately allow these algorithms to be used with confidence for SG studies e.g. of complex human diseases or food crop improvement. The book is primarily intended for researchers with a background in the life sciences, not for computer scientists or statisticians.
| Author | : Attila Becskei |
| Publisher | : Humana Press |
| Total Pages | : 0 |
| Release | : 2011-04-12 |
| Genre | : Science |
| ISBN | : 9781617790850 |
Download Yeast Genetic Networks Book in PDF, ePub and Kindle
Regulation of gene expression, a major determinant of gene activity, occupies a central place in molecular biology. Yeast Genetic Networks: Methods and Protocols covers approaches to the systems biological analysis of small-scale gene networks in yeast. Divided into four convenient sections, this detailed volume discusses the methods used to analyze gene expression quantitatively, presents a collection of mathematical and computational tools to analyze stochasticity, adaptation, sensitivity in signal transmission, and oscillations in gene expression, provides instructional methods on how to utilize the tools of quantitative genetics to identify genes that regulate stochasticity and oscillations in gene expression, and concludes with a section devoted to the analysis of conserved gene expression systems and networks in different fungal species. Written in the highly successful Methods in Molecular BiologyTM series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Yeast Genetic Networks: Methods and Protocols serves as an ideal and valuable resource for both novices and experienced researchers.
| Author | : Ilya Shmulevich |
| Publisher | : SIAM |
| Total Pages | : 276 |
| Release | : 2010-01-21 |
| Genre | : Mathematics |
| ISBN | : 0898716926 |
Download Probabilistic Boolean Networks Book in PDF, ePub and Kindle
The first comprehensive treatment of probabilistic Boolean networks, unifying different strands of current research and addressing emerging issues.
| Author | : Etsuko Miyamoto-Sato |
| Publisher | : Humana |
| Total Pages | : 220 |
| Release | : 2014-06-14 |
| Genre | : Medical |
| ISBN | : 9781493908042 |
Download Transcription Factor Regulatory Networks Book in PDF, ePub and Kindle
Transcription Factor Regulatory Methods details various techniques ranging from cutting-edge to general techniques use to study transcription factor regulatory networks. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Transcription Factor Regulatory Methods aids scientists in the further study into post-genomic or the personal genomic era.
| Author | : Jason C. Hung |
| Publisher | : Springer |
| Total Pages | : 2003 |
| Release | : 2019-05-18 |
| Genre | : Technology & Engineering |
| ISBN | : 9811336482 |
Download Frontier Computing Book in PDF, ePub and Kindle
This book presents the proceedings of the 6th International Conference on Frontier Computing, held in Kuala Lumpur, Malaysia on July 3–6, 2018, and provides comprehensive coverage of the latest advances and trends in information technology, science and engineering. It addresses a number of broad themes, including communication networks, business intelligence and knowledge management, web intelligence, and related fields that inspire the development of information technology. The contributions cover a wide range of topics: database and data mining, networking and communications, web and internet of things, embedded systems, soft computing, social network analysis, security and privacy, optical communication, and ubiquitous/pervasive computing. Many of the papers outline promising future research directions. The book is a valuable resource for students, researchers and professionals, and also offers a useful reference guide for newcomers to the field.
| Author | : Jean-Michel Mérillon |
| Publisher | : |
| Total Pages | : |
| Release | : |
| Genre | : Fungi |
| ISBN | : 9783319194561 |
Download Fungal Metabolites Book in PDF, ePub and Kindle
| Author | : Institute of Medicine |
| Publisher | : National Academies Press |
| Total Pages | : 570 |
| Release | : 2011-12-30 |
| Genre | : Science |
| ISBN | : 0309219396 |
Download The Science and Applications of Synthetic and Systems Biology Book in PDF, ePub and Kindle
Many potential applications of synthetic and systems biology are relevant to the challenges associated with the detection, surveillance, and responses to emerging and re-emerging infectious diseases. On March 14 and 15, 2011, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to explore the current state of the science of synthetic biology, including its dependency on systems biology; discussed the different approaches that scientists are taking to engineer, or reengineer, biological systems; and discussed how the tools and approaches of synthetic and systems biology were being applied to mitigate the risks associated with emerging infectious diseases. The Science and Applications of Synthetic and Systems Biology is organized into sections as a topic-by-topic distillation of the presentations and discussions that took place at the workshop. Its purpose is to present information from relevant experience, to delineate a range of pivotal issues and their respective challenges, and to offer differing perspectives on the topic as discussed and described by the workshop participants. This report also includes a collection of individually authored papers and commentary.
| Author | : Florian Markowetz |
| Publisher | : Cambridge University Press |
| Total Pages | : 287 |
| Release | : 2015-07-02 |
| Genre | : Science |
| ISBN | : 131638098X |
Download Systems Genetics Book in PDF, ePub and Kindle
Whereas genetic studies have traditionally focused on explaining heritance of single traits and their phenotypes, recent technological advances have made it possible to comprehensively dissect the genetic architecture of complex traits and quantify how genes interact to shape phenotypes. This exciting new area has been termed systems genetics and is born out of a synthesis of multiple fields, integrating a range of approaches and exploiting our increased ability to obtain quantitative and detailed measurements on a broad spectrum of phenotypes. Gathering the contributions of leading scientists, both computational and experimental, this book shows how experimental perturbations can help us to understand the link between genotype and phenotype. A snapshot of current research activity and state-of-the-art approaches to systems genetics are provided, including work from model organisms such as Saccharomyces cerevisiae and Drosophila melanogaster, as well as from human studies.
| Author | : Shangbin Chen |
| Publisher | : Springer Nature |
| Total Pages | : 246 |
| Release | : 2021-02-09 |
| Genre | : Medical |
| ISBN | : 9813340339 |
Download Quantitative Physiology Book in PDF, ePub and Kindle
Stephen Hawking says that the 21st century will be the century of complexity and indeed now systems biology or medicine means dealing with complexity. Both the genome and physiome have emerged in studying complex physiological systems. Computational and mathematical modeling has been regarded as an efficient tool to boost the understanding about living systems in normal or pathophysiological states. Covering applied methodology, basic case studies and complex applications, this volume provides researchers with an overview of modeling and computational studies of physiology (i.e. quantitative physiology), which is becoming an increasingly important branch of systems biology. This book aims to build multi-scale models to investigate functions in living systems and explain how biomolecules, cells, organs, organ systems and organisms carry out the chemical or physical functions. Some of the models addressed are related to gene expression, calcium signalling, neural activity, blood dynamics and bone mechanics. Combining theory and practice, with extensive use of MATLAB, this book is designed to establish a paradigm for quantitative physiology by integrating biology, mathematics, physics and informatics etc. To benefit from this book, the readers are expected to have a background in general physiology and mathematics
