Computer Aided Applications In Pharmaceutical Technology PDF Download
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| Author | : Jelena Djuris |
| Publisher | : Elsevier Inc. Chapters |
| Total Pages | : 31 |
| Release | : 2013-04-10 |
| Genre | : Technology & Engineering |
| ISBN | : 0128091894 |
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This chapter provides a basic theoretical background on experimental design application and interpretation. Techniques described include screening designs, full and fractional factorial designs, Plackett–Burman design, D-optimal designs, response surface methodology, central composite designs, Box–Behnken design, and mixture designs, etc. The reader will be introduced to the experimental domains covered by specific design, making it easier to select the one appropriate for the problem. After theoretical introduction, a number of illustrative examples of design of experiments application in the field of pharmaceutical technology are presented.
| Author | : Jelena Duris |
| Publisher | : Elsevier |
| Total Pages | : 340 |
| Release | : 2023-09-18 |
| Genre | : Medical |
| ISBN | : 0443186561 |
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Computer-Aided Applications in Pharmaceutical Technology: Delivery Systems, Dosage Forms, and Pharmaceutical Unit Operations, Second Edition covers the fundamentals of experimental design application and interpretation in pharmaceutical technology, chemometric methods with an emphasis on their applications in process control, neural computing, data science, computer-aided biopharmaceutical characterization, as well as the application of computational fluid dynamics in pharmaceutical technology. Completely updated, the book introduces the theory and practice of computational tools through new case studies. Chapters cover Quality by Design in pharmaceutical development, overview data mining methodologies, present computer-aided formulation development, cover experimental design applications, and much more. Presents a comprehensive review of the current state of the art on various computer-aided applications in pharmaceutical technology Includes case studies to facilitate understanding of various concepts in computer-aided applications Covers applications such as the development of dosage forms and/or delivery systems, pharmaceutical unit operations, and relevant physiologically based pharmacokinetic simulations
| Author | : Ljiljana Djekic |
| Publisher | : Elsevier Inc. Chapters |
| Total Pages | : 18 |
| Release | : 2013-04-10 |
| Genre | : Technology & Engineering |
| ISBN | : 0128091886 |
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This chapter introduces the concept of formulation development assisted by computer applications. Development and optimization of various types of pharmaceutical emulsions microemulsions, self-microemulsifying systems, and double emulsions are presented. Illustrative examples are presented to demonstrate the ability of computer-aided tools to facilitate formulation development. Various techniques, such as design of experiments and artificial neural networks, are implemented for optimization of the formulation and/or processing parameters. Furthermore, some of the critical quality attributes and processing parameters are optimized simultaneously. The examples presented should serve as the foundation for the future quality-by-design development of pharmaceutical emulsion and (self) microemulsion formulations.
| Author | : Jelena Djuris |
| Publisher | : Elsevier Inc. Chapters |
| Total Pages | : 13 |
| Release | : 2013-04-10 |
| Genre | : Technology & Engineering |
| ISBN | : 0128091878 |
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This first chapter introduces the concept of quality-by-design (QbD) and its role in pharmaceutical product development. QbD assures the quality of a pharmaceutical product through scientific development and risk management tools, and will eventually enable real-time release, regardless of the formulation type. Several guidelines on pharmaceutical development, quality risk management, and pharmaceutical quality systems are presented that are applicable throughout the product lifecycle. Design space appointment and control strategies for risk management are introduced. The meaning of the QbD concept is presented from both regulatory and manufacturers’ points of view. Several illustrative examples are provided to facilitate the understanding of the QbD concept and ease of its application.
| Author | : Jelena Djuris |
| Publisher | : Elsevier Inc. Chapters |
| Total Pages | : 94 |
| Release | : 2013-04-10 |
| Genre | : Technology & Engineering |
| ISBN | : 0128091916 |
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This chapter presents a review of the possible applications of methods based on neural computing in pharmaceutical products and process development. Some of the methods described are used for classification purposes, whereas others can be applied to modeling and optimization, or even induction of rules. Basic concepts of each method are theoretically described, followed by examples of their application in pharmaceutical technology. A theoretical background aims to provide a better understanding of the methods and is based upon their most important features. Examples should encourage the reader to embrace the above-mentioned methods and use them to complement conventional statistical methods for classification and regression.
| Author | : Sandra Grbic |
| Publisher | : Elsevier Inc. Chapters |
| Total Pages | : 65 |
| Release | : 2013-04-10 |
| Genre | : Technology & Engineering |
| ISBN | : 0128091924 |
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This chapter introduces the concept of gastrointestinal absorption simulation using in silico methodology. Parameters used for model construction and the sensitivity predicted pharmacokinetic responses to various input parameters are described. Virtual trials for in silico modeling of drug absorption are presented. The influence of food on drug absorption, as well as correlation between the in vitro and in vivo results, are also addressed, followed by biowaiver considerations. Numerous examples are provided throughout the chapter.
| Author | : Jelena Djuris |
| Publisher | : Elsevier Inc. Chapters |
| Total Pages | : 39 |
| Release | : 2013-04-10 |
| Genre | : Technology & Engineering |
| ISBN | : 0128091908 |
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This chapter provides a basic theoretical background on chemometrics and chemometric methods for the analysis of multivariate data. Multivariate data analysis is essential for both product and process development and optimization. Depending on the problem studied, classification and/or regression multivariate methods are applied for data analysis. Different supervised and unsupervised methods for classification and regression are presented, followed by examples of their application in pharmaceutical technology. Some of the methods described include principal component analysis, various supervised classification methods, multiple linear regression, principal component regression, partial least squares regression, support vector machines, etc.
| Author | : Ivana Masic |
| Publisher | : Elsevier Inc. Chapters |
| Total Pages | : 40 |
| Release | : 2013-04-10 |
| Genre | : Technology & Engineering |
| ISBN | : 0128091932 |
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This chapter introduces the concept of computational fluid dynamics (CFD) and its applications in pharmaceutical technology. Basic theoretical explanations on the mathematics of fluid flow and numerical grids are provided. CFD is a versatile tool that is mainly used in complex dynamical process characterization. Examples of CFD applications in development of inhalers, analysis of dissolution apparatus hydrodynamics, and fluidized bed process simulations are presented.
| Author | : S. L. Lim |
| Publisher | : |
| Total Pages | : |
| Release | : 2019-09-19 |
| Genre | : |
| ISBN | : 9781645321095 |
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Research and development in the pharmaceutical industry is a time-consuming and expensive process, making it difficult for newly developed drugs to be formulated into commercially available products. Both formulation and process development can be optimized by means of statistically organized experiments, artificial intelligence and other computational methods. Simultaneous development and investigation of pharmaceutical products and processes enables application of quality by design concept that is being promoted by the regulatory authorities worldwide. Computer-aided applications in pharmaceutical technology covers the fundamentals of experimental design application and interpretation in pharmaceutical technology, chemometric methods with emphasis of their application in process control, neural computing. It explains how applications are used at various stages. The book offers readers a unique framework and systems perspective from which they can devise strategies to thoroughly exploit the use of computers in their organizations during all phases of the discovery and development process. This is essential reading for IT professionals and scientists in the pharmaceutical industry as well as researchers involved in informatics. The book's cross-functional, all-phases approach provides a unique opportunity for a holistic analysis and assessment of computer applications in pharmaceutics.
| Author | : Vikas Anand Saharan |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2022 |
| Genre | : |
| ISBN | : 9789811651816 |
Download Computer Aided Pharmaceutics and Drug Delivery Book in PDF, ePub and Kindle
This book examines the role of computer-assisted techniques for discovering, designing, optimizing and manufacturing new, effective, and safe pharmaceutical formulations and drug delivery systems. The book discusses computational approaches, statistical modeling and molecular modeling for the development and safe delivery of drugs in humans. The application of concepts of QbD (Quality by Design), DoE (Design of Experiments), artificial intelligence and in silico pharmacokinetic assessment/simulation have been made a lot easier with the help of commercial software and expert systems. This title provides in-depth knowledge of such useful software with illustrations from the latest researches. The book also fills in the gap between pharmaceutics and molecular modeling at micro, meso and maro scale by covering topics such as advancements in computer-aided Drug Design (CADD), drug-polymer interactions in drug delivery systems, molecular modeling of nanoparticles and pharmaceutics/bioinformatics. This book provides abundant applications of computers in formulation designing and characterization are provided as examples, case studies and illustrations. Short reviews of software, databases and expert systems have also been added to culminate the interest of readers for novel applications in formulation development and drug delivery. Computer-aided pharmaceutics and drug delivery is an authoritative reference source for all the latest scholarly update on emerging developments in computed assisted techniques for drug designing and development. The book is ideally designed for pharmacists, medical practitioners, students and researchers. .
