Computer Aided Antibody Design PDF Download
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Author | : Kouhei Tsumoto |
Publisher | : Springer Nature |
Total Pages | : 481 |
Release | : 2022-11-08 |
Genre | : Medical |
ISBN | : 1071626094 |
Download Computer-Aided Antibody Design Book in PDF, ePub and Kindle
This volume details state-of-the- art methods on computer-aided antibody design. Chapters guide readers through information on antibody sequences and structures, modeling antibody structures and dynamics, prediction and optimization of biological and biophysical properties of antibodies, prediction of antibody-antigen interactions, and computer-aided antibody affinity maturation and beyond. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Computer-Aided Antibody Design aims to be a useful and practical guide to new researchers and experts looking to expand their knowledge. Chapter 2 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Author | : Joo Chuan Tong |
Publisher | : Elsevier |
Total Pages | : 164 |
Release | : 2013-07-31 |
Genre | : Medical |
ISBN | : 1908818417 |
Download Computer-Aided Vaccine Design Book in PDF, ePub and Kindle
Computational pre-screening of antigens is now routinely applied to the discovery of vaccine candidates. Computer-aided vaccine design is a comprehensive introduction to this exciting field of study. The book is intended to be a textbook for researchers and for courses in bioinformatics, as well as a laboratory reference guide. It is written mainly for biologists who want to understand the current methods of computer-aided vaccine design. The contents are designed to help biologists appreciate the underlying concepts and algorithms used, as well as limitations of the methods and strategies for their use. Chapters include: MHC and T cell responses; Immunoglobulins and B cell responses; Scientific publications and databases; Database design; Computational T cell vaccine design; Computational B cell vaccine design; infectious disease informatics; Vaccine safety and quality assessments; and Vaccine adjuvant informatics. Essential reading for any biologist who wants to understand methods of computer-aided vaccine design Description of available data sources and publicly available software, with detailed analysis of strengths and weaknesses Theoretical concepts and practical examples of database design and development for a virtual screening campaign
Author | : Mithun Rudrapal |
Publisher | : Elsevier |
Total Pages | : 324 |
Release | : 2022-05-26 |
Genre | : Science |
ISBN | : 0323914330 |
Download Computer Aided Drug Design (CADD): From Ligand-Based Methods to Structure-Based Approaches Book in PDF, ePub and Kindle
Computer-Aided Drug Design (CADD): From Ligand-Based Methods to Structure-Based Approaches outlines the basic theoretical principles, methodologies and applications of different fundamental and advanced CADD approaches and techniques. Including information on current protocols as well as recent developments in the computational methods, tools and techniques used for rational drug design, the book explains the fundamental aspects of CADD, combining this with a practical understanding of the various in silico approaches used in modern drug discovery processes to assess the field in a comprehensive and systematic manner. Providing up-to-date, information and guidance for scientists, researchers, students and teachers, the book helps readers address specific academic and research related problems using illustrative explanations, examples and case studies, which are systematically reviewed. Highlights in silico approaches to drug design and discovery using computational tools and techniques Details ligand-based and structure-based drug design in a comprehensive and systematic approach Summarizes recent developments in computational drug design strategy as novel approaches of rational drug designing
Author | : Jared Adolf-Bryfogle |
Publisher | : |
Total Pages | : 560 |
Release | : 2015 |
Genre | : Cytology |
ISBN | : |
Download A Generalized Framework for Computational Antibody Design Book in PDF, ePub and Kindle
A novel knowledge-based computational antibody design methodology an application have been developed for the design of antibodies and antibody therapeutics to targets of interest. It has been rigorously benchmarked to reproduce native antibody structures and sequences, and has been used to successfully design an antibody to a target antigen as a proof of concept of de novo design. Our lab’s recent clustering of the structures of antibody Complementary Determining Regions (CDRs) in the Protein Data Bank (PDB) enabled the development of the antibody analysis software and database, PyIgClassify, which forms the core of this knowledge-based approach where we use the structural clusters and associated sequence profiles to guide design. The Program uses the Rosetta energy function and new methods for reliable CDR grafting, cluster-based constraints, profile-based sequence design, and flexible-backbone design to computationally test hundreds of thousands of prospective antibody designs in the span of days. Methods were developed for quickly analyzing structural properties of potential designs using the Rosetta FeatureReporter framework, while a Graphical User Interface (GUI), PyIgDesign, was created to aid in antibody design selection. The Rosetta Antibody Design (RAbD) program is meant to sample the diverse sequence, structure, and binding space of an antibody to an antigen. It was developed to enable near-complete customization for a variety of design strategies and projects and can design antibodies for a broad range of applications, from affinity of existing antibody-antigen complex structures to de novo design in which whole new sequences and antibody-antigen contacts are created.
Author | : |
Publisher | : ScholarlyEditions |
Total Pages | : 758 |
Release | : 2013-06-21 |
Genre | : Medical |
ISBN | : 1481680102 |
Download Serum Globulins—Advances in Research and Application: 2013 Edition Book in PDF, ePub and Kindle
Serum Globulins—Advances in Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about ZZZAdditional Research. The editors have built Serum Globulins—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Serum Globulins—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author | : Fei Ye |
Publisher | : Frontiers Media SA |
Total Pages | : 205 |
Release | : 2022-08-17 |
Genre | : Science |
ISBN | : 2889767841 |
Download Computer-Aided Drug Design: Drug Discovery, Computational Modelling, and Artificial Intelligence Book in PDF, ePub and Kindle
Author | : Mohane S. Coumar |
Publisher | : Academic Press |
Total Pages | : 522 |
Release | : 2021-02-17 |
Genre | : Medical |
ISBN | : 0128223138 |
Download Molecular Docking for Computer-Aided Drug Design Book in PDF, ePub and Kindle
Molecular Docking for Computer-Aided Drug Design: Fundamentals, Techniques, Resources and Applications offers in-depth coverage on the use of molecular docking for drug design. The book is divided into three main sections that cover basic techniques, tools, web servers and applications. It is an essential reference for students and researchers involved in drug design and discovery. Covers the latest information and state-of-the-art trends in structure-based drug design methodologies Includes case studies that complement learning Consolidates fundamental concepts and current practice of molecular docking into one convenient resource
Author | : Theam Soon Lim |
Publisher | : Springer |
Total Pages | : 0 |
Release | : 2018-12-12 |
Genre | : Medical |
ISBN | : 9783030101534 |
Download Recombinant Antibodies for Infectious Diseases Book in PDF, ePub and Kindle
There are many principles and applications of recombinant antibodies for infectious diseases. The preferred technology associated to recombinant antibody generation is mainly phage display. The adaptation of antibodies for infectious diseases is an area lacking information as most literature is focused on oncology or autoimmunity. This project highlights the power and potential of antibody phage display for infectious diseases. In addition to that, supplementary information regarding technologies associated to antibody generation and engineering in the context of infectious disease will also help to provide greater insight to the potential of recombinant antibodies for infectious diseases.
Author | : Ruidan Su |
Publisher | : Springer Nature |
Total Pages | : 567 |
Release | : 2024-01-20 |
Genre | : Technology & Engineering |
ISBN | : 9811667756 |
Download Medical Imaging and Computer-Aided Diagnosis Book in PDF, ePub and Kindle
This book covers virtually all aspects of image formation in medical imaging, including systems based on ionizing radiation (x-rays, gamma rays) and non-ionizing techniques (ultrasound, optical, thermal, magnetic resonance, and magnetic particle imaging) alike. In addition, it discusses the development and application of computer-aided detection and diagnosis (CAD) systems in medical imaging. Given its coverage, the book provides both a forum and valuable resource for researchers involved in image formation, experimental methods, image performance, segmentation, pattern recognition, feature extraction, classifier design, machine learning / deep learning, radiomics, CAD workstation design, human–computer interaction, databases, and performance evaluation.
Author | : Jonathan S. Harris |
Publisher | : |
Total Pages | : 152 |
Release | : 1996 |
Genre | : |
ISBN | : |
Download Computer-aided Modeling of the Binding Sites of Anti-fluorescein Antibodies Book in PDF, ePub and Kindle