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Computational Modeling in Tissue Engineering

Computational Modeling in Tissue Engineering
Author: Liesbet Geris
Publisher: Springer Science & Business Media
Total Pages: 438
Release: 2012-10-30
Genre: Technology & Engineering
ISBN: 3642325637

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One of the major challenges in tissue engineering is the translation of biological knowledge on complex cell and tissue behavior into a predictive and robust engineering process. Mastering this complexity is an essential step towards clinical applications of tissue engineering. This volume discusses computational modeling tools that allow studying the biological complexity in a more quantitative way. More specifically, computational tools can help in: (i) quantifying and optimizing the tissue engineering product, e.g. by adapting scaffold design to optimize micro-environmental signals or by adapting selection criteria to improve homogeneity of the selected cell population; (ii) quantifying and optimizing the tissue engineering process, e.g. by adapting bioreactor design to improve quality and quantity of the final product; and (iii) assessing the influence of the in vivo environment on the behavior of the tissue engineering product, e.g. by investigating vascular ingrowth. The book presents examples of each of the above mentioned areas of computational modeling. The underlying tissue engineering applications will vary from blood vessels over trachea to cartilage and bone. For the chapters describing examples of the first two areas, the main focus is on (the optimization of) mechanical signals, mass transport and fluid flow encountered by the cells in scaffolds and bioreactors as well as on the optimization of the cell population itself. In the chapters describing modeling contributions in the third area, the focus will shift towards the biology, the complex interactions between biology and the micro-environmental signals and the ways in which modeling might be able to assist in investigating and mastering this complexity. The chapters cover issues related to (multiscale/multiphysics) model building, training and validation, but also discuss recent advances in scientific computing techniques that are needed to implement these models as well as new tools that can be used to experimentally validate the computational results.


Advances on Modeling in Tissue Engineering

Advances on Modeling in Tissue Engineering
Author: Paulo R. Fernandes
Publisher: Springer Science & Business Media
Total Pages: 181
Release: 2011-05-21
Genre: Computers
ISBN: 9400712545

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This book presents a collection of chapters describing the state of the art on computational modelling and fabrication in tissue engineering. Tissue Engineering is a multidisciplinary field involving scientists from different fields. The development of mathematical methods is quite relevant to understand cell biology and human tissues as well to model, design and fabricate optimized and smart scaffolds. The chapter authors are the distinguished keynote speakers at the first Eccomas thematic conference on Tissue Engineering where the emphasis was on mathematical and computational modeling for scaffold design and fabrication. This particular area of tissue engineering, whose goal is to obtain substitutes for hard tissues such as bone and cartilage, is growing in importance.


Tissue Engineering

Tissue Engineering
Author: Paulo Rui Fernandes
Publisher: Springer Science & Business Media
Total Pages: 191
Release: 2013-07-31
Genre: Technology & Engineering
ISBN: 9400770731

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This book describes the state of the art on computational modeling and fabrication in Tissue Engineering. It is inspired by the ECCOMAS thematic conference, the European Committee on Computational Methods in Applied Sciences, on Tissue Engineering, held in Lisbon, Portugal, June 2-4, 2011. Tissue Engineering is a multidisciplinary field involving scientists from different fields. The development of mathematical methods is quite relevant to understand cell biology and human tissues as well to model, design and fabricate optimized and smart scaffolds. Emphasis is put on mathematical and computational modeling for scaffold design and fabrication. This particular area of tissue engineering, whose goal is to obtain substitutes for hard tissues such as bone and cartilage, is growing in importance.


Advances on Modeling in Tissue Engineering

Advances on Modeling in Tissue Engineering
Author: Paulo Rui Fernandes
Publisher: Springer
Total Pages: 176
Release: 2011-05-22
Genre: Computers
ISBN: 9789400712539

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This book presents a collection of chapters describing the state of the art on computational modelling and fabrication in tissue engineering. Tissue Engineering is a multidisciplinary field involving scientists from different fields. The development of mathematical methods is quite relevant to understand cell biology and human tissues as well to model, design and fabricate optimized and smart scaffolds. The chapter authors are the distinguished keynote speakers at the first Eccomas thematic conference on Tissue Engineering where the emphasis was on mathematical and computational modeling for scaffold design and fabrication. This particular area of tissue engineering, whose goal is to obtain substitutes for hard tissues such as bone and cartilage, is growing in importance.


Computational Modeling in Biomedical Engineering and Medical Physics

Computational Modeling in Biomedical Engineering and Medical Physics
Author: Alexandru Morega
Publisher: Academic Press
Total Pages: 320
Release: 2020-10-02
Genre: Science
ISBN: 0128178973

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Mathematical and numerical modelling of engineering problems in medicine is aimed at unveiling and understanding multidisciplinary interactions and processes and providing insights useful to clinical care and technology advances for better medical equipment and systems. When modelling medical problems, the engineer is confronted with multidisciplinary problems of electromagnetism, heat and mass transfer, and structural mechanics with, possibly, different time and space scales, which may raise concerns in formulating consistent, solvable mathematical models. Computational Medical Engineering presents a number of engineering for medicine problems that may be encountered in medical physics, procedures, diagnosis and monitoring techniques, including electrical activity of the heart, hemodynamic activity monitoring, magnetic drug targeting, bioheat models and thermography, RF and microwave hyperthermia, ablation, EMF dosimetry, and bioimpedance methods. The authors discuss the core approach methodology to pose and solve different problems of medical engineering, including essentials of mathematical modelling (e.g., criteria for well-posed problems); physics scaling (homogenization techniques); Constructal Law criteria in morphing shape and structure of systems with internal flows; computational domain construction (CAD and, or reconstruction techniques based on medical images); numerical modelling issues, and validation techniques used to ascertain numerical simulation results. In addition, new ideas and venues to investigate and understand finer scale models and merge them into continuous media medical physics are provided as case studies. Presents the fundamentals of mathematical and numerical modeling of engineering problems in medicine Discusses many of the most common modelling scenarios for Biomedical Engineering, including, electrical activity of the heart hemodynamic activity monitoring, magnetic drug targeting, bioheat models and thermography, RF and microwave hyperthermia, ablation, EMF dosimetry, and bioimpedance methods Includes discussion of the core approach methodology to pose and solve different problems of medical engineering, including essentials of mathematical modelling, physics scaling, Constructal Law criteria in morphing shape and structure of systems with internal flows, computational domain construction, numerical modelling issues, and validation techniques used to ascertain numerical simulation results


Uncertainty in Biology

Uncertainty in Biology
Author: Liesbet Geris
Publisher: Springer
Total Pages: 471
Release: 2015-10-26
Genre: Technology & Engineering
ISBN: 3319212966

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Computational modeling allows to reduce, refine and replace animal experimentation as well as to translate findings obtained in these experiments to the human background. However these biomedical problems are inherently complex with a myriad of influencing factors, which strongly complicates the model building and validation process. This book wants to address four main issues related to the building and validation of computational models of biomedical processes: 1. Modeling establishment under uncertainty 2. Model selection and parameter fitting 3. Sensitivity analysis and model adaptation 4. Model predictions under uncertainty In each of the abovementioned areas, the book discusses a number of key-techniques by means of a general theoretical description followed by one or more practical examples. This book is intended for graduate students and researchers active in the field of computational modeling of biomedical processes who seek to acquaint themselves with the different ways in which to study the parameter space of their model as well as its overall behavior.


Computational Modeling and Simulation Examples in Bioengineering

Computational Modeling and Simulation Examples in Bioengineering
Author: Nenad Filipovic
Publisher: John Wiley & Sons
Total Pages: 386
Release: 2021-12-14
Genre: Science
ISBN: 1119563941

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A systematic overview of the quickly developing field of bioengineering—with state-of-the-art modeling software! Computational Modeling and Simulation Examples in Bioengineering provides a comprehensive introduction to the emerging field of bioengineering. It provides the theoretical background necessary to simulating pathological conditions in the bones, muscles, cardiovascular tissue, and cancers, as well as lung and vertigo disease. The methodological approaches used for simulations include the finite element, dissipative particle dynamics, and lattice Boltzman. The text includes access to a state-of-the-art software package for simulating the theoretical problems. In this way, the book enhances the reader's learning capabilities in the field of biomedical engineering. The aim of this book is to provide concrete examples of applied modeling in biomedical engineering. Examples in a wide range of areas equip the reader with a foundation of knowledge regarding which problems can be modeled with which numerical methods. With more practical examples and more online software support than any competing text, this book organizes the field of computational bioengineering into an accessible and thorough introduction. Computational Modeling and Simulation Examples in Bioengineering: Includes a state-of-the-art software package enabling readers to engage in hands-on modeling of the examples in the book Provides a background on continuum and discrete modeling, along with equations and derivations for three key numerical methods Considers examples in the modeling of bones, skeletal muscles, cartilage, tissue engineering, blood flow, plaque, and more Explores stent deployment modeling as well as stent design and optimization techniques Generates different examples of fracture fixation with respect to the advantages in medical practice applications Computational Modeling and Simulation Examples in Bioengineering is an excellent textbook for students of bioengineering, as well as a support for basic and clinical research. Medical doctors and other clinical professionals will also benefit from this resource and guide to the latest modeling techniques.


Modelling Organs, Tissues, Cells and Devices

Modelling Organs, Tissues, Cells and Devices
Author: Socrates Dokos
Publisher: Springer
Total Pages: 504
Release: 2017-03-08
Genre: Technology & Engineering
ISBN: 3642548016

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This book presents a theoretical and practical overview of computational modeling in bioengineering, focusing on a range of applications including electrical stimulation of neural and cardiac tissue, implantable drug delivery, cancer therapy, biomechanics, cardiovascular dynamics, as well as fluid-structure interaction for modelling of organs, tissues, cells and devices. It covers the basic principles of modeling and simulation with ordinary and partial differential equations using MATLAB and COMSOL Multiphysics numerical software. The target audience primarily comprises postgraduate students and researchers, but the book may also be beneficial for practitioners in the medical device industry.


Multiscale Computer Modeling in Biomechanics and Biomedical Engineering

Multiscale Computer Modeling in Biomechanics and Biomedical Engineering
Author: Amit Gefen
Publisher: Springer Science & Business Media
Total Pages: 397
Release: 2014-07-08
Genre: Technology & Engineering
ISBN: 3642364829

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This book reviews the state-of-the-art in multiscale computer modeling, in terms of both accomplishments and challenges. The information in the book is particularly useful for biomedical engineers, medical physicists and researchers in systems biology, mathematical biology, micro-biomechanics and biomaterials who are interested in how to bridge between traditional biomedical engineering work at the organ and tissue scales, and the newer arenas of cellular and molecular bioengineering.


Biofabrication and 3D Tissue Modeling

Biofabrication and 3D Tissue Modeling
Author: Dong-Woo Cho
Publisher: Royal Society of Chemistry
Total Pages: 369
Release: 2019-01-02
Genre: Medical
ISBN: 1788011988

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3D tissue modelling is an emerging field used for the investigation of disease mechanisms and drug development. Integrating physics, chemistry, materials science, and stem cell and biomedical engineering, this book provides a complete foundation to this exciting, and interdisciplinary field.