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Companion and Complementary Diagnostics

Companion and Complementary Diagnostics
Author: Jan Trøst Jørgensen
Publisher: Academic Press
Total Pages: 508
Release: 2019-05-08
Genre: Medical
ISBN: 0128135409

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Companion and Complementary Diagnostics: From Biomarker Discovery to Clinical Implementation provides readers with in-depth insights into the individual steps in the development of companion diagnostic assays, from the early biomarker discovery phase straight through to final regulatory approval. Further, the clinical implementation of companion diagnostic testing in the clinic is also discussed. As the development of predictive or selective biomarker assays linked to specific drugs is substantially increasing, this book offers comprehensive information on this quickly-evolving area of biomedicine. It is an essential resource for those in academic institutions, hospitals and pharma, and biotech and diagnostic commercial companies. Covers all aspects, from biomarker discovery, to development and regulatory approval Explains the "how to" aspects of companion diagnostics Incorporates information on the entire process, allowing for easier and deeper understanding of the topic


Companion Diagnostics (CDx) in Precision Medicine

Companion Diagnostics (CDx) in Precision Medicine
Author: Il-Jin Kim
Publisher: CRC Press
Total Pages: 256
Release: 2019-03-06
Genre: Computers
ISBN: 1000007219

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There is a new trend in anti-cancer therapeutics development: a targeted therapy and precision medicine that targets a subgroup of patients with specific biomarkers. An in vitro diagnostic (IVD) assay is required to identify a subgroup of cancer patients who would benefit from the targeted therapy, or not likely benefit, or have a high risk of side effects from the specific drug treatment. This IVD or medical device is called a companion diagnostic (CDx) assay. It is key to have a robust CDx assay or device for the success of targeted therapy and precision medicine. This book covers the technical, historical, clinical, and regulatory aspects of CDx in precision medicine. Clearly, more and more newly developed oncology drugs will require accompanying CDx assays, and this book, with chapters contributed by renowned oncologists, provides a comprehensive foundation for the knowledge and application of CDx for precision medicine.


Precision Medicine and Artificial Intelligence

Precision Medicine and Artificial Intelligence
Author: Michael Mahler
Publisher: Academic Press
Total Pages: 300
Release: 2021-03-12
Genre: Science
ISBN: 032385432X

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Precision Medicine and Artificial Intelligence: The Perfect Fit for Autoimmunity covers background on artificial intelligence (AI), its link to precision medicine (PM), and examples of AI in healthcare, especially autoimmunity. The book highlights future perspectives and potential directions as AI has gained significant attention during the past decade. Autoimmune diseases are complex and heterogeneous conditions, but exciting new developments and implementation tactics surrounding automated systems have enabled the generation of large datasets, making autoimmunity an ideal target for AI and precision medicine. More and more diagnostic products utilize AI, which is also starting to be supported by regulatory agencies such as the Food and Drug Administration (FDA). Knowledge generation by leveraging large datasets including demographic, environmental, clinical and biomarker data has the potential to not only impact the diagnosis of patients, but also disease prediction, prognosis and treatment options. Allows the readers to gain an overview on precision medicine for autoimmune diseases leveraging AI solutions Provides background, milestone and examples of precision medicine Outlines the paradigm shift towards precision medicine driven by value-based systems Discusses future applications of precision medicine research using AI Other aspects covered in the book include regulatory insights, data analytics and visualization, types of biomarkers as well as the role of the patient in precision medicine


DSM-5 Guidebook

DSM-5 Guidebook
Author: Donald W. Black, M.D.
Publisher: American Psychiatric Pub
Total Pages: 570
Release: 2014-02-01
Genre: Medical
ISBN: 1585624659

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As a companion to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5®), the DSM-5® Guidebook acts as a guide for busy clinicians on the use of diagnostic criteria and codes, documentation, and compensation. It also serves as an educational text and includes a structured curriculum that facilitates its use in courses.


Biopsy Interpretation of the Breast

Biopsy Interpretation of the Breast
Author: Stuart J. Schnitt
Publisher: Lippincott Williams & Wilkins
Total Pages: 569
Release: 2012-10-08
Genre: Medical
ISBN: 1451178158

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A practical guide for the diagnostic surgical pathologist, this new edition of Biopsy Interpretation of the Breast presents the diverse spectrum of pathologic alterations that occur in the breast in a manner analogous to that in which they are encountered in daily practice. Lesions are grouped together according to their histologic patterns rather than by the traditional benign-malignant categorization in order to simulate the way pathologists face these lesions as they examine microscopic slides on a daily basis. The role of adjunctive studies in solving diagnostic problems in breast pathology is emphasized where appropriate. In addition, the clinical significance and impact on patient management of the various diagnoses are discussed and key clinical and management points highlighted.


Rickettsial Diseases

Rickettsial Diseases
Author: Didier Raoult
Publisher: CRC Press
Total Pages: 400
Release: 2007-04-26
Genre: Medical
ISBN: 142001997X

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The only available reference to comprehensively discuss the common and unusual types of rickettsiosis in over twenty years, this book will offer the reader a full review on the bacteriology, transmission, and pathophysiology of these conditions. Written from experts in the field from Europe, USA, Africa, and Asia, specialists analyze specific patho


HER2-Positive Breast Cancer

HER2-Positive Breast Cancer
Author: Sara Hurvitz
Publisher: Elsevier Health Sciences
Total Pages: 264
Release: 2018-07-26
Genre: Medical
ISBN: 0323581234

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Get a quick, expert overview of clinically-focused topics and guidelines that are relevant to testing for HER2, which contributes to approximately 25% of breast cancers today. This concise resource by Drs. Sara Hurvitz, and Kelly McCann consolidates today’s available information on this growing topic into one convenient resource, making it an ideal, easy-to-digest reference for practicing and trainee oncologists.


Biopsy Interpretation of the Prostate

Biopsy Interpretation of the Prostate
Author: Jonathan I. Epstein
Publisher: Lippincott Williams & Wilkins
Total Pages: 608
Release: 2019-11-11
Genre: Medical
ISBN: 197513656X

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Part of the highly regarded Biopsy Interpretation Series, this fully revised volume is your definitive guide to mastering biopsy pathology interpretation for prostate cancer care. Biopsy Interpretation of the Prostate, 6th Edition, provides superbly illustrated guidance from a top expert in the field, guiding you through the best utilization of H&E microscopy as well as the latest immunohistochemical markers in order to deliver accurate, reliable diagnoses. Hundreds of full-color illustrations depict the full range of benign and malignant prostatic entities.


Clinical Case Studies for the Family Nurse Practitioner

Clinical Case Studies for the Family Nurse Practitioner
Author: Leslie Neal-Boylan
Publisher: John Wiley & Sons
Total Pages: 432
Release: 2011-11-28
Genre: Medical
ISBN: 1118277856

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Clinical Case Studies for the Family Nurse Practitioner is a key resource for advanced practice nurses and graduate students seeking to test their skills in assessing, diagnosing, and managing cases in family and primary care. Composed of more than 70 cases ranging from common to unique, the book compiles years of experience from experts in the field. It is organized chronologically, presenting cases from neonatal to geriatric care in a standard approach built on the SOAP format. This includes differential diagnosis and a series of critical thinking questions ideal for self-assessment or classroom use.