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High-Throughput Analysis

High-Throughput Analysis
Author: Radislav A. Potyrailo
Publisher: Springer Science & Business Media
Total Pages: 642
Release: 2012-12-06
Genre: Technology & Engineering
ISBN: 1441989897

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This book, edited by Potyrailo and Amis, addresses a new paradigm-shifting approach in the search for new materials-Combinatorial Materials Science. One way to consider such an approach is to imagine an adventurous chef who decides to look for new entrees by cooking food ingredients in many pots using different combinations in every pot, and boil ing, steaming, or frying them in various ways. Although most of the pots will not have the tastiest food ever devised, some recipes will taste intriguing, and some eventually will lead to a discovery of a new fascinating cuisine. Of course, having a skilled chef design the com binatorial formulation will certainly be helpful in ensuring a successful outcome. Similar to food, each engineering material is a complex product of its chemical composition, structure, and processing. Generally, each of these components matters---change one and you get another material. Most of these "new" materials will be less good than ones we use now since existing materials have been refined with the extensive work of scientists and engi neers. At the same time if one prepares diverse materials like our adventurous chef, chang ing material composition, processing conditions and time, etc. , some of these materials will be superior to existing ones and a few might represent breakout technology.


Combinatorial Materials Science

Combinatorial Materials Science
Author: Marc D. Porter
Publisher: John Wiley & Sons
Total Pages: 247
Release: 2007-08-17
Genre: Technology & Engineering
ISBN: 0470140461

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Combinatorial Materials Science describes new developments and research results in catalysts, biomaterials, and nanomaterials, together with informatics approaches to the analysis of Combinatorial Science (CombiSci) data. CombiSci has been used extensively in the pharmaceutical industry, but there is enormous potential in its application to materials design and characterization. Addressing advances and applications in both fields, Combinatorial Materials Science: Integrates the scientific fundamentals and interdisciplinary underpinnings required to develop and apply CombiSci concepts Discusses the development and use of CombiSci for the systematic and accelerated investigation of new phenomena and of the complex structure-function interplay in materials Covers the development of new library design strategies for materials processing and for high-throughput tools for rapid sampling Uses a unique, unified approach of applying combinatorial methods to unravel the non-linear structure-function relationships in diverse materials (both hard and soft), together with advances in informatics With chapters written by leading researchers in their specialty areas, this authoritative guide is a must-have resource for scientists and engineers in materials science research, biochemists, chemists, immunologists, cell biologists, polymer scientists, chemical and mechanical engineers, statisticians, and computer scientists. It is also a great text for graduate-level courses in materials science/engineering, polymer science, chemical engineering, and chemistry.


Combinatorial Materials Synthesis

Combinatorial Materials Synthesis
Author: Xiao-Dong Xiang
Publisher: CRC Press
Total Pages: 477
Release: 2003-08-19
Genre: Science
ISBN: 0824756339

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Pioneered by the pharmaceutical industry and adapted for the purposes of materials science and engineering, the combinatorial method is now widely considered a watershed in the accelerated discovery, development, and optimization of new materials. Combinatorial Materials Synthesis reveals the gears behind combinatorial materials chemistry and thin-film technology, and discusses the prime techniques involved in synthesis and property determination for experimentation with a variety of materials. Funneling historic innovations into one source, the book explores core approaches to synthesis and rapid characterization techniques for work with combinatorial materials libraries.


Materials Science and Engineering

Materials Science and Engineering
Author: James N. Cawse
Publisher: Elsevier Inc. Chapters
Total Pages: 47
Release: 2013-07-10
Genre: Technology & Engineering
ISBN: 0128059397

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Design of combinatorial and high-throughput experiments has continued to build on the progress of the last two decades. New variations of factorial and mixture designs have expanded their capability. Increasing attention is being paid to adapting designs to the constraints of the physical apparatus, in the form of split-plot methods or conscious understanding of the statistical penalties to be paid. Rapidly increasing computer power has allowed the use of more sophisticated algorithmic designs and evolutionary methods. Finally, descriptor-based design and analysis of data is making steady progress and there are hopes of its reaching a mature state in the coming decade.


Combinatorial and High-Throughput Discovery and Optimization of Catalysts and Materials

Combinatorial and High-Throughput Discovery and Optimization of Catalysts and Materials
Author: Radislav A. Potyrailo
Publisher: CRC Press
Total Pages: 504
Release: 2006-07-19
Genre: Science
ISBN: 1420005383

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The development of parallel synthesis and high-throughput characterization tools offer scientists a time-efficient and cost-effective solution for accelerating traditional synthesis processes and developing the structure-property relationships of multiple materials under variable conditions. Written by renowned contributors to the field, Combina


Materials Science and Engineering

Materials Science and Engineering
Author: Radislav Potyrailo
Publisher: Elsevier Inc. Chapters
Total Pages: 62
Release: 2013-07-10
Genre: Technology & Engineering
ISBN: 0128059427

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Sensing materials play a critical role in advancing selectivity, response speed, and sensitivity of gas determinations with sensors. The desirable capabilities of sensing materials originate from their numerous functional parameters, which can be tailored to meet specific sensing needs. By increasing the structural and functional complexity of sensing materials, the ability to rationally define the precise requirements that will result in desired materials properties becomes increasingly limited. Combinatorial experimentation methodologies impact all areas of sensing materials research. This chapter demonstrates the broad applicability of combinatorial technologies in discovery and optimization of new sensing materials for gas detection. We discuss general principles of combinatorial materials screening, followed by the discussion of the opportunities facilitated by combinatorial technologies for discovery and optimization of new sensing materials. We further critically analyze results of sensing materials development using discrete and gradient materials arrays. The emphasis of this chapter is on the analysis of results focused on the improvements of sensor selectivity and long-term stability of sensing materials. Examples from a wide variety of sensors based on various energy-transduction principles that involve radiant, mechanical, and electrical types of energy demonstrate the impact of combinatorial methodologies across diverse kinds of sensing materials.


Combinatorial Methods and Informatics in Materials Science: Volume 894

Combinatorial Methods and Informatics in Materials Science: Volume 894
Author: M. J. Fasolka
Publisher:
Total Pages: 390
Release: 2006-05-17
Genre: Computers
ISBN:

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Combinatorial and high-throughput experimental approaches and related informatics, modeling and data-mining methods have permitted researchers to accelerate the pace at which new, complex materials and device systems are discovered, optimized and understood. Today, the development and application of these revolutionary approaches continue to grow and diversify. This book offers an international, interdisciplinary perspective for scientists and engineers interested in combinatorial, high-throughput and advanced informatics approaches to materials research. The range of disciplines includes materials science; chemistry; physics; electrical, chemical and mechanical engineering; materials modeling; and data systems engineering. Presentations share successful studies, and illuminate current and emerging challenges in areas including: the design and fabrication of combinatorial libraries for materials and devices; high-throughput characterization methods for such systems; automation of instrumentation and data analysis; advanced modeling and data mining techniques for rapid materials design and properties prediction; and data system design and software for combinatorial workflows.


Dynamic Combinatorial Chemistry

Dynamic Combinatorial Chemistry
Author: Benjamin L. Miller
Publisher: John Wiley & Sons
Total Pages: 280
Release: 2009-12-30
Genre: Science
ISBN: 9780470551547

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Effective techniques for applying Dynamic Combinatorial Chemistry In a relatively short period, Dynamic Combinatorial Chemistry (DCC) has grown from proof-of-concept experiments in a few isolated labs to a broad conceptual framework with applications to an exceptional range of problems in molecular recognition, lead compound identification, catalyst design, nanotechnology, polymer science, and others. Bringing together a group of respected experts, this overview explains how chemists can apply DCC and fragment-based library methods to lead generation for drug discovery and molecular recognition in bioorganic chemistry and materials science. Chapters cover: Basic theory Approaches to binding in proteins and nucleic acids Molecular recognition Self-sorting Catalyst discovery Materials discovery Analytical chemistry challenges A comprehensive, single-source reference about DCC methods and applications including aspects of fragment-based drug discovery, this is a core reference that will spark the development of new solutions and strategies for chemists building structure libraries and designing compounds and materials.


Combinatorial Materials Synthesis

Combinatorial Materials Synthesis
Author: Xiao-Dong Xiang
Publisher: CRC Press
Total Pages: 496
Release: 2003-08-19
Genre: Science
ISBN: 9780824741198

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Pioneered by the pharmaceutical industry and adapted for the purposes of materials science and engineering, the combinatorial method is now widely considered a watershed in the accelerated discovery, development, and optimization of new materials. Combinatorial Materials Synthesis reveals the gears behind combinatorial materials chemistry and thin-film technology, and discusses the prime techniques involved in synthesis and property determination for experimentation with a variety of materials. Funneling historic innovations into one source, the book explores core approaches to synthesis and rapid characterization techniques for work with combinatorial materials libraries.