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Hormones, Cognition and Dementia

Hormones, Cognition and Dementia
Author: Eef Hogervorst
Publisher: Cambridge University Press
Total Pages: 293
Release: 2009-09-24
Genre: Medical
ISBN: 0521899370

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Basic and clinical research on sex steroids, ageing, and cognition to integrate existing findings with emerging data.


Estrogen and Cognitive Functioning in the Menopause Transition

Estrogen and Cognitive Functioning in the Menopause Transition
Author: Julia Anne Grummisch
Publisher:
Total Pages: 0
Release: 2021
Genre:
ISBN:

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Most women report cognitive problems in the menopause transition (i.e. 'perimenopause'), which refers to the five or so years preceding the final menstrual period. Chief concerns allude to forgetfulness, fuzzy thinking, poor working memory, and poor concentration. Although it has been proposed that the hormonal changes associated with the menopause transition may be a contributing factor, very little research has been devoted to studying the effect of reproductive hormones on cognitive functioning during this transition period. The goal of this study was therefore to improve our understanding of the role that reproductive hormone changes play in triggering perimenopausal cognitive difficulties. As such, this is the first study to repeatedly assess the relationship between estradiol levels and subjective and objective cognitive ability within the same perimenopausal woman, allowing for the detection of any transient cognitive weaknesses and their possible relation to temporarily low levels of estradiol. Participants were women (n = 43) aged 45-55 years and who are currently in the menopause transition (defined according to menstrual bleeding patterns). Once a week for 12 weeks, participants provided a urine sample for the measurement of estrone-3- glucuronide (E1G), a urinary metabolite of estradiol, and completed questionnaires assessing subjective cognitive performance. Every three weeks across the 12-week period, participants also underwent cognitive testing, including assessments of immediate and delayed memory, attention, and executive function. Potential confounding variables including sleep quality, vasomotor symptoms, and depressive symptoms were also assessed. It was hypothesized that weeks characterized by low relative E1G would also be characterized by weaknesses in both subjective and objective cognitive ability. Findings suggest that in perimenopause, low levels of endogenous estradiol are associated with worse performance on objective measures of attention, particularly the ability to passively register auditory information on the first pass, subjective measures of memory, specifically relating to a higher frequency of forgetting things in everyday life, and objective attention and short-term memory among perimenopausal women with lower estimated levels of intellectual functioning. Depressive symptoms, vasomotor symptoms and sleep quality did not significantly account for the effects on objective cognitive outcomes. In addition, despite subjective complaints of cognitive dysfunction, all participants performed within the broad average range or higher on objective cognitive measures. As such, while the impact of estradiol on cognitive function was noticeable to some participants, estradiol's impact on objective cognitive performance was relatively small. Taken together, these findings provide evidence that validates and legitimizes perimenopausal women's cognitive complaints. Findings also provide reassurance that these weaknesses are normal and, while bothersome, transient. This research points to the potential for investigating interventions such as hormone therapy for women reporting disruptive cognitive weaknesses.


Neuroscience of Menopause

Neuroscience of Menopause
Author: Maureen M Oviedo
Publisher: Independently Published
Total Pages: 0
Release: 2024-06-03
Genre: Health & Fitness
ISBN:

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Unlock the secrets of the menopausal brain and reclaim your cognitive vitality with this groundbreaking guide! Are you experiencing memory lapses, foggy thinking, or difficulty concentrating? You're not alone. Discover how to navigate these cognitive changes and embrace mental wellness during menopause with the help of neuroscience. Neuroscience of Menopause: Navigating Cognitive Changes & Embracing Mental Wellness" by Maureen M. Oviedo offers an enlightening and empowering journey through the complexities of menopause, providing you with the tools and insights needed to maintain and enhance your brain health during this transformative phase of life. What Makes This Book Special? Scientific Insight: Grounded in the latest research, this book demystifies the cognitive changes associated with menopause, explaining the biological processes behind them in accessible language. Holistic Approach: Integrating lifestyle modifications, nutritional strategies, physical and mental exercises, and medical interventions, this book offers a comprehensive plan to support your cognitive function and overall well-being. Empowering Stories: Real-life stories from women who have successfully navigated menopausal cognitive changes provide inspiration and practical advice. Essential Content and Key Themes Understanding Cognitive Changes: Learn about the hormonal shifts that affect brain function and why some women experience more pronounced cognitive symptoms. Lifestyle Strategies: Discover how sleep, stress management, and social connections play a crucial role in brain health. Nutrition for the Brain: Explore dietary choices that support cognitive function and overall health. Physical and Mental Exercises**: Find out how to incorporate effective exercises into your routine to boost brain power. Medical Interventions: Gain insights into the role of hormone replacement therapy (HRT) and other treatments in managing cognitive symptoms. Mental Wellness: Embrace strategies for fostering a positive mindset and building resilience. This book enables to Gain a deeper understanding of how menopause affects cognitive function. Learn practical tips for improving memory, attention, and processing speed. Discover nutritional and lifestyle changes that can enhance brain health. Find inspiration and guidance from the experiences of other women. Empower yourself with knowledge and strategies to maintain mental clarity and well-being. Who Will Benefit Most from This Book? - Women experiencing menopause and seeking to understand and manage cognitive changes. - Healthcare professionals looking to deepen their understanding of menopause and cognitive health. - Family members and friends supporting loved ones through menopause. - Anyone interested in women's health and the science of the brain. Take Action Now! Empower yourself with the knowledge and tools to navigate cognitive changes and embrace mental wellness during menopause. Purchase "Neuroscience of Menopause: Navigating Cognitive Changes & Embracing Mental Wellness" today and start your journey towards a healthier, more vibrant mind. Don't forget to leave a review and share this transformative guide with others! Transform your understanding of menopause and reclaim your cognitive vitality with Maureen M. Oviedo's expert guidance. Order now and take the first step towards a brighter, more empowered future!


The Menopause Brain

The Menopause Brain
Author: Lisa Mosconi PhD
Publisher: Penguin
Total Pages: 321
Release: 2024-03-12
Genre: Health & Fitness
ISBN: 0593541251

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An instant New York Times bestseller! The New York Times bestselling author of The XX Brain shows women how to navigate menopause successfully and come out the other side with an even better brain. Menopause and perimenopause are still a black box to most doctors, leaving patients exasperated as they grapple with symptoms ranging from hot flashes to insomnia to brain fog. As a leading neuroscientist and women’s brain health specialist, Dr. Mosconi unravels these mysteries by revealing how menopause doesn’t just impact the ovaries—it’s a hormonal show in which the brain takes center stage. The decline of the hormone estrogen during menopause influences everything from body temperature to mood to memory, potentially paving the way for cognitive decline later in life. To conquer these challenges successfully, Dr. Mosconi brings us the latest approaches—explaining the role of cutting-edge hormone replacement therapies like “designer estrogens,” hormonal contraception, and key lifestyle changes encompassing diet, exercise, self-care, and self-talk. Best of all, Dr. Mosconi dispels the myth that menopause signifies an end, demonstrating that it’s actually a transition. Contrary to popular belief, if we know how to take care of ourselves during menopause, we can emerge with a renewed, enhanced brain—ushering in a meaningful and vibrant new chapter of life.


Summary of The Menopause Brain by Lisa Mosconi PhD and Maria Shriver

Summary of The Menopause Brain by Lisa Mosconi PhD and Maria Shriver
Author: gp summary
Publisher: BookRix
Total Pages: 63
Release: 2024-03-17
Genre: Study Aids
ISBN: 3755472198

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DISCLAIMER This book does not in any capacity mean to replace the original book but to serve as a vast summary of the original book. Summary of The Menopause Brain by Lisa Mosconi PhD and Maria Shriver: New Science Empowers Women to Navigate the Pivotal Transition with Knowledge and Confidence IN THIS SUMMARIZED BOOK, YOU WILL GET: Chapter provides an astute outline of the main contents. Fast & simple understanding of the content analysis. Exceptionally summarized content that you may skip in the original book Dr. Mosconi, a leading neuroscientist and women's brain health specialist, explains that menopause is a hormonal show affecting the brain, affecting body temperature, mood, and memory. She suggests using hormone replacement therapies, hormonal contraception, and lifestyle changes to overcome these challenges. She also dispels the myth that menopause signifies an end, stating that if women take care of themselves during menopause, they can emerge with a renewed, enhanced brain.


Cognitive Functioning and Physical Activity During Menopause

Cognitive Functioning and Physical Activity During Menopause
Author: Greer Alicia Raggio
Publisher:
Total Pages: 130
Release: 2015
Genre: Menopause
ISBN:

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Background: Cognitive problems such as forgetfulness, concentration difficulty, and inattention are commonly reported among women in or around the menopause transition. However, objective neurocognitive data do not consistently corroborate subjective cognitive complaints, nor do they effectively distinguish women in different reproductive stages. Further assessments must be conducted to determine the specific cognitive changes occurring around the menopause transition in comparison to other reproductive stages (e.g., late postmenopause). Furthermore, non-pharmacological methods for addressing reported cognitive difficulties should be explored. Aims: The primary study aim (Aim 1) was to evaluate cross-sectional differences in subjective and objective cognitive function among women in perimenopause (irregular menstruation to 1 year after the final menstrual period), early postmenopause (1-5 years after the final menstrual period) and late menopause (> 5 years after the final menstrual period). The secondary aim (Aim 2) was to compare changes in cognitive function and physical activity among women who completed a six-month physical activity intervention. Hypotheses: It was hypothesized that women in perimenopause would score lower on tests of attention and working memory than women in postmenopause. It was also hypothesized that increases in physical activity would be significantly associated with improvements on attention and working memory tasks. Procedure: Forty-five women age 40 to 63 (mean age = 53.6 years) were recruited for a six-month, group-based intervention designed to help midlife women increase sustained aerobic activity. Neurocognitive and physical activity assessments occurred at baseline and 6 months. Participants were given weekly exercise prescriptions, gradually working toward 250 minutes of MVPA per week. Measures: The following neurocognitive domains were evaluated using clinician-administered tests: Global cognition (MoCA) and intelligence (WTAR), attention and working memory (Letter N-Back computer test; Digit Span), verbal learning and memory (Selective Reminding Test), verbal fluency (COWA), and executive function (Trails A and B). Physical activity was quantified by seven-day ActiGraph GT3X accelerometer readings. Statistical Analyses: Regression and ANOVA tests were performed (using the GLM procedure in SPSS), in addition to Pearson's r correlations. Results: At baseline, women in early postmenopause showed significantly worse verbal memory performance than women in perimenopause or late postmenopause (p


The Effects of Estrogen on Brain Function

The Effects of Estrogen on Brain Function
Author: Natalie L. Rasgon
Publisher: JHU Press
Total Pages: 181
Release: 2006-05-05
Genre: Health & Fitness
ISBN: 0801888905

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This timely volume reviews current data on the effects of estrogen on the central nervous system, highlighting clinical aspects of this topic. Experts from the fields of psychiatry, pharmacology, neurology, and geriatrics collaborate to clarify the known risks and benefits of hormone therapy and explore questions that remain to be elucidated. Among the topics discussed: " Preclinical data on estrogen's effects on cognitive performance " The short-lived effects of hormone replacement therapy on cognitive function " Structural and functional brain imaging data regarding estrogen's effects on the central nervous system " Preclinical efforts to develop effective NeuroSERMs for the brain " The effects of estrogen on mood Citing the ongoing confusion over the risks and benefits of estrogen therapy, the contributors emphasize the need for additional research on medication, doses, preparations, methods of administration, alternative therapies, and supplements. This volume educates researchers, clinicians, and students on the current knowledge—including the effects of estrogen on mood, cognition, and brain metabolism—and provides guidelines for clinical practice and future research. Contributors: Roberta Diaz Brinton, Ph.D., University of Southern California; Cheri L. Geist, B.A., David Geffen School of Medicine, University of California at Los Angeles; Robert B. Gibbs, Ph.D., University of Pittsburgh School of Pharmacy; Eva Hogervorst, Ph.D., University of Loughborough and University of Oxford; Pauline M. Maki, Ph.D., Neuropsychiatric Institute, University of Illinois–Chicago; Peter J. Schmidt, M.D., National Institute of Mental Health; Daniel H. S. Silverman, M.D., Ph.D., David Geffen School of Medicine, University of California at Los Angeles; Katherine E. Williams, M.D., Stanford University School of Medicine; Kristine Yaffe, M.D., University of California, San Francisco, and San Francisco VA Medical Center; Laurel N. Zappert, B.A., Stanford University School of Medicine; Liqin Zhao, Ph.D., University of Southern California


Menopause and My Brain

Menopause and My Brain
Author: Ann E Springfield
Publisher: Independently Published
Total Pages: 0
Release: 2024-07-30
Genre: Health & Fitness
ISBN:

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Ever wondered how menopause might impact your mind? Are you feeling a bit lost as you grapple with brain fog, mood swings, or memory lapses? You're not alone. Menopause brings about profound changes that can affect both your body and your brain. But how can you manage these changes and thrive in this new phase of life? In "Menopause and My Brain - A Comprehensive Guide to Navigating Cognitive Changes, Hormonal Shifts, and Emotional Well-being", you'll discover an empowering guide to understanding the connection between menopause and cognitive health. This book is designed to support you through the emotional and mental shifts that accompany menopause, offering practical advice and heartfelt encouragement. Inside, you'll learn about: - The Connection Between Hormones and Brain Function: Explore how hormonal changes impact your brain and what you can do to keep it sharp. - Strategies for Maintaining Mental Sharpness: From engaging in lifelong learning to incorporating stress management techniques, find out how to boost your cognitive function. - The Power of Lifestyle Choices: Discover how diet, exercise, and sleep can support your brain health and overall well-being. - Effective Therapies: Learn about both pharmaceutical and non-pharmaceutical therapies that can help manage symptoms and improve quality of life. Packed with easy-to-understand insights and actionable steps, "Menopause and My Brain" is your companion for navigating this significant life transition with grace and confidence. Embrace the changes, take control of your mental health, and thrive through menopause and beyond. Click on the BUY button to get a copy of this book for yourself today...