Co-expression of Vaccine Antigens in Vaccinia Virus
Author | : Alice Marie Bennett |
Publisher | : |
Total Pages | : 283 |
Release | : 1995 |
Genre | : |
ISBN | : |
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Author | : Alice Marie Bennett |
Publisher | : |
Total Pages | : 283 |
Release | : 1995 |
Genre | : |
ISBN | : |
Author | : Gerald V. Quinnan |
Publisher | : Elsevier Publishing Company |
Total Pages | : 280 |
Release | : 1985 |
Genre | : Medical |
ISBN | : |
Author | : Stuart N. Isaacs |
Publisher | : Springer Science & Business Media |
Total Pages | : 402 |
Release | : 2008-02-03 |
Genre | : Science |
ISBN | : 1592597890 |
The Right Book at the Right Time The poxviruses comprise a family of complex DNA viruses that replicate in the cytoplasm of vertebrate or invertebrate cells. Of the eight recognized g- era of vertebrate poxviruses, those belonging to the orthopoxvirus genus have been most intensively studied. This group includes variola virus, the agent of smallpox, as well as cowpox virus and vaccinia virus. Jenner’s original sma- pox vaccine, described in 1798, consisted of live cowpox virus, but vaccinia virus later replaced it (1). There has been speculation as to the origin of v- cinia virus; the most likely idea is that it is a separate species, possibly ori- nally isolated from a horse, and is now extinct or rare in nature (2). Recent genome sequencing studies confirm the distinctness of variola virus, cowpox virus, and vaccinia virus and also their very close genetic relationship, which accounts for the cross protection of smallpox vaccines. The novelty of the smallpox vaccine can be readily appreciated by the time it took, about 80 years, before the next live vaccine against rabies was developed, and another 50 years for the yellow fever vaccine. Moreover, the eradication of smallpox in 1977 stands as a unique medical achievement. Because of its historical role, sma- pox vaccination contributed greatly to present concepts of infectious disease, immunity, and pathogenesis. Less well known, however, are the many other “firsts” for vaccinia virus.
Author | : Sara Cohen |
Publisher | : Springer Science & Business Media |
Total Pages | : 197 |
Release | : 2013-06-29 |
Genre | : Medical |
ISBN | : 1489913823 |
Vaccination is one of the most efficient and cost effective methods of promoting human health and has been in clinical use for at least 200 years. Nevertheless, infectious diseases continue to constitute a constant threat to the well being of humanity. Common pathogens, once believed to be under control, acquire increased virulence and resistance to drugs, while exotic microorganisms emerged from hidden reservoirs to cause yet incurable diseases in humans. These changes, together with epidemic outbreaks related to political and socio-economic instabilities, increase the needs for the development of new, advanced vaccines. In this volume, devoted to the proceedings of the 39th OHOLO Conference, we present some of the recent strategies for the design and production of novel vaccines. The advent of recombinant DNA technology has stimulated the production of several subunit vaccines. In spite of the obvious advantages to this approach, the limited immuno genicity of many subunit candidates has hindered their development. Strategies to enhance the immunogenicity of subunit vaccines is therefore critical. Several approaches toward this goal, including design of novel adjuvants and delivery systems as well as design of advantageous carriers, are presented here. Among the carriers evaluated here are polypep tides (flagellin, HBV core antigen, J3-galactosidase), attenuated virions (Vaccinia, Sindbis), and nonpathogenic licensed bacteria (Salmonella).
Author | : Jeffrey Laurence |
Publisher | : Academic Press |
Total Pages | : 356 |
Release | : 2015-11-18 |
Genre | : Technology & Engineering |
ISBN | : 0128005521 |
Translating Regenerative Medicine to the Clinic reviews the current methodological tools and experimental approaches used by leading translational researchers, discussing the uses of regenerative medicine for different disease treatment areas, including cardiovascular disease, muscle regeneration, and regeneration of the bone and skin. Pedagogically, the book concentrates on the latest knowledge, laboratory techniques, and experimental approaches used by translational research leaders in this field. It promotes cross-disciplinary communication between the sub-specialties of medicine, but remains unified in theme by emphasizing recent innovations, critical barriers to progress, the new tools that are being used to overcome them, and specific areas of research that require additional study to advance the field as a whole. Volumes in the series include Translating Gene Therapy to the Clinic, Translating Regenerative Medicine to the Clinic, Translating MicroRNAs to the Clinic, Translating Biomarkers to the Clinic, and Translating Epigenetics to the Clinic. Encompasses the latest innovations and tools being used to develop regenerative medicine in the lab and clinic Covers the latest knowledge, laboratory techniques, and experimental approaches used by translational research leaders in this field Contains extensive pedagogical updates aiming to improve the education of translational researchers in this field Provides a transdisciplinary approach that supports cross-fertilization between different sub-specialties of medicine
Author | : R.C. Kennedy |
Publisher | : Elsevier |
Total Pages | : 557 |
Release | : 1997-11-19 |
Genre | : Medical |
ISBN | : 0080534430 |
This is the most comprehensive review of the idiotypic network available. All the current knowledge of idiotypes of the various antibodies is incorporated in this volume. The pathogenic role of idiotypes in autoimmunity and cancer is reviewed in depth. The therapeutic part focusses on harnessing anti-idiotypes for treating autoimmunological disorders, and on the employment of idiotypes for vaccines in cancer and infectious diseases, as well as explaining the manipulation of the idiotypic network in autoimmunity and cancer idiotypes and vaccines.
Author | : Daan J. A. Crommelin |
Publisher | : CRC Press |
Total Pages | : 456 |
Release | : 2002-11-14 |
Genre | : Medical |
ISBN | : 9780415285018 |
The field of pharmaceutical biotechnology is evolving rapidly. A whole new arsenal of protein pharmaceuticals is being produced by recombinant techniques for cancer, viral infections, cardiovascular and hereditary disorders, and other diseases. In addition, scientists are confronted with new technologies such as polymerase chain reactions, combinatorial chemistry and gene therapy. This introductory textbook provides extensive coverage of both the basic science and the applications of biotechnology-produced pharmaceuticals, with special emphasis on their clinical use. Pharmaceutical Biotechnology serves as a complete one-stop source for undergraduate pharmacists, and it is valuable for researchers and professionals in the pharmaceutical industry as well.
Author | : J. M. Maurice |
Publisher | : World Health Organization |
Total Pages | : 204 |
Release | : 2009-07-20 |
Genre | : Medical |
ISBN | : 9241563869 |
This casebook collects 64 case studies each of which raises an important and difficult ethical issue connected with planning, reviewing or conducting health-related research. The book's purpose is to contribute to thoughtful analysis of these issues by researchers and members of research ethics committees (REC's known in some places as ethical review committees or institutional review boards) particularly those involved with studies that are conducted or sponsored internationally. . This collection is envisioned principally as a tool to aid educational programs from short workshops on research.
Author | : Allan Granoff |
Publisher | : Academic Press |
Total Pages | : 926 |
Release | : 1999-09-03 |
Genre | : Medical |
ISBN | : |
Reference source of current virological knowledge. It is also the first to bring together all aspects of the subject for a wide variety of readers. Unique in its use of concise 'mini-review' articles, the mate rial covers biological, molecular, and medical topics concerning viruses in animals, plants, bacteria, and insects. More general articles focus on the effects of viruses on the immune system, the role of viruses in disease, oncology, gene therapy, and evolution, plus a wide range of related topics.
Author | : |
Publisher | : |
Total Pages | : 146 |
Release | : 1975 |
Genre | : Immunoenzyme technique |
ISBN | : |