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| Author | : Bertram Pitt |
| Publisher | : Bailliere Tindall Limited |
| Total Pages | : 408 |
| Release | : 1997 |
| Genre | : Medical |
| ISBN | : |
This text, aimed at the clinical cardiologist, covers the planning of and partcipation in a clinical trial. It interprets the importance of past clinical trials in current clinical practice.
| Author | : Marcus Flather |
| Publisher | : John Wiley & Sons |
| Total Pages | : 421 |
| Release | : 2012-12-03 |
| Genre | : Medical |
| ISBN | : 1405162155 |
The pace of therapeutic advances in the treatment of cardiovascular diseases is rapid, and new clinically-relevant information appears with such frequency that it can be extremely challenging for clinicians to keep up. Still, knowledge and interpretation of major clinical trials is crucial for the range of clinicians who manage cardiovascular patients, especially since important trial evidence often needs to be implemented soon after it is published. Confidently apply gold standard treatment for 10 of the most critical areas of cardiology Written by an international team of experts, Cardiovascular Clinical Trials: Putting the Evidence into Practice: Provides a succinct overview of recent major clinical trials - the gold standard for all medical treatment - across all the major cardiovascular subspecialties, to ensure you’re up-to-date on the most critical findings Guides cardiology trainees and clinicians on how cardiovascular clinical trials are designed and conducted, including statistical methodology, so you can conduct and/or appraise future trials yourself Addresses methodology as well as clinical effectiveness Offers evidence-based assessments on the most effective treatments and authoritative clinical information on management of the conditions so you can confidently apply what you learn Physicians, surgeons, specialist nurses – any clinician seeking an accessible resource for designing and conducting cardiovascular trials and then translating their results into practice will appreciate this book’s clear guidance and succinct and practical approach.
| Author | : JoAnn E. Manson |
| Publisher | : |
| Total Pages | : 456 |
| Release | : 2004 |
| Genre | : Medical |
| ISBN | : |
This new edition covers important new trials in cardiology therapies and prevention of cardiovascular problems. The world authorities on pharmacologic clinical trials write about the trials, the outcomes and importance for clinical practice. This book gives the general cardiologist insight into the development of new therapies in cardiology as well as the process of how trials were used for those therapies. In addition to providing a manual for how to establish trials, trials for treatment and prevention are covered.
| Author | : Weili He |
| Publisher | : Springer |
| Total Pages | : 420 |
| Release | : 2014-10-15 |
| Genre | : Medical |
| ISBN | : 1493911007 |
This edited volume is a definitive text on adaptive clinical trial designs from creation and customization to utilization. As this book covers the full spectrum of topics involved in the adaptive designs arena, it will serve as a valuable reference for researchers working in industry, government and academia. The target audience is anyone involved in the planning and execution of clinical trials, in particular, statisticians, clinicians, pharmacometricians, clinical operation specialists, drug supply managers, and infrastructure providers. In spite of the increased efficiency of adaptive trials in saving costs and time, ultimately getting drugs to patients sooner, their adoption in clinical development is still relatively low. One of the chief reasons is the higher complexity of adaptive design trials as compared to traditional trials. Barriers to the use of clinical trials with adaptive features include the concerns about the integrity of study design and conduct, the risk of regulatory non-acceptance, the need for an advanced infrastructure for complex randomization and clinical supply scenarios, change management for process and behavior modifications, extensive resource requirements for the planning and design of adaptive trials and the potential to relegate key decision makings to outside entities. There have been limited publications that address these practical considerations and recommend best practices and solutions. This book fills this publication gap, providing guidance on practical considerations for adaptive trial design and implementation. The book comprises three parts: Part I focuses on practical considerations from a design perspective, whereas Part II delineates practical considerations related to the implementation of adaptive trials. Putting it all together, Part III presents four illustrative case studies ranging from description and discussion of specific adaptive trial design considerations to the logistic and regulatory issues faced in trial implementation. Bringing together the expertise of leading key opinion leaders from pharmaceutical industry, academia, and regulatory agencies, this book provides a balanced and comprehensive coverage of practical considerations for adaptive trial design and implementation.
| Author | : Institute of Medicine |
| Publisher | : National Academies Press |
| Total Pages | : 304 |
| Release | : 2010-12-04 |
| Genre | : Medical |
| ISBN | : 030915698X |
The Social Security Administration (SSA) uses a screening tool called the Listing of Impairments to identify claimants who are so severely impaired that they cannot work at all and thus immediately qualify for benefits. In this report, the IOM makes several recommendations for improving SSA's capacity to determine disability benefits more quickly and efficiently using the Listings.
| Author | : Matthijs Blankesteijn |
| Publisher | : Academic Press |
| Total Pages | : 221 |
| Release | : 2014-12-05 |
| Genre | : Medical |
| ISBN | : 0128004851 |
Inflammation in Heart Failure, edited by W. Matthijs Blankesteijn and Raffaele Altara, is the first book in a decade to provide an in-depth assessment on the causes, symptoms, progression and treatments of cardiac inflammation and related conditions. This reference uses two decades of research to introduce new methods for identifying inflammatory benchmarks from early onset to chronic heart failure and specifically emphasizes the importance of classifying at-risk subgroups within large populations while determining the patterns of cytokines in such classifications. Further, the book details clinical applications of the pathophysiological mechanisms of heart failure, diagnosis and therapeutic strategies. Inflammation in Heart Failure’s breadth of subject matter, easy-to-follow structure, portability, and high-quality illustrations create an accessible benefit for researchers, clinicians and students. Presents updated information and research on the relevant inflammatory mediators of heart failure to aid in targeting future translational research as well as the improvement of early diagnosis and treatment Provides research into better understanding the different inflammatory mediators that signal the underlying diseases that potentially lead to heart failure Contains 20 years of research, offering a brief overview of the topic leading to current opinions on, and treatment of, heart failure Provides a structured, systematic and balanced overview of the role of inflammation in heart failure making it a useful resource for researchers and clinicians, as well as those studying cardiovascular diseases
| Author | : Peter J. Sharis |
| Publisher | : Lippincott Williams & Wilkins |
| Total Pages | : 390 |
| Release | : 2003 |
| Genre | : Medical |
| ISBN | : 9780781739108 |
Thoroughly updated with the most current clinical trials and the latest American College of Cardiology and American Heart Association guidelines, this pocket-sized handbook provides quick, easy access to clinical trial data that support or refute clinical interventions. Each chapter summarizes the pathophysiology of a disease and the guideline-recommended diagnostic tests and treatments, and presents synopses of the major clinical trials for all therapies. This edition includes a new preventive cardiology section, an index of trial acronyms, highlights of selected pivotal trials, and a new mini-section covering clinical reference formulas. This Second Edition is also available electronically for PDAs. See Media Products section for details.
| Author | : Christopher C. Cannon |
| Publisher | : Lippincott Williams & Wilkins |
| Total Pages | : 496 |
| Release | : 2012-03-28 |
| Genre | : Medical |
| ISBN | : 1451148186 |
Thoroughly updated for its Third Edition, this pocket-sized handbook provides easy access to clinical trial data that are crucial in therapeutic decision-making. The book enables clinicians to quickly review the studies that support or refute an intervention and choose the most appropriate, cost-effective treatment. Each chapter summarizes the pathophysiology of a disease and guideline-recommended diagnostic tests and treatments, and presents synopses of the major clinical trials for all therapies. New sections in this Third Edition cover peripheral artery disease and drug-eluting stents. This edition also features expanded coverage of pacers and ICDs and an expanded section on preventive pre-hospital cardiology.
| Author | : Alexandre Mebazaa |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 922 |
| Release | : 2009-12-24 |
| Genre | : Medical |
| ISBN | : 1846287820 |
For many years, there has been a great deal of work done on chronic congestive heart failure while acute heart failure has been considered a difficult to handle and hopeless syndrome. However, in recent years acute heart failure has become a growing area of study and this is the first book to cover extensively the diagnosis and management of this complex condition. The book reflects the considerable amounts of new data reported and many new concepts which have been proposed in the last 3-4 years looking at the epidemiology, diagnostic and treatment of acute heart failure.
| Author | : Emerson c. Perin |
| Publisher | : Academic Press |
| Total Pages | : 538 |
| Release | : 2015-08-21 |
| Genre | : Medical |
| ISBN | : 0128018631 |
Stem Cell and Gene Therapy for Cardiovascular Disease is a state-of-the-art reference that combines, in one place, the breadth and depth of information available on the topic. As stem cell and gene therapies are the most cutting-edge therapies currently available for patients with heart failure, each section of the book provides information on medical trials from contributors and specialists from around the world, including not only what has been completed, but also what is planned for future research and trials. Cardiology researchers, basic science clinicians, fellows, residents, students, and industry professionals will find this book an invaluable resource for further study on the topic. Provides information on stem and gene therapy medical trials from contributors and specialists around the world, including not only what has been completed, but also what is planned for future research and trials Presents topics that can be applied to allogeneic cells, mesenchymal cells, gene therapy, cardiomyoctyes, iPS cells, MAPC's, and organogenesis Covers the three areas with the greatest clinical trials to date: chronic limb ischemia, chronic angina, and acute MI Covers the prevailing opinions on how to harness the body’s natural repair mechanisms Ideal resource for cardiology researchers, basic science clinicians, fellows, residents, students, and industry professionals
