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Genetic Disorders Among Arab Populations

Genetic Disorders Among Arab Populations
Author: Ahmad S. Teebi
Publisher: Springer Science & Business Media
Total Pages: 776
Release: 2010-07-30
Genre: Medical
ISBN: 3642050808

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Arab populations have their “own” genetic disorders, both universal and particular. Genetic diversity within these source populations, along with the fact that the rates of inbreeding are often high and family sizes are often large, constitute conditions that facilitate the emergence and detection of phenotypes explained notably by autosomal recessive inheritance; in which case, the use of homozygosity gene mapping can facilitate the discovery of the corresponding genes. The present book includes 5 parts dealing with various aspects that relate to the genetic structure of Arabs and minorities within the Arab world as well as genetic disorders prevalent in this part of the world. It includes updated reviews of the genetic disorders in various Arab countries and geographic regions. The focus is primarily, but not exclusively, on the group of single-gene disorders with particular emphasis on autosomal recessive conditions. It further includes epidemiological and clinical data as well as inheritance patterns, mutation and polymorphism data, and available haplotype analysis data. The ethnic and genetic diversity of the Arab populations is discussed as well as aspects of genetic counseling practice in this region together with a proposal for an ethical framework for genetic research and prevention of genetic disorders. The target audience of this book includes human and medical geneticists, genetic counselors, researchers, medical specialists dealing with Arab patients or practicing in Arab countries, medical and genetic counseling students, and nurses.


Primary Immunodeficiency Diseases

Primary Immunodeficiency Diseases
Author: Hans D. Ochs
Publisher:
Total Pages: 745
Release: 2007
Genre: Medical
ISBN: 019514774X

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The second edition of Primary Immunodeficiency Diseases presents discussions of gene identification, mutation detection, and clinical and research applications for over 100 genetic immune disorders--disorders featuring an increased susceptibility to infections and, in certain conditions, an icreased rate of malignancies and autoimmune disorders. Since the publication of the first edition, a flurry of new disease entities has been defined and new treatment regimens have been introduced, the most spectacular being successful treatment by gene therapy for two genotypes of combined immunodeficiency. The first edition marked a historic turning point in the field of immunodeficiencies, demonstrating that many of the disorders of the immune systam could be understood at a molecular level. This new edition can proudly document the tremendous pace of progress in dissecting the complex immunologic networks responsible for protecting individuals from these disorders.


A Characterization of Pyrin

A Characterization of Pyrin
Author: Philip E. Schaner
Publisher:
Total Pages: 520
Release: 2003
Genre:
ISBN:

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The Genetics of Renal Disease

The Genetics of Renal Disease
Author: Frances Flinter
Publisher:
Total Pages: 600
Release: 2003
Genre: Medical
ISBN:

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Renal genetic disorders may become apparent at any time in life and recognition of specific renal disorders is important in allowing accurate genetic counselling. Active counselling requires knowledge about the natural history of the disorder, an understanding of the genetic component and mode of inheritance, risk of the disorder in other family members, information about patient attitudes towards family planning and the possibility of pre-natal diagnosis. The Genetics of Renal Disease covers these issues in detail. The book provides a comprehensive account of both the hereditary nephropathies and more generalised disorders which may affect the renal tract. It includes comprehensive guidelines from an international group of authors on renal function and development, choromosomal disorders, dysmorphic syndromes, inherited predisposition to kidney cancer and gene therapy for renal cancer. Specific chapters deal with individual renal tract disorders such as an extensive discussion of Alport's disease, cystic renal diseases, the Bardet-Biedl and Alstrom syndromes. Each section gives a brief description of the clinical and pathological features of a particular disorder, followed by a review of the genetics of the disorder including incidence, inheritance of familial occurrence, genetic linkage and gene assignment, and prenatal diagnosis and carrier detection. Original studies are extensively quoted and are referenced at the end of each section. There are a great many dysmorphic syndromes which involve the urinary tract. These are incorporated within the book. Aimed primarily at clinical and medical geneticists, this book will also appeal to researchers into genetic kidney disease and genetic counsellors as well as nephrologists with an interest in this area.


Inflammation, Lifestyle and Chronic Diseases

Inflammation, Lifestyle and Chronic Diseases
Author: Bharat B. Aggarwal
Publisher: CRC Press
Total Pages: 483
Release: 2016-04-19
Genre: Medical
ISBN: 1439839905

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Oxidative stress and inflammation are among the most important factors of disease. Chronic infections, obesity, alcohol and tobacco usage, radiation, environmental pollutants, and high-calorie diets have been recognized as major risk factors for a variety of chronic diseases from cancer to metabolic diseases. All these risk factors are linked to ch


Victims of the Chilean Miracle

Victims of the Chilean Miracle
Author: Peter Winn
Publisher: Duke University Press
Total Pages: 443
Release: 2004-07-20
Genre: History
ISBN: 0822385856

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Chile was the first major Latin American nation to carry out a complete neoliberal transformation. Its policies—encouraging foreign investment, privatizing public sector companies and services, lowering trade barriers, reducing the size of the state, and embracing the market as a regulator of both the economy and society—produced an economic boom that some have hailed as a “miracle” to be emulated by other Latin American countries. But how have Chile’s millions of workers, whose hard labor and long hours have made the miracle possible, fared under this program? Through empirically grounded historical case studies, this volume examines the human underside of the Chilean economy over the past three decades, delineating the harsh inequities that persist in spite of growth, low inflation, and some decrease in poverty and unemployment. Implemented in the 1970s at the point of the bayonet and in the shadow of the torture chamber, the neoliberal policies of Augusto Pinochet’s dictatorship reversed many of the gains in wages, benefits, and working conditions that Chile’s workers had won during decades of struggle and triggered a severe economic crisis. Later refined and softened, Pinochet’s neoliberal model began, finally, to promote economic growth in the mid-1980s, and it was maintained by the center-left governments that followed the restoration of democracy in 1990. Yet, despite significant increases in worker productivity, real wages stagnated, the expected restoration of labor rights faltered, and gaps in income distribution continued to widen. To shed light on this history and these ongoing problems, the contributors look at industries long part of the Chilean economy—including textiles and copper—and industries that have expanded more recently—including fishing, forestry, and agriculture. They not only show how neoliberalism has affected Chile’s labor force in general but also how it has damaged the environment and imposed special burdens on women. Painting a sobering picture of the two Chiles—one increasingly rich, the other still mired in poverty—these essays suggest that the Chilean miracle may not be as miraculous as it seems. Contributors. Paul Drake Volker Frank Thomas Klubock Rachel Schurman Joel Stillerman Heidi Tinsman Peter Winn


Politicians, Bureaucrats and Leadership in Organizations

Politicians, Bureaucrats and Leadership in Organizations
Author: J. Burnham
Publisher: Springer
Total Pages: 273
Release: 2009-04-28
Genre: Political Science
ISBN: 0230233821

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This is the first book in English on the French agency DATAR-DIACT that has been the envy of regional planners worldwide. It sheds new light on political leadership in a bureaucracy and demonstrates convincingly the impact of political leaders on institutions. It is a study of France with lessons for other political and administrative systems.


Security Patterns in Practice

Security Patterns in Practice
Author: Eduardo Fernandez-Buglioni
Publisher: John Wiley & Sons
Total Pages: 532
Release: 2013-06-25
Genre: Computers
ISBN: 1119970482

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Learn to combine security theory and code to produce secure systems Security is clearly a crucial issue to consider during the design and implementation of any distributed software architecture. Security patterns are increasingly being used by developers who take security into serious consideration from the creation of their work. Written by the authority on security patterns, this unique book examines the structure and purpose of security patterns, illustrating their use with the help of detailed implementation advice, numerous code samples, and descriptions in UML. Provides an extensive, up-to-date catalog of security patterns Shares real-world case studies so you can see when and how to use security patterns in practice Details how to incorporate security from the conceptual stage Highlights tips on authentication, authorization, role-based access control, firewalls, wireless networks, middleware, VoIP, web services security, and more Author is well known and highly respected in the field of security and an expert on security patterns Security Patterns in Practice shows you how to confidently develop a secure system step by step.


Index Medicus

Index Medicus
Author:
Publisher:
Total Pages: 2324
Release: 2004
Genre: Medicine
ISBN:

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Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.