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Cholesterol Homeostasis

Cholesterol Homeostasis
Author: Ingrid C. Gelissen
Publisher: Humana
Total Pages: 0
Release: 2017-02-17
Genre: Science
ISBN: 9781493968732

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This volume provides state-of-the-art techniques for studying various aspects of cholesterol homeostasis, including its uptake, synthesis and efflux from the cell, as well as its trafficking within the cell. Chapters also cover techniques for studying the regulation of cholesterol homeostasis at both the transcriptional and post-translational levels, as well as studying the membrane topology and structure of cholesterol-related proteins. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Cholesterol Homeostasis: Methods and Protocols aims to provide key techniques in tackling the investigation of cholesterol homeostasis.


Cholesterol-homeostasis

Cholesterol-homeostasis
Author: Reinhard Niemann
Publisher:
Total Pages:
Release: 1988
Genre:
ISBN:

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Cholesterol Transport Systems and Their Relation to Atherosclerosis

Cholesterol Transport Systems and Their Relation to Atherosclerosis
Author: Armin Steinmetz
Publisher: Springer Science & Business Media
Total Pages: 196
Release: 2012-12-06
Genre: Medical
ISBN: 3642836658

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A number of clinical and epidemiological studies have shown that disorders of lipoprotein metabolism constitute one of the most important risk factors for the development of atherosclerosis and coronary heart disease. This volume examines the state of the art of lipoprotein subclass metabolism and its relation to these diseases. The authors also report on new developments concerning the role of lipoprotein recptors, macrophages and apolipoprotein E polymorphism in cholesterol homeostasis. The combination of general outline form and very specific aspects of cholesterol transport will interest those in other disciplines following developments in the field, as well as those directly involved in lipoprotein research.


Cholesterol Transporters of the START Domain Protein Family in Health and Disease

Cholesterol Transporters of the START Domain Protein Family in Health and Disease
Author: Barbara J. Clark
Publisher: Springer
Total Pages: 197
Release: 2014-07-24
Genre: Medical
ISBN: 1493911120

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Non-vesicular intracellular cholesterol transport is an important mechanism for maintaining membrane cholesterol homeostasis. Recent reports of studies directed at soluble cholesterol transport proteins indicate that aberrant expression of the START proteins may contribute to disease states associated with disorders in cholesterol homeostasis. This is an exciting new direction in the field and the purpose of this book will be to highlight the current research directed at potential roles for the START family in diabetes, cancer and atherogenesis. This book also provides a personal and historical perspective of the discovery-to-publication journey that the authors had for their particular START domain family member. The goal will be to provide perspectives to graduate students, post-doctoral fellows and endocrinology fellows on the research discovery process.


Mammalian Sterols

Mammalian Sterols
Author: Damjana Rozman
Publisher: Springer Nature
Total Pages: 174
Release: 2020-08-10
Genre: Science
ISBN: 3030396843

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This book provides a comprehensive description of sterols and their novel biological roles in mammalian signaling, the book covers their biosynthesis and structure, describes sterol receptor -mediated actions, their tissue distribution and their role in disease. It offers insight into new research findings, focusing specifically on novel discoveries in bile acid and oxysterol signaling, including the lanosterol-to-cholesterol intermediates. Special attention is paid on the sex distribution of these sterols (male or female) and their sexually dimorphic roles in mammalian species, such as human, rat and mouse. Since sterols and drugs (xenobiotics) use many identical receptor-mediated signaling pathways, the book will be interesting for researchers working on the cross-road of endogenous and xenobiotic metabolism, it is intended for advanced students and scientists in molecular biology and biochemistry as well as for medical doctors in hepatology.


Cholesterol Homeostasis and Disorders in Brain

Cholesterol Homeostasis and Disorders in Brain
Author: Ito Jin-Ichi
Publisher: LAP Lambert Academic Publishing
Total Pages: 128
Release: 2015-10-27
Genre:
ISBN: 9783659716911

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Do you know that cholesterol is very abundantly distributed in the brain? Unexpectedly, it is not sufficiently known that the brain is an organ owning high level content of cholesterol. Cholesterol is also widely distributed in the blood as lipoproteins such as HDL and LDL. Surprisingly, cholesterol accounts for as much as 25% of total body cholesterol in human brain. Why is cholesterol distributed abundantly in the brain? What is the role of cholesterol in the brain? This book describes the role of astrocytes in brain cholesterol homeostasis and the relationship between cholesterol homeostasis and brain disorders.


Intracellular Cholesterol Trafficking

Intracellular Cholesterol Trafficking
Author: T.Y. Chang
Publisher: Springer Science & Business Media
Total Pages: 298
Release: 2012-12-06
Genre: Science
ISBN: 1461551137

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INTRODUCTION AND RATIONALE FOR INTRACELLULAR CHOLESTEROL TRAFFICKING This volume is an elaboration of an earlier small meeting held in St. Louis, Missouri. In April 1997, many of the authors met for a two-day meeting devoted entirely to intracellular cholesterol trafficking. The rationale for this meeting was that investigators interested in this topic worked in a variety of fields, and rarely, if ever, all met together. Everybody knew each other's papers but mostly worked in isolation from one another. Understanding of cholesterol trafficking also appeared to have reached the point where it would start to rapidly expand beyond these few laboratories. Understanding of cholesterol trafficking was moving from a largely descriptive science into the molecular age. It seemed a good time to get together and see how much we agreed upon up to this point. More authors contributed to this volume than attended the St. Louis meeting. That meeting was generously funded by grants from Bristol-Myers Squibb, Merck and Company and Parke-Davis, however, the total funding available limited the size of the meeting. For the book, we are not so limited and have tried to be as inclusive as possible and pretty much invited everyone who is presently active in this area. We were quite fortunate to successfully recruit the authors we sought for each of these chapters. The authors and their contributions can be organized by particular interests and particular areas of expertise.