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Chelation Therapy in the Treatment of Metal Intoxication

Chelation Therapy in the Treatment of Metal Intoxication
Author: Jan Aaseth
Publisher: Academic Press
Total Pages: 390
Release: 2016-04-18
Genre: Medical
ISBN: 0128030739

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Chelation Therapy in the Treatment of Metal Intoxication presents a practical guide to the use of chelation therapy, from its basic chemistry, to available chelating antidotes, and the application of chelating agents. Several metals have long been known to be toxic to humans, and continue to pose great difficulty to treat. These challenges pose particular problems in industrial settings, with lead smelting known to be associated with hemopoietic alterations and paralyses, and the inhalation of mercury vapor in mercury mining being extremely detrimental to the central nervous system. Clinical experience has demonstrated that acute and chronic human intoxications with a range of metals can be treated efficiently by administration of chelating agents. Chelation Therapy in the Treatment of Metal Intoxication describes the chemical and biological principles of chelation in the treatment of these toxic metal compounds, including new chelators such as meso-2,3-dimercaptosuccinic acid (DMSA) and D,L-2,3-dimercapto-1-propanesulfonic acid (DMPS). Presents all the current findings on the potential for chelation as a therapy for metal intoxication Presents practical guidelines for selecting the most appropriate chelating agent Includes coverage on radionuclide exposure and metal storage diseases Describes the chemical and biological principles of chelation in the treatment of toxic metal compounds


Evidence-Based Clinical Chelation

Evidence-Based Clinical Chelation
Author: Dr. Eleonore Blaurock-Busch, PhD
Publisher: BoD – Books on Demand
Total Pages: 122
Release: 2020-06-02
Genre: Medical
ISBN: 3750428670

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This is an easy-to-read manual about chelation therapy. It contains specific protocols for the treatment of chronic metal overexposure, all of which are evidence-based, aiding the inexperienced and the experienced therapist in selecting the optimal chelating agent for the metal(s) in question. Expert chemists and chelation therapists have contributed invaluable knowledge and experience to this book. Most importantly, this is not a book promoting personal views or preferences. In fact, the information presents and explains different approaches, and allows the reader to draw his own conclusion. All the protocols listed have been modified for the treatment of chronic metal intoxication, included are oral and intravenous treatment plans. The authors explain in simple terms how a chelating agent ́s bioavailability affects metal binding and how various protocols such as the Cutler Protocol affect the detoxification process, why DMPS binds mercury and which chelators are useful for the detoxification of certain organ system. Also discussed is the importance and effect of treatment pauses. Diagnostic tests are discussed, and which are useful under certain conditions. Shown are tables comparing the average metal binding ability of the various EDTAs, DMPS, DMSA and other chelating agents. Detailed information explains which chelator binds which metal and why, all of which aids the therapist in finding optimal treatment schedules. Novel chelating agents are presented such as MIADMSA, a new oral chelator specifically designed for arsenic intoxication, or how natural Pectin may be used an alternative for gadolinium intoxication, which metals are bound by lipoic acid and why a slightly alkaline environment supports metal binding, even preventing the often-feared metal redistribution. All in all, this evidence-based chelation "cookbook" should be in medical libraries and on the bookshelf of every physician treating environmental disease.


Metal Chelation in Medicine

Metal Chelation in Medicine
Author: Robert R Crichton
Publisher: Royal Society of Chemistry
Total Pages: 336
Release: 2016-10-18
Genre: Science
ISBN: 1782623892

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Metal chelators are emerging as versatile tool with many medical applications. Their versatility allows them to be used in chelation therapy for treating diseases caused by toxic and heavy metal poisoning, chelating agents are capable of binding to toxic metal ions to form complex structures which are easily excreted from the body removing them from intracellular or extracellular spaces. In addition, metal chelators can also be applied as contrast agents in MRI scanning. Metal Chelation in Medicine provides a clear and timely perspective on the role of chelating agents in the management of metal intoxications and storage diseases. Written by leaders in the field of chelators, this publication is at the cutting-edge of the subject. It covers a broad range of topics such as the use of metal chelators in non-invasive assessment of brain iron overload, and the treatment of systemic iron overload and neurodegenerative diseases. As such it is particularly valuable to clinicians treating metal poisonings and metal storage diseases. However, it is also a useful text for researchers, industry professionals and university students with a specific interest in medicinal chemistry, chelation, metal ions, imaging and non-invasive techniques.


Iron Chelation Therapy

Iron Chelation Therapy
Author: Chaim Hershko
Publisher: Springer Science & Business Media
Total Pages: 275
Release: 2012-12-06
Genre: Science
ISBN: 1461505933

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Within the last few years, iron research has yielded exciting new insights into the under standing of normal iron homeostasis. However, normal iron physiology offers little protec tion from the toxic effects of pathological iron accumulation, because nature did not equip us with effective mechanisms of iron excretion. Excess iron may be effectively removed by phlebotomy in hereditary hemochromatosis, but this method cannot be applied to chronic anemias associated with iron overload. In these diseases, iron chelating therapy is the only method available for preventing early death caused mainly by myocardial and hepatic iron toxicity. Iron chelating therapy has changed the quality of life and life expectancy of thalassemic patients. However, the high cost and rigorous requirements of deferoxamine therapy, and the significant toxicity of deferiprone underline the need for the continued development of new and improved orally effective iron chelators. Such development, and the evolution of improved strategies of iron chelating therapy require better understanding of the pathophysiology of iron toxicity and the mechanism of action of iron chelating drugs. The timeliness of the present volume is underlined by several significant develop ments in recent years. New insights have been gained into the molecular basis of aberrant iron handling in hereditary disorders and the pathophysiology of iron overload (Chapters 1-5).


Hepatotoxicity

Hepatotoxicity
Author: Hyman J. Zimmerman
Publisher: Lippincott Williams & Wilkins
Total Pages: 848
Release: 1999
Genre: Medical
ISBN: 9780781719520

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Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.


Why You Need Chelation Therapy and Other Vital Detox Methods to Save Your Life

Why You Need Chelation Therapy and Other Vital Detox Methods to Save Your Life
Author: Edward C. Kondrot
Publisher: Advantage Media Group
Total Pages: 238
Release: 2015-05-14
Genre: Chelation therapy
ISBN: 1599325713

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Many of my colleagues asked me to bring the latest and now greatest news about chelation to the public as well as to the medical community at large. I interviewed a number of doctors who provide chelation treatment and asked them to describe their approach as well as their clinical results. Voila - this book - a compendium of chelation protocols, products, and spectacular cases.


Heavy Metals and Health

Heavy Metals and Health
Author: Lance Castillo
Publisher: Nova Science Publishers
Total Pages: 0
Release: 2016
Genre: Heavy metals
ISBN: 9781634856102

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Heavy metals are persistent in the environment and their elevated emission during longer periods of time can cause contamination of the environment. They are emitted in all environmental media, but can also be easily transported between them due to the atmospheric deposition, water runoff, etc., and thus accumulate in the environment or penetrate the food chains. The main routes of human exposure to heavy metals are through ingestion, inhalation or via dermal contact. Hence, there is a need for better understanding of absorption, distribution and deposition of heavy metals in the human body. This information is of a crucial importance for the evaluation of heavy metal potential health implications. In this book, Chapter One provides an overview of the heavy metal health hazards, presented as a consequence of heavy metal pollution, their availability and cycling between different media in the environment. Chapter Two comprehensively discusses the roles and harmful effects of heavy metals on human health, as well as the sources and techniques of removing heavy metals from the environment. Chapter Three explores the mechanisms of mercury cardiovascular toxicity, with a particular emphasis on its effects toward endothelial cells. Chapter Four focuses on the effects of exposure to soil contaminated by metals. Chapter Five examines antimicrobial functionalized textiles. Chapter Six discusses thallium poisoning. Chapter Seven provides a review of heavy metal pollution, human exposure and public health implications in Nigeria.


Lead Toxicity

Lead Toxicity
Author: Sarah E. Royce
Publisher:
Total Pages: 60
Release: 2000
Genre: Lead
ISBN:

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Metallothionein IV

Metallothionein IV
Author: C. Klaasen
Publisher: Birkhäuser
Total Pages: 641
Release: 2012-12-06
Genre: Science
ISBN: 3034888473

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The Proceedings of the Fourth International Metallothionein Meeting (MT-97) feature the latest research on metallothionein. The book covers a broad range of topics which provide important information for both basic and clinical investigators. The selected 94 articles in this book are written by the leading scientists in the field around the world. This is an increasingly important, multi-disciplinary area of study that has benefitted from recent advances in concepts and methodologies from other fields.


Chelation Therapy

Chelation Therapy
Author: Sharon G Brown
Publisher: Independently Published
Total Pages: 0
Release: 2024-07-12
Genre: Medical
ISBN:

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Revolutionizing Health through Heavy Metal Removal Imagine a treatment that can rid your body of dangerous heavy metals, enhance heart health, and even provide relief for chronic ailments. This is not science fiction; it is the promise of chelation therapy, a medical procedure based on detoxification and rejuvenation. Chelation therapy involves administering chelating agents, which are chemicals that bind to heavy metals and minerals in the body allowing them to be eliminated. Chelation therapy, which was first created to treat heavy metal poisoning, has now evolved to treat a wide range of health concerns, such as atherosclerosis, neurological illnesses (autism spectrum disorders, brain tumors, cerebral palsy and ADD, ), and cardiovascular disease. This guide will provide you with the following: A thorough examination of the history, mechanisms of chelation therapy Several approaches to chelation, such as EDTA, DMSA and natural chelators. Detailed protocols that demonstrate the practical implementation of chelation therapy. Potential advantages, hazards, and the most recent scientific discoveries that substantiate the effectiveness of chelation therapy. The significance of tailored treatment regimens and the influence of diet and lifestyle in optimizing the advantages of detoxification. Whether you are a healthcare practitioner, a patient seeking alternative treatments, or simply inquisitive about the latest medical developments, this book offers useful insights and practical guidance on incorporating chelation therapy into a comprehensive health plan. Acquire the necessary knowledge to make well-informed decisions regarding your health and explore the potential of obtaining optimal well-being via the strategic application of chelation therapy.