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Changes in Eukaryotic Gene Expression in Response to Environmental Stress

Changes in Eukaryotic Gene Expression in Response to Environmental Stress
Author: Burr Atkinson
Publisher: Elsevier
Total Pages: 400
Release: 2012-12-02
Genre: Science
ISBN: 0323162223

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Changes in Eukaryotic Gene Expression in Response to Environmental Stress focuses on various aspects of eukaryotic cell's response to heat stress (shock) and other stress stimuli. This book is organized into two major sections, encompassing 17 chapters that reflect the emphasis on research utilizing Drosophila, a variety of animal systems, and plants. This book first provides a brief introduction to the organization, sequences, and induction of heat shock proteins and related genes. It then describes the control of transcription during heat shock from the standpoint of molecular biology and evolutionary variations of the mechanisms in organisms with diverse metabolic needs. It goes on to discuss the issue of coordinate and noncoordinate responses of heat shock genes. It presents a model for post-transcriptional regulation on certain aspects of coordinate and noncoordinate regulations. Chapters 6-12 discuss heat shock proteins and genes and the effects of stress on gene expression of sea urchin, avian, and mammalian cells. The second part of the book focuses on the physiological role of heat shock proteins and genes in plants and fungi. It includes a discussion on experimental problems encountered during studies of the mechanisms of inhibition of photosynthesis by unfavorable environmental conditions. The changes in transcription and translation of specific mRNAs in the developing embryo during heat shock at various temperatures are described. The concluding chapters deal with heat shock response in plants, particularly the response in soybeans and maize, covering both physiological and molecular analyses. Research scientists, clinicians, and agriculturists will greatly benefit from the information presented in this book.


Inducible Gene Expression, Volume 1

Inducible Gene Expression, Volume 1
Author: P.A. Baeuerle
Publisher: Springer Science & Business Media
Total Pages: 294
Release: 2013-12-01
Genre: Medical
ISBN: 1468468405

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Cells have evolved multiple strategies to adapt the composition and quality of their protein equipment to needs imposed by changes in intra- and extracellular conditions. The appearance of pro teins transmit ting novel functional properties to cells can be controlled at a transcrip tional, posttranscriptional, translational or posttranslational level. Extensive research over the past 15 years has shown that transcriptional regulation is used as the predominant strategy to control the production of new proteins in response to extracellular stimuli. At the level of gene transcription, the initiation ofmRNA synthesis is used most frequently to govern gene expression. The key elements controlling transcription initiation in eukaryotes are activator proteins (transactivators) that bind in a sequence-specific manner to short DNA sequences in the of genes. The activator binding sites are elements of larger proximity control units, ca lied promoters and enhancers, which bind many distinct proteins. These may synergize or negatively cooperate with the activators. The do novo binding of an activator to DNA or, if already bound to DNA, its functional activation is what ultimately turns on a high-level expression of genes. The activity of transactivators is controlled by signalling pathways and, in some cases, transactivators actively partici pate in signal transduction by moving from the cytoplasm into the nuc1eus. In this first volume of Inducible Gene Expression, leading scientists in the field review six eukaryotic transactivators that allow cells to respond to various extracellular stimuli by the expression of new proteins.


Stress-Activated Protein Kinases

Stress-Activated Protein Kinases
Author: Francesc Posas
Publisher: Springer Science & Business Media
Total Pages: 322
Release: 2008-01-24
Genre: Science
ISBN: 3540755691

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In this book leading researchers in the field discuss the state-of-the-art of many aspects of SAPK signaling in various systems from yeast to mammals. These include various chapters on regulatory mechanisms as well as the contribution of the SAPK signaling pathways to processes such as gene expression, metabolism, cell cycle regulation, immune responses and tumorigenesis. Written by international experts, the book will appeal to cell biologists and biochemists.


Environmental Stress and Gene Regulation

Environmental Stress and Gene Regulation
Author: Kenneth B. Storey
Publisher: Garland Science
Total Pages: 181
Release: 1999
Genre: Science
ISBN: 9781859960578

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Environmental physiology and comparative biochemistry are shifting to a new level of focus-the gene. New developments in molecular biology have put simplified techniques for screening and analysis of gene expression into the hands of physiologists and biochemists who are using these for novel explorations of organismal responses to environmental stress. Selected topics cover both animal and plant systems to focus on recent advances in gene expression responses to environmental stresses including low and high temperature, freezing, oxygen limitation, reactive oxygen species, nutrient restriction as well as environmentally-cued programmed cell death. The book highlights the latest techniques and approaches for exploring the regulation of gene expression and illustrates, in selected systems, the interactions between genes and environmental stress that underlie adaptive responses.


Structure and Function of Eukaryotic Chromosomes

Structure and Function of Eukaryotic Chromosomes
Author: Wolfgang Hennig
Publisher: Springer Science & Business Media
Total Pages: 332
Release: 2013-06-29
Genre: Science
ISBN: 3540477837

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This book presents an overview of various aspects of chromosome research, written by leading experts of the respective fields, combining classic and recent molecular biological results. The variety and comprehensiveness make it a handbook of chromosome research for all scientists, teachers and graduate students interested in this field. Dieses Buch faßt die unterschiedlichen Aspekte der Chromosomenforschung in Beiträgen von führenden Wissenschaftlern zusammen, wobei die klassischen Erkenntnisse mit neuesten Forschungsdaten zu einem umfassenden Überblick über das Gebiet kombiniert werden.


Stress-Induced Mutagenesis

Stress-Induced Mutagenesis
Author: David Mittelman
Publisher: Springer Science & Business Media
Total Pages: 284
Release: 2013-03-12
Genre: Medical
ISBN: 1461462800

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The discovery of stress-induced mutagenesis has changed ideas about mutation and evolution, and revealed mutagenic programs that differ from standard spontaneous mutagenesis in rapidly proliferating cells. The stress-induced mutations occur during growth-limiting stress, and can include adaptive mutations that allow growth in the otherwise growth-limiting environment. The stress responses increase mutagenesis specifically when cells are maladapted to their environments, i.e. are stressed, potentially accelerating evolution then. The mutation mechanism also includes temporary suspension of post-synthesis mismatch repair, resembling mutagenesis characteristic of some cancers. Stress-induced mutation mechanisms may provide important models for genome instability underlying some cancers and genetic diseases, resistance to chemotherapeutic and antibiotic drugs, pathogenicity of microbes, and many other important evolutionary processes. This book covers pathways of stress-induced mutagenesis in all systems. The principle focus is mammalian systems, but much of what is known of these pathways comes from non-mammalian systems.


Epigenetic Mechanisms of Gene Regulation

Epigenetic Mechanisms of Gene Regulation
Author: Vincenzo E. A. Russo
Publisher:
Total Pages: 716
Release: 1996
Genre: Medical
ISBN:

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Many inheritable changes in gene function are not explained by changes in the DNA sequence. Such epigenetic mechanisms are known to influence gene function in most complex organisms and include effects such as transposon function, chromosome imprinting, yeast mating type switching and telomeric silencing. In recent years, epigenetic effects have become a major focus of research activity. This monograph, edited by three well-known biologists from different specialties, is the first to review and synthesize what is known about these effects across all species, particularly from a molecular perspective, and will be of interest to everyone in the fields of molecular biology and genetics.


Yeast Stress Responses

Yeast Stress Responses
Author: Stefan Hohmann
Publisher: Springer Science & Business Media
Total Pages: 398
Release: 2007-10-23
Genre: Science
ISBN: 3540456112

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Every cell has developed mechanisms to respond to changes in its environment and to adapt its growth and metabolism to unfavorable conditions. The unicellular eukaryote yeast has long proven as a particularly useful model system for the analysis of cellular stress responses, and the completion of the yeast genome sequence has only added to its power This volume comprehensively reviews both the basic features of the yeast genral stress response and the specific adapations to different stress types (nutrient depletion, osmotic and heat shock as well as salt and oxidative stress). It includes the latest findings in the field and discusses the implications for the analysis of stress response mechanisms in higher eukaryotes as well.