Centrifugal Microfluidics Based Point Of Care Diagnostics At Resource Limited Settings PDF Download
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Author | : Ahmad Saleem Akhtar |
Publisher | : |
Total Pages | : 0 |
Release | : 2023 |
Genre | : |
ISBN | : 9789180405638 |
Download Centrifugal Microfluidics-based Point of Care Diagnostics at Resource Limited Settings Book in PDF, ePub and Kindle
Author | : David Kinahan |
Publisher | : MDPI |
Total Pages | : 123 |
Release | : 2021-09-06 |
Genre | : Technology & Engineering |
ISBN | : 3036513663 |
Download Advances in Microfluidics Technology for Diagnostics and Detection Book in PDF, ePub and Kindle
Microfluidics and lab-on-a-chip have, in recent years, come to the forefront in diagnostics and detection. At point-of-care, in the emergency room, and at the hospital bed or GP clinic, lab-on-a-chip offers the potential to rapidly detect time-critical and life-threatening diseases such as sepsis and bacterial meningitis. Furthermore, portable and user-friendly diagnostic platforms can enable disease diagnostics and detection in resource-poor settings where centralised laboratory facilities may not be available. At point-of-use, microfluidics and lab-on-chip can be applied in the field to rapidly identify plant pathogens, thus reducing the need for damaging broad spectrum pesticides while also reducing food losses. Microfluidics can also be applied to the continuous monitoring of water quality and can support policy-makers and protection agencies in protecting the environment. Perhaps most excitingly, microfluidics also offers the potential to enable entirely new diagnostic tests that cannot be implemented using conventional laboratory tools. Examples of microfluidics at the frontier of new medical diagnostic tests include early detection of cancers through circulating tumour cells (CTCs) and highly sensitive genetic tests using droplet-based digital PCR. This Special Issue on “Advances in Microfluidics Technology for Diagnostics and Detection” aims to gather outstanding research and to carry out comprehensive coverage of all aspects related to microfluidics in diagnostics and detection.
Author | : Mary Amasia |
Publisher | : |
Total Pages | : 181 |
Release | : 2012 |
Genre | : |
ISBN | : 9781267157911 |
Download Sample-driven Design Book in PDF, ePub and Kindle
Microfluidic diagnostic systems are positioned to revolutionize healthcare by enabling the miniaturization and integration of complex diagnostic analyses into platforms that can deliver fast, low-cost diagnostic results and minimize the burden at the point-of-care, serving populations at sites that are remote, resource-limited, and lack access to large hospital laboratory technologies and specialized medical technicians. In order to be successful, the design of novel platforms for microfluidic diagnostics must therefore attend to real-world scenarios of use and consider sample-to-answer viability. Arguably one of the greatest challenges for point-of-care microfluidic diagnostics is sample preparation. While a rich research stream has pushed the frontiers of microfluidic systems, demonstrating their viability in achieving rapid results with miniscule samples, the real-world sample concerns have received little attention. These sample-related properties present unique challenges to the design of microfluidic diagnostic systems and are vital to the success of point-of-care diagnostics. This dissertation contributes to the emerging field of point-of-care microfluidic diagnostic systems through the development of two novel centrifugal microfluidic platforms that address the significant challenges of real-world sample properties. It provides a detailed account of the design of two integrated microfluidic systems: 1) a blood sample preparation disc and 2) an automated PCR analysis disc. Together these two systems provide a case for sample-driven design by addressing and overcoming significant sample-related challenges. The first disc design addresses the unique requirements of a large-volume sample and the second highlights engineering problems associated with low-concentration samples. The dissertation presents work in the design and development of these systems and explores fundamental engineering implications of sample-driven design. It first presents the motivation for sample-to-answer nucleic acid diagnostic systems and the need for attention to sample-driven design concerns by exploring the benefits and challenges of adapting diagnostic systems onto point-of-care microfluidic platforms. Background information on the history and current state-of-the-art in compact-disc microfluidics technologies, practices and theory is provided. Next, the motivation for sample-driven design is discussed in further depth through its application to large-volume and low-concentration sample device design including in-depth modeling of CD microfluidic behavior as it pertains to uniform filling of and dynamic temperature distributions within a microchamber. Novel research is then presented on 1) a centrifugal microfluidic platform for large-volume blood sample preparation and 2) a centrifugal microfluidic platform for real-time PCR amplification for low-concentration nucleic acid sample detection. Finally, an outlook on the future of point-of-care microfluidic systems is discussed along with future work needed to fully realize the vision for the systems presented here.
Author | : Raju Khan |
Publisher | : CRC Press |
Total Pages | : 416 |
Release | : 2021-03-11 |
Genre | : Medical |
ISBN | : 1000548376 |
Download Advanced Microfluidics Based Point-of-Care Diagnostics Book in PDF, ePub and Kindle
This book provides a well-focused and comprehensive overview of novel technologies involved in advanced microfluidics based diagnosis via various types of prognostic and diagnostic biomarkers. This authors examine microfluidics based diagnosis in the biomedical field as an upcoming field with extensive applications. It provides a unique approach and comprehensive technology overview for diagnosis management towards early stages of various bioanalytes via cancer diagnostics diabetes, alzheimer disease, toxicity in food products, brain and retinal diseases, cardiovascular diseases, and bacterial infections etc. Thus, this book would encompass a combinatorial approach of medical science, engineering and biomedical technology. The authors provide a well-focused and comprehensive overview of novel technologies involved in advanced microfluidics based diagnosis via various types of prognostic and diagnostic biomarkers. Moreover, this book contains detailed description on the diagnosis of novel techniques. This book would serve as a guide for students, scientists, researchers, and microfluidics based point of care technologies via smart diagnostics and to plan future research in this valuable field.
Author | : Na Hui Kim |
Publisher | : |
Total Pages | : 246 |
Release | : 2008 |
Genre | : |
ISBN | : |
Download Centrifugal Microfluidic Platforms for Life Science and Point-of-care Diagnostics Book in PDF, ePub and Kindle
Author | : Arvind K. Chavali |
Publisher | : Springer |
Total Pages | : 129 |
Release | : 2018-02-01 |
Genre | : Medical |
ISBN | : 3319666479 |
Download Frugal Innovation in Bioengineering for the Detection of Infectious Diseases Book in PDF, ePub and Kindle
This book introduces readers to the concept of 'frugal innovation' and describes novel low-cost technologies that aid in diagnosing infectious diseases. Rapidly deployable, portable, and affordable diagnostic tools have the potential to tremendously benefit populations in resource-limited settings and improve global health outcomes. Specifically, the book includes the following features: Cutting-Edge Research: Thorough coverage of scientific advances related to frugal bioengineering that have been developed within the last few years. A few examples of technologies covered in detail include low-cost paper-based and CD-based microfluidic diagnostic systems. Industry and Non-Profit Voices: Chapters written by scientists currently working in industry and philanthropic sectors.
Author | : David Kinahan |
Publisher | : |
Total Pages | : 123 |
Release | : 2021 |
Genre | : |
ISBN | : 9783036513652 |
Download Advances in Microfluidics Technology for Diagnostics and Detection Book in PDF, ePub and Kindle
Microfluidics and lab-on-a-chip have, in recent years, come to the forefront in diagnostics and detection. At point-of-care, in the emergency room, and at the hospital bed or GP clinic, lab-on-a-chip offers the potential to rapidly detect time-critical and life-threatening diseases such as sepsis and bacterial meningitis. Furthermore, portable and user-friendly diagnostic platforms can enable disease diagnostics and detection in resource-poor settings where centralised laboratory facilities may not be available. At point-of-use, microfluidics and lab-on-chip can be applied in the field to rapidly identify plant pathogens, thus reducing the need for damaging broad spectrum pesticides while also reducing food losses. Microfluidics can also be applied to the continuous monitoring of water quality and can support policy-makers and protection agencies in protecting the environment. Perhaps most excitingly, microfluidics also offers the potential to enable entirely new diagnostic tests that cannot be implemented using conventional laboratory tools. Examples of microfluidics at the frontier of new medical diagnostic tests include early detection of cancers through circulating tumour cells (CTCs) and highly sensitive genetic tests using droplet-based digital PCR.This Special Issue on “Advances in Microfluidics Technology for Diagnostics and Detection” aims to gather outstanding research and to carry out comprehensive coverage of all aspects related to microfluidics in diagnostics and detection.
Author | : Kevin J. Land |
Publisher | : Springer |
Total Pages | : 220 |
Release | : 2018-12-11 |
Genre | : Technology & Engineering |
ISBN | : 331996870X |
Download Paper-based Diagnostics Book in PDF, ePub and Kindle
This book explores the status of paper-based diagnostic solutions, or Microfluidics 2.0. The contributors explore: how paper-based tests can be widely distributed and utilized by semi-skilled personnel; how close to commercial applications the technology has become, and what is still required to make paper-based diagnostics the game-changer it can be. The technology is examined through the lens of the World Health Organization’s ASSURED criteria for low-resource countries (Affordable, Sensitive, Specific, User-friendly, Rapid and robust, Equipment-free, and Deliverable to end-users). Its applications have to include: health technology, environmental technology, food safety, and more. This book is appropriate for researchers in these areas, as well as those interested in microfluidics, and includes chapters dedicated to principles such as theory of flow and surface treatments; components such as biomarkers and detection; and current methods of manufacturing. Discusses how paper-based diagnostics can be used in developing countries by comparing current diagnostic tests with the World Health Organization's ASSURED criteria Examines how paper-based diagnostics could be integrated with other technologies, such as printed electronics, and the Internet of Things. Outlines how semi-skilled personnel across a variety of fields can implement paper-based diagnostics
Author | : Indradumna Banerjee |
Publisher | : |
Total Pages | : 63 |
Release | : 2019 |
Genre | : |
ISBN | : 9789178731220 |
Download Point of Care Microfluidic Tool Development for Resource Limited Settings Book in PDF, ePub and Kindle
Author | : Tassaneewan Laksanasopin |
Publisher | : |
Total Pages | : |
Release | : 2015 |
Genre | : |
ISBN | : |
Download Microfluidic-based Point-of-Care Testing for Global Health Book in PDF, ePub and Kindle
Due to increasing clinical demand for detection of DNA and RNA signatures for diagnosis and monitoring of patients in resource-limited settings, we also explored how microfluidic and nanoparticle technologies can improve nucleic acid amplification test at the point of care. Nucleic acid tests are arguably some of the most challenging assays to develop due to additional steps required for sample pre-treatment (e.g. cell sorting, isolation, and lysis, as well as nucleic acid extraction), signal amplification (due to low physiological concentrations, target contamination, and instability) and product detection. Here we developed a sputum processor to isolate and lyse mycobacteria (M.smegmatis) from a more complex sample matrix, using magnetic beads-based target isolation to replace the need of a centrifuge or other complicated sample preparation technique. We also investigated a technique to detect Mycobacterium tuberculosis using multiplex polymerase chain reaction (PCR) and silver-gold amplification detection.