Cell Kinetic Modelling And The Chemotherapy Of Cancer PDF Download
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Author | : Helmut Knolle |
Publisher | : Springer Science & Business Media |
Total Pages | : 170 |
Release | : 2013-03-08 |
Genre | : Medical |
ISBN | : 3642456510 |
Download Cell Kinetic Modelling and the Chemotherapy of Cancer Book in PDF, ePub and Kindle
During the last 30 years, many chemical compounds that are active against tumors have been discovered or developed. At the same time, new methods of testing drugs for cancer therapy have evolved. nefore 1964, drug testing on animal tumors was directed to observation of the incfease in life span of the host after a single dose. A new approach, in which the effects of multiple doses on the proliferation kinetics of the tumor in vivo as well as of cell lines in vitro are investigated, has been outlined by Skipper and his co-workers in a series of papers beginning in 1964 (Skipper, Schabel and Wilcox, 1964 and 1965). They also investigated the influence of the time schedule in the treatment of experimental tumors. Since the publication of those studies, cell population kinetics cannot be left out of any discussion of the rational basis of chemotherapy. When clinical oncologists began to apply cell kinetic concepts in practice about 15 years ago, the theoretical basis was still very poor, in spite of Skipper's progress, and the lack of re levant cytokinetic and pharmacologic data was apparent. Subsequently, much theoretical work has been done and many cell kinetic models have been elaborated (for a review see Eisen, 1977).
Author | : M. Eisen |
Publisher | : Springer Science & Business Media |
Total Pages | : 444 |
Release | : 2013-03-13 |
Genre | : Mathematics |
ISBN | : 364293126X |
Download Mathematical Models in Cell Biology and Cancer Chemotherapy Book in PDF, ePub and Kindle
The purpose of this book is to show how mathematics can be applied to improve cancer chemotherapy. Unfortunately, most drugs used in treating cancer kill both normal and abnormal cells. However, more cancer cells than normal cells can be destroyed by the drug because tumor cells usually exhibit different growth kinetics than normal cells. To capitalize on this last fact, cell kinetics must be studied by formulating mathematical models of normal and abnormal cell growth. These models allow the therapeutic and harmful effects of cancer drugs to be simulated quantitatively. The combined cell and drug models can be used to study the effects of different methods of administering drugs. The least harmful method of drug administration, according to a given criterion, can be found by applying optimal control theory. The prerequisites for reading this book are an elementary knowledge of ordinary differential equations, probability, statistics, and linear algebra. In order to make this book self-contained, a chapter on cell biology and a chapter on control theory have been included. Those readers who have had some exposure to biology may prefer to omit Chapter I (Cell Biology) and only use it as a reference when required. However, few biologists have been exposed to control theory. Chapter 7 provides a short, coherent and comprehensible presentation of this subject. The concepts of control theory are necessary for a full understanding of Chapters 8 and 9.
Author | : M Eisen |
Publisher | : |
Total Pages | : 452 |
Release | : 1979-11-01 |
Genre | : |
ISBN | : 9783642931277 |
Download Mathematical Models in Cell Biology and Cancer Chemotherapy Book in PDF, ePub and Kindle
Author | : Robert C. Jackson |
Publisher | : |
Total Pages | : 472 |
Release | : 1992 |
Genre | : Medical |
ISBN | : |
Download The Theoretical Foundations of Cancer Chemotherapy Introduced by Computer Models Book in PDF, ePub and Kindle
Describes the principles of cancer chemotherapy quantitatively, using computer modelling. The book includes a computer program on disk to allow the user to model tumour biology and drug effects. This allows a trial and error approach to understanding the principles of chemotherapy.
Author | : T. E. Wheldon |
Publisher | : CRC Press |
Total Pages | : 272 |
Release | : 1988 |
Genre | : Art |
ISBN | : |
Download Mathematical Models in Cancer Research, Book in PDF, ePub and Kindle
Cancer research deals with all aspects of malignant transformation, tumour growth and the effects of treatment. Mathematical models enable quantitative representations of the changes affecting cell state and cell number. This book provides a review of the scope of mathematical modelling in cancer research, bringing together for the first time a group of related mathematical topics including multistage carcinogenesis, tumour growth kinetics, growth control, radiotherapy, chemotherapy and biological targeting in cancer treatment. Physicists and mathematicians interested in medical research, biomathematicians, biostatisticians, radiation and medical oncologists and experimental and theoretical biologists will welcome this critical review of mathematical modelling in cancer research. This book will also be of interest to clinicians, basic cancer scientists and physicists working in radiotherapy departments, and to postgraduate students on courses in oncology and subjects.
Author | : Kang Geun Shin |
Publisher | : |
Total Pages | : 312 |
Release | : 1978 |
Genre | : Cancer |
ISBN | : |
Download A Structured Approach to Cell Kinetics and Cancer Therapy Using System Theory Book in PDF, ePub and Kindle
Author | : Manfred Schwab |
Publisher | : Springer Science & Business Media |
Total Pages | : 3307 |
Release | : 2008-09-23 |
Genre | : Medical |
ISBN | : 3540368477 |
Download Encyclopedia of Cancer Book in PDF, ePub and Kindle
This comprehensive encyclopedic reference provides rapid access to focused information on topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the first edition, which appeared in 2001, and fast development in the different fields of cancer research, it has been decided to publish a second fully revised and expanded edition. With an A-Z format of over 7,000 entries, more than 1,000 contributing authors provide a complete reference to cancer. The merging of different basic and clinical scientific disciplines towards the common goal of fighting cancer makes such a comprehensive reference source all the more timely.
Author | : Ben-Fillippo Krippendorff |
Publisher | : |
Total Pages | : 0 |
Release | : 2009 |
Genre | : Hamilton Institute Theses |
ISBN | : |
Download Integrating Cell-level Kinetic Modeling Into the Optimization of Cancer Therapeutics Book in PDF, ePub and Kindle
Author | : Robert C. Bast, Jr. |
Publisher | : John Wiley & Sons |
Total Pages | : 2008 |
Release | : 2017-03-10 |
Genre | : Medical |
ISBN | : 111900084X |
Download Holland-Frei Cancer Medicine Book in PDF, ePub and Kindle
Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Author | : Michael Breitenbach |
Publisher | : Frontiers Media SA |
Total Pages | : 176 |
Release | : 2019-02-05 |
Genre | : |
ISBN | : 288945701X |
Download Cancer Models Book in PDF, ePub and Kindle
Cancer research, like research on other diseases, highly depends on representative and reliable model systems. In the Research Topic “Cancer Models”, we collected original papers and review articles addressing the topic of tumor modeling from molecular biology, biochemistry, microorganisms, cells and organoids, fishes, animals and xenografts, up to computational cancer models and patient data analysis. This representative eBook describes that there is not a single molecular defined tumor but rather a heterogenic and highly variable complex of different individual diseases. This is what makes research on cancer so difficult, expensive, and explains the broad number of models needed for research. Our authors describe new next-generation sequencing-based methods to analyze complex patterns of chromosomal aberrations in order to understand the molecular biology of tumorigenesis as well as the role of cellular senescence and dormancy in the aetiology of tumor formation and development of therapy resistance of tumors. The current developments on 3D cultures are thoroughly reviewed, as these models help to overcome the current limitations of cell cultures and allow a more accurate mimicry of the native cancer tissue, including cellular heterogeneity and restore specific biochemical and morphological. Reviews about tumor models in zebrafish, different transgenic mouse strains and pigs conclude the book. In the final two chapters of this volume, the authors discuss the theoretical and mathematical models developed in cancer research.