Cell Cycle Regulators In Cancer PDF Download
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Author | : Kiran Musunuru |
Publisher | : S. Karger AG (Switzerland) |
Total Pages | : 182 |
Release | : 1997 |
Genre | : Medical |
ISBN | : |
Download Cell Cycle Regulators in Cancer Book in PDF, ePub and Kindle
Cancer can be tersely yet accurately described as improper cell proliferation. To understand cancer we must first understand the genetic and biochemical mechanisms responsible for proper cell proliferation. The last five years have witnessed the characterization of several families of novel proteins involved in cell cycle regulation and the clarification of the biochemical processes in which they participate. This book illuminates the roles of various cell cycle regulators - cyclins, cyclindependent kinases (CDKs) and CDK inhibitors - and describes the connections between these proteins and oncogenesis. Possible ways of clinical intervention that might be developed into potent cancer therapies are also explored. By chronologically documenting the discovery of cell regulators and providing clear, brief synopses of current findings, this work offers an easily accessible guide for both students and experienced researchers. An extensive list of excellent reviews for further reading rounds off the reference value of this timely publication.
Author | : Philip W. Hinds |
Publisher | : R. G. Landes |
Total Pages | : 200 |
Release | : 1997-01-01 |
Genre | : Medical |
ISBN | : 9780412131516 |
Download Cell Cycle Regulators in Cancer Book in PDF, ePub and Kindle
Author | : Philipp Kaldis |
Publisher | : Results and Problems in Cell Differentiation |
Total Pages | : 400 |
Release | : 2006-06-26 |
Genre | : Medical |
ISBN | : |
Download Cell Cycle Regulation Book in PDF, ePub and Kindle
This book is a state-of-the-art summary of the latest achievements in cell cycle control research with an outlook on the effect of these findings on cancer research. The chapters are written by internationally leading experts in the field. They provide an updated view on how the cell cycle is regulated in vivo, and about the involvement of cell cycle regulators in cancer.
Author | : Philipp Kaldis |
Publisher | : Springer |
Total Pages | : 0 |
Release | : 2010-11-18 |
Genre | : Science |
ISBN | : 9783642070938 |
Download Cell Cycle Regulation Book in PDF, ePub and Kindle
This book is a state-of-the-art summary of the latest achievements in cell cycle control research with an outlook on the effect of these findings on cancer research. The chapters are written by internationally leading experts in the field. They provide an updated view on how the cell cycle is regulated in vivo, and about the involvement of cell cycle regulators in cancer.
Author | : Antonio Giordano |
Publisher | : Springer Science & Business Media |
Total Pages | : 481 |
Release | : 2002-11-20 |
Genre | : Medical |
ISBN | : 1592594018 |
Download Cell Cycle Inhibitors in Cancer Therapy Book in PDF, ePub and Kindle
Leading clinicians and investigators review in a comprehensible and user-friendly style all the latest information about the molecular biology of cell cycle control and demonstrate its clinical relevance to understanding neoplastic diseases. Topics range from Cdk inhibitors and cell cycle regulators to the prognostic value of p27 and tumor suppressor genes as diagnostic tools. Actual case studies show how the new molecular understanding has produced such drugs as Flavopiridol and Sulindac. The book brings all the recent critical research findings to bear on clinical practice, and clearly shows their powerful impact on the diagnostics, prognostics, and therapeutics of cancer, AIDS, and cardiovascular disease.
Author | : Guillermina Lozano |
Publisher | : |
Total Pages | : 0 |
Release | : 2016 |
Genre | : Medical |
ISBN | : 9781621821335 |
Download The P53 Protein Book in PDF, ePub and Kindle
Decades of research on the tumor suppressor p53 have revealed that it plays a significant role as a "guardian of the genome," protecting cells against genotoxic stress. In recent years, p53 research has begun to move into the clinic in attempts to understand how p53 is frequently inactivated in-and sometimes even promotes-human cancer. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers the rapid progress that has recently been made in basic and clinical research on p53. The contributors review new observations about its basic biology, providing updates on the functions of its isoforms and domains, the myriad stresses and signals that trigger its activation or repression, and its downstream effects on genome stability and the cell cycle that enforce tumor suppression in different cell and tissue types. They also discuss how p53 dysfunction contributes to cancer, exploring the various inherited and somatic mutations in the human TP53 gene, the impact of mutant p53 proteins on tumorigenesis, and the prognostic value and clinical outcomes of these mutations. Drugs that are being developed to respond to tumors harboring aberrant p53 are also described. This book is therefore essential reading for all cancer biologists, cell and molecular biologists, and pharmacologists concerned with the treatment of this disease.
Author | : Yueming Sun |
Publisher | : Frontiers Media SA |
Total Pages | : 291 |
Release | : 2022-03-07 |
Genre | : Medical |
ISBN | : 2889717690 |
Download Emerging Molecular Mechanisms of Cell Cycle Regulation in Cancer: Functions and Potential Applications Book in PDF, ePub and Kindle
Author | : Greg H. Enders |
Publisher | : Springer Science & Business Media |
Total Pages | : 204 |
Release | : 2010-03-10 |
Genre | : Medical |
ISBN | : 1441917705 |
Download Cell Cycle Deregulation in Cancer Book in PDF, ePub and Kindle
Cancer is fundamentally a disease of abnormal cell proliferation: Cancer cells multiply when and where they should not. This proliferation entails escape from normal bounds imposed by the tissue environment, the internal biology of the cell (DNA damage, chromosomal imbalances, disorganized mitotic spindles), and the proliferative history of the cell (normal generational times). Some of the key oncogenic events in cancer directly perturb proteins that regulate progression through the cell division cycle, others alter cell cycle progression indirectly, through effects on signaling pathway that impinge on the cell cycle. This biology is fundamentally important in cancer therapy. Many of the workhorse treatments for cancer rely on killing proliferating cells. Furthermore, there is growing recognition that stem cell-transit amplifying cell hierarchies may persist or be generated during tumorigenesis, generating important functional heterogeneity in cell cycle control among tumor cells, with far-reaching scientific and clinical implications. This volume outlines major cell cycle perturbations that drive tumorigenesis and considers the prospects for using such knowledge in cancer therapy.
Author | : Valerie W. Hu |
Publisher | : Springer Science & Business Media |
Total Pages | : 407 |
Release | : 2012-12-06 |
Genre | : Science |
ISBN | : 1461524210 |
Download The Cell Cycle Book in PDF, ePub and Kindle
Interest in the cell cycle has grown explosively in recent years as a result of the identification of key cell cycle regulators and their substrates. Aside from enhancing our understanding of normal cellular growth controls, this new knowledge has also becn valuable in elucidating mechanisms of growth deregulation which occur in diseased states, such as cancer and, in some instances, viral or parasitic infections. The Thirteenth Washington International Spring Symposium was organized with the intention of bringing together scientists working on different aspects of the cell cycle. Scientific topics presented ranged from molecular regulators and effectors to mitosis specific changes in cell architecture to the role of the cell cycle in development and disease. The goal of this gathering was to help formulate a more comprehensive and integrated picture of events driving and being driven by the cell cycle, as well as to evaluate the possibilities for clinical application of this knowledge. This symposium, held in Washington, D.C. from May 10-14, 1993, was attended by more than 400 scientists from 20 countries, including many of the scientific leaders in this field. This volume contains most of the papers presented at the seven plenary sessions in addition to selected contributions from a total of nine special oral and poster sessions.
Author | : Bruce Alberts |
Publisher | : |
Total Pages | : 0 |
Release | : 2002 |
Genre | : Cytology |
ISBN | : 9780815332183 |
Download Molecular Biology of The Cell Book in PDF, ePub and Kindle