Cell Biology Of The Axon PDF Download
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Author | : Edward Koenig |
Publisher | : Springer Science & Business Media |
Total Pages | : 369 |
Release | : 2009-09-01 |
Genre | : Science |
ISBN | : 364203019X |
Download Cell Biology of the Axon Book in PDF, ePub and Kindle
Recent years have witnessed striking advances in research on axons at a cellular level that substantially impact our current understanding of axonal biology. Newer findings and their ramifications are critically reviewed in the 16 chapters of this volume by authors highly qualified by virtue of their scientific contributions to research areas they know and write about. Five basic areas (I to V) germane to axonal biology are highlighted, beginning with (I) signaling interactions mediating myelination, and differentiation of axonal membrane domains; (IIa) issues surrounding organization and transport dynamics of neurofilaments in axons, (IIb) mechanisms regulating microtubule organization and dynamics, misregulation of which causes axonal degeneration, and (IIc) the roles actin binding proteins play in regulating organization and functions of the actin filament system in mature and growing axons; (IIIa) myosin motor proteins and cargoes intrinsic to the axon compartment, (IIIb) mitochondrial transport motors, and imperatives governing transport dynamics and directional delivery, (IIIc) mechanisms mediating retrograde signaling associated with NGF’s role in trophic-dependent neuronal survival, and (IIId) potential for impaired subcellular targeting of a -synuclein as a mechanism for accumulation of Lewy body inclusions in synucleinopathies; (IVa) occurrence and organization of discrete ribosome-containing domains in axons, (IVb) endogenous mRNAs, classes of proteins translated locally, and RNP trafficking in axons, (IVc) importance of locally synthesized nuclear encoded mitochondrial proteins for maintenance, function and survival of axons, (IVd) occurrence of RNA trafficking from glial cells to axons, and significance glial RNA transcripts may play in expression in axons and axon terminals, (IVe) RNA trafficking and localization of RNA transcripts in axonal growth cones, and signaling pathways that modulate local protein synthesis for directional elongation, and (IVf) genetic and molecular defects underlying spinal muscular atrophy, and roles that SMN gene product plays as a molecular chaperone in mRNA transport and translation; (Va) injury-induced local synthesis of a protein forming a retrograde signaling complex in axons to stimulate regeneration, and (Vb) endogenous and exogenous factors that condition axonal regenerative capacity in PNS and CNS, including injury-induced activation of specific genes governing regeneration. Emergent complexities revealed in this volume compel a major revision in the traditional conceptual model of the axon’s intrinsic makeup and capacities.
Author | : Bruce Alberts |
Publisher | : |
Total Pages | : 0 |
Release | : 2002 |
Genre | : Cytology |
ISBN | : 9780815332183 |
Download Molecular Biology of The Cell Book in PDF, ePub and Kindle
Author | : |
Publisher | : Academic Press |
Total Pages | : 552 |
Release | : 2016-01-12 |
Genre | : Science |
ISBN | : 0128033541 |
Download The Neuronal Cytoskeleton, Motor Proteins, and Organelle Trafficking in the Axon Book in PDF, ePub and Kindle
The Neuronal Cytoskeleton, Motor Proteins, and Organelle Trafficking in the Axon, a new volume in the Methods in Cell Biology series continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in neuronal cells, and includes sections on such topics as actin transport in axons and neurofilament transport. Covers an increasingly appreciated field in cell biology Includes both established and new technologies Contributed by experts in the field
Author | : Hiro Yamamoto |
Publisher | : Nova Science Publishers |
Total Pages | : 0 |
Release | : 2014-02-10 |
Genre | : Axons |
ISBN | : 9781629480510 |
Download Axons Book in PDF, ePub and Kindle
Axons are nerve fibres that typically conduct electrical impulses away from the neuron's cell body. The function of the axon is to transmit information to different neurons, muscles and glands. In this book, the authors discuss the cell biology, molecular dynamics and role in neural repair and rehabilitation of axons. Topics include the traumatic retraction of living neural processes and their inhibitions; water translocation from the axoplasm into the glioplasm during reactive reorganisation of myelinated nerve fibres; problems and mechanisms in axonal afterdischarges; the putative role of axon cytoskeleton protein in MS repair; microtubules as a potential therapeutic target for the treatment of neurodegenerative diseases; morphometrical and molecular biological analyses of facial nerves in healthy adults and patients with facial nerve palsy; intrinsic axon growth potential; and sensory axonal guidance by chemorepulsive and chemoattractive cues in higher vertebrates.
Author | : Samuel H. Barondes |
Publisher | : Academic Press |
Total Pages | : 398 |
Release | : 2014-05-10 |
Genre | : Science |
ISBN | : 1483220001 |
Download Cellular Dynamics of the Neuron Book in PDF, ePub and Kindle
Cellular Dynamics of the Neuron covers advances in the study of the cellular dynamics of the neuron. The book discusses the synthesis and transport of the neuroplasm, as well as the synthesis, transport, and action of neurotransmitters. The text also describes the functional implications of synaptic ultrastructure and the morphological and biochemical correlates of neuronal plasticity. Cell biologists, neurobiologists, cell pathologists, molecular biologists, and physiologists will find the book invaluable.
Author | : Irwin B. Levitan |
Publisher | : Oxford University Press, USA |
Total Pages | : 601 |
Release | : 2015 |
Genre | : Medical |
ISBN | : 0199773890 |
Download The Neuron Book in PDF, ePub and Kindle
Intended for use by advanced undergraduate, graduate and medical students, this book presents a study of the unique biochemical and physiological properties of neurons, emphasising the molecular mechanisms that generate and regulate their activity.
Author | : |
Publisher | : Elsevier |
Total Pages | : 459 |
Release | : 2003-10-02 |
Genre | : Science |
ISBN | : 0080496636 |
Download Neurons: Methods and Applications for the Cell Biologist Book in PDF, ePub and Kindle
Neurons: Methods and Applications for the Cell Biologist lays out numerous simple techniques for growing and carrying out experiments with many varieties of neurons. Subjects include peripheral and central neurons from vertebrate and invertebrate sources, as well as neuron-like cell lines. It also explains recent advances in our ability to introduce exogenous proteins and genes to neurons in culture. Procedures for successful protein infiltration, biolistic transfection, electroporation, and viral transgenic methods in neurons are also presented. Contains culture methodology for more than a dozen types of CNS and PNS neurons Includes most recent and reliable techniques from expert practitioners for specific experimental applications Addresses the latest strategies for transfecting neurons
Author | : Stephen G. Waxman |
Publisher | : |
Total Pages | : 710 |
Release | : 1995 |
Genre | : Axons |
ISBN | : 0195082931 |
Download The Axon Book in PDF, ePub and Kindle
The axon, interposed between the cell body and the synaptic terminals in most neurons, plays a crucial role in connecting neurons and acting as a conduit for the transmission of information between them. This book provides a comprehensive and up-to-date compendium that brings together chapterson the structure, function, and pathophysiology of axons in both the PNS and CNS. Carefully written, well-illustrated with superb illustrations, and generously referenced, the 33 chapters and introduction have been authored by 49 world-renowned authorities. Recent advances in the molecularneurobiology of axons are carefully reviewed, and new areas, such as the molecular biology of ion channels and myelination, the role of calcium in pathophysiology and regeneration, cell adhesion molecules and their roles in axo-glial interactions and axonal guidance, and optical recording methods,are highlighted. This book will provide an essential reference for neuroscientists as well as clinicians such as neurologists, neurosurgeons, and clinical electrophysiologists interested in axons.
Author | : R. W. Davies |
Publisher | : OUP Oxford |
Total Pages | : 500 |
Release | : 2004-04-08 |
Genre | : Medical |
ISBN | : 0191585831 |
Download Molecular Biology of the Neuron Book in PDF, ePub and Kindle
Nerve cells - neurons - are arguably the most complex of all cells. From the action of these cells comes movement, thought and consciousness. It is a challenging task to understand what molecules direct the various diverse aspects of their function. This has produced an ever-increasing amount of molecular information about neurons, and only in Molecular Biology of the Neuron can a large part of this information be found in one source. In this book, a non-specialist can learn about the molecules that control information flow in the brain or the progress of brain disease in an approachable format, while the expert has access to a wealth of detailed information from a wide range of topics impacting on his or her field of endeavour. The text is designed to achieve a balance of accessibility and broad coverage with up-to-date molecular detail. In the six years since the first edition of Molecular Biology of the Neuron there has been an explosion in the molecular information about neurons that has been discovered, and this information is incorporated into this second edition. Entirely new chapters have been introduced where recent advances have made a new aspect of neuronal function more comprehensible at the molecular level. Written by leading researchers in the field, the book provides an essential overview of the molecular structure and function of neurons, and will be an invaluable tool to students and researchers alike.
Author | : Irwin B. Levitan |
Publisher | : Oxford University Press, USA |
Total Pages | : 640 |
Release | : 2002 |
Genre | : Molecular neurobiology |
ISBN | : 9780195145236 |
Download The Neuron Book in PDF, ePub and Kindle
Intended for use by advanced undergraduate, graduate and medical students, this book presents a study of the unique biochemical and physiological properties of neurons, emphasising the molecular mechanisms that generate and regulate their activity.