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Cancer, Complexity, Computation

Cancer, Complexity, Computation
Author: Igor Balaz
Publisher: Springer Nature
Total Pages: 349
Release: 2022-08-11
Genre: Technology & Engineering
ISBN: 3031043790

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This book presents unique compendium of groundbreaking ideas where scientists from many different backgrounds are united in their interest in interdisciplinary approaches towards origins and development of cancers, innovative ways of searching for cancer treatment and the role of cancer in the evolution. Chapters give an unequivocal slice of all areas that relate to a quest for understanding cancer and its origin as many-fold nonlinear system, complexity of the cancer developments, a search for cancer treatment using artificial intelligence and evolutionary optimisation, novel modelling techniques, molecular origin of cancer, the role of cancer in evolution of species, interpretation of cancer in terms of artificial life and artificial immune systems, swarm intelligence, cellular automata, computational systems biology, genetic networks, cellular computing, validation through in vitro/vivo tumour models and tumour on chip devices. The book is an inspiring blend of theoretical and experimental results, concepts and paradigms. Distinctive features The book advances widely popular topics of cancer origin, treatment and understanding of its progress The book is comprised of unique chapters written by world top experts in theoretical and applied oncology, complexity theory, mathematics, computer science. The book illustrates attractive examples of mathematical and computer models and experimental setups.


Computational Systems Biology of Cancer

Computational Systems Biology of Cancer
Author: Emmanuel Barillot
Publisher: CRC Press
Total Pages: 463
Release: 2012-08-25
Genre: Science
ISBN: 1439831440

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The future of cancer research and the development of new therapeutic strategies rely on our ability to convert biological and clinical questions into mathematical models—integrating our knowledge of tumour progression mechanisms with the tsunami of information brought by high-throughput technologies such as microarrays and next-generation sequencing. Offering promising insights on how to defeat cancer, the emerging field of systems biology captures the complexity of biological phenomena using mathematical and computational tools. Novel Approaches to Fighting Cancer Drawn from the authors’ decade-long work in the cancer computational systems biology laboratory at Institut Curie (Paris, France), Computational Systems Biology of Cancer explains how to apply computational systems biology approaches to cancer research. The authors provide proven techniques and tools for cancer bioinformatics and systems biology research. Effectively Use Algorithmic Methods and Bioinformatics Tools in Real Biological Applications Suitable for readers in both the computational and life sciences, this self-contained guide assumes very limited background in biology, mathematics, and computer science. It explores how computational systems biology can help fight cancer in three essential aspects: Categorising tumours Finding new targets Designing improved and tailored therapeutic strategies Each chapter introduces a problem, presents applicable concepts and state-of-the-art methods, describes existing tools, illustrates applications using real cases, lists publically available data and software, and includes references to further reading. Some chapters also contain exercises. Figures from the text and scripts/data for reproducing a breast cancer data analysis are available at www.cancer-systems-biology.net.


Computational Biology of Cancer

Computational Biology of Cancer
Author: Dominik Wodarz
Publisher: World Scientific
Total Pages: 266
Release: 2005
Genre: Science
ISBN: 9812560270

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- Provides an introduction to computational methods in cancer biology - Follows a multi-disciplinary approach


Computational Methods for Understanding Complexity: The Use of Formal Methods in Biology

Computational Methods for Understanding Complexity: The Use of Formal Methods in Biology
Author: David A. Rosenblueth,
Publisher: Frontiers Media SA
Total Pages: 115
Release: 2016-11-21
Genre:
ISBN: 2889450422

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The complexity of living organisms surpasses our unaided habilities of analysis. Hence, computational and mathematical methods are necessary for increasing our understanding of biological systems. At the same time, there has been a phenomenal recent progress allowing the application of novel formal methods to new domains. This progress has spurred a conspicuous optimism in computational biology. This optimism, in turn, has promoted a rapid increase in collaboration between specialists of biology with specialists of computer science. Through sheer complexity, however, many important biological problems are at present intractable, and it is not clear whether we will ever be able to solve such problems. We are in the process of learning what kind of model and what kind of analysis and synthesis techniques to use for a particular problem. Some existing formalisms have been readily used in biological problems, others have been adapted to biological needs, and still others have been especially developed for biological systems. This Research Topic has examples of cases (1) employing existing methods, (2) adapting methods to biology, and (3) developing new methods. We can also see discrete and Boolean models, and the use of both simulators and model checkers. Synthesis is exemplified by manual and by machine-learning methods. We hope that the articles collected in this Research Topic will stimulate new research.


Computational Systems Biology of Cancer

Computational Systems Biology of Cancer
Author: Emmanuel Barillot
Publisher: CRC Press
Total Pages: 461
Release: 2012
Genre: SCIENCE
ISBN: 9780429093920

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The future of cancer research and the development of new therapeutic strategies rely on our ability to convert biological and clinical questions into mathematical models-integrating our knowledge of tumour progression mechanisms with the tsunami of information brought by high-throughput technologies such as microarrays and next-generation sequencing. Offering promising insights on how to defeat cancer, the emerging field of systems biology captures the complexity of biological phenomena using mathematical and computational tools.


Computational Systems Biology Approaches in Cancer Research

Computational Systems Biology Approaches in Cancer Research
Author: Inna Kuperstein
Publisher: CRC Press
Total Pages: 167
Release: 2019-09-09
Genre: Computers
ISBN: 1000682927

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Praise for Computational Systems BiologyApproaches in Cancer Research: "Complex concepts are written clearly and with informative illustrations and useful links. The book is enjoyable to read yet provides sufficient depth to serve as a valuable resource for both students and faculty." — Trey Ideker, Professor of Medicine, UC Xan Diego, School of Medicine "This volume is attractive because it addresses important and timely topics for research and teaching on computational methods in cancer research. It covers a broad variety of approaches, exposes recent innovations in computational methods, and provides acces to source code and to dedicated interactive web sites." — Yves Moreau, Department of Electrical Engineering, SysBioSys Centre for Computational Systems Biology, University of Leuven With the availability of massive amounts of data in biology, the need for advanced computational tools and techniques is becoming increasingly important and key in understanding biology in disease and healthy states. This book focuses on computational systems biology approaches, with a particular lens on tackling one of the most challenging diseases - cancer. The book provides an important reference and teaching material in the field of computational biology in general and cancer systems biology in particular. The book presents a list of modern approaches in systems biology with application to cancer research and beyond. It is structured in a didactic form such that the idea of each approach can easily be grasped from the short text and self-explanatory figures. The coverage of topics is diverse: from pathway resources, through methods for data analysis and single data analysis to drug response predictors, classifiers and image analysis using machine learning and artificial intelligence approaches. Features Up to date using a wide range of approaches Applicationexample in each chapter Online resources with useful applications’


Computational Biology

Computational Biology
Author: Tuan Pham
Publisher: Springer Science & Business Media
Total Pages: 309
Release: 2009-09-23
Genre: Medical
ISBN: 1441908110

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This volume covers techniques in computational biology and their applications in oncology. It details advanced statistical methods, heuristic algorithms, cluster analysis, data modeling, and image and pattern analysis applied to cancer research.


Multi-omic Data Integration in Oncology

Multi-omic Data Integration in Oncology
Author: Chiara Romualdi
Publisher: Frontiers Media SA
Total Pages: 187
Release: 2020-12-03
Genre: Medical
ISBN: 2889661512

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.


Explaining Disease: Philosophical Reflections on Medical Research and Clinical Practice

Explaining Disease: Philosophical Reflections on Medical Research and Clinical Practice
Author: Raffaella Campaner
Publisher: Springer Nature
Total Pages: 207
Release: 2022-08-09
Genre: Medical
ISBN: 3031058836

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This interdisciplinary monograph in philosophy of medicine examines models of explanation in health science and their relation with current medical trends, such as personalized and person-centered medicine. Medicine has provided challenging case studies for the general philosophy of science that have prompted rethinking of a wide range of philosophical notions – such as scientific law, theory and evidence – and contributed to the elaboration of pluralistic approaches to modeling, causality and explanation. The health sciences have increasingly recognized the role of philosophy of medicine as both a field of conceptual and methodological reflection, capable of addressing practical issues, and hence relevant for a proper understanding of the construction of medical knowledge, modeling practices, therapeutic strategies and preventive decisions. 'Explaining Disease' contains various case studies in medicine to describe the assumptions underpinning the construction of explanatory models of diseases. It shows the impact different explanatory strategies can have on practical matters, which in turn affect clinical evaluation and therapy and public health decisions. The book concludes with a few open-ended reflections to foster more thorough consideration of the role of philosophy of medicine can play its dialogue with the health sciences.


Guiding Cancer Control

Guiding Cancer Control
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
Total Pages: 175
Release: 2019-08-30
Genre: Medical
ISBN: 0309492319

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Throughout history, perhaps no other disease has generated the level of social, scientific, and political discourse or has had the degree of cultural significance as cancer. A collective in the truest sense of the word, "cancer" is a clustering of different diseases that afflict individuals in different ways. Its burdens are equally broad and diverse, from the physical, financial, and psychological tolls it imposes on individuals to the costs it inflicts upon the nation's clinical care and public health systems, and despite decades of concerted efforts often referred to as the "war on cancer", those costs have only continued to grow over time. The causes and effects of cancer are complexâ€"in part preventable and treatable, but also in part unknown, and perhaps even unknowable. Guiding Cancer Control defines the key principles, attributes, methods, and tools needed to achieve the goal of implementing an effective national cancer control plan. This report describes the current structure of cancer control from a local to global scale, identifies necessary goals for the system, and formulates the path towards integrated disease control systems and a cancer-free future. This framework is a crucial step in establishing an effective, efficient, and accountable system for controlling cancer and other diseases.