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Calcium in Drug Actions

Calcium in Drug Actions
Author: Peter F. Baker
Publisher: Springer Science & Business Media
Total Pages: 579
Release: 2012-12-06
Genre: Medical
ISBN: 364271806X

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The Editorial Board and the Publishers of the Handbook of Experimental Pharmacology wish to express their profound grief at the untimely death of Professor Peter Baker. Aware of his international recognition as an expert on the ubiquitous role of calcium in physiological processes and their pharma cological control, the Board was gratified when Professor Baker accepted its invitation to edit a new Handbook volume on "Calcium in Drug Actions". He went about this task with his usual energy and effectiveness so that, in the few months before his unexpected death, Professor Baker had mustered his distinguished contributors, got them to provide their manuscripts, and seen almost the entire material into the press. This achievement is all the more remarkable when one bears in mind the extraordinary number of his other commitments during the same time; they are mentioned in Sir Alan Hodgkin's preface to this volume. With so many other professional and personal responsibilities upon him, the Board of the Handbook wishes to record its grateful appreciation for the admirable way in which Professor Baker took on and carried out the additional work of bringing this fine book into existence; and the Board wishes it to be dedicated to the memory of Professor Peter Frederick Baker. The Editorial Board: G. V. R. BORN, P. CUATRECASAS, H. HERKEN, A.


Calcium in Drug Action

Calcium in Drug Action
Author: G. B. Weiss
Publisher: Springer Science & Business Media
Total Pages: 366
Release: 2012-12-06
Genre: Medical
ISBN: 1468433547

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Anyone surveying physiological and pharmacological journals can readily see that the biological actions of calcium ion are of increasingly widespread current interest. The scope of investi gated actions and reactions in which a role for calcium ion is of some importance is so numerous as to convey the impression that calcium ion is everywhere and interacts with everything. This being so, the challenge in contemporary research is to focus on investigation of those actions of calcium ion which, in some manner, influence either significant physiological parameters or the manner in which pharmacological agents act. This multi-authored book originated from a more limited Symposium on "Importance of Calcium as a Primary Locus of Drug Action" co-chaired by myself and Dr. Frank R. Goodman at the April, 1977 FASEB meeting in Chicago. This Symposium was organized in response to a perceived need for increased communication among 2 workers in different areas of Ca +-related research. In the pro cess of selecting the maximum of six areas for presentation within the format provided, it soon became apparent that this would result in only a limited sampling of current research efforts. Expansion of the number of areas to fourteen within a book format appeared to be the most logical mechanism to provide a more coherent inter disciplinary approach to consideration of various aspects of the 2 roles of Ca + in drug action. This is not to imply that all rele 2 vant Ca +-related areas are surveyed within this volume.


The Role of Calcium in Drug Action

The Role of Calcium in Drug Action
Author: Michael Denborough
Publisher: Pergamon
Total Pages: 208
Release: 1987
Genre: Medical
ISBN:

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The role of the calcium ion is central to many homeostatic processes and as a result any perturbation in the concentration can cause profound metabolic effects. Disorders of red blood cells, platelets, the heart, bone, hypertension and asthma are all linked by this common factor and this book describes the effects of the drugs currently used in the control of calcium concentration. In describing the actions of these drugs on calcium metabolism, this volume of the International Encyclopedia of Pharmacology & Therapeutics will provide a greater understanding of the processes at work, and will undoubtedly lead to greater, more effective control of calcium concentration. It should thus be invaluable reading for those dealing with both the clinical and experimental control of calcium metabolism.


Control and Manipulation of Calcium Movement

Control and Manipulation of Calcium Movement
Author: Biological Council. Co-ordinating Committee for Symposia on Drug Action
Publisher: Raven Press (ID)
Total Pages: 420
Release: 1985
Genre: Medical
ISBN:

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Molecular Mechanisms Of Drug Action

Molecular Mechanisms Of Drug Action
Author: Christopher J. Coulson
Publisher: CRC Press
Total Pages: 318
Release: 1994-02-03
Genre: Medical
ISBN: 9780748400683

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In this book the targets of drug action are the central focus - whether they be enzymes in a pathway or membrane-bound receptors and ion channels. This approach distinguishes the book from others in the f ield which consider the subject mainly in terms of disease.; The introductory chapter is concerned with the basic principles that cover enzyme inhibition and receptor binding by drugs. The next seven chapters deal with drugs that modulate biochemical pathways, both of synthesis and breakdown, while the last four chapters are concerned with organizational structures of the cell.; The book brings together the state of knowledge with respect to drug action and emphasizes mechanistic aspects of drug action. It encompasses the modes of action of drugs for infectious disease and those for endogenous conditions. There is a listing of reviews and essay questions are provided for each chapter.


Calcium Antagonists

Calcium Antagonists
Author: International Society for Heart Research. American Section. Meeting
Publisher: Springer
Total Pages: 376
Release: 1984-05-31
Genre: Medical
ISBN:

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From the Proceedings of the Meeting of the American Section of the International Society for Heart Research (ISHR) at Hilton Head, South Carolina, September 21-24, 1983


Calcium Entry Channels in Non-Excitable Cells

Calcium Entry Channels in Non-Excitable Cells
Author: Juliusz Ashot Kozak
Publisher: CRC Press
Total Pages: 343
Release: 2017-07-14
Genre: Science
ISBN: 149875273X

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Calcium Entry Channels in Non-Excitable Cells focuses on methods of investigating the structure and function of non-voltage gated calcium channels. Each chapter presents important discoveries in calcium entry pathways, specifically dealing with the molecular identification of store-operated calcium channels which were reviewed by earlier volumes in the Methods in Signal Transduction series. Crystallographic and pharmacological approaches to the study of calcium channels of epithelial cells are also discussed. Calcium ion is a messenger in most cell types. Whereas voltage gated calcium channels have been studied extensively, the non-voltage gated calcium entry channel genes have only been identified relatively recently. The book will fill this important niche.


Drug Actions

Drug Actions
Author: Mutschler
Publisher: CRC Press
Total Pages: 830
Release: 1995
Genre: Medical
ISBN: 9780849377747

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The most highly acclaimed pharmacology and toxicology text/reference used in Europe is now available in English. This excellent translation of Mutschler's Arzneimittelwirkungen combines a clear, informative narrative with 255 figures, 261 diagrams, and 198 tables to appeal to both new students and experts in pharmacy, pharmacology, and therapeutics. Drug structure and activity relationships are emphasized as an important dimension that is sometimes lacking in other pharmacology texts. Drug Actions is organized into three major sections covering general drug action and dosing principles, specific drug therapeutics, and toxicology. The first section provides an integrated overview of basic principles in pharmacology with chapters addressing pharmacokinetics, pharmacodynamics, drug side effects, drug interactions, chronopharmacology, rational and irrational drug combinations as well as drug developments and drug trials. The second section systematically describes specific drug actions with pharmacology, clinical indications, standard doses side effects, and contraindications described for each approved drug category. The third section addresses toxicology where specific drug toxicities are identified and treatment options for accidental and drug associated poisoning are presented. Topics covered include environmental, occupational, and nutritional exposure to toxins.