Blood Unbound PDF Download
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Author | : Bat Collazo |
Publisher | : Troth |
Total Pages | : 226 |
Release | : 2021-03-17 |
Genre | : |
ISBN | : 9781941136492 |
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Thief and giver of gifts. Liar and revealer of difficult truths. Friend to Thor, blood-brother to Odin, and enemy of the Aesir gods at Ragnarok. Cunning trickster. Loving parent and spouse. Changemaker. The Norse god Loki occupies an ambiguous and controversial position in both modern polytheistic practice and old Scandinavian mythology. He (or they, or she...) disrupts the status quo and crosses borders between worlds and identities, offering a home to those who feel like outsiders. In this book, Bat Collazo and a community of 15 other contributors offer art, poetry, essays, fiction, rituals, and more in devotion to Loki. Whether you know Loki well, or are just beginning your journey, this book offers a path leading closer to this bound and boundless god.
Author | : Rachel Vincent |
Publisher | : HarperCollins Australia |
Total Pages | : 432 |
Release | : 2011-11-01 |
Genre | : Fiction |
ISBN | : 146080094X |
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Most can't touch the power, but Liv Warren is special. A paranormal tracker who follows the scent of blood, Liv makes her own rules and the most important one is trust no one. When her friend's daughter goes missing, Liv has no choice but to find the young girl. And thanks to a childhood oath, she can't rest until the child is home safe. Except that means trusting Cam Caballero the former lover forbidden to her. Bound by oath and lost in desire for a man she cannot have, Liv is racing to save the child from a dark criminal underworld where secrets, lies, trauma and danger lurk around every corner, every touch and every kiss... But more blood will be spilled before it's over
Author | : Alan Talevi |
Publisher | : Springer Nature |
Total Pages | : 1209 |
Release | : 2022-06-14 |
Genre | : Medical |
ISBN | : 3030848604 |
Download The ADME Encyclopedia Book in PDF, ePub and Kindle
The ADME Encyclopedia covers pharmacokinetic phenomena (Absorption, Distribution, Metabolism and Excretion processes) and their relationship with the design of pharmaceutical carriers and the success of drug therapies. It covers both basic and advanced knowledge, serving as introductory material for students of biomedical careers and also as reference, updated material for graduates and professionals working in any field related to pharmaceutical sciences (medicine, pharmaceutical technology, materials science, medicinal chemistry). Structured as alphabetically ordered entries with cross-references, the Encyclopedia not only provides basic knowledge on ADME processes, but also detailed entries on some advanced subjects such as drug transporters, last generation pharmaceutical carriers, pharmacogenomics, personalized medicine, bioequivalence studies, biowaivers, biopharmaceuticals, gene delivery, pharmacometrics, pharmacokinetic drug interactions or in silico and in vitro assessment of ADME properties
Author | : John Caldwell |
Publisher | : Elsevier |
Total Pages | : 444 |
Release | : 2012-12-02 |
Genre | : Nature |
ISBN | : 0323150101 |
Download Biological Basis of Detoxication Book in PDF, ePub and Kindle
Biological Basis of Detoxication focuses on the biological processes involved in detoxication, with emphasis on the biochemistry of the removal of xenobiotics from an organism. Topics range from the formation of toxic metabolites and compounds that are not metabolized at all to the tissue distribution and nutritional considerations, the kinetics and mechanisms of the metabolic and excretory processes, and the integration of xenobiotic metabolism in the activation and detoxication of carcinogens. Organized into 14 chapters, this book begins with an overview of the enzymatic basis for the metabolic activation of foreign compounds in forming reactive chemical intermediates. The first few chapters discuss the identification of reactive electrophiles derived from xenobiotics, intratissue distribution of activating and detoxicating enzymes, enzymatic and non-enzymatic modes of xenobiotic metabolism, and unmetabolized compounds. The middle chapters explore the biological basis of detoxication of oxygen free radicals, physiologic and kinetic aspects of the fate of xenobiotics, excretion of xenobiotics, and effects of nutrition on detoxication. The remaining chapters look at the relationships between the enzymes of detoxication and host defense mechanisms, metabolic basis of target organ toxicity, the enzymatic factor in selective toxicity, and intraindividual and interindividual variations in rates of hepatic metabolism of exogenous chemicals. Pharmacologists, toxicologists, and biochemists will find this book highly informative.
Author | : Neal Shusterman |
Publisher | : Simon and Schuster |
Total Pages | : 336 |
Release | : 2016-12-13 |
Genre | : Juvenile Fiction |
ISBN | : 1481457241 |
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Find out what happens to Connor, Risa, and Lev now that they've finally destroyed the Proactive Citizenry in this collection of short stories set in the world of the New York Times bestselling Unwind Dystology by Neal Shusterman. Connor Lassiter's fight to bring down Proactive Citizenry and find a suitable alternative to unwinding concluded in UnDivided. Now Connor, Risa, and Lev are free to live in a peaceful future--or are they? Neal Shusterman brings back his beloved Unwind characters for his fans to see what's left for those who were destined to be unwound.
Author | : Hannah Batchelor |
Publisher | : John Wiley & Sons |
Total Pages | : 324 |
Release | : 2021-12-13 |
Genre | : Medical |
ISBN | : 1119678374 |
Download Biopharmaceutics Book in PDF, ePub and Kindle
Explore the latest research in biopharmaceutics from leading contributors in the field In Biopharmaceutics - From Fundamentals to Industrial Practice, distinguished Scientists from the UK's Academy of Pharmaceutical Sciences Biopharmaceutica Focus Group deliver a comprehensive examination of the tools used within the field of biopharmaceutics and their applications to drug development. This edited volume is an indispensable tool for anyone seeking to better understand the field of biopharmaceutics as it rapidly develops and evolves. Beginning with an expansive introduction to the basics of biopharmaceutics and the context that underpins the field, the included resources go on to discuss how biopharmaceutics are integrated into product development within the pharmaceutical industry. Explorations of how the regulatory aspects of biopharmaceutics function, as well as the impact of physiology and anatomy on the rate and extent of drug absorption, follow. Readers will find insightful discussions of physiologically based modeling as a valuable asset in the biopharmaceutics toolkit and how to apply the principles of the field to special populations. The book goes on to discuss: Thorough introductions to biopharmaceutics, basic pharmacokinetics, and biopharmaceutics measures Comprehensive explorations of solubility, permeability, and dissolution Practical discussions of the use of biopharmaceutics to inform candidate drug selection and optimization, as well as biopharmaceutics tools for rational formulation design In-depth examinations of biopharmaceutics classification systems and regulatory biopharmaceutics, as well as regulatory biopharmaceutics and the impact of anatomy and physiology Perfect for professionals working in the pharmaceutical and biopharmaceutical industries, Biopharmaceutics - From Fundamentals to Industrial Practice is an incisive and up-to-date resource on the practical, pharmaceutical applications of the field.
Author | : K. Sandy Pang |
Publisher | : Springer Science & Business Media |
Total Pages | : 742 |
Release | : 2009-12-17 |
Genre | : Medical |
ISBN | : 1441908404 |
Download Enzyme- and Transporter-Based Drug-Drug Interactions Book in PDF, ePub and Kindle
Germination of the thought of "Enzymatic- and Transporter-Based Drug-Drug Interactions: Progress and Future Challenges" Proceedings came about as part of the annual meeting of The American Association of Pharmaceutical Scientists (AAPS) that was held in San Diego in November of 2007. The attendance of workshop by more than 250 pharmaceutical scientists reflected the increased interest in the area of drug-drug interactions (DDIs), the greater focus of PhRMA, academia, and regulatory agencies, and the rapid pace of growth in knowledge. One of the aims of the workshop was to address the progress made in quantitatively predicting enzyme- and transporter-based DDIs as well as highlighted areas where such predictions are poor or areas that remain challenging for the future. Because of the serious clinical implications, initiatives have arisen from the FDA (http://www.fda.gov/cber/gdlns/interactstud.htm) to highlight the importance of enzyme- and transporter-based DDIs. During the past ten to fifteen years, we have come to realize that transporters, in addition to enzymes, play a vital role in drug elimination. Such insight has been possible because of the continued growth in PK-ADME (pharmacokinetics-absorption-distribution-metabolism-excretion) knowledge, fueled by further advances in molecular biology, greater availability of human tissues, and the development of additional and sophisticated model systems and sensitive assay methods for studying drug metabolism and transport in vitro and in vivo. This has sparked an in-depth probing into mechanisms surrounding DDIs, resulting from ligand-induced changes in nuclear receptors, as well as alterations in transporter and enzyme expression and function. Despite such advances, the in vitro and in vivo study of drug interactions and the integration of various data sets remain challenging. Therefore, it has become apparent that a proceeding that serves to encapsulate current strategies, approaches, methods and applications is necessary. As Editors, we have assembled a number of opinion leaders and asked them to contribute chapters surrounding these issues. Many of these are the original Workshop speakers whereas others had been selected specially to contribute on topics related to basic and applied information that had not been covered in other reference texts on DDI. The resulting tome, entitled Enzyme- and Transporter-Based Drug Interactions: Progress and Future Challenges, comprises of four sections. Twenty-eight chapters covering various topics and perspectives related to the subject of metabolic and transporter-based drug-drug interactions are presented.
Author | : Li Di |
Publisher | : John Wiley & Sons |
Total Pages | : 600 |
Release | : 2014-12-29 |
Genre | : Medical |
ISBN | : 1118788540 |
Download Blood-Brain Barrier in Drug Discovery Book in PDF, ePub and Kindle
Focused on central nervous system (CNS) drug discovery efforts,this book educates drug researchers about the blood-brain barrier(BBB) so they can affect important improvements in one of the mostsignificant – and most challenging – areas of drugdiscovery. • Written by world experts to provide practicalsolutions to increase brain penetration or minimize CNSside-effects • Reviews state-of-the-art in silico, in vitro, and invivo tools to assess brain penetration and advanced CNS drugdelivery strategies • Covers BBB physiology, medicinal chemistry designprinciples, free drug hypothesis for the BBB, and transportmechanisms including passive diffusion, uptake/efflux transporters,and receptor-mediated processes • Highlights the advances in modelling BBBpharmacokinetics and dynamics relationships (PK/PD) andphysiologically-based pharmacokinetics (PBPK) • Discusses case studies of successful CNS and non-CNSdrugs, lessons learned and paths to the market
Author | : Dean King |
Publisher | : Little, Brown |
Total Pages | : 347 |
Release | : 2010-03-24 |
Genre | : History |
ISBN | : 0316072176 |
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In October 1934, the Chinese Communist Army found itself facing annihilation, surrounded by hundreds of thousands of Nationalist soldiers. Rather than surrender, 86,000 Communists embarked on an epic flight to safety. Only thirty were women. Their trek would eventually cover 4,000 miles over 370 days. Under enemy fire they crossed highland awamps, climbed Tibetan peaks, scrambled over chain bridges, and trudged through the sands of the western deserts. Fewer than 10,000 of them would survive, but remarkably all of the women would live to tell the tale. Unbound is an amazing story of love, friendship, and survival written by a new master of adventure narrative.
Author | : Lily Dunn |
Publisher | : Unbound Publishing |
Total Pages | : 283 |
Release | : 2021-05-13 |
Genre | : Fiction |
ISBN | : 1783529660 |
Download A Wild and Precious Life Book in PDF, ePub and Kindle
Featuring a foreword by Will Self We’ll all experience recovery at some point in our lives, whether from addiction, physical illness, mental health issues or loss. Many of us heal, and we may discover ways to live with our changed selves, to reclaim a life. We may find a new voice, or unearth a voice that has been submerged. Vitally, recovery can mean community. This anthology – which grew out of a small creative writing class run by Lily Dunn at Hackney Recovery Service, and was later broadened into a nationwide call for submissions by Dunn and her teaching partner, Zoe Gilbert – represents a community of writers: new, unheard voices alongside emerging and established authors. Theirs are stories from the dark back alleys, the deep crevices of the mind, and from the wild, ecstatic heights of life before, during and after recovery. These are voices that urgently need to be heard, in all their variety.