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Trauma Induced Coagulopathy

Trauma Induced Coagulopathy
Author: Hunter B. Moore
Publisher: Springer Nature
Total Pages: 802
Release: 2020-10-12
Genre: Medical
ISBN: 3030536068

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The first edition of this publication was aimed at defining the current concepts of trauma induced coagulopathy by critically analyzing the most up-to-date studies from a clinical and basic science perspective. It served as a reference source for any clinician interested in reviewing the pathophysiology, diagnosis, and management of the coagulopathic trauma patient, and the data that supports it. By meticulously describing the methodology of most traditional as well as state of the art coagulation assays the reader is provided with a full understanding of the tests that are used to study trauma induced coagulopathy. With the growing interest in understanding and managing coagulation in trauma, this second edition has been expanded to 46 chapters from its original 35 to incorporate the massive global efforts in understanding, diagnosing, and treating trauma induced coagulopathy. The evolving use of blood products as well as recently introduced hemostatic medications is reviewed in detail. The text provides therapeutic strategies to treat specific coagulation abnormalities following severe injury, which goes beyond the first edition that largely was based on describing the mechanisms causing coagulation abnormalities. Trauma Induced Coagulopathy 2nd Edition is a valuable reference to clinicians that are faced with specific clinical challenges when managing coagulopathy.


Fluid Resuscitation

Fluid Resuscitation
Author: Institute of Medicine
Publisher: National Academies Press
Total Pages: 208
Release: 1999-11-05
Genre: Medical
ISBN: 0309064813

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Historically, 20% of all injured combatants die on the battlefield before they can be evacuated to a field hospital. Blood lossâ€"hemorrhageâ€"is the single major cause of death among those killed in action whose lives might otherwise be saved. Fluid resuscitation and the treatment of hypovolemia (the abnormally decreased volume of circulating fluid in the body) offer the greatest opportunity for reducing mortality and morbidity associated with battlefield casualties. In Fluid Resuscitation, a committee of experts assess current resuscitation fluids and protocols for the treatment of combat casualties and make recommendations for future research. Chapters focus on the pathophysiology of acute hemorrhagic shock, experience with and complications of fluid resuscitation, novel approaches to the treatment of shock, protocols of care at the site of injury, and future directions for research. The committee explicitly describes the similarities and differences between acute medical care during combat and civilian emergency trauma care. Fluid Resuscitation should help energize and focus research in both civilian and military emergency care and help save the lives of citizens and soldiers alike.


Modern Monitoring in Anesthesiology and Perioperative Care

Modern Monitoring in Anesthesiology and Perioperative Care
Author: Andrew B. Leibowitz
Publisher: Cambridge University Press
Total Pages: 419
Release: 2020-05-07
Genre: Medical
ISBN: 1108581803

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Close monitoring of patients during anesthesia is crucial for ensuring positive treatment outcomes and patient safety. The increasing availability of new technologies and the repurposing of older monitors means more patient data is at anesthesiologists' fingertips than ever before. However, this flood of options can be overwhelming. A practical resource for understanding this array of clinical monitoring options in anesthesia, this important text focuses on real-world applications in anesthesia and perioperative care. Reviewing the evidence for improved patient outcomes for monitoring technology, neurological monitoring, echocardiography systems and ultrasound are amongst the techniques covered in a head-to-toe approach. Statistics used by manufacturers to gain approval for their technology are discussed, as well as the under-appreciated risks associated with monitoring such as digital distraction. Future monitoring technologies including wearable systems are explored in depth. Focusing on applied practice, this book is an essential text for front-line healthcare professionals in anesthesia.


Regulation of Tissue Oxygenation, Second Edition

Regulation of Tissue Oxygenation, Second Edition
Author: Roland N. Pittman
Publisher: Biota Publishing
Total Pages: 117
Release: 2016-08-18
Genre: Medical
ISBN: 1615047212

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This presentation describes various aspects of the regulation of tissue oxygenation, including the roles of the circulatory system, respiratory system, and blood, the carrier of oxygen within these components of the cardiorespiratory system. The respiratory system takes oxygen from the atmosphere and transports it by diffusion from the air in the alveoli to the blood flowing through the pulmonary capillaries. The cardiovascular system then moves the oxygenated blood from the heart to the microcirculation of the various organs by convection, where oxygen is released from hemoglobin in the red blood cells and moves to the parenchymal cells of each tissue by diffusion. Oxygen that has diffused into cells is then utilized in the mitochondria to produce adenosine triphosphate (ATP), the energy currency of all cells. The mitochondria are able to produce ATP until the oxygen tension or PO2 on the cell surface falls to a critical level of about 4–5 mm Hg. Thus, in order to meet the energetic needs of cells, it is important to maintain a continuous supply of oxygen to the mitochondria at or above the critical PO2 . In order to accomplish this desired outcome, the cardiorespiratory system, including the blood, must be capable of regulation to ensure survival of all tissues under a wide range of circumstances. The purpose of this presentation is to provide basic information about the operation and regulation of the cardiovascular and respiratory systems, as well as the properties of the blood and parenchymal cells, so that a fundamental understanding of the regulation of tissue oxygenation is achieved.


Clinical Methods

Clinical Methods
Author: Henry Kenneth Walker
Publisher: Butterworth-Heinemann
Total Pages: 1128
Release: 1990
Genre: Medical
ISBN:

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A guide to the techniques and analysis of clinical data. Each of the seventeen sections begins with a drawing and biographical sketch of a seminal contributor to the discipline. After an introduction and historical survey of clinical methods, the next fifteen sections are organized by body system. Each contains clinical data items from the history, physical examination, and laboratory investigations that are generally included in a comprehensive patient evaluation. Annotation copyrighted by Book News, Inc., Portland, OR


Darkhouse

Darkhouse
Author: Alex Barclay
Publisher: Delacorte Press
Total Pages: 354
Release: 2007-05-29
Genre: Fiction
ISBN: 044033697X

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In this electrifying thriller—a bestseller in Great Britain and Ireland—Alex Barclay creates a stunning array of contrasts—from the violence of a cop’s world to the fragility of an embattled marriage, from the danger of New York’s gritty streets to the quiet of a seaside Irish village. With brilliance and subtlety, Barclay delivers a nerve-wracking tale of a troubled family, facing a brutal danger rushing relentlessly out of the past. One year has passed since a kidnapping drama exploded into violence on a New York street. And for NYPD detective Joe Lucchesi, the memory of that terrible moment is still alive. Joe’s wife, Anna, has brought him and their teenage son to Ireland, hoping to repair their fragile marriage—and cut the cord between Joe and the job. But when the girlfriend of their son vanishes, Joe begins to suspect that the crime may have its roots in his old life—and that someone has followed him all the way there…. An outsider in Ireland, Joe watches with rising apprehension as local cops try to solve the disappearance—and then reacts with fury when his son becomes the leading suspect. Frantically, Joe tries to piece together clues to the crime, certain that a predator has come to Ireland in a twisted act of vengeance. And in a culture he doesn’t understand, among people who may or may not be his friends, Joe must find a way to strike back…against a vicious killer who has Joe’s family in his sights.... A novel that plunges like a knife, Darkhouse delves into the intimate struggles between a husband and wife, between lovers and desperate friends. Seething with menace and mounting dread, Alex Barclay’s ingenious tale of a family under siege ratchets up the suspense one shocking revelation at a time as it races to its shattering climax....


Blood Loss

Blood Loss
Author: Alex Barclay
Publisher: Charnwood
Total Pages: 432
Release: 2013
Genre: Fiction
ISBN: 9781444816204

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When a teenage girl is found beaten and raped in the grounds of a derelict asylum, FBI agent Ren Bryce is called in to assist. But she is soon diverted to a missing persons' case when an eleven-year-old girl and her teenage babysitter vanish without a trace from their hotel room. Faced with conflicting evidence and inconsistent witnesses, Ren works obsessively to unravel the dark family secrets at the heart of the case, before it's too late. Determined to uncover the truth, Ren's behaviour becomes increasingly reckless. Putting her own safety at risk, she enters a world where innocent lives are ruined for profit - and kidnap, rape and murder are all part of the deal.


Damage Control Resuscitation

Damage Control Resuscitation
Author: Philip C. Spinella
Publisher: Springer
Total Pages: 376
Release: 2019-08-12
Genre: Medical
ISBN: 3030208206

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This book provides a comprehensive overview of damage control resuscitation (DCR), an evidence-based approach to the resuscitation of patients with severe life-threatening hemorrhage (LTH). It focuses on both civilian and military applications as DCR is utilized in civilian trauma situations as well as combat casualty care settings. The book covers the history of fluid resuscitation for bleeding, epidemiology of severe traumatic injuries, prediction of life-threatening hemorrhage, pathophysiology and diagnosis of blood failure, and permissive hypotension. Chapters provide in-depth detail on hemostatic resuscitation principles, dried plasma, dried platelet surrogates, and recent developments in frozen red blood cells and oxygen carriers. The book also discusses how DCR principles can be used in a variety of situations such as when there are large numbers of patients with hemorrhagic lesions, non-trauma scenarios, and on distinct populations such as children. Finally, it concludes with a discussion of training and education methods for the implementation of DCR and remote DCR principles as well as learning healthcare system principles to facilitate the implementation of DCR and ultimately improve outcomes for patients with life-threatening hemorrhage. Damage Control Resuscitation: Identification and Treatment of Life-Threatening Hemorrhage is an essential resource for physicians and related professionals, residents, nurses and medical students in emergency medicine, anesthesia, surgery, and critical care, as well as civilian and military EMS providers.


Hematology in Clinical Practice, Fifth Edition

Hematology in Clinical Practice, Fifth Edition
Author: Robert S. Hillman
Publisher: McGraw Hill Professional
Total Pages: 512
Release: 2010-10-22
Genre: Medical
ISBN: 0071766537

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The most practical and efficient guide to the diagnosis and management of blood disorders – now in full color 200 full-color illustrations! Hematology in Clinical Practice is a succinct, cutting-edge guide to the diagnosis and treatment of disorders of red blood cells, white blood cells, and hemostasis, and the use of blood components for transfusion. Each disease state is discussed in detail, incorporating the pathophysiology, clinical features, up-to-date laboratory testing, and current management strategies into a comprehensive and practical approach to hematologic disorders. Features: New full-color presentation includes over 200 superb illustrations and classic images of blood morphology, tissue pathology, and clinical findings New Case Histories introduce and continue through relevant chapters, highlighting critical clinical points for diagnosis and management New end-of-chapter Points to Remember encapsulate key clinical information New chapters include Anemia in the Elderly and expanded and updated coverage of Transplantation and treatment of hematologic malignancies Outstanding collection of tables, charts, and illustrations that translate basic science into valuable clinical context Strong focus on practical clinical management and supportive care Coverage of state-of-the-art drugs and chemotherapies and the latest advances in genetic testing and molecular pathways Conveniently organized into sections on Red Cells, White Cells, Hemostasis, and Transfusion Medicine