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| Author | : Roland E. Kontermann |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 381 |
| Release | : 2011-07-21 |
| Genre | : Medical |
| ISBN | : 3642209106 |
Download Bispecific Antibodies Book in PDF, ePub and Kindle
The concept of using bispecific antibodies for cancer therapy by retargeting immune effector cells was developed several years ago. Initial clinical studies were rather disappointing mainly due to low efficacy, severe side effects and the immunogenicity of the bispecific antibodies. The progress in antibody engineering finally led to the generation of new classes of bispecific antibodies lacking these obstacles. In addition, new applications were established, such as pre-targeting strategies in radioimmunotherapy and dual targeting approaches in order to improve binding, selectivity and efficacy. In this book, the different ways of generating bispecific antibodies are described, with emphasis on recombinant formats. The various applications of bispecific antibodies, e.g. in cellular cancer immunotherapy, radioimmunotherapy and pretargeting strategies are covered, and emerging applications such as dual targeting strategies, which involve the simultaneous inhibition of two targets, are addressed.
| Author | : Brian H. Santich |
| Publisher | : Frontiers Media SA |
| Total Pages | : 97 |
| Release | : 2021-01-21 |
| Genre | : Medical |
| ISBN | : 2889664155 |
Download Bispecific Antibodies for T-Cell Based Immunotherapy Book in PDF, ePub and Kindle
CK is affiliated with the Roche Innovation Center Zurich, holds stocks and has patents with Hoffmann-La Roche company. NKC reports receiving commercial research grants from Y-mabs Therapeutics and Abpro-Labs Inc.; holding ownership interest/equity/options in Y-Mabs Therapeutics Inc., and in Abpro-Labs, and owning stock options in Eureka Therapeutics. NKC is the inventor of pending and issued patents filed by MSK, including hu3F8 and 8H9 licensed to Ymabs Therapeutics, beta-glucan to Biotec Pharmacon, and HER2 bispecific antibody to Abpro-labs. NKC is an advisory board member for Abpro-Labs and Eureka Therapeutics
| Author | : Allan Matte |
| Publisher | : Elsevier |
| Total Pages | : 222 |
| Release | : 2020-09-07 |
| Genre | : Business & Economics |
| ISBN | : 0081030193 |
Download Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics Book in PDF, ePub and Kindle
Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics provides the interested and informed reader with an overview of current approaches, strategies and considerations relating to the purification, analytics and characterization of therapeutic antibodies and related molecules. While there are obviously other books published in and around this subject area, they seem to be either older (c.a. year 2000 publication date) or are more limited in scope. The book will include an extensive bibliography of the published literature in the respective areas covered. It is not, however, intended to be a how-to methods book. Covers the vital new area of R&D on therapeutic antibodies Written by leading scientists and researchers Up-to-date coverage and includes a detailed bibliography
| Author | : Roland E. Kontermann |
| Publisher | : |
| Total Pages | : 392 |
| Release | : 2011-08-31 |
| Genre | : |
| ISBN | : 9783642209116 |
Download Bispecific Antibodies Book in PDF, ePub and Kindle
| Author | : Uwe Gottschalk |
| Publisher | : John Wiley & Sons |
| Total Pages | : 849 |
| Release | : 2017-03-07 |
| Genre | : Medical |
| ISBN | : 1119126932 |
Download Process Scale Purification of Antibodies Book in PDF, ePub and Kindle
Promoting a continued and much-needed renaissance in biopharmaceutical manufacturing, this book covers the different strategies and assembles top-tier technology experts to address the challenges of antibody purification. • Updates existing topics and adds new ones that include purification of antibodies produced in novel production systems, novel separation technologies, novel antibody formats and alternative scaffolds, and strategies for ton-scale manufacturing • Presents new and updated discussions of different purification technologies, focusing on how they can address the capacity crunch in antibody purification • Emphasizes antibodies and innovative chromatography methods for processing
| Author | : Florian Rüker |
| Publisher | : Springer Nature |
| Total Pages | : 388 |
| Release | : 2021-01-04 |
| Genre | : Medical |
| ISBN | : 3030546306 |
Download Introduction to Antibody Engineering Book in PDF, ePub and Kindle
This highly readable textbook serves as a concise and engaging primer to the emerging field of antibody engineering and its various applications. It introduces readers to the basic science and molecular structure of antibodies, and explores how to characterize and engineer them. Readers will find an overview of the latest methods in antibody identification, improvement and biochemical engineering. Furthermore, alternative antibody formats and bispecific antibodies are discussed. The book’s content is based on lectures for the specializations “Protein Engineering” and “Medical Biotechnology” within the Master’s curriculum in “Biotechnology.” The lectures have been held at the University of Natural Resources and Life Sciences, Vienna, in cooperation with the Medical University of Vienna, since 2012 and are continuously adapted to reflect the latest developments in the field. The book addresses Master’s and PhD students in biotechnology, molecular biology and immunology, and all those who are interested in antibody engineering.
| Author | : Ashish S. Verma |
| Publisher | : Academic Press |
| Total Pages | : 685 |
| Release | : 2013-11-04 |
| Genre | : Science |
| ISBN | : 0123914345 |
Download Animal Biotechnology Book in PDF, ePub and Kindle
Animal Biotechnology introduces applications of animal biotechnology and implications for human health and welfare. It begins with an introduction to animal cell cultures and genome sequencing analysis and provides readers with a review of available cell and molecular tools. Topics here include the use of transgenic animal models, tissue engineering, nanobiotechnology, and proteomics. The book then delivers in-depth examples of applications in human health and prospects for the future, including cytogenetics and molecular genetics, xenografts, and treatment of HIV and cancers. All this is complemented by a discussion of the ethical and safety considerations in the field.Animal biotechnology is a broad field encompassing the polarities of fundamental and applied research, including molecular modeling, gene manipulation, development of diagnostics and vaccines, and manipulation of tissue. Given the tools that are currently available and the translational potential for these studies, animal biotechnology has become one of the most essential subjects for those studying life sciences. Highlights the latest biomedical applications of genetically modified and cloned animals with a focus on cancer and infectious diseases Provides firsthand accounts of the use of biotechnology tools, including molecular markers, stem cells, and tissue engineering
| Author | : Michael W. Fanger |
| Publisher | : Springer |
| Total Pages | : 151 |
| Release | : 1995-01-01 |
| Genre | : Antibody-drug conjugates |
| ISBN | : 9783540588856 |
Download Bispecific Antibodies Book in PDF, ePub and Kindle
Murine, human, and chimeric monoclonal antibodies (mAB) are currently being used for the treatment of a variety of human disorders including cancer. Bispecific antibodies (BsAB) have been developed as reagents that may permit even more specific linkages and mediate more efficient and appropriate bridges than mAB. The volume contains eight chapters: the production of BsAB; T cell-targeted cytotoxicity; myeloid cell-targeted cytotoxicity of tumor cells; natural killer cell-directed BsAB; targeted cytotoxicity of infectious agents and infectious cells; targeting drugs, toxins, and radionuclides with BsAB; targeting immune complexes and enzymes to cell surface receptors; and antigen targeting. Annotation copyright by Book News, Inc., Portland, OR
| Author | : Gunter Jagschies |
| Publisher | : Elsevier |
| Total Pages | : 1310 |
| Release | : 2018-01-18 |
| Genre | : Technology & Engineering |
| ISBN | : 0128125527 |
Download Biopharmaceutical Processing Book in PDF, ePub and Kindle
Biopharmaceutical Processing: Development, Design, and Implementation of Manufacturing Processes covers bioprocessing from cell line development to bulk drug substances. The methods and strategies described are essential learning for every scientist, engineer or manager in the biopharmaceutical and vaccines industry. The integrity of the bioprocess ultimately determines the quality of the product in the biotherapeutics arena, and this book covers every stage including all technologies related to downstream purification and upstream processing fields. Economic considerations are included throughout, with recommendations for lowering costs and improving efficiencies. Designed for quick reference and easy accessibility of facts, calculations and guidelines, this book is an essential tool for industrial scientists and managers in the biopharmaceutical industry. Offers a comprehensive, go-to reference for daily work decisions Covers both upstream and downstream processes Includes case studies that emphasize financial outcomes Presents summaries, decision grids, graphs and overviews for quick reference
| Author | : Jennie R. Lill |
| Publisher | : John Wiley & Sons |
| Total Pages | : 378 |
| Release | : 2017-08-14 |
| Genre | : Science |
| ISBN | : 1119053102 |
Download Analytical Characterization of Biotherapeutics Book in PDF, ePub and Kindle
The definitive guide to the myriad analytical techniques available to scientists involved in biotherapeutics research Analytical Characterization of Biotherapeutics covers all current and emerging analytical tools and techniques used for the characterization of therapeutic proteins and antigen reagents. From basic recombinant antigen and antibody characterization, to complex analyses for increasingly complex molecular designs, the book explores the history of the analysis techniques and offers valuable insights into the most important emerging analytical solutions. In addition, it frames critical questions warranting attention in the design and delivery of a therapeutic protein, exposes analytical challenges that may occur when characterizing these molecules, and presents a number of tested solutions. The first single-volume guide of its kind, Analytical Characterization of Biotherapeutics brings together contributions from scientists at the leading edge of biotherapeutics research and manufacturing. Key topics covered in-depth include the structural characterization of recombinant proteins and antibodies, antibody de novo sequencing, characterization of antibody drug conjugates, characterization of bi-specific or other hybrid molecules, characterization of manufacturing host-cell contaminant proteins, analytical tools for biologics molecular assessment, and more. Each chapter is written by a recognized expert or experts in their field who discuss current and cutting edge approaches to fully characterizing biotherapeutic proteins and antigen reagents Covers the full range of characterization strategies for large molecule based therapeutics Provides an up-to-date account of the latest approaches used for large molecule characterization Chapters cover the background needed to understand the challenges at hand, solutions to characterize these large molecules, and a summary of emerging options for analytical characterization Analytical Characterization of Biotherapeutics is an up-to-date resource for analytical scientists, biologists, and mass spectrometrists involved in the analysis of biomolecules, as well as scientists employed in the pharmaceuticals and biotechnology industries. Graduate students in biology and analytical science, and their instructors will find it to be fascinating and instructive supplementary reading.
