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Biomimetic Radical Chemistry and Applications

Biomimetic Radical Chemistry and Applications
Author: Chryssostomos Chatgilialoglu
Publisher: MDPI
Total Pages: 300
Release: 2020-03-25
Genre: Technology & Engineering
ISBN: 3039283928

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The enormous importance of free radical chemistry for a variety of biological events, including ageing and inflammation, has attracted a strong interest in understanding the related mechanistic steps at the molecular level. Modelling the free radical chemical reactivity of biological systems is an important research area. When studying free-radical-based chemical mechanisms, biomimetic chemistry and the design of established biomimetic models come into play to perform experiments in a controlled environment that is suitably designed to be in strict connection with cellular conditions. This Special Issue gives the reader a wide overview of biomimetic radical chemistry, where molecular mechanisms have been defined and molecular libraries of products are developed to also be used as traces for the discovery of some relevant biological processes. Several subjects are presented, with 12 articles and 6 reviews written by specialists in the fields of DNA, proteins, lipids, biotechnological applications, and bioinspired synthesis, having “free radicals” as a common denominator.


Biomimetic Radical Chemistry and Applications

Biomimetic Radical Chemistry and Applications
Author: Chryssostomos Chatgilialoglu
Publisher:
Total Pages: 300
Release: 2020
Genre: Biology (General)
ISBN: 9783039283934

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The enormous importance of free radical chemistry for a variety of biological events, including ageing and inflammation, has attracted a strong interest in understanding the related mechanistic steps at the molecular level. Modelling the free radical chemical reactivity of biological systems is an important research area. When studying free-radical-based chemical mechanisms, biomimetic chemistry and the design of established biomimetic models come into play to perform experiments in a controlled environment that is suitably designed to be in strict connection with cellular conditions. This Special Issue gives the reader a wide overview of biomimetic radical chemistry, where molecular mechanisms have been defined and molecular libraries of products are developed to also be used as traces for the discovery of some relevant biological processes. Several subjects are presented, with 12 articles and 6 reviews written by specialists in the fields of DNA, proteins, lipids, biotechnological applications, and bioinspired synthesis, having “free radicals” as a common denominator.


Biomimetic Radical Chemistry and Applications 2021

Biomimetic Radical Chemistry and Applications 2021
Author: Chryssostomos Chatgilialoglu
Publisher: Mdpi AG
Total Pages: 244
Release: 2022-05-19
Genre: Science
ISBN: 9783036543505

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The high importance of free radical chemistry for a variety of biological events, including ageing and inflammation, has attracted considerable interest in understanding the related mechanistic steps at the molecular level. Modelling the free radical chemical reactivity of biological systems is an important research area. When studying free-radical-based chemical mechanisms, biomimetic chemistry and the design of established biomimetic models come into play to perform experiments in a controlled environment, suitably designed to be a similar as possible to cellular conditions. This Special Issue provides readers with a wide overview of biomimetic radical chemistry, where molecular mechanisms have been defined and molecular libraries of products are developed to be used as traces for the discoveries of some relevant biological processes. Several subjects are presented, with five articles and five reviews written by specialists in the fields of DNA, proteins, lipids, biotechnological applications and bioinspired synthesis, with "free radicals" as the common denominator.


Organosilanes in Radical Chemistry

Organosilanes in Radical Chemistry
Author: Chryssostomos Chatgilialoglu
Publisher: John Wiley & Sons
Total Pages: 240
Release: 2004-04-02
Genre: Science
ISBN: 0470094257

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In recent years silicon-centered radicals have played an important role in organic synthesis, polymer chemistry and material sciences. The aim of this book is to offer for the first time a description of silyl radicals within an interdisciplinary context, connecting structural characteristics and chemical properties to their application in different areas of chemistry. The first time different aspects of silyl radicals have been brought together Excellent reference tool for experienced practitioners of radical and/or silicon chemistry Presents various aspects of these intermediates in an original, comprehensive fashion This book is essential for anyone working in free radical and/or silicon chemistry as well as for those who want to approach these fields for the first time.


Radical Reactions in Aqueous Media

Radical Reactions in Aqueous Media
Author: V. Tamara Perchyonok
Publisher: Royal Society of Chemistry
Total Pages: 142
Release: 2010
Genre: Science
ISBN: 1849730008

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Radical Reactions in Aqueous Media provides a step-wise introduction, taking students from the basic principles of radical reactions through to their applications in industry and their role in biological and environmental processes."--Jacket.


Biomimetic Chemistry: Radical Reactions in Vesicle Suspensions

Biomimetic Chemistry: Radical Reactions in Vesicle Suspensions
Author: Chryssostomos Chatgilialoglu
Publisher:
Total Pages:
Release: 2010
Genre:
ISBN: 9789533070254

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The chapter offered an overview of main processes studied by the membrane model of liposomes. The use of liposomes as carrier for drugs and active compound delivery cannot be forgotten, and some aspects of the liposome technology and reactivity shown in this chapter can have relevance also in this field. The system of monolamellar liposomes is expected to be extensively used for the examination of free radical reactivity, especially from a chemical biology approach exploring the biomimetic chemistry of radical species in detail, where the experimental set up of the liposomal model can satisfactorily represent the biological scenarios. In this context an improvement of interdisciplinarity is needed, among the fields of chemistry, biochemistry, biology and medicine, in order to create a common territory where the achievements of free radical reactivity can be straightforwardly transferred to a better comprehension of the biological pathways in health and diseases.


Biomimetics

Biomimetics
Author: Amitava Mukherjee
Publisher: IntechOpen
Total Pages: 544
Release: 2010-03-01
Genre: Medical
ISBN: 9789533070254

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Nature’s evolution has led to the introduction of highly efficient biological mechanisms. Imitating these mechanisms offers an enormous potential for the improvement of our day to day life. Ideally, by bio-inspiration we can get a better view of nature’s capability while studying its models and adapting it for our benefit. This book takes us into the interesting world of biomimetics and describes various arenas where the technology is applied. The 25 chapters covered in this book disclose recent advances and new ideas in promoting the mechanism and applications of biomimetics.


Membrane Lipidomics for Personalized Health

Membrane Lipidomics for Personalized Health
Author: Carla Ferreri
Publisher: John Wiley & Sons
Total Pages: 204
Release: 2015-08-31
Genre: Science
ISBN: 1118540417

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Lipidomics is an important aspect of personalized medicine in relation to nutrition and metabolism. This approach has become important due to the substantial presence of nutraceuticals in the market, since it gives personalized criteria on how to choose the right nutraceutical strategy for both prevention and for quality of life. This multi-disciplinary textbook uses a simple and practical approach to provide a comprehensive overview of lipidomics and their connection with health and nutrition. The text is divided into two parts: - Part 1 outlines the basics of lipidomics and focuses on the biochemical and nutritional aspects with descriptions of the analytical methods employed for the examination of cell membrane fatty acid composition. - Part 2 familiarizes the reader with the use of membrane lipidomic diagnostics in practical health care, using health conditions as examples to introduce the concept of lipidomic profiles in different physiological and pathological situations including prevention. Through the various properties of membrane lipidomics, readers will be able to combine the molecular status of the cell membrane with the evaluation of the subject for personalized nutritional and nutraceutical strategies. Membrane Lipidomics for Personalized Health will be beneficial to biologists, biochemists and medical researchers, as well as health care professionals, pharmacists, and nutritionists seeking in-depth information on the topic.


Sulfur-Centered Reactive Intermediates in Chemistry and Biology

Sulfur-Centered Reactive Intermediates in Chemistry and Biology
Author: C. Chatgilialoglu
Publisher: Springer Science & Business Media
Total Pages: 448
Release: 2013-03-08
Genre: Science
ISBN: 1468458744

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A wonderfully successful NATO Advanced Study Institute on "Sulfur-Centered Reactive Intermediates in Chemistry and Biology" was held 18-30 June, 1989, at the Hotel Villa del Mare in Maratea, Italy. Despite the beautiful setting with mountains behind us and over looking the clear blue Mediterranean Sea under a cloudless sky (and with a private beach available), the lectures were extremely well attended. While some credit can go to the seriousness of the students, more must go to the calibre of speakers and the high quality of C. Chatgilialoglu, and Co-Director, Professor K. -D. their presentations. The Director, Dr. Asmus, are to be congratulated for putting together such an outstanding scientific program. Dr. Chatgilialoglu is also to be commended for arranging an equally stimulating social pro gram which included bus, train and boat trips to many local sites of interest. It was particularly fitting that a meeting on the chemistry and biochemistry of sulfur should be held in Italy since Italian chemists have made major contributions to our under standing of the organic chemistry of sulfur, including the chemistry of its reactive inter mediates. The early Italian interest in sulfur chemistry arose from the fact that Italy, or more specifically, Sicily, was a major world producer of sulfur prior to the development and exploitation of the Frasch process in Texas and Louisiana.