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Biological Effects of Low Level Exposures to Chemical and Radiation

Biological Effects of Low Level Exposures to Chemical and Radiation
Author: Edward J. Calabrese
Publisher: CRC Press
Total Pages: 241
Release: 2017-07-28
Genre: Medical
ISBN: 1351367994

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This book features papers presented at a workshop discussing current knowledge about the biological effects of low level exposures (BELLE). The book is designed to help establish a scientific base for future BELLE initiatives and is focused on the issue of the toxicological implications of biological adaptations. Hormesis is considered in a broad, conceptual manner, as well as at molecular and biochemical levels. Other topics covered include the effects of low levels of radiation on biological systems, how the liver adapts to genetic insults, biostatistical considerations when designing studies that address issues associated with biological responses to low doses of chemicals and radiation, and the issues that surround the interpretation of findings from such studies.


Biological Effects of Low Level Exposures Dose-Response Relationships

Biological Effects of Low Level Exposures Dose-Response Relationships
Author: Edward J. Calabrese
Publisher: CRC Press
Total Pages: 320
Release: 1994-05-19
Genre: Science
ISBN: 9781566700931

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Biological Effects of Low-Level Exposures, more commonly referred to as BELLE, began as a conference in May 1990. Its members are committed to the enhanced understanding of low-dose responses of all types to human exposures to chemical and physical agents, whether of an expected or paradoxical nature. The focus of BELLE encompasses dose-response relationships to toxic agents, pharmaceuticals, and natural products over wide dosage ranges in both in vitro systems and in vivo systems, including human populations. While BELLE promotes the scientific understanding of low-level effects, its primary goal is the scientific evaluation of existing literature and ways to improve research and assessment methods.


Biological Effects of Low Level Exposures to Chemicals and Radiation

Biological Effects of Low Level Exposures to Chemicals and Radiation
Author:
Publisher:
Total Pages: 155
Release: 2018
Genre: Electronic books
ISBN: 9781351367981

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"This book features papers presented at a workshop discussing current knowledge about the biological effects of low level exposures (BELLE). The book is designed to help establish a scientific base for future BELLE initiatives and is focused on the issue of the toxicological implications of biological adaptations. Hormesis is considered in a broad, conceptual manner, as well as at molecular and biochemical levels. Other topics covered include the effects of low levels of radiation on biological systems, how the liver adapts to genetic insults, biostatistical considerations when designing studies that address issues associated with biological responses to low doses of chemicals and radiation, and the issues that surround the interpretation of findings from such studies."--Provided by publisher.


Revival

Revival
Author: Edward J. Calabrese
Publisher: CRC Press Revivals
Total Pages: 172
Release: 2019-01-28
Genre: Electronic books
ISBN: 9781138557741

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Cover -- Title -- Copyright -- Preface -- Contents -- 1. Hypotheses on Mammalian Aging, Toxicity, and Longevity Hormesis: Explication by a Generalized Gompertz Function -- 2. The Role of the "Stress Protein Response" in Hormesis -- 3. DNA Repair: As Influenced by Age, Nutrition, and Exposure to Toxic Substances -- 4. Biochemical Mechanisms of Biphasic Dose-Response Relationships: Role of Hormesis -- 5. Effects of Low-Dose Radiation on the Immune Response -- 6. Cellular Adaptation as an Important Response During Chemical Carcinogenesis -- 7. Biostatistical Approaches for Modeling U-Shaped Dose-Response Curves and Study Design Considerations in Assessing the Biological Effects of Low Doses -- List of Contributors -- Index


Health Risks from Exposure to Low Levels of Ionizing Radiation

Health Risks from Exposure to Low Levels of Ionizing Radiation
Author: Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation
Publisher: National Academies Press
Total Pages: 422
Release: 2006-03-23
Genre: Science
ISBN: 0309133343

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This book is the seventh in a series of titles from the National Research Council that addresses the effects of exposure to low dose LET (Linear Energy Transfer) ionizing radiation and human health. Updating information previously presented in the 1990 publication, Health Effects of Exposure to Low Levels of Ionizing Radiation: BEIR V, this book draws upon new data in both epidemiologic and experimental research. Ionizing radiation arises from both natural and man-made sources and at very high doses can produce damaging effects in human tissue that can be evident within days after exposure. However, it is the low-dose exposures that are the focus of this book. So-called “late” effects, such as cancer, are produced many years after the initial exposure. This book is among the first of its kind to include detailed risk estimates for cancer incidence in addition to cancer mortality. BEIR VII offers a full review of the available biological, biophysical, and epidemiological literature since the last BEIR report on the subject and develops the most up-to-date and comprehensive risk estimates for cancer and other health effects from exposure to low-level ionizing radiation.


Health Effects of Exposure to Low Levels of Ionizing Radiation

Health Effects of Exposure to Low Levels of Ionizing Radiation
Author: National Research Council
Publisher: National Academies
Total Pages: 436
Release: 1990-02-01
Genre: Science
ISBN: 0309039959

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This book reevaluates the health risks of ionizing radiation in light of data that have become available since the 1980 report on this subject was published. The data include new, much more reliable dose estimates for the A-bomb survivors, the results of an additional 14 years of follow-up of the survivors for cancer mortality, recent results of follow-up studies of persons irradiated for medical purposes, and results of relevant experiments with laboratory animals and cultured cells. It analyzes the data in terms of risk estimates for specific organs in relation to dose and time after exposure, and compares radiation effects between Japanese and Western populations.


Assessment of Risk from Low-Level Exposure to Radiation and Chemicals

Assessment of Risk from Low-Level Exposure to Radiation and Chemicals
Author: A. D. Woodhead
Publisher: Springer Science & Business Media
Total Pages: 531
Release: 2013-11-21
Genre: Medical
ISBN: 1468449702

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The present workshop had its orlglns in discussions among Alexander Hollaender, Oddvar Nygaard, Donald Borg, Richard Setlow and Victor Bond on the need for a symposium that would deal with a broad spectrum of pressing subjects related to the physics, chemistry, and biological actions of ionizing radiations, and the theoretical and practical problems of risk assessment. It soon became apparent that the spectrum of subjects considered was too broad for the desired depth of coverage; in fact, it seemed un likely that the conference participants would have the background knowledge to span the gamut. Therefore, two separate meetings were decided upon, the first of which, Comparison of Mechanisms of Carcinogenesis by Radiation and Chemical Agents, was held at the National Bureau of Standards, Gaithersburg on December 6-7, 1983. The meeting was sponsored by the NCI. The second meeting has emerged as the present workshop at Brookhaven National Laboratory. An interface between the two conferences has been provided by Michael Fry and Donald Borg, who have summarized the salient points emanating from the NCI Symposium. We intended that the first conference should focus on the basic mechanisms of radiation and chemical carcinogenesis, while the second, the present meeting, would emphasize exposure-response relationships, particularly the theoretical and practical similar ities and differences between exposure to chemical carcinogens compared to exposure to ionizing radiation.


Holland-Frei Cancer Medicine

Holland-Frei Cancer Medicine
Author: Robert C. Bast, Jr.
Publisher: John Wiley & Sons
Total Pages: 2004
Release: 2017-03-10
Genre: Medical
ISBN: 111900084X

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Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates