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| Author | : Edward J. Calabrese |
| Publisher | : CRC Press |
| Total Pages | : 320 |
| Release | : 1994-05-19 |
| Genre | : Science |
| ISBN | : 9781566700931 |
Download Biological Effects of Low Level Exposures Dose-Response Relationships Book in PDF, ePub and Kindle
Biological Effects of Low-Level Exposures, more commonly referred to as BELLE, began as a conference in May 1990. Its members are committed to the enhanced understanding of low-dose responses of all types to human exposures to chemical and physical agents, whether of an expected or paradoxical nature. The focus of BELLE encompasses dose-response relationships to toxic agents, pharmaceuticals, and natural products over wide dosage ranges in both in vitro systems and in vivo systems, including human populations. While BELLE promotes the scientific understanding of low-level effects, its primary goal is the scientific evaluation of existing literature and ways to improve research and assessment methods.
| Author | : National Research Council |
| Publisher | : National Academies Press |
| Total Pages | : 422 |
| Release | : 2009-03-24 |
| Genre | : Political Science |
| ISBN | : 0309120462 |
Download Science and Decisions Book in PDF, ePub and Kindle
Risk assessment has become a dominant public policy tool for making choices, based on limited resources, to protect public health and the environment. It has been instrumental to the mission of the U.S. Environmental Protection Agency (EPA) as well as other federal agencies in evaluating public health concerns, informing regulatory and technological decisions, prioritizing research needs and funding, and in developing approaches for cost-benefit analysis. However, risk assessment is at a crossroads. Despite advances in the field, risk assessment faces a number of significant challenges including lengthy delays in making complex decisions; lack of data leading to significant uncertainty in risk assessments; and many chemicals in the marketplace that have not been evaluated and emerging agents requiring assessment. Science and Decisions makes practical scientific and technical recommendations to address these challenges. This book is a complement to the widely used 1983 National Academies book, Risk Assessment in the Federal Government (also known as the Red Book). The earlier book established a framework for the concepts and conduct of risk assessment that has been adopted by numerous expert committees, regulatory agencies, and public health institutions. The new book embeds these concepts within a broader framework for risk-based decision-making. Together, these are essential references for those working in the regulatory and public health fields.
| Author | : Edward J. Calabrese |
| Publisher | : CRC Press Revivals |
| Total Pages | : 172 |
| Release | : 2019-01-28 |
| Genre | : Electronic books |
| ISBN | : 9781138557741 |
Download Revival Book in PDF, ePub and Kindle
Cover -- Title -- Copyright -- Preface -- Contents -- 1. Hypotheses on Mammalian Aging, Toxicity, and Longevity Hormesis: Explication by a Generalized Gompertz Function -- 2. The Role of the "Stress Protein Response" in Hormesis -- 3. DNA Repair: As Influenced by Age, Nutrition, and Exposure to Toxic Substances -- 4. Biochemical Mechanisms of Biphasic Dose-Response Relationships: Role of Hormesis -- 5. Effects of Low-Dose Radiation on the Immune Response -- 6. Cellular Adaptation as an Important Response During Chemical Carcinogenesis -- 7. Biostatistical Approaches for Modeling U-Shaped Dose-Response Curves and Study Design Considerations in Assessing the Biological Effects of Low Doses -- List of Contributors -- Index
| Author | : Edward J. Calabrese |
| Publisher | : CRC Press |
| Total Pages | : 241 |
| Release | : 2017-07-28 |
| Genre | : Medical |
| ISBN | : 1351367994 |
Download Biological Effects of Low Level Exposures to Chemical and Radiation Book in PDF, ePub and Kindle
This book features papers presented at a workshop discussing current knowledge about the biological effects of low level exposures (BELLE). The book is designed to help establish a scientific base for future BELLE initiatives and is focused on the issue of the toxicological implications of biological adaptations. Hormesis is considered in a broad, conceptual manner, as well as at molecular and biochemical levels. Other topics covered include the effects of low levels of radiation on biological systems, how the liver adapts to genetic insults, biostatistical considerations when designing studies that address issues associated with biological responses to low doses of chemicals and radiation, and the issues that surround the interpretation of findings from such studies.
| Author | : Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation |
| Publisher | : National Academies Press |
| Total Pages | : 422 |
| Release | : 2006-03-23 |
| Genre | : Science |
| ISBN | : 0309133343 |
Download Health Risks from Exposure to Low Levels of Ionizing Radiation Book in PDF, ePub and Kindle
This book is the seventh in a series of titles from the National Research Council that addresses the effects of exposure to low dose LET (Linear Energy Transfer) ionizing radiation and human health. Updating information previously presented in the 1990 publication, Health Effects of Exposure to Low Levels of Ionizing Radiation: BEIR V, this book draws upon new data in both epidemiologic and experimental research. Ionizing radiation arises from both natural and man-made sources and at very high doses can produce damaging effects in human tissue that can be evident within days after exposure. However, it is the low-dose exposures that are the focus of this book. So-called “late” effects, such as cancer, are produced many years after the initial exposure. This book is among the first of its kind to include detailed risk estimates for cancer incidence in addition to cancer mortality. BEIR VII offers a full review of the available biological, biophysical, and epidemiological literature since the last BEIR report on the subject and develops the most up-to-date and comprehensive risk estimates for cancer and other health effects from exposure to low-level ionizing radiation.
| Author | : National Research Council |
| Publisher | : National Academies Press |
| Total Pages | : 273 |
| Release | : 2000-04-21 |
| Genre | : Medical |
| ISBN | : 0309068754 |
Download Strategies to Protect the Health of Deployed U.S. Forces Book in PDF, ePub and Kindle
Since Operation Desert Shield/Desert Storm, Gulf War veterans have expressed concerns about health effects that could be associated with their deployment and service during the war. Although similar concerns were raised after other military operations, the Gulf War deployment focused national attention on the potential, but uncertain, relationship between the presence of chemical and biological (CB) agents and other harmful agents in theater and health symptoms reported by military personnel. Strategies to Protect the Health of Deployed U.S. Forces which is one of the four two-year studies, examines the detection and tracking of exposures of deployed personnel to multiple harmful agents.
| Author | : |
| Publisher | : |
| Total Pages | : 155 |
| Release | : 2018 |
| Genre | : Electronic books |
| ISBN | : 9781351367981 |
Download Biological Effects of Low Level Exposures to Chemicals and Radiation Book in PDF, ePub and Kindle
"This book features papers presented at a workshop discussing current knowledge about the biological effects of low level exposures (BELLE). The book is designed to help establish a scientific base for future BELLE initiatives and is focused on the issue of the toxicological implications of biological adaptations. Hormesis is considered in a broad, conceptual manner, as well as at molecular and biochemical levels. Other topics covered include the effects of low levels of radiation on biological systems, how the liver adapts to genetic insults, biostatistical considerations when designing studies that address issues associated with biological responses to low doses of chemicals and radiation, and the issues that surround the interpretation of findings from such studies."--Provided by publisher.
| Author | : Oddvar F. Nygaard |
| Publisher | : Academic Press |
| Total Pages | : 349 |
| Release | : 2013-10-22 |
| Genre | : Medical |
| ISBN | : 1483281833 |
Download Effects of Low Dose and Low Dose Rate Radiation Book in PDF, ePub and Kindle
Advances in Radiation Biology, Volume 6: Effects of Low Dose and Low Dose Rate Radiation examines the biological effects of low dose and low dose rate ionizing radiation on a broad scale, covering various articles from microdosimetry to analyses of human responses. Estimates of the effects on humans from low doses or from sustained exposures to low dose rates of ionizing radiations are of critical importance for the assessment of radiation risks under occupational and environmental conditions. This book consists of such knowledge that is essential for radiation protection and governmental regulatory activities pertaining to radiation exposure. This volume is intended for radiobiologists, radiation epidemiologists, radiation physicists, radiation safety personnel, health officials, and individuals involved in regulatory activities.
| Author | : National Research Council |
| Publisher | : National Academies Press |
| Total Pages | : 364 |
| Release | : 2000-09-27 |
| Genre | : Nature |
| ISBN | : 0309171717 |
Download Toxicological Effects of Methylmercury Book in PDF, ePub and Kindle
Mercury is widespread in our environment. Methylmercury, one organic form of mercury, can accumulate up the aquatic food chain and lead to high concentrations in predatory fish. When consumed by humans, contaminated fish represent a public health risk. Combustion processes, especially coal-fired power plants, are major sources of mercury contamination in the environment. The U.S. Environmental Protection Agency (EPA) is considering regulating mercury emissions from those plants. Toxicological Effects of Methylmercury reviews the health effects of methylmercury and discusses the estimation of mercury exposure from measured biomarkers, how differences between individuals affect mercury toxicity, and appropriate statistical methods for analysis of the data and thoroughly compares the epidemiological studies available on methylmercury. Included are discussions of current mercury levels on public health and a delineation of the scientific aspects and policy decisions involved in the regulation of mercury. This report is a valuable resource for individuals interested in the public health effects and regulation of mercury. The report also provides an excellent example of the implications of decisions in the risk assessment process for a larger audience.
| Author | : National Research Council |
| Publisher | : National Academies |
| Total Pages | : 436 |
| Release | : 1990-02-01 |
| Genre | : Science |
| ISBN | : 0309039959 |
Download Health Effects of Exposure to Low Levels of Ionizing Radiation Book in PDF, ePub and Kindle
This book reevaluates the health risks of ionizing radiation in light of data that have become available since the 1980 report on this subject was published. The data include new, much more reliable dose estimates for the A-bomb survivors, the results of an additional 14 years of follow-up of the survivors for cancer mortality, recent results of follow-up studies of persons irradiated for medical purposes, and results of relevant experiments with laboratory animals and cultured cells. It analyzes the data in terms of risk estimates for specific organs in relation to dose and time after exposure, and compares radiation effects between Japanese and Western populations.
