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Biodefense Research Supporting the DoD

Biodefense Research Supporting the DoD
Author: Coleen K. Martinez
Publisher:
Total Pages: 44
Release: 2007-01-31
Genre: Biological warfare
ISBN: 9781461157649

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The Department of Defense (DoD) has had a unique mission in biological defense research over the past 4 decades. Throughout this history, the military biological disease threats were relatively straightforward, there was little urgency linked to successful product fielding, there was no mechanism by which to gain Food and Drug Administration (FDA) product licensure, and there was little competition for mission or funds. In the post-September 11, 2001 (9/11) environment, however, the scope of potential threats has increased immeasurably, relative funding for the DoD has decreased, urgency to field solutions has skyrocketed, the FDA has provided a way forward to product licensure, and active non-DoD players in this arena have grown exponentially, aligning with newly designated, congressionally mandated funding sources. The old paradigms that governed the DoD research program structure and mission are no longer viable in this changing environment. This monograph examines the current organization of the DoD biodefense research program in light of the changing national biodefense landscape and industry best practices, and argues that all aspects of the DoD biodefense program should be consolidated with all other federal biodefense resources, including those within the National Institutes of Health, to create a single, focused, and productive program. This new agency, subordinate to the Department of Health and Human Services, will be positioned and equipped to provide medical solutions to the warfighter on the battlefield, as well as to U.S. citizens.


Giving Full Measure to Countermeasures

Giving Full Measure to Countermeasures
Author: National Research Council
Publisher: National Academies Press
Total Pages: 160
Release: 2004-04-06
Genre: Political Science
ISBN: 0309166519

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In recent years, substantial efforts have been initiated to develop new drugs, vaccines, and other medical interventions against biological agents that could be used in bioterrorist attacks against civilian populations. According to a new congressionally mandated report from the Institute of Medicine and National Research Council of the National Academies, to successfully develop these drugs, vaccines, and other medical interventions against biowarfare agents, Congress should authorize the creation of a new agency within the Office of the Secretary of the U.S. Department of Defense. The committee recommended that Congress should improve liability protections for those who develop and manufacture these products, to stimulate willingness to invest in new research and development for biowarfare protection. Giving Full Measure to Countermeasures also identifies other challengesâ€"such as the need for appropriate animal models and laboratories equipped with high-level biosafety protectionsâ€"that will require attention if DoD efforts to develop new medical countermeasures are to be successful.


Giving Full Measure to Countermeasures

Giving Full Measure to Countermeasures
Author: National Research Council
Publisher: National Academies Press
Total Pages: 161
Release: 2004-05-06
Genre: Political Science
ISBN: 0309091535

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In recent years, substantial efforts have been initiated to develop new drugs, vaccines, and other medical interventions against biological agents that could be used in bioterrorist attacks against civilian populations. According to a new congressionally mandated report from the Institute of Medicine and National Research Council of the National Academies, to successfully develop these drugs, vaccines, and other medical interventions against biowarfare agents, Congress should authorize the creation of a new agency within the Office of the Secretary of the U.S. Department of Defense. The committee recommended that Congress should improve liability protections for those who develop and manufacture these products, to stimulate willingness to invest in new research and development for biowarfare protection. Giving Full Measure to Countermeasures also identifies other challengesâ€"such as the need for appropriate animal models and laboratories equipped with high-level biosafety protectionsâ€"that will require attention if DoD efforts to develop new medical countermeasures are to be successful.


American Biodefense

American Biodefense
Author: Frank L. Smith III
Publisher: Cornell University Press
Total Pages: 156
Release: 2014-09-19
Genre: Political Science
ISBN: 0801455154

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Biological weapons have threatened U.S. national security since at least World War II. Historically, however, the U.S. military has neglected research, development, acquisition, and doctrine for biodefense. Following September 11 and the anthrax letters of 2001, the United States started spending billions of dollars per year on medical countermeasures and biological detection systems. But most of this funding now comes from the Department of Health and Human Services rather than the Department of Defense. Why has the U.S. military neglected biodefense and allowed civilian organizations to take the lead in defending the country against biological attacks? In American Biodefense, Frank L. Smith III addresses this puzzling and largely untold story about science, technology, and national security.Smith argues that organizational frames and stereotypes have caused both military neglect and the rise of civilian biodefense. In the armed services, influential ideas about kinetic warfare have undermined defense against biological warfare. The influence of these ideas on science and technology challenges the conventional wisdom that national security policy is driven by threats or bureaucratic interests. Given the ideas at work inside the U.S. military, Smith explains how the lessons learned from biodefense can help solve other important problems that range from radiation weapons to cyber attacks.


Biodefense in the Age of Synthetic Biology

Biodefense in the Age of Synthetic Biology
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
Total Pages: 189
Release: 2019-01-05
Genre: Technology & Engineering
ISBN: 0309465184

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Scientific advances over the past several decades have accelerated the ability to engineer existing organisms and to potentially create novel ones not found in nature. Synthetic biology, which collectively refers to concepts, approaches, and tools that enable the modification or creation of biological organisms, is being pursued overwhelmingly for beneficial purposes ranging from reducing the burden of disease to improving agricultural yields to remediating pollution. Although the contributions synthetic biology can make in these and other areas hold great promise, it is also possible to imagine malicious uses that could threaten U.S. citizens and military personnel. Making informed decisions about how to address such concerns requires a realistic assessment of the capabilities that could be misused. Biodefense in the Age of Synthetic Biology explores and envisions potential misuses of synthetic biology. This report develops a framework to guide an assessment of the security concerns related to advances in synthetic biology, assesses the levels of concern warranted for such advances, and identifies options that could help mitigate those concerns.


Department of Defense Biological Safety and Security Program

Department of Defense Biological Safety and Security Program
Author: Office of the Under Secretary of Defense for Acquisition Technology and Logistics
Publisher: CreateSpace
Total Pages: 94
Release: 2014-08-21
Genre: Political Science
ISBN: 9781500901547

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Since renouncing the development, production, stockpiling, and use of biological weapons in 1969, the Department of Defense (DoD) has invested in militarily relevant biological defense. Also in 1969, the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) was created to develop medical defensive countermeasures. Medical biological defensive research has focused mainly on the development of vaccines, drugs, and diagnostics as defensive countermeasures. DoD maintains a network of laboratories and centers dedicated to developing defensive capabilities to protect against biological select agents and toxins (BSATs). Most of these facilities evolved from small specialized laboratories that focused on a particular area of today's modern research and development-performing work that ranges from basic science and technology to supporting systems in biological defense. All laboratories participating in DoD research, development, test, and evaluation (RDT&E) are required to comply with the code of federal regulations and DoD directives, policies, and regulations. These sets of regulations specify safety and security policy, responsibilities, and procedures for service and contract laboratories conducting research and development in support of the DoD biological defense program. In general, biosafety encompasses risk assessment, safe practices, and containment equipment to protect researchers from exposure to infectious agents and facility barrier systems that prevent the release of an agent into the environment to ensure protection of the public health. Biosecurity includes physical security, select agent accountability, and personnel reliability in an effort to prevent unauthorized access to biological select agents and toxins. There is obvious overlap between the two terms. The DoD labs employ an in-depth approach to securing BSATs during operations that require manipulation, storage, or transport of these hazardous materials. Layers of security include physical security of facilities, secured storage equipment, secured transportation of BSATs, surveillance systems, and personnel security processes that assure only the most reliable and skilled personnel have access to the materials necessary to conduct research appropriate to the mission. There are numerous directives and regulations, established by different government agencies that govern biological safety and security (see list of References and Regulations at the end of this report).


The Biological Threat Reduction Program of the Department of Defense

The Biological Threat Reduction Program of the Department of Defense
Author: National Research Council
Publisher: National Academies Press
Total Pages: 120
Release: 2007-10-10
Genre: Political Science
ISBN: 0309179513

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This Congressionally-mandated report identifies areas for further cooperation with Russia and other states of the former Soviet Union under the Cooperative Threat Reduction (CTR) program of the Department of Defense in the specific area of prevention of proliferation of biological weapons. The report reviews relevant U.S. government programs, and particularly the CTR program, and identifies approaches for overcoming obstacles to cooperation and for increasing the long-term impact of the program. It recommends strong support for continuation of the CTR program.


The Role of Veterans Affairs (VA) in Support of the Department of Defense (DoD) in Biodefense - Preparing for Bioterrorism, Bioterrorist Attack, Global Biological Weapons Usage and Anthrax Threat

The Role of Veterans Affairs (VA) in Support of the Department of Defense (DoD) in Biodefense - Preparing for Bioterrorism, Bioterrorist Attack, Global Biological Weapons Usage and Anthrax Threat
Author: U. S. Military
Publisher:
Total Pages: 70
Release: 2017-03-04
Genre:
ISBN: 9781520754079

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In 2001, the United States suffered from a bioterrorist anthrax attack. The US government recognized that it was unprepared to respond to such bioterrorist attacks. This monograph will argue that the Department of Veterans Affairs (VA) provides robust biodefense support to the Department of Defense (DOD). Bioterrorist agents, like anthrax, are easily accessible and inexpensive weapons of mass destruction and may be highly favored by terrorist organizations. Given the dramatic expansion of terrorism in both Africa and Middle East, it is not a question of whether terrorists will attack the United States again, but when and how. Since 2001, the VA has instituted several biodefense strategies. However, the White House report on the VA has recently criticized agency leadership, which may conceivably render VA's current emergency preparedness process unsuitable to support the DOD and the Department of Homeland Security (DHS) in a future bioterrorist attack. This monograph proposes several ways to enhance VA's biodefense capabilities to provide proper support to the DOD and the DHS. In addition, VA can also use its network of facilities to conduct surveillance of imminent endemic of infectious diseases. Based on these findings, the monograph concludes that the VA can play a very important supportive role in DOD's biodefense program. Section One will provide a history and overview of global biological weapons usage and the anthrax threat, including bioterrorism's inherent characteristics and the connection between terrorism and human diseases. It will also provide an overview of the most likely Center for Diseases Control and Prevention (CDC) Category A, bioterrorist agent anthrax. Because the focus of this monograph is on the strategy of biodefense rather than the tactical details of countermeasures against the myriad of bioagents, anthrax will be the archetype bioagent typified for discussion and illustration. The clinical properties of anthrax and the capabilities of currently available diagnostic and therapeutic interventions will also be examined. Section Two will examine the current US bioterror strategy and policy, including risks to the United States. Section Three will explore the VA's role in the biodefense strategy. Section Four will conduct some analysis in order to discuss from a VA's perspective. In addition, Section Four will introduce specific recommendations that would enable the VA rectify the root cause of the current biodefense gap and employ its institutional resources more efficiently and effectively to support the DOD and the DHS in a future anthrax attack on the United States. Section Five will provide the conclusion.


Determining Core Capabilities in Chemical and Biological Defense Science and Technology

Determining Core Capabilities in Chemical and Biological Defense Science and Technology
Author: National Research Council
Publisher: National Academies Press
Total Pages: 141
Release: 2013-01-13
Genre: Technology & Engineering
ISBN: 0309265355

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The goal of the U.S. Department of Defense's (DoD's) Chemical and Biological Defense Program (CBDP) is to provide support and world-class capabilities enabling he U.S. Armed Forces to fight and win decisively in chemical, biological, radiological, and nuclear (CBRN) environments. To accomplish this objective, the CBDP must maintain robust science and technology capabilities to support the research, development, testing, and evaluation required for the creation and validation of the products the program supplies. The threat from chemical and biological attack evolves due to the changing nature of conflict and rapid advances in science and technology (S&T), so the core S&T capabilities that must be maintained by the CBDP must also continue to evolve. In order to address the challenges facing the DoD, the Deputy Assistant Secretary of Defense (DASD) for Chemical and Biological Defense (CBD) asked the National Research Council (NRC) to conduct a study to identify the core capabilities in S&T that must be supported by the program. The NRC Committee on Determining Core Capabilities in Chemical and Biological Defense Research and Development examined the capabilities necessary for the chemical and biological defense S&T program in the context of the threat and of the program's stated mission and priorities. Determining Core Capabilities in Chemical and Biological Defense Science and Technology contains the committee's findings and recommendations. It is intended to assist the DASD CBD in determining the best strategy for acquiring, developing, and/or maintaining the needed capabilities.