Biochemistry Of Collagens Laminins And Elastin PDF Download
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| Author | : Morten Karsdal |
| Publisher | : Academic Press |
| Total Pages | : 274 |
| Release | : 2016-07-29 |
| Genre | : Science |
| ISBN | : 0128098996 |
Download Biochemistry of Collagens, Laminins and Elastin Book in PDF, ePub and Kindle
Biochemistry of Collagens, Laminins, and Elastin: Structure, Function, and Biomarkers provides a comprehensive introduction to collagen and structural proteins. Type I collagen is one of the most abundant molecules in the body, playing essential roles in different tissues, particularly bone and skin. A key aspect of type I collagen is its post-translational modifications which are essential for correct synthesis and structural integrity of collagens, for tissue-specific functionality, as well as for application as biomarkers of different pathologies. This volume summarizes current data on key structural proteins (collagens, laminins and elastin), reviews how these molecules affect pathologies, and describes selected modifications of proteins that result in altered signaling properties of the original extracellular matrix component. Further, it discusses the novel concept that an increasing number of components of the ECM harbor cryptic signaling functions that may be viewed as endocrine functions. Additionally, it highlights how this knowledge can be exploited to modulate fibrotic disease. Provides a comprehensive introduction to collagen and structural proteins Provides insight into emerging analytical technologies that can detect biomarkers of extracellular matrix degradation Includes a chapter dedicated to the biomarkers of structural proteins Contains insights into the biochemical interactions and changes to structural composition of proteins in disease states
| Author | : Morten Karsdal |
| Publisher | : Elsevier |
| Total Pages | : 586 |
| Release | : 2023-11-07 |
| Genre | : Science |
| ISBN | : 0443156182 |
Download Biochemistry of Collagens, Laminins and Elastin Book in PDF, ePub and Kindle
Biochemistry of Collagens, Laminins, and Elastin: Structure, Function and Biomarkers, Third Edition provides current data on key structural proteins (collagens, laminins, and elastin), reviews on how these molecules affect pathologies, and information on how selected modifications of these proteins can result in altered signaling properties of the original extracellular matrix (ECM). Further, it discusses the novel concept that an increasing number of components of the extracellular matrix harbor cryptic signaling functions with ties to endocrine function, and how this knowledge may be used to modulate various pathologies, including fibrotic disease. This new edition has been expanded and revised to incorporate recent research advances. Several new chapters explore a range of chronic diseases in which the ECM and collagens, laminin and elastin are central players in disease modulation, including new chapters on lung, skin and intestinal disease, as well as cancers. The new edition also considers emerging analytical technologies that can detect biomarkers of ECM degradation, with discussion of protein quantification and detecting aging of collagens. Provides an updated, comprehensive discussion of collagen and related structural proteins Contains insights into biochemical interactions and changes to structural composition of proteins in disease states Proves the importance of proteins for collagen assembly, function and durability Examines details on how collagens play a key role in a range of chronic diseases Offers approaches for protein quantification and detection of collagen aging
| Author | : Jaroslava Halper |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 246 |
| Release | : 2014-01-18 |
| Genre | : Medical |
| ISBN | : 9400778937 |
Download Progress in Heritable Soft Connective Tissue Diseases Book in PDF, ePub and Kindle
This volume is a reference handbook focusing on diseases like Marfan syndrome, Ehlers-Danlos syndrome, Loeys-Dietz syndrome and other heritable soft connective tissue diseases. The book presents detailed information for both basic scientists and for clinicians seeing patients. It is also a stepping stone for new investigations and studies that goes beyond the facts about the composition and biochemistry of the connective tissue and extracellular matrix, as the authors connect individual components to specific aspects of various soft tissue disorders and to the actual or potential treatment of them. Progress in Heritable Soft Connective Tissue Diseases features very prominent physicians and scientists as contributors who bring their most recent discoveries to the benefit of readers. Their expertise will help clinicians with proper diagnosis of sometimes elusive and uncommon heritable diseases of soft connective tissues. This book also offers an update on the pathophysiology of these diseases, including an emphasis on unifying aspects such as connections between embryonic development of the different types of connective tissues and systems, and the role of TGF-beta in development and physiology of soft tissues. This new set of data explains, at least in part, why many of these disorders are interconnected, though the primary pathophysiological events, such as gene mutations, may be different for each disorder.
| Author | : Robert Mecham |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 429 |
| Release | : 2011-02-16 |
| Genre | : Science |
| ISBN | : 3642165559 |
Download The Extracellular Matrix: an Overview Book in PDF, ePub and Kindle
Knowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling. This volume of the series “Biology of Extracellular Matrix” provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins, proteoglycans, microfibrils, elastin, fibulins and matricellular proteins, such as thrombospondin. It also explores the concept that ECM components together with their cell surface receptors can be viewed as intricate nano-devices that allow cells to physically organize their 3-D-environment. Further, the role of the ECM in human disease and pathogenesis is discussed as well as the use of model organisms in elucidating ECM function.
| Author | : Jay D. Humphrey |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 642 |
| Release | : 2013-11-11 |
| Genre | : Science |
| ISBN | : 1489903259 |
Download An Introduction to Biomechanics Book in PDF, ePub and Kindle
Designed to meet the needs of undergraduate students, "Introduction to Biomechanics" takes the fresh approach of combining the viewpoints of both a well-respected teacher and a successful student. With an eye toward practicality without loss of depth of instruction, this book seeks to explain the fundamental concepts of biomechanics. With the accompanying web site providing models, sample problems, review questions and more, Introduction to Biomechanics provides students with the full range of instructional material for this complex and dynamic field.
| Author | : J. Robin Harris |
| Publisher | : Springer |
| Total Pages | : 499 |
| Release | : 2019-03-19 |
| Genre | : Medical |
| ISBN | : 9811336814 |
Download Biochemistry and Cell Biology of Ageing: Part II Clinical Science Book in PDF, ePub and Kindle
This volume of the subcellular Biochemistry series will attempt to bridge the gap between the subcellular events that are related to aging as they were described in the first volume of this set of two books and the reality of aging as this is seen in clinical practice. All chapters will start from the biochemistry or cell biology, where the data is available and work up towards the understanding that we have of aging in the various areas that are related to the subject. Key focus points for this volume are nutrition, external factors and genetics on aging. There will also be chapters that will focus on various organs or tissues in which aging has been well studied, like the eyes, the muscles, the immune system and the bones. The aim of the book project and the book project that is published in concert with this volume is to bring the subcellular and clinical areas into closer contact.
| Author | : Douglas W. DeSimone |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 260 |
| Release | : 2013-03-15 |
| Genre | : Science |
| ISBN | : 3642359353 |
Download Extracellular Matrix in Development Book in PDF, ePub and Kindle
Cells in the developing embryo depend on signals from the extracellular environment to help guide their differentiation. An important mediator in this process is the extracellular matrix – secreted macromolecules that interact to form large protein networks outside the cell. During development, the extracellular matrix serves to separate adjacent cell groups, participates in establishing morphogenic gradients, and, through its ability to interact directly will cell-surface receptors, provides developmental clocks and positional information. This volume discusses how the extracellular matrix influences fundamental developmental processes and how model systems can be used to elucidate ECM function. The topics addressed range from how ECM influences early development as well as repair processes in the adult that recapitulate developmental pathways.
| Author | : Magnus Hook |
| Publisher | : Frontiers Media SA |
| Total Pages | : 170 |
| Release | : 2021-07-14 |
| Genre | : Science |
| ISBN | : 2889710467 |
Download Cell Surface Proteins of Gram-positive Pathogenic Bacteria Book in PDF, ePub and Kindle
| Author | : E.D. Hay |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 478 |
| Release | : 2013-11-11 |
| Genre | : Science |
| ISBN | : 1461537703 |
Download Cell Biology of Extracellular Matrix Book in PDF, ePub and Kindle
In the ten-year interval since the first edition of this volume went to press, our knowledge of extracellular matrix (ECM) function and structure has enor mously increased. Extracellular matrix and cell-matrix interaction are now routine topics in the meetings and annual reviews sponsored by cell biology societies. Research in molecular biology has so advanced the number of known matrix molecules and the topic of gene structure and regulation that we won dered how best to incorporate the new material. For example, we deliberated over the inclusion of chapters on molecular genetics. We decided that with judicious editing we could present the recent findings in molecular biology within the same cell biology framework that was used for the first edition, using three broad headings: what is extracellular matrix, how is it made, and what does it do for cells? Maintaining control over the review of literature on the subject of ECM was not always an easy task, but we felt it was essential to production of a highly readable volume, one compact enough to serve the the student as an introduction and the investigator as a quick update on graduate the important recent discoveries. The first edition of this volume enjoyed con hope the reader finds this edition equally useful. siderable success; we D. Hay Elizabeth vii Contents Introductory Remarks 1 Elizabeth D. Hay PART I. WHAT IS EXTRACELLULAR MATRIX? Chapter 1 Collagen T. F. Linsenmayer 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 2. The Collagen Molecule . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 2. 1. Triple-Helical Domain(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
| Author | : C. Ross Ethier |
| Publisher | : Cambridge University Press |
| Total Pages | : 10 |
| Release | : 2007-03-12 |
| Genre | : Technology & Engineering |
| ISBN | : 1139461826 |
Download Introductory Biomechanics Book in PDF, ePub and Kindle
Introductory Biomechanics is a new, integrated text written specifically for engineering students. It provides a broad overview of this important branch of the rapidly growing field of bioengineering. A wide selection of topics is presented, ranging from the mechanics of single cells to the dynamics of human movement. No prior biological knowledge is assumed and in each chapter, the relevant anatomy and physiology are first described. The biological system is then analyzed from a mechanical viewpoint by reducing it to its essential elements, using the laws of mechanics and then tying mechanical insights back to biological function. This integrated approach provides students with a deeper understanding of both the mechanics and the biology than from qualitative study alone. The text is supported by a wealth of illustrations, tables and examples, a large selection of suitable problems and hundreds of current references, making it an essential textbook for any biomechanics course.
