Biochemical Clinical Pharmacology PDF Download
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Author | : P.S. Randall |
Publisher | : Springer Science & Business Media |
Total Pages | : 509 |
Release | : 2013-11-27 |
Genre | : Medical |
ISBN | : 3642463142 |
Download Concepts in Biochemical Pharmacology Book in PDF, ePub and Kindle
Part 3 of the Handbook of Experimental Pharmacology (Concepts in Biochem ical Pharmacology) applies the principles enunciated in Parts 1 and 2 to clinical pharmacology and toxicology. The major objective is to elucidate the many factors that determine the relationships between pharmacokinetic aspects of the disposition and metabolism of drugs and their therapeutic or toxic actions in man. Because of the more restricted information obtainable in human studies, this volume reflects the editors' bias that an understanding of pharmacokinetics is fundamental for assessing pharmacologic or toxicologic effects of drugs in humans. The first chapter is a unique primer on when to apply and how to use pharmaco kinetic tools in human pharmacology. The second chapter explains the general assumptions underlying pharmacokinetic approaches both in simple terms for the novice and in mathematical form for the more sophisticated reader. Several chapters on determinants of drug concentration and activity discuss drug absorption, drug latentiation, drugs acting through metabolites, entero hepatic drug circulation, influence of route of drug administration on response, genetic variations in drug disposition and response, age differences in absorption, distribution and excretion of drugs, and pathologic and physiologic factors affecting absorption, distribution and excretion of drugs and drug response. The focus of these chapters is data obtained in human, rather than animal, studies. Most of the chapters contain new material never summarized previously.
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Total Pages | : |
Release | : 1979 |
Genre | : Pharmacology |
ISBN | : |
Download Biochemical-clinical pharmacology Book in PDF, ePub and Kindle
Author | : William A. Creasey |
Publisher | : Elsevier |
Total Pages | : 249 |
Release | : 2013-10-22 |
Genre | : Health & Fitness |
ISBN | : 1483139409 |
Download Symposium on Clinical Pharmacology Book in PDF, ePub and Kindle
Symposium on Clinical Pharmacology reviews advances in clinical pharmacology, with emphasis on how to materially improve the efficacy of cancer chemotherapy. Topics range from absorption, protein binding, distribution, and excretion of antineoplastic drugs to factors affecting the biotransformation and activity of antitumor drugs. The transport of tumor-inhibitory agents across cell membranes is also examined, together with factors influencing drug selectivity and the mechanisms of clinical drug resistance. This volume is comprised of 23 chapters and begins with a brief summary of the different kinds of pharmacokinetic models and how detailed kinetic investigations of a drug in animals may provide further insight into modes of its clinical use. The next chapter considers the chief factors in determining the effective concentration of a drug at a receptor site as well as the duration and intensity of drug effect, citing antineoplastic agents as examples. The role of enzymatic activation and inactivation in drug selectivity is also discussed, along with the general mechanisms of clinical resistance to cancer chemotherapy; biochemical and pharmacological principles of combination chemotherapy; and the reaction and effects of nitrosoureas. This book will be of interest to clinicians, pharmacologists, and biochemists.
Author | : Bernard B. Brodie |
Publisher | : Springer Science & Business Media |
Total Pages | : 797 |
Release | : 2013-11-27 |
Genre | : Medical |
ISBN | : 3642651771 |
Download Concepts in Biochemical Pharmacology Book in PDF, ePub and Kindle
This volume of the Handbook of Experimental Pharmacology (Concepts in Biochemical Pharmacology) will show that pharma cology has finally arrived as a true discipline in its own right, and is no longer the handmaiden of organic chemistry and physiology. Instead it is an amalgam of all the biological sciences including biochemistry, biophysical chemistry, physiology, pathology and clinical medicine. In the volumes that make up Concepts in Bio chemical Pharmacology we hope to convince Medical Schools what should now be obvious, that pharmacology is no longer that dull topic bridging the basic sciences with medicine, but is probably the most important subject in the medical curriculum. We are grateful for the advice of Dr. Byron Clark, Director of the Pharmacology-Toxicology Program at the National Institutes of Health whose support made possible much of the work described in this volume. Contents Section Four: Methods 01 Stooging the MetoholiBm 01 Drugs Subsection A. Assay 01 Drugs and Their M etoholites Chapter 22 : Basic Principles in Development of Methods for Drug Assay. B. B. BRODIE. With 2 Figures 1 1 A. Introduction . . . . . . . . . . B. Principles of Developing a Method. . . . . . 1 I. Section of Method of Assay . . . . . . 1 II. Choice of Solvent for Extraction of Drug 2 III. Adsorption of Drugs by Glass Surfaces . . . . . . . . . . . . . . 3 IV. Recoveries of Known Amounts of Compound from Biological Material. 4 V. Assessment of Sensitivity 5 VI. Assessment of Specificity 5 References. . . . . . . . . . .
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Total Pages | : |
Release | : 1979 |
Genre | : |
ISBN | : |
Download Biochemical-clinical pharmacology, J. P. Tillement, ed Book in PDF, ePub and Kindle
Author | : H.S. Ackermann |
Publisher | : Springer Science & Business Media |
Total Pages | : 486 |
Release | : 2013-11-27 |
Genre | : Medical |
ISBN | : 364265052X |
Download Concepts in Biochemical Pharmacology Book in PDF, ePub and Kindle
This volume of the Handbook of Experimental Pharmacology (Concepts in Biochemical Pharmacology) will show that pharma cology has finally arrived as a true discipline in its own right, and is no longer the handmaiden of organic chemistry and physiology. Instead it is an amalgam of all the biological sciences including biochemistry, biophysical chemistry, physiology, pathology and clinical medicine. In the volumes that make up Concepts in Bioche mical Pharmacology we hope to convince Medical Schools what should now be obvious, that pharmacology is no longer that dull topic bridging the basic sciences with medicine, but is probably the most important subject in the medical curriculum. We are grateful for the advice of Dr. BYRON CLARKE, Director of the Pharmacology-Toxicology Program at the National Insti tutes of Health, whose support made possible much of the work described in this volume. Contents Section One: Routes of Drug Administration Chapter 1: Biological Membranes and Their Passage by Drugs. C. A. M. HOGBEN 1 References. . . . . . . . . . . . . . . . . . . . . . . . . . 8 Chapter 2: Absorption of Drugs from the Gastrointestinal Tract. L. S. SCHANKER. With 5 Figures. 9 I. Introduction. . . . . . . . . . . . . . . . . . . . . . . 9 II. Methods of Study. . . . . . . . . . . . . . . . . . . . . 9 III. Absorption from the Stomach . . . . . . . . . . . . . . . 11 IV. Intestinal Absorption of Non-Electrolytes and Weak Electrolytes 15 V. Absorption of Weak Electrolytes from the Colon and Rectum 18 VI. Intestinal Absorption of Organic Ions. . . . . . . . . . 19 VII. Intestinal Absorption of Macromolecules . . . . . . . . . . 19 VIII. Active Transport across the Intestinal Epithelium . . . . . 20 IX. Effect of EDTA on Drug Absorption from the Intestine . . . . . . .
Author | : Jean-Paul Tillement |
Publisher | : Pergamon |
Total Pages | : 340 |
Release | : 1979 |
Genre | : Medical |
ISBN | : |
Download Biochemical-clinical Pharmacology Book in PDF, ePub and Kindle
Author | : Shashank Kumar |
Publisher | : CRC Press |
Total Pages | : 265 |
Release | : 2020-11-01 |
Genre | : Science |
ISBN | : 1000730891 |
Download Clinical Biochemistry and Drug Development Book in PDF, ePub and Kindle
This new volume focuses on clinical biochemistry fundamentals, cell culture techniques, and drug discovery and development concepts. It deals with three different fields of clinical research: cell culture, clinical biochemistry, and drug discovery and development. The book introduces cell animal and bacterial culture techniques and their potential uses as well as cell culture techniques. The biochemistry aspect of the book covers the principles of clinical biochemistry and biochemical analysis, biochemical aids to clinical diagnosis, measurement, and quality control. The book also presents important concepts in cell membrane receptor signal transduction pathways as drug targets. The drug development focus of the book discusses the fundamentals of human disease and drug discovery. Various in silico, in vitro, and in vivo approaches for drug discovery are examined, along with a discussion on drug delivery carriers and clinical trials. Overall, the volume provides an overview of the journey from clinical fundamentals to clinical output.
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Total Pages | : 0 |
Release | : 1979 |
Genre | : |
ISBN | : |
Download Advances in Pharmacology and Therapeutics: Biochemical-clinical pharmacology Book in PDF, ePub and Kindle
Author | : Charles P. Woodbury |
Publisher | : Jones & Bartlett Publishers |
Total Pages | : 522 |
Release | : 2012 |
Genre | : Medical |
ISBN | : 0763763845 |
Download Biochemistry for the Pharmaceutical Sciences Book in PDF, ePub and Kindle
Biochemistry for the Pharmaceutical Sciences is a concise, practical resource for pharmacy students to apply and expand their understanding of biochemistry as it relates to pharmacy practice. With pedagogical features designed to make complex concepts comprehensible, this text presents biochemistry in a clear and comprehensible format with a pharmaceutical focus. Real-world applications of scientific principles allow students to better comprehend and appreciate how biochemistry will impact their professional practice. Chapter Features • Learning Objectives • Glossary of Key Terms • Clinical Application Boxes • Discussion Questions Includes over 400 figures and tables to help students formulate an understanding of the mathematical, chemical, and biological concepts. Instructor Resources: PowerPoint Slides, Image Bank