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| Author | : Thomas Peters |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 317 |
| Release | : 2007-01-05 |
| Genre | : Science |
| ISBN | : 3540490779 |
With contributions by numerous experts
| Author | : Thomas Peters |
| Publisher | : |
| Total Pages | : |
| Release | : 2007 |
| Genre | : Bioactive compounds |
| ISBN | : |
| Author | : Thomas Peters |
| Publisher | : Springer |
| Total Pages | : 244 |
| Release | : 2009-11-04 |
| Genre | : Science |
| ISBN | : 3540490809 |
This series presents critical reviews of the present position and future trends in modern chemical research. It contains short and concise reports on chemistry, each written by the world renowned experts. The volume is still valid and useful after five or ten years. More information, as well as the electronic version of the whole content, is available at: springerlink.com.
| Author | : Arun K. Ghosh |
| Publisher | : John Wiley & Sons |
| Total Pages | : 474 |
| Release | : 2014-08-11 |
| Genre | : Medical |
| ISBN | : 3527333657 |
Drug design is a complex, challenging and innovative research area. Structure-based molecular design has transformed the drug discovery approach in modern medicine. Traditionally, focus has been placed on computational, structural or synthetic methods only in isolation. This one-of-akind guide integrates all three skill sets for a complete picture of contemporary structure-based design. This practical approach provides the tools to develop a high-affinity ligand with drug-like properties for a given drug target for which a high-resolution structure exists. The authors use numerous examples of recently developed drugs to present "best practice" methods in structurebased drug design with both newcomers and practicing researchers in mind. By way of a carefully balanced mix of theoretical background and case studies from medicinal chemistry applications, readers will quickly and efficiently master the basic skills of successful drug design. This book is aimed at new and active medicinal chemists, biochemists, pharmacologists, natural product chemists and those working in drug discovery in the pharmaceutical industry. It is highly recommended as a desk reference to guide students in medicinal and chemical sciences as well as to aid researchers engaged in drug design today.
| Author | : Shaoping Nie |
| Publisher | : Academic Press |
| Total Pages | : 568 |
| Release | : 2017-10-19 |
| Genre | : Technology & Engineering |
| ISBN | : 0128114517 |
Bioactive Polysaccharides offers a comprehensive review of the structures and bioactivities of bioactive polysaccharides isolated from traditional herbs, fungi, and seaweeds. It describes and discusses specific topics based on the authors’ rich experience, including extraction technologies, practical techniques required for purification and fractionation, strategies and skills for elucidating the fine structures, in-vitro and in-vivo protocols, and methodologies for evaluating the specific bioactivities, including immune-modulating activities, anti-cancer activities, anti-oxidant activities, and others. This unique book also discusses partial structure-functionality (bioactivities) relationships based on conformational studies. This comprehensive work can be used as a handbook to explore potential applications in foods, pharmaceuticals, and nutraceutical areas for commercial interests. Serves as a comprehensive review on extraction technologies, and as a practical guide for the purification and fractionation of bioactive polysaccharides Brings step-by-step strategies for elucidating the fine structures and molecular characterizations of bioactive polysaccharides Includes detailed experimental design and methodologies for investigation bioactivities using both in-vitro and in-vivo protocols Clarifies how to extract, purify, and fractionate bioactive polysaccharides, also exploring health benefits Useful as a guide to explore the commercial potentials of bioactive polysaccharides as pharmaceuticals, medicine, and functional foods
| Author | : Yvonne Connolly Martin |
| Publisher | : |
| Total Pages | : 308 |
| Release | : 1998 |
| Genre | : Biomolecules |
| ISBN | : |
Three-dimensional structural information often provides the key to dis covering or designing bioactive molecules and compounds. This volume c overs the principal computational techniques for processing three-dime nsional structures of small molecules and compounds. It describes data base construction and searching, analysis of structure-activity relati onships by pharmacophore mapping and QSAR, prediction of biological po tency of small molecules and compounds by QSAR and by docking to macro molecular targets. The book also includes a chapter on de novo design of ligands to fit a macromolecular target.
| Author | : Daniela Quarzago |
| Publisher | : |
| Total Pages | : 99 |
| Release | : 1995 |
| Genre | : |
| ISBN | : |
| Author | : Parul Sharma |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2012-10 |
| Genre | : |
| ISBN | : 9783659219825 |
| Author | : Lai Chun Chan |
| Publisher | : |
| Total Pages | : |
| Release | : 1992 |
| Genre | : |
| ISBN | : |
| Author | : Chariklia I. Stassinopoulou |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 367 |
| Release | : 2013-06-29 |
| Genre | : Science |
| ISBN | : 3642791581 |
Provided here are the latest techniques of NMR as applied to the study of proteins, carbohydrates and nucleic acids. The first chapters are devoted to an introduction to NMR and parameters related to molecular structure and molecular interactions. NMR experiments from basic 1D to 2D, 3D and 4D, used in combination with isotopically labelled molecules, are described and a general strategy is presented for biomacromolecular structure determination. Subsequent chapters deal with more advanced principles and techniques and their applications to structural and dynamic processes involving biomacromolecules in solution. Advanced results on peptide, protein, oligosaccharide and nucleic acid structure and recognition are presented.
