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Bio/CMOS Interfaces and Co-Design

Bio/CMOS Interfaces and Co-Design
Author: Sandro Carrara
Publisher: Springer Science & Business Media
Total Pages: 266
Release: 2012-11-19
Genre: Technology & Engineering
ISBN: 1461446902

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The application of CMOS circuits and ASIC VLSI systems to problems in medicine and system biology has led to the emergence of Bio/CMOS Interfaces and Co-Design as an exciting and rapidly growing area of research. The mutual inter-relationships between VLSI-CMOS design and the biophysics of molecules interfacing with silicon and/or onto metals has led to the emergence of the interdisciplinary engineering approach to Bio/CMOS interfaces. This new approach, facilitated by 3D circuit design and nanotechnology, has resulted in new concepts and applications for VLSI systems in the bio-world. This book offers an invaluable reference to the state-of-the-art in Bio/CMOS interfaces. It describes leading-edge research in the field of CMOS design and VLSI development for applications requiring integration of biological molecules onto the chip. It provides multidisciplinary content ranging from biochemistry to CMOS design in order to address Bio/CMOS interface co-design in bio-sensing applications.


Bio/CMOS Interfaces and Co-Design

Bio/CMOS Interfaces and Co-Design
Author: Sandro Carrara
Publisher: Springer Nature
Total Pages: 530
Release: 2023-09-09
Genre: Technology & Engineering
ISBN: 3031318323

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This textbook demonstrates new paradigms for the interface between CMOS circuits and the biological world. A deep theoretical description of such an interface is defined and discussed, while various real applications are demonstrated by also discussing several analog CMOS circuits. Electrochemical techniques are proposed in detail to learn how to design integrated biosensors. Biological materials are described to provide devices selectivity. Nanoscale materials are discussed to provide device sensitivity. CMOS circuits are analyzed to provide real applications. Extensive examples with solutions are provided, as well as exercises at the end of each chapter. This book introduces students to the state-of-the-art in Bio/CMOS interfaces, describing leading-edge research in CMOS design and VLSI development for applications requiring intimate integration of biological molecules onto the chip. It provides multidisciplinary content ranging from biochemistry to CMOS design in order to address Bio/CMOS interface co-design in biosensing applications.


CMOS Biomicrosystems

CMOS Biomicrosystems
Author: Krzysztof Iniewski
Publisher: John Wiley & Sons
Total Pages: 425
Release: 2011-10-14
Genre: Technology & Engineering
ISBN: 1118016483

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The book will address the-state-of-the-art in integrated Bio-Microsystems that integrate microelectronics with fluidics, photonics, and mechanics. New exciting opportunities in emerging applications that will take system performance beyond offered by traditional CMOS based circuits are discussed in detail. The book is a must for anyone serious about microelectronics integration possibilities for future technologies. The book is written by top notch international experts in industry and academia. The intended audience is practicing engineers with electronics background that want to learn about integrated microsystems. The book will be also used as a recommended reading and supplementary material in graduate course curriculum.


Security and Privacy for Implantable Medical Devices

Security and Privacy for Implantable Medical Devices
Author: Wayne Burleson
Publisher: Springer Science & Business Media
Total Pages: 204
Release: 2013-12-03
Genre: Technology & Engineering
ISBN: 1461416744

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This book presents a systematic approach to analyzing the challenging engineering problems posed by the need for security and privacy in implantable medical devices (IMD). It describes in detail new issues termed as lightweight security, due to the associated constraints on metrics such as available power, energy, computing ability, area, execution time, and memory requirements. Coverage includes vulnerabilities and defense across multiple levels, with basic abstractions of cryptographic services and primitives such as public key cryptography, block ciphers and digital signatures. Experts from Computer Security and Cryptography present new research which shows vulnerabilities in existing IMDs and proposes solutions. Experts from Privacy Technology and Policy will discuss the societal, legal and ethical challenges surrounding IMD security as well as technological solutions that build on the latest in Computer Science privacy research, as well as lightweight solutions appropriate for implementation in IMDs.


Design and implementation of a CMOS interface for non-invase optical biosensors

Design and implementation of a CMOS interface for non-invase optical biosensors
Author: Eduardo Andrés Barredo Ochoa
Publisher:
Total Pages:
Release: 2009
Genre:
ISBN:

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In this thesis, I propose an optoelectronic interface as those required in non-invasive micro sensors. The interface was implemented on a 0.35u.m CMOS technology and consists of a photodiode to capture and transform light into a current, and an amplifier to convert this current into a voltage level. I have designed three different photodiodes. Because of their structures, they are called p+/nwell, n+/p-substrate, nwell/p-substrate photodiodes. Additionally, I have implemented the spatially modulated technique in order to increase the photodiodes bandwidth. The required ring to avoid interference and to protect the input pads had also been incorporated in the layout. I have reviewed mathematical approximations that describe the photocurrent in the frequency domain. These approximations could be used in later studies aimed to characterize photodiode. Finally, the amplifier consists on a current to voltage conversion, a bandwidth expansion module and a voltage amplifier. The amplifier has showed a transimpedance of 47 ^/mj[, a frequency bandwidth of 852MHz and a gain-bandwidth of 2GHz.


Handbook of Bioelectronics

Handbook of Bioelectronics
Author: Sandro Carrara
Publisher: Cambridge University Press
Total Pages: 1157
Release: 2015-08-06
Genre: Technology & Engineering
ISBN: 1316240010

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This wide-ranging summary of bioelectronics provides the state of the art in electronics integrated and interfaced with biological systems in one single book. It is a perfect reference for those involved in developing future distributed diagnostic devices, from smart bio-phones that will monitor our health status to new electronic devices serving our bodies and embedded in our clothes or under our skin. All chapters are written by pioneers and authorities in the key branches of bioelectronics and provide examples of real-word applications and step-by-step design details. Through expert guidance, you will learn how to design complex circuits whilst cutting design time and cost and avoiding mistakes, misunderstandings, and pitfalls. An exhaustive set of recently developed devices is also covered, providing the implementation details and inspiration for innovating new solutions and devices. This all-inclusive reference is ideal for researchers in electronics, bio/nanotechnology, and applied physics, as well as circuit and system-level designers in industry.


CMOS Capacitive Sensors for Lab-on-Chip Applications

CMOS Capacitive Sensors for Lab-on-Chip Applications
Author: Ebrahim Ghafar-Zadeh
Publisher: Springer Science & Business Media
Total Pages: 154
Release: 2010-03-10
Genre: Technology & Engineering
ISBN: 9048137276

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1.1 Overview of Lab-on-Chip Laboratory-on-Chip (LoC) is a multidisciplinary approach used for the miniaturization, integration and automation of biological assays or procedures in analytical chemistry [1–3]. Biology and chemistry are experimental sciences that are continuing to evolve and develop new protocols. Each protocol offers step-by-step laboratory instructions, lists of the necessary equipments and required biological and/or chemical substances [4–7]. A biological or chemical laboratory contains various pieces of equipment used for performing such protocols and, as shown in Fig. 1.1, the engineering aspect of LoC design is aiming to embed all these components in a single chip for single-purpose applications. 1.1.1 Main Objectives of LoC Systems Several clear advantages of this technology over conventional approaches, including portability, full automation, ease of operation, low sample consumption and fast assays time, make LoC suitable for many applications including. 1.1.1.1 Highly Throughput Screening To conduct an experiment, a researcher fills a well with the required biological or chemical analytes and keeps the sample in an incubator for some time to allowing the sample to react properly. Afterwards, any changes can be observed using a microscope. In order to quickly conduct millions of biochemical or pharmacolo- cal tests, the researchers will require an automated highly throughput screening (HTS) [8], comprised of a large array of wells, liquid handling devices (e.g., mic- channel, micropump and microvalves [9–11]), a fully controllable incubator and an integrated sensor array, along with the appropriate readout system.