Balancing Between T Cell Tolerance and Immunity
Author | : Linda Diehl |
Publisher | : |
Total Pages | : 79 |
Release | : 2002 |
Genre | : |
ISBN | : |
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Author | : Linda Diehl |
Publisher | : |
Total Pages | : 79 |
Release | : 2002 |
Genre | : |
ISBN | : |
Author | : Nathalie Cools |
Publisher | : LAP Lambert Academic Publishing |
Total Pages | : 176 |
Release | : 2010 |
Genre | : |
ISBN | : 9783838333120 |
During the past 10 years, important progress has been made in the field of immunology, leading to a better notion of the relationship between the immune system and disease. While new immunotherapeutic efforts pave the way for the treatment of old diseases, understanding the biology, function and mechanisms of immune cell populations is of utmost concern for the development and optimisation of cellular immune therapies for the induction of effective immune responses in cancer and chronic infections on the one hand, and for the induction of T cell tolerance in autoimmune disorders and transplantation on the other hand. With the data presented in this book, we believe to have contributed to the knowledge on the role of immune effector cells, such as dendritic cells, in maintaining the subtle balance between immunity and tolerance. The data presented clearly open up new avenues in order to improve dendritic cell-based immunotherapies for immune stimulation and tolerance and should be especially usefull to professionals in immunology or anyone else interested in cell-based therapies.
Author | : Li-Fan Lu |
Publisher | : |
Total Pages | : 424 |
Release | : 2006 |
Genre | : B cells |
ISBN | : |
Author | : Nathalie Cools |
Publisher | : |
Total Pages | : 172 |
Release | : 2007 |
Genre | : |
ISBN | : 9789090219585 |
Author | : Kenneth Murphy |
Publisher | : Garland Science |
Total Pages | : |
Release | : 2010-06-22 |
Genre | : Medical |
ISBN | : 9780815344575 |
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Author | : Isabelle Catherine Arnold |
Publisher | : |
Total Pages | : 193 |
Release | : 2010 |
Genre | : |
ISBN | : |
Author | : Haisu Guo |
Publisher | : |
Total Pages | : |
Release | : 2010 |
Genre | : |
ISBN | : |
Dendritic cells have the ability to control the balance between immunity and tolerance. Upon viral exposure, dendritic cells (DCs) steadily detect pathogens and exert their antigen presentation function to induce adaptive T cell response. Respiratory Syncytial Virus (RSV) is an important respiratory pathogen in infants and young children worldwide. Here we show that RSV exposure polarizes DC maturation to a tolerogenic state. RSV exposed DCs (RSV-DCs) are unable to prime allogeneic CD4+ T cell proliferation and cytokine production. Strikingly, RSV exposed DCs are able to efficiently inhibit on-going Mixed Leukocyte Reaction (MLR) in trans. Phenotypic characterization of RSV-DCs indicates that they express a variety of surface inhibitory molecules and secrete high amount of the cytokine IL-10. Autocrine IL-10 receptor signaling is required for tolerogenic conversion. A direct comparison with pharmacologically generated tolerogenic DCs indicates RSV-DCs are much more potent at inhibiting CD4+ T cell alloproliferation. Furthermore, we find that RSV-DCs propagate their tolerogenic signal through expansion of regulatory T cells (Tregs). RSV-DCs induce the selective expansion of CD4+/CD25+/FoxP3+/CTLA+/GITR+ Tregs in the bulk T cell population. These Tregs are able to inhibit on-going MLR in trans, indicating their functional potency. An analysis of the non-proliferating target CD4+ T cells indicates that they are in a state of phenotypic and functional anergy. These T cells express anergy markers and are unresponsive to secondary anti-CD3/CD28 restimulation. Interaction of B7 negative co-stimualtor PD-L1 and its receptor PD-1 are required for Treg expansion and function as blockade led to a reversal of anergy induction in the target population. These in vitro observations led us to investigate the impact of RSV-DCs on immune tolerance in vivo. We did preliminary studies demonstrating RSV exposure induces BALB/c bone marrow derived DCs (BM-DCs) tolerogenic characterized by inhibition of C57BL/6 CD4 T cell alloproliferation and upregulation of mouse PD-L1 molecule. Similarly to what we observed in human cells, RSV-mouse DCs are able to expand a population of CD4+CD25+FoxP3+ regulatory T cells. These cells with immune suppressive function can then be adoptively transferred into murine models of autoimmune diseases and organ transplantion to suppress antigen-specific immune activation in vivo.
Author | : Richard D. Granstein |
Publisher | : S. Karger AG (Switzerland) |
Total Pages | : 360 |
Release | : 1994 |
Genre | : Medical |
ISBN | : |
Among the topics reviewed are T and B cell tolerance, clonal deletion, suppressor cells, mechanisms of immune privileged sites and experimental models of tumor immunity. Oral tolerance, ultraviolet radiation and photosensitized effects on immunity, allograft management, T cell vaccination and regulation of immunity with T cell epitopes are discussed from the point of view of possible therapeutic application.
Author | : Marc Feldmann |
Publisher | : Springer Science & Business Media |
Total Pages | : 384 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 1461249961 |
Leukocyte culture conferences have a long pedigree. This volume records some of the scientific highlights of the 16th such annual con ference, and is a witness to the continuing evolution and popularity of leukocyte culture and of immunology. There is strong evidence of the widening horizons of immunology, both technically, with the obviously major impact of molecular biology into our understanding of cellular processes, and also conceptually. Traditionally, the 'proceedings' of these conferences have been published. But have the books produced really recorded the major part of the conference, the informal, friendly, but intense and some times heated exchanges that take place between workers in tackling very similar problems and systems and which are at the heart of every successful conference? Unfortunately this essence cannot be incorpo rated by soliciting manuscripts. For this reason, we have changed the format of publication, retaining published versions of the symposium papers, but requesting the workshop chairmen to produce a summary of the major new observations and areas of controversy highlighted in their sessions, as a vehicle for defining current areas of interest and debate. Not an easy task, as the workshop topics were culled from the abstracts submitted by the participants, rather than being on predefined topics. The unseasonal warmth in Cambridge was reflected in the atmos phere of the conference, the organization of which benefited from the administrative skills of Jean Bacon, Philippa Wells, Mr. Peter Irving, and Mrs.
Author | : Maryam Mahmoudi |
Publisher | : Springer |
Total Pages | : 515 |
Release | : 2019-07-30 |
Genre | : Medical |
ISBN | : 3030160734 |
This volume provides readers with a systematic assessment of current literature on the link between nutrition and immunity. Chapters cover immunonutrition topics such as child development, cancer, aging, allergic asthma, food intolerance, obesity, and chronic critical illness. It also presents a thorough review of microflora of the gut and the essential role it plays in regulating the balance between immune tolerance and inflammation. Written by experts in the field, Nutrition and Immunity helps readers to further understand the importance of healthy dietary patterns in relation to providing immunity against disorders and offering readily available immunonutritional programming in clinical care. It will be a valuable resource for dietitians, immunologists, endocrinologists and other healthcare professionals.