Bacterial Pangenomics
| Author | : Alessio Mengoni |
| Publisher | : |
| Total Pages | : 298 |
| Release | : 2015 |
| Genre | : Bacterial genetics |
| ISBN | : 9781493917204 |
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The Pangenome
| Author | : Hervé Tettelin |
| Publisher | : Springer Nature |
| Total Pages | : 311 |
| Release | : 2020-04-30 |
| Genre | : Science |
| ISBN | : 3030382818 |
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This open access book offers the first comprehensive account of the pan-genome concept and its manifold implications. The realization that the genetic repertoire of a biological species always encompasses more than the genome of each individual is one of the earliest examples of big data in biology that opened biology to the unbounded. The study of genetic variation observed within a species challenges existing views and has profound consequences for our understanding of the fundamental mechanisms underpinning bacterial biology and evolution. The underlying rationale extends well beyond the initial prokaryotic focus to all kingdoms of life and evolves into similar concepts for metagenomes, phenomes and epigenomes. The book’s respective chapters address a range of topics, from the serendipitous emergence of the pan-genome concept and its impacts on the fields of microbiology, vaccinology and antimicrobial resistance, to the study of microbial communities, bioinformatic applications and mathematical models that tie in with complex systems and economic theory. Given its scope, the book will appeal to a broad readership interested in population dynamics, evolutionary biology and genomics.
Pan-genomics: Applications, Challenges, and Future Prospects
| Author | : Debmalya Barh |
| Publisher | : Academic Press |
| Total Pages | : 476 |
| Release | : 2020-03-06 |
| Genre | : Science |
| ISBN | : 0128170778 |
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Pan-genomics: Applications, Challenges, and Future Prospects covers current approaches, challenges and future prospects of pan-genomics. The book discusses bioinformatics tools and their applications and focuses on bacterial comparative genomics in order to leverage the development of precise drugs and treatments for specific organisms. The book is divided into three sections: the first, an "overview of pan-genomics and common approaches, brings the main concepts and current approaches on pan-genomics research; the second, “case studies in pan-genomics, thoroughly discusses twelve case, and the last, “current approaches and future prospects in pan-multiomics , encompasses the developments on omics studies to be applied on bacteria related studies. This book is a valuable source for bioinformaticians, genomics researchers and several members of biomedical field interested in understanding further bacterial organisms and their relationship to human health. Covers the entire spectrum of pangenomics, highlighting the use of specific approaches, case studies and future perspectives Discusses current bioinformatics tools and strategies for exploiting pangenomics data Presents twelve case studies with different organisms in order to provide the audience with real examples of pangenomics applicability
Comparative Pangenomics
| Author | : Jason Hyun |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2023 |
| Genre | : |
| ISBN | : |
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Rapid developments in genome sequencing technology have revealed tremendous genetic diversity in the bacterial kingdom. The full genetic repertoire, or pangenome, of any microbial species has been found to be far more expansive than that of any individual organism, and understanding this complexity promises insights into both fundamental and practical questions regarding the diversity of microbial life. This dissertation aims to systematize the analysis of pangenomes to enable comparisons between multiple pangenomes and build generalizable workflows for investigating complex biological phenomena not limited to individual species. First, a robust pipeline for pangenome construction is presented as the foundation of this work and used to identify constants in intraspecies genetic diversity across twelve microbial species. Second, pangenome construction is combined with machine learning to elucidate global patterns of antimicrobial resistance (AMR) and identify novel AMR-conferring gene candidates. Finally, pangenome analysis is scaled to limits of publicly available data to construct and compare the core genomes of 183 species, and integrated with phylogenetics to reconstruct the core genome of the last bacterial common ancestor and identify implications regarding the minimum genetic requirements for life. These results demonstrate how pangenomes can reveal novel facets of genetic diversity previously invisible at smaller scales, and continued development of pangenomics will be necessary to close the gap between the pace of data collection and the pace of discovery.
The Pangenome
| Author | : Hervé Tettelin |
| Publisher | : |
| Total Pages | : 310 |
| Release | : 2020-10-09 |
| Genre | : Science |
| ISBN | : 9781013277078 |
Download The Pangenome Book in PDF, ePub and Kindle
This open access book offers the first comprehensive account of the pan-genome concept and its manifold implications. The realization that the genetic repertoire of a biological species always encompasses more than the genome of each individual is one of the earliest examples of big data in biology that opened biology to the unbounded. The study of genetic variation observed within a species challenges existing views and has profound consequences for our understanding of the fundamental mechanisms underpinning bacterial biology and evolution. The underlying rationale extends well beyond the initial prokaryotic focus to all kingdoms of life and evolves into similar concepts for metagenomes, phenomes and epigenomes. The book's respective chapters address a range of topics, from the serendipitous emergence of the pan-genome concept and its impacts on the fields of microbiology, vaccinology and antimicrobial resistance, to the study of microbial communities, bioinformatic applications and mathematical models that tie in with complex systems and economic theory. Given its scope, the book will appeal to a broad readership interested in population dynamics, evolutionary biology and genomics. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.
The Pangenome
| Author | : Hervé Tettelin |
| Publisher | : Springer |
| Total Pages | : 307 |
| Release | : 2020-09-18 |
| Genre | : Science |
| ISBN | : 9783030382834 |
Download The Pangenome Book in PDF, ePub and Kindle
This open access book offers the first comprehensive account of the pan-genome concept and its manifold implications. The realization that the genetic repertoire of a biological species always encompasses more than the genome of each individual is one of the earliest examples of big data in biology that opened biology to the unbounded. The study of genetic variation observed within a species challenges existing views and has profound consequences for our understanding of the fundamental mechanisms underpinning bacterial biology and evolution. The underlying rationale extends well beyond the initial prokaryotic focus to all kingdoms of life and evolves into similar concepts for metagenomes, phenomes and epigenomes. The book’s respective chapters address a range of topics, from the serendipitous emergence of the pan-genome concept and its impacts on the fields of microbiology, vaccinology and antimicrobial resistance, to the study of microbial communities, bioinformatic applications and mathematical models that tie in with complex systems and economic theory. Given its scope, the book will appeal to a broad readership interested in population dynamics, evolutionary biology and genomics.
Microbial Pathogenomics
| Author | : Hilde de Reuse |
| Publisher | : Karger Medical and Scientific Publishers |
| Total Pages | : 224 |
| Release | : 2009-01-01 |
| Genre | : Medical |
| ISBN | : 3805591926 |
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'Microbial Pathogenomics' contains a unique collection of reviews demonstrating how genomics has revolutionized our understanding of virulence, host-adaptation strategies and the evolution of bacterial pathogens. Current technologies - computational tools and functional approaches to genome analysis - are carefully documented and clearly illustrated. These include visualization tools for genome comparison, databases, in silico metabolic reconstructions and function prediction as well as interactomics for the study of protein-protein interactions. The concepts of pan-genomics and reverse vaccinology are introduced as strategies when addressing the challenge presented by bacterial diversity in the prevention and treatment of infectious diseases. The authors explore individual bacterial pathogens and discuss the mechanisms that have contributed to their evolutionary success. Special cases of host adaptation, for example, are illustrated by Helicobacter pylori and 'Mycobacterium tuberculosis' which are human-specific and highly persistent; further bacteria discussed include 'Escherichia coli, Campylobacter, Pseudomonas, Legionella, Bartonella, Burkholderia' and 'Staphylococcus'.'Microbial Pathogenomics' provides the reader with a global view of key aspects and future trends in bacterial pathogenomics and evaluates their impact on the understanding and treatment of infectious diseases. Well illustrated and accessible to both specialists and nonspecialists, it is recommended not only for researchers in microbiology, genomics and biotechnology, but also for lecturers and teachers.
Visualising the Bacterial Pangenome
| Author | : Joshua D. Harling-Lee |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2023 |
| Genre | : |
| ISBN | : |
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Prokaryotic Genomics
| Author | : Michel Blot |
| Publisher | : Birkhäuser |
| Total Pages | : 220 |
| Release | : 2013-12-01 |
| Genre | : Science |
| ISBN | : 3034889631 |
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Prokaryotic Genomics provides molecular microbiologists in particular and researchers working with bacteria in general with the most important established recipes needed for their work. The volume covers both revisited classical methods and new tools for global analysis such as genomics or proteomics. It is written for those in need of a bench manual to complete their experiments and for those wanting to understand the modern tools used in microbiology.
Structural Approaches to Sequence Evolution
| Author | : Ugo Bastolla |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 375 |
| Release | : 2007-05-26 |
| Genre | : Science |
| ISBN | : 3540353062 |
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Recent advances in understanding the thermodynamics of macromolecules, the topological properties of gene networks, the organization and mutation capabilities of genomes, and the structure of populations make it possible to incorporate these key elements into a broader and deeply interdisciplinary view of molecular evolution. This book gives an account of such a new approach, through clear tutorial contributions by leading scientists.
